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Planned Analysis: Analysis of recurrent fusions #10

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PichaiRaman opened this issue Jul 12, 2019 · 4 comments
Closed

Planned Analysis: Analysis of recurrent fusions #10

PichaiRaman opened this issue Jul 12, 2019 · 4 comments
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fusion Related to or requires fusion data in progress Someone is working on this issue, but feel free to propose an alternative approach!

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@PichaiRaman
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This should probably be partitioned by cancer type and/or molecular subtype. This could be a stacked bar chart (one bar per fusion) for instance with colors representing different cancer types.

@cgreene cgreene changed the title Planned Analysis: Barchart showing recurrent fusions Planned Analysis: Analysis of recurrent fusions Jul 14, 2019
@jharenza
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jharenza commented Jul 25, 2019

@kgaonkar6 and I would like to work on this analysis. We have already created a workflow for annotating and identifying high-confidence fusions from the two fusion algorithms.

@jharenza jharenza added good first issue Good for newcomers in progress Someone is working on this issue, but feel free to propose an alternative approach! labels Jul 28, 2019
@jaclyn-taroni jaclyn-taroni removed the good first issue Good for newcomers label Aug 15, 2019
@kgaonkar6 kgaonkar6 mentioned this issue Aug 29, 2019
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@jharenza
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@kgaonkar6 - for this recurrent analysis, we should pay special attention to samples in which we have diagnosis/relapse pairs (#155) or patient/cell line matched data and should separate/plot differently. For example, we can look at cell line results separately (or exclude from this analysis). For patients with more than one RNA sample, I think we should look into how similar/different they are/if this differs by phase of therapy and think about how to describe this data.

@jaclyn-taroni jaclyn-taroni added the fusion Related to or requires fusion data label Oct 26, 2019
This was referenced Nov 15, 2019
@jharenza
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jharenza commented Dec 5, 2019

@kgaonkar6 - in writing up some comments for @cansavvy for #18, I realize we could use the recurrent fusion list here. Can you possibly create a quick PR to create a table of recurrently-fused genes and recurrent fusions by broad cancer type? I think @cansavvy can perhaps start with that for survival analysis.

@jaclyn-taroni
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Closing all planned analysis tickets in favor of opening new proposed analysis/updated analysis tickets as needed.

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fusion Related to or requires fusion data in progress Someone is working on this issue, but feel free to propose an alternative approach!
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