From bd3a94d3742c5bfad7b3af1577cf49ee07e4add9 Mon Sep 17 00:00:00 2001 From: Krutika Gaonkar Date: Mon, 7 Dec 2020 15:12:20 -0500 Subject: [PATCH 1/9] update to use base histologies file --- .../collapse-rnaseq/02-analyze-drops.nb.html | 24 +++++++++--------- ...ion-rsem-fpkm-collapsed_table.stranded.rds | Bin 520545 -> 520508 bytes .../collapse-rnaseq/run-collapse-rnaseq.sh | 0 3 files changed, 12 insertions(+), 12 deletions(-) mode change 100644 => 100755 analyses/collapse-rnaseq/run-collapse-rnaseq.sh diff --git a/analyses/collapse-rnaseq/02-analyze-drops.nb.html b/analyses/collapse-rnaseq/02-analyze-drops.nb.html index 762abf4039..b9ee257de0 100644 --- a/analyses/collapse-rnaseq/02-analyze-drops.nb.html +++ b/analyses/collapse-rnaseq/02-analyze-drops.nb.html @@ -4642,8 +4642,8 @@

Annotation Table

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+ @@ -4655,8 +4655,8 @@

Summary of biotypes that are dropped due to zero expression:

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+ @@ -4668,8 +4668,8 @@

Summary of biotypes that are dropped due to merging multiple Ensembl identif -
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+ @@ -4684,8 +4684,8 @@

Annotation Table

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+ @@ -4697,8 +4697,8 @@

Summary of biotypes that are dropped due to low expression:

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+ @@ -4710,8 +4710,8 @@

Summary of biotypes that are dropped due to merging multiple Ensembl identif -
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update to use base histology file --- .../00-repeated-samples.Rmd | 9 +++ .../00-repeated-samples.nb.html | 30 ++++++---- ...specimens.rnaseq.primary-plus-stranded.tsv | 58 +++++++++++-------- ...independent-specimens.wgs.primary-plus.tsv | 44 +++++++------- .../independent-specimens.wgs.primary.tsv | 23 ++++---- ...ependent-specimens.wgswxs.primary-plus.tsv | 44 +++++++------- .../independent-specimens.wgswxs.primary.tsv | 23 ++++---- .../run-independent-samples.sh | 19 +++++- 8 files changed, 144 insertions(+), 106 deletions(-) mode change 100644 => 100755 analyses/independent-samples/run-independent-samples.sh diff --git a/analyses/independent-samples/00-repeated-samples.Rmd b/analyses/independent-samples/00-repeated-samples.Rmd index 8d7471493f..81d2d9a5cb 100644 --- a/analyses/independent-samples/00-repeated-samples.Rmd +++ b/analyses/independent-samples/00-repeated-samples.Rmd @@ -4,6 +4,11 @@ output: html_notebook: toc: true toc_float: true +params: + base_run: + label: "1/0 to read pbta-histologies-base.tsv" + value: 0 + input: integer --- ## Purpose @@ -26,7 +31,11 @@ set.seed(201910) ```{r load files} root_dir <- rprojroot::find_root(rprojroot::has_dir(".git")) +if(params$base_run == 0) { sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies.tsv"), guess_max = 10000) +} else { +sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies-base.tsv"), guess_max = 10000) +} ``` ## WGS and WXS samples diff --git a/analyses/independent-samples/00-repeated-samples.nb.html b/analyses/independent-samples/00-repeated-samples.nb.html index 461c3803ba..4ed6a695ce 100644 --- a/analyses/independent-samples/00-repeated-samples.nb.html +++ b/analyses/independent-samples/00-repeated-samples.nb.html @@ -2968,16 +2968,22 @@

Purpose

- + 
root_dir <- rprojroot::find_root(rprojroot::has_dir(".git"))
-sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies.tsv"), guess_max = 10000)
+if(params$base_run == 0) { +sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies.tsv"), guess_max = 10000) +} else { +sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies-base.tsv"), guess_max = 10000) +} - + 
Parsed with column specification:
 cols(
   .default = col_character(),
+  Notes = col_logical(),
   OS_days = col_double(),
   age_last_update_days = col_double(),
+  molecular_subtype = col_logical(),
   normal_fraction = col_double(),
   tumor_fraction = col_double(),
   tumor_ploidy = col_double()
@@ -3013,7 +3019,7 @@ 
WGS and WXS samples

 
 

 
 

 
@@ -3042,7 +3048,7 @@ 
WGS and WXS samples

 
 

 
 

 
@@ -3082,7 +3088,7 @@ 
Derived cell lines

 
 

 
 

 
@@ -3105,7 +3111,7 @@ 
Unlabeled composition samples

 
 

 
 

 
@@ -3186,7 +3192,7 @@ 
Summarize repeated samples

 
 

 
 

 
@@ -3209,8 +3215,8 @@ 
Select independent samples

 
 nrow(independents)
- -
[1] 671
+ +
[1] 670
@@ -3225,7 +3231,7 @@

Select independent samples

@@ -3273,7 +3279,7 @@

Session info

-
---
title: "Repeated sample analysis"
output: 
  html_notebook:
    toc: true
    toc_float: true
---

## Purpose

There are many specimens in the full dataset that are repeated samples from the same participants.
This workbook is a quick summary of those samples, so that we can better select a unique set of specimens for downstream analysis. 
This is particularly important for analyses such as mutation co-occurence, where repeated sampling will inflate apparent co-ocurrence measures.


```{r setup}
# load libraries
library(dplyr)

# source sample selection funciton
source("independent-samples.R")

set.seed(201910)
```


```{r load files}
root_dir <- rprojroot::find_root(rprojroot::has_dir(".git"))
sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies.tsv"), guess_max = 10000)
```

## WGS and WXS samples
Sort to just sequencing samples of tumors
```{r}
seq_samples <- sample_df %>%
  filter(experimental_strategy %in% c("WGS", "WXS"), 
         sample_type == "Tumor")
```

How many WGS, how many WXS, summarize #s of samples and participants by 
```{r}
seq_samples %>%
  group_by(experimental_strategy, composition, tumor_descriptor) %>%
  summarise(samples = length(unique(Kids_First_Biospecimen_ID)),
            participants = length(unique(Kids_First_Participant_ID)), 
  ) 
```

~~What if we reduce to the earliest sample for each participant?~~
Note: this analysis was based on an earlier version of the data where `age_at_diagnosis_days` was not uniform across samples and was presumed to indicate sampling date. 
This was incorrect.
All samples from an individual now have the same `age_at_diagnosis_days`.

```{r}
early_samples <- seq_samples %>%
  group_by(Kids_First_Participant_ID) %>%
  summarize(age_at_diagnosis_days = min(age_at_diagnosis_days)) %>%
  left_join(seq_samples) %>%
  pull(Kids_First_Biospecimen_ID) %>%
  unique()

seq_samples %>% 
  filter(Kids_First_Biospecimen_ID %in% early_samples) %>%
  group_by(experimental_strategy, composition, tumor_descriptor) %>%
  summarise(samples = length(unique(Kids_First_Biospecimen_ID)),
            participants = length(unique(Kids_First_Participant_ID)), 
  )
```

There are still many samples for which there are more samples than participants, indicating duplicates, even among the earliest samples.


## Derived cell lines

Are there any samples for which we only have derived cell lines?

```{r}
derived_participants <- seq_samples %>%
  filter(composition == "Derived Cell Line") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

non_derived_participants <- seq_samples %>% 
  filter(composition != "Derived Cell Line") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

notissue_participants  <- derived_participants[!(derived_participants %in% non_derived_participants)]
length(notissue_participants)

```

Looks like there is a cell line sample with no corresponding tumor.

```{r}
seq_samples %>%
  filter(Kids_First_Participant_ID %in% notissue_participants)
```

Since this is only one sample it seems like the best move will be to remove all derived cell lines.

## Unlabeled composition samples

~~9 samples are listed as "Not Reported" for `composition`.~~ 
What are these, and do we have correponding samples for which composition is known?
*This has apparently been fixed in later updates*

```{r}
notreported_participants <- seq_samples %>%
  filter(composition == "Not Reported") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

seq_samples %>% 
  filter(Kids_First_Participant_ID %in% notreported_participants)
```

~~In one case (`PT_N8W26H19`), we do have Solid Tissue samples, but not for the others.~~
Should these samples be included in further analysis?

## WGS vs WXS
```{r}
WXS_participants <- seq_samples %>%
  filter(experimental_strategy == "WXS") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

WGS_participants <- seq_samples %>%
  filter(experimental_strategy == "WGS") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

No_WGS <- WXS_participants[!(WXS_participants %in% WGS_participants)]

length(No_WGS)
```

So there are currently 16 samples with missing WGS data, but that may change in a future release.

Just to check, is this still true when we restrict to early samples?
```{r}
WXS_participants <- seq_samples %>%
  filter(experimental_strategy == "WXS", 
         Kids_First_Biospecimen_ID %in% early_samples) %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

WGS_participants <- seq_samples %>%
  filter(experimental_strategy == "WGS", 
         Kids_First_Biospecimen_ID %in% early_samples) %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

No_WGS <- WXS_participants[!(WXS_participants %in% WGS_participants)]

length(No_WGS)
```

No change. For now, we will look only at WGS samples, but this could be adjusted in future analysis.



## Summarize repeated samples

```{r}
repeat_samples <- seq_samples %>% 
  dplyr::filter(Kids_First_Biospecimen_ID %in% early_samples, 
                experimental_strategy == "WGS") %>%
  dplyr::filter(composition != "Derived Cell Line") %>%
  dplyr::filter(Kids_First_Participant_ID %in% 
                  Kids_First_Participant_ID[duplicated(Kids_First_Participant_ID)])

repeat_samples %>% 
  group_by(Kids_First_Participant_ID) %>%
  summarise(samples = paste(Kids_First_Biospecimen_ID, collapse = ", "), 
         descriptors = paste(sort(unique(tumor_descriptor)),  collapse = ", "),
         age_diagnosis = paste(sort(unique(age_at_diagnosis_days)), collapse = ", "),
         experimental_stragegy = paste(sort(unique(experimental_strategy)), collapse = ", ")
  )
```


## Select independent samples

Using the information described above, I created a function `independent_samples()`
to select the earliest biospecimen from each participant, or in the case of more 
than one with the same date, randomly select among the available samples.

An example of this function is below, applied to the WGS Solid Tissue tumor samples.
Note that in this case, only tumors designated as primary will be included, 
though this can be adjusted with `tumor_types = "prefer_primary"` or 
`tumor_types = "any"` if we want to be less presecriptive. As of v5, primary tumors
are defined as those designated "Initial CNS Tumor" or "Diagnosis" in the
`tumor_descriptor` field.

In the accompanying script, I will generate both `primary_only` and `primary_plus` 
sets using the `"primary"` and `"prefer_primary"` resepectively.



```{r}
independents <- sample_df %>%
  filter(experimental_strategy == "WGS",
         sample_type == "Tumor", 
         composition == "Solid Tissue"
         ) %>%
  independent_samples(tumor_types = "primary")

nrow(independents)
```

Just for reference, lets see what tumor types we end up with in this set:

```{r}
sample_df %>% 
  filter(Kids_First_Biospecimen_ID %in% independents$Kids_First_Biospecimen_ID) %>%
  group_by(broad_histology) %>%
  summarize(n = n())
```



### Session info

```{r}
sessionInfo()
```

+
---
title: "Repeated sample analysis"
output: 
  html_notebook:
    toc: true
    toc_float: true
params:
  base_run:
    label: "1/0 to read pbta-histologies-base.tsv" 
    value: 0
    input: integer
---

## Purpose

There are many specimens in the full dataset that are repeated samples from the same participants.
This workbook is a quick summary of those samples, so that we can better select a unique set of specimens for downstream analysis. 
This is particularly important for analyses such as mutation co-occurence, where repeated sampling will inflate apparent co-ocurrence measures.


```{r setup}
# load libraries
library(dplyr)

# source sample selection funciton
source("independent-samples.R")

set.seed(201910)
```


```{r load files}
root_dir <- rprojroot::find_root(rprojroot::has_dir(".git"))
if(params$base_run == 0) {
sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies.tsv"), guess_max = 10000)
} else {
sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies-base.tsv"), guess_max = 10000)
}
```

## WGS and WXS samples
Sort to just sequencing samples of tumors
```{r}
seq_samples <- sample_df %>%
  filter(experimental_strategy %in% c("WGS", "WXS"), 
         sample_type == "Tumor")
```

How many WGS, how many WXS, summarize #s of samples and participants by 
```{r}
seq_samples %>%
  group_by(experimental_strategy, composition, tumor_descriptor) %>%
  summarise(samples = length(unique(Kids_First_Biospecimen_ID)),
            participants = length(unique(Kids_First_Participant_ID)), 
  ) 
```

~~What if we reduce to the earliest sample for each participant?~~
Note: this analysis was based on an earlier version of the data where `age_at_diagnosis_days` was not uniform across samples and was presumed to indicate sampling date. 
This was incorrect.
All samples from an individual now have the same `age_at_diagnosis_days`.

```{r}
early_samples <- seq_samples %>%
  group_by(Kids_First_Participant_ID) %>%
  summarize(age_at_diagnosis_days = min(age_at_diagnosis_days)) %>%
  left_join(seq_samples) %>%
  pull(Kids_First_Biospecimen_ID) %>%
  unique()

seq_samples %>% 
  filter(Kids_First_Biospecimen_ID %in% early_samples) %>%
  group_by(experimental_strategy, composition, tumor_descriptor) %>%
  summarise(samples = length(unique(Kids_First_Biospecimen_ID)),
            participants = length(unique(Kids_First_Participant_ID)), 
  )
```

There are still many samples for which there are more samples than participants, indicating duplicates, even among the earliest samples.


## Derived cell lines

Are there any samples for which we only have derived cell lines?

```{r}
derived_participants <- seq_samples %>%
  filter(composition == "Derived Cell Line") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

non_derived_participants <- seq_samples %>% 
  filter(composition != "Derived Cell Line") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

notissue_participants  <- derived_participants[!(derived_participants %in% non_derived_participants)]
length(notissue_participants)

```

Looks like there is a cell line sample with no corresponding tumor.

```{r}
seq_samples %>%
  filter(Kids_First_Participant_ID %in% notissue_participants)
```

Since this is only one sample it seems like the best move will be to remove all derived cell lines.

## Unlabeled composition samples

~~9 samples are listed as "Not Reported" for `composition`.~~ 
What are these, and do we have correponding samples for which composition is known?
*This has apparently been fixed in later updates*

```{r}
notreported_participants <- seq_samples %>%
  filter(composition == "Not Reported") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

seq_samples %>% 
  filter(Kids_First_Participant_ID %in% notreported_participants)
```

~~In one case (`PT_N8W26H19`), we do have Solid Tissue samples, but not for the others.~~
Should these samples be included in further analysis?

## WGS vs WXS
```{r}
WXS_participants <- seq_samples %>%
  filter(experimental_strategy == "WXS") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

WGS_participants <- seq_samples %>%
  filter(experimental_strategy == "WGS") %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

No_WGS <- WXS_participants[!(WXS_participants %in% WGS_participants)]

length(No_WGS)
```

So there are currently 16 samples with missing WGS data, but that may change in a future release.

Just to check, is this still true when we restrict to early samples?
```{r}
WXS_participants <- seq_samples %>%
  filter(experimental_strategy == "WXS", 
         Kids_First_Biospecimen_ID %in% early_samples) %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

WGS_participants <- seq_samples %>%
  filter(experimental_strategy == "WGS", 
         Kids_First_Biospecimen_ID %in% early_samples) %>%
  pull(Kids_First_Participant_ID) %>%
  unique() 

No_WGS <- WXS_participants[!(WXS_participants %in% WGS_participants)]

length(No_WGS)
```

No change. For now, we will look only at WGS samples, but this could be adjusted in future analysis.



## Summarize repeated samples

```{r}
repeat_samples <- seq_samples %>% 
  dplyr::filter(Kids_First_Biospecimen_ID %in% early_samples, 
                experimental_strategy == "WGS") %>%
  dplyr::filter(composition != "Derived Cell Line") %>%
  dplyr::filter(Kids_First_Participant_ID %in% 
                  Kids_First_Participant_ID[duplicated(Kids_First_Participant_ID)])

repeat_samples %>% 
  group_by(Kids_First_Participant_ID) %>%
  summarise(samples = paste(Kids_First_Biospecimen_ID, collapse = ", "), 
         descriptors = paste(sort(unique(tumor_descriptor)),  collapse = ", "),
         age_diagnosis = paste(sort(unique(age_at_diagnosis_days)), collapse = ", "),
         experimental_stragegy = paste(sort(unique(experimental_strategy)), collapse = ", ")
  )
```


## Select independent samples

Using the information described above, I created a function `independent_samples()`
to select the earliest biospecimen from each participant, or in the case of more 
than one with the same date, randomly select among the available samples.

An example of this function is below, applied to the WGS Solid Tissue tumor samples.
Note that in this case, only tumors designated as primary will be included, 
though this can be adjusted with `tumor_types = "prefer_primary"` or 
`tumor_types = "any"` if we want to be less presecriptive. As of v5, primary tumors
are defined as those designated "Initial CNS Tumor" or "Diagnosis" in the
`tumor_descriptor` field.

In the accompanying script, I will generate both `primary_only` and `primary_plus` 
sets using the `"primary"` and `"prefer_primary"` resepectively.



```{r}
independents <- sample_df %>%
  filter(experimental_strategy == "WGS",
         sample_type == "Tumor", 
         composition == "Solid Tissue"
         ) %>%
  independent_samples(tumor_types = "primary")

nrow(independents)
```

Just for reference, lets see what tumor types we end up with in this set:

```{r}
sample_df %>% 
  filter(Kids_First_Biospecimen_ID %in% independents$Kids_First_Biospecimen_ID) %>%
  group_by(broad_histology) %>%
  summarize(n = n())
```



### Session info

```{r}
sessionInfo()
```

diff --git a/analyses/independent-samples/results/independent-specimens.rnaseq.primary-plus-stranded.tsv b/analyses/independent-samples/results/independent-specimens.rnaseq.primary-plus-stranded.tsv index 827be01b89..7e3d01f642 100644 --- a/analyses/independent-samples/results/independent-specimens.rnaseq.primary-plus-stranded.tsv +++ b/analyses/independent-samples/results/independent-specimens.rnaseq.primary-plus-stranded.tsv @@ -37,7 +37,7 @@ PT_1DRAVX4S BS_Q9V7A95C PT_1DSX4VJM BS_Q13FQ8FV PT_1DY2TP9N BS_E4F1D721 PT_1EB5KHZX BS_SBFNFZ8B -PT_1H2REHT2 BS_WKESC3XN +PT_1H2REHT2 BS_E0N3PTPN PT_1J2DT6MM BS_GHNJ4CYC PT_1KEER2Q1 BS_YY5B2XDD PT_1MW98VR1 BS_6H1C1ME9 @@ -78,7 +78,7 @@ PT_2QZJ4T95 BS_B1C6GZ84 PT_2SCVQ2N6 BS_NGHK9RZP PT_2VSDT9CK BS_G9XE3N9T PT_2WA5PM32 BS_86Q14TZG -PT_2WVW55DA BS_CXVGG342 +PT_2WVW55DA BS_D8N31T39 PT_2YCHME6S BS_EXYHZ6D4 PT_2YT37G8P BS_VW85Q4XJ PT_2Z7GVDTM BS_DV86M0Y7 @@ -95,6 +95,7 @@ PT_39HBKSGG BS_61E80SD6 PT_3A0B29QT BS_264RCK7G PT_3A2Q62RD BS_RGPSEMHC PT_3A87PCQK BS_JXNZYGCR +PT_3AWKWXEV BS_SB12W1XT PT_3C6QA9MA BS_FW5ECXXK PT_3CHB9PK5 BS_W9N9844Q PT_3CVMBGD7 BS_9SJWWYQ4 @@ -147,7 +148,7 @@ PT_50ZFWMZE BS_X16PENSA PT_54MH6Q46 BS_PN2CE34A PT_57YP9ABV BS_YK6VQ9SJ PT_596H0BQF BS_B24PKKQB -PT_59D00MBQ BS_TM9MH0RP +PT_59D00MBQ BS_ZVWE73JZ PT_59FJRPVX BS_AWH9757B PT_5ABCFCSK BS_A1VEGWTR PT_5AF1501D BS_VMEX27TN @@ -184,7 +185,7 @@ PT_6MB6RED3 BS_ABYF92Z9 PT_6MWPJ96F BS_NPQJ20KX PT_6N1QWCXE BS_4HQ3T2NC PT_6PFFSB6D BS_QBR4WCQ2 -PT_6PP78VNE BS_M85CXHDV +PT_6PP78VNE BS_6VPKXXMR PT_6PYNBA9C BS_NQFH3GZH PT_6Q0NPVP3 BS_5JM573JC PT_6R7AE0P3 BS_MGAMKKBD @@ -232,15 +233,17 @@ PT_8CZ6ANE0 BS_273HKCT4 PT_8ECE2D92 BS_F4E8R9VY PT_8FWP7BR3 BS_TMTV769C PT_8GBF5MTD BS_GMJBGBWB -PT_8GN3TQRM BS_WAXJY4XQ +PT_8GN3TQRM BS_P0QF87WC PT_8GW4J4TD BS_ARFQ1WG3 PT_8M6W215T BS_JR5ATB7G +PT_8P368R5B BS_FXJY0MNH PT_8PV84CNE BS_74G5K7JF PT_8R00BMHH BS_EBMCTR80 PT_8RB3EKNP BS_W9AT0MR7 -PT_8RB7TPS2 BS_HC44ZA0V +PT_8RB7TPS2 BS_3F4FQJMR PT_8SDJXNFR BS_TZ5D0A7R PT_8V3360DR BS_479S95Q6 +PT_8VRZRZ7R BS_8QB4S4VA PT_8WNA6M94 BS_HBJZR69P PT_8XZY6MM1 BS_T4JFN54G PT_90W4HCNR BS_JX449BF5 @@ -253,18 +256,18 @@ PT_99S5BPE3 BS_MT15SGJN PT_9A6RPJ97 BS_4D9DD103 PT_9AHA6KW3 BS_6NTXGQAC PT_9B6KWJT2 BS_Z7Y2466H -PT_9BZETM0M BS_5P1TN10Z +PT_9BZETM0M BS_TV5B86ZD PT_9C2G356W BS_MBSTWZA6 PT_9CSZBV2P BS_YBJBSRHV PT_9D2N4S5Z BS_8SKZ7BRN PT_9DER14KH BS_HE57E1RP -PT_9DMMZ08D BS_3V3KE3VT +PT_9DMMZ08D BS_44A3ES23 PT_9HMVHQEH BS_4CP4T22V PT_9JT1441X BS_7GJT4A6A PT_9M4CQX3M BS_ARBQDTT5 PT_9N0SR1D7 BS_YEW22W35 PT_9P7P6YAQ BS_QB7YGKN1 -PT_9PJR0ZK7 BS_6JHXXVR7 +PT_9PJR0ZK7 BS_KE56MMY0 PT_9S6WMQ92 BS_TW8DQH8J PT_9W4WTVFZ BS_PQVTB6BB PT_9YMRNZHH BS_9NZ2D6AD @@ -290,7 +293,7 @@ PT_ARCM3PXM BS_FYRDYBMZ PT_ATE3YRH5 BS_BPSTSCBJ PT_ATS9XDJ5 BS_JK0VPG1T PT_AWBPNFM5 BS_2AR3AP0N -PT_AWMZ12NP BS_S9929Z8B +PT_AWMZ12NP BS_3H71BH6Q PT_AXMVG8QE BS_K2FHZGTK PT_AXVH36AM BS_1XJ73KBQ PT_AYVKQZRB BS_T0RKFEKR @@ -381,7 +384,7 @@ PT_DPVW4M1W BS_SFRQXM76 PT_DQ3ZCHB6 BS_258RRGDM PT_DQT78GS5 BS_37GTVG4N PT_DTP4MMRA BS_2HN96129 -PT_DW2XRPC9 BS_8ZS9F31R +PT_DW2XRPC9 BS_5CTVXVRX PT_DW6V5V8E BS_EFEZB0ZH PT_DXF7ZZQZ BS_ERJAJ0KA PT_E1TRJP8V BS_HQ5BJ6MW @@ -414,7 +417,7 @@ PT_EW604JB3 BS_SDA4RMMG PT_EXJAEW1M BS_T1QMEH1N PT_EXYXBDGP BS_4BWB0FA0 PT_EYHJQQ8E BS_G7AGNB5G -PT_EYWDFKA7 BS_TYKJ8G2G +PT_EYWDFKA7 BS_J4GQPZS0 PT_EYZ25B99 BS_ZRM0W01M PT_EZEMVRVT BS_F8N6CFQE PT_EZS4SRH6 BS_HD4EJYE3 @@ -440,7 +443,7 @@ PT_FWD7NZQ0 BS_M4NVX721 PT_FXPJM0MW BS_RRAEQZ97 PT_FYECBRPP BS_B1HVNV0T PT_FYPWZBH0 BS_2A5R9MEJ -PT_FZHGKJ0H BS_2SHWPB5P +PT_FZHGKJ0H BS_JBGZ7HHZ PT_FZP24XYK BS_Z8F3GM85 PT_G16WS1MW BS_J60G8DMK PT_G1QNGVCZ BS_A14Z8BBK @@ -503,7 +506,7 @@ PT_J0SZ1SX5 BS_R13X6TMW PT_J302B8Y5 BS_K25F4J3V PT_J3B812DT BS_AMQGM1V9 PT_J4MWGQFQ BS_Q2T9ZRM0 -PT_J50NZYZF BS_B9V8RGTA +PT_J50NZYZF BS_PSNBFWQV PT_J5NSRW1Y BS_GG9W3J9Y PT_JC4DHFJR BS_QB84TBA3 PT_JCECCFPB BS_90B22NGP @@ -518,6 +521,7 @@ PT_JP1FDKN9 BS_T1DVKKJB PT_JPWVCTAJ BS_R244Z0WX PT_JQ45JK94 BS_QH82PBMB PT_JSFBMK5V BS_1A6MQ9ZA +PT_JT9HH7M6 BS_HE0WJRW6 PT_JV9G8MFD BS_9FHSNVS0 PT_JW2FDK4W BS_KVAJYZ6F PT_JW6FBEFK BS_3BVVWHP5 @@ -534,7 +538,7 @@ PT_K8ZV7APT BS_GDHH6T5A PT_K94ZVZMX BS_N4B1SZZH PT_KBA2VNA2 BS_9755PSCS PT_KBDP8ZCR BS_M1PVEHCM -PT_KCTZZA3G BS_ENKG5GF3 +PT_KCTZZA3G BS_TAHV8N04 PT_KDW5HHWQ BS_C7N3J4NW PT_KEQ53KRH BS_K17VQECG PT_KFYJBQB8 BS_52C576HH @@ -548,7 +552,7 @@ PT_KX84KH6K BS_52MPKTJH PT_KXB1PJV0 BS_3Q0GTSYH PT_KZ04SDDS BS_JS95PE0J PT_M04EC74B BS_31TF0P1N -PT_M0AP3Z15 BS_Z7PKVY9J +PT_M0AP3Z15 BS_QEYPFYHD PT_M0FVZ88D BS_THSPSG2Z PT_M1RYN7B0 BS_WVW3W6ZB PT_M2J30CF7 BS_9GJ23RHH @@ -556,8 +560,8 @@ PT_M5HDHQNQ BS_9Q6Z6VJC PT_M7NFAC5G BS_TQ5QHR17 PT_MA0J8DSN BS_VTJ9ESSV PT_MBAXTJET BS_401R3KV0 -PT_MDWPRDBT BS_H0QWRJE2 -PT_MKDQZ17N BS_QP6MSKRE +PT_MDWPRDBT BS_TK84K675 +PT_MKDQZ17N BS_1J2WQ08M PT_MNR94DEV BS_0WVJYM9R PT_MPRBGGEJ BS_S50KQEXV PT_MQHST8YC BS_DRD9QXR5 @@ -585,7 +589,7 @@ PT_NCDHZ8H8 BS_7C40TRCY PT_ND34A6PR BS_DHA5FMVW PT_NDVJE438 BS_4PH1MBGR PT_NEB4WEAT BS_XHCYEE2S -PT_NESAQHB1 BS_QT3NZ2YZ +PT_NESAQHB1 BS_QHS3V0GP PT_NFDHYPGT BS_AG4H9S3J PT_NGDW8WVP BS_W41S7B55 PT_NH8CJ84W BS_C0XFDP38 @@ -629,7 +633,7 @@ PT_Q38AT6JY BS_78QX3XDF PT_Q3EP24V1 BS_06AMMCXR PT_Q90R6M3E BS_5PJCHF6V PT_QAX38GM7 BS_044XZ8ST -PT_QD6KKKJH BS_M7QJ8VF0 +PT_QD6KKKJH BS_7ZV3DPGT PT_QDGVJKE0 BS_A0DYVX9J PT_QEMT1845 BS_1T19NFJ8 PT_QEP13FH4 BS_K3ER45RV @@ -659,7 +663,7 @@ PT_RDJ40M73 BS_1EN5V3XW PT_RFB07MZS BS_TZVFR600 PT_RFF7MKTC BS_5YJEPPTP PT_RFGZ2JGP BS_M84H3KXA -PT_RGX23JFP BS_ZZWMD6FA +PT_RGX23JFP BS_PQ6QEVE8 PT_RH59ET3M BS_EFE4YEK3 PT_RJ1TJ2KH BS_4E1G7E3G PT_RJ98S3KZ BS_DFWFBYSN @@ -676,17 +680,18 @@ PT_RV0RDER2 BS_XKKB4MZV PT_RX1EWBP9 BS_996ZS2A4 PT_RXJZ3C5G BS_8RCR7Y4B PT_RXT6KRR6 BS_NFRXNAFE +PT_RYMG3M91 BS_D7XRFE0R PT_S0PBN4M7 BS_RWJZFTP9 PT_S0Q27J13 BS_Z8YZ6QGS PT_S21ZTKPS BS_014EVM2D PT_S2ASFBP7 BS_A7MC2KR2 PT_S2BEPYQ0 BS_JRYJGYC4 PT_S2CXXZCF BS_Y0PCBNJV -PT_S2SQJVGK BS_S458NMKH +PT_S2SQJVGK BS_JFR750KD PT_S3FJSBJT BS_ZV9Z3SY6 PT_S4A0R1PM BS_M15PW2N0 PT_S4H6KA09 BS_07ANYSYQ -PT_S4YNE17X BS_VXEFKW5P +PT_S4YNE17X BS_GR46VD0Q PT_S7WJ99PC BS_AVYNZHSB PT_S8E3281G BS_TNRHHYNC PT_SA94083W BS_8S86CM61 @@ -748,9 +753,10 @@ PT_VVCN8DXT BS_X4X1SFSE PT_VWZZTK38 BS_TXZ7KHTQ PT_VY45XTT7 BS_AHEFXG7W PT_VZTTTP3Q BS_E4QK839R -PT_W17NV5YG BS_V4W81SFC +PT_W17NV5YG BS_TCGEZJ5F PT_W3FSA7NH BS_VARR255N PT_W4XVT4AJ BS_MKM0EEN1 +PT_W5GP3F6B BS_KABQQA0T PT_W6AWJJK7 BS_478TN841 PT_W6CW60K9 BS_NGY0TE6S PT_W7FK539G BS_XBQZYS8G @@ -775,6 +781,7 @@ PT_X1PRY0FC BS_FJWZ3M7V PT_X1XVE1XX BS_A87NPZAP PT_X648RVMK BS_N6N147BY PT_X71D7G5S BS_C6ZZ3FY5 +PT_X7HC5YCY BS_FN07P04C PT_X84SD608 BS_9HA238XS PT_X8S0H6TG BS_1N9XZXGE PT_X8SK8120 BS_DGTPWJ59 @@ -796,7 +803,7 @@ PT_XX2VW3D9 BS_VJVDJABP PT_XXZHRPNM BS_MF9X3PKH PT_XY404K0D BS_8F9BDWY4 PT_Y4FN0XN1 BS_4NWHYH53 -PT_Y572BRC1 BS_EN2VK7NY +PT_Y572BRC1 BS_V0Q1G94N PT_Y5KY6KN9 BS_4QW2S1Q8 PT_Y660CKCB BS_XG0DBWVT PT_Y6Y9JJ9P BS_0WQJP6ZG @@ -824,6 +831,7 @@ PT_YXZPWFVB BS_P78SMRBS PT_YY7CRV21 BS_Z2NWPQKF PT_YZ8A8A36 BS_GSVCN2XC PT_YZME6QCY BS_68BW2163 +PT_Z4BF2NSB BS_SHJA4MR0 PT_Z4GS3ZQQ BS_EVCAC3NH PT_Z4PJA6KT BS_6WP1FHTE PT_Z7YJ7MSM BS_F6V1Y4QS diff --git a/analyses/independent-samples/results/independent-specimens.wgs.primary-plus.tsv b/analyses/independent-samples/results/independent-specimens.wgs.primary-plus.tsv index b8273ec062..9c2579462a 100644 --- a/analyses/independent-samples/results/independent-specimens.wgs.primary-plus.tsv +++ b/analyses/independent-samples/results/independent-specimens.wgs.primary-plus.tsv @@ -37,7 +37,7 @@ PT_1DSX4VJM BS_KYPMZZSY PT_1DY2TP9N BS_376Q9QKG PT_1E3E6GMF BS_7GKF6M85 PT_1EB5KHZX BS_C0YDDQKB -PT_1H2REHT2 BS_96S0VQBN +PT_1H2REHT2 BS_79SYEHY3 PT_1J2DT6MM BS_THH0CE5A PT_1KEER2Q1 BS_F1B71HTZ PT_1MW98VR1 BS_007JTNB8 @@ -65,7 +65,7 @@ PT_2C63FJAM BS_F48RA7QF PT_2CJ31SBX BS_JC2187NA PT_2D1KGV99 BS_CFEWVDG1 PT_2E552BAR BS_6Z213H2V -PT_2ECVKTTQ BS_DW1CYEXP +PT_2ECVKTTQ BS_ERMGD2N5 PT_2FK75B27 BS_B3RH9V17 PT_2FVTD0WR BS_8TFBNHT0 PT_2GPH62JS BS_2VHFP7M8 @@ -75,10 +75,10 @@ PT_2PRV78FX BS_17AXPP1Y PT_2SCVQ2N6 BS_ST3Z2B9B PT_2VSDT9CK BS_CQ8C6X4X PT_2WA5PM32 BS_AJFG2QDD -PT_2WVW55DA BS_NYVVN7SD +PT_2WVW55DA BS_M28HG0NT PT_2Y3R515E BS_5RD8KEED PT_2YCHME6S BS_MZB884N9 -PT_2YT37G8P BS_4QFSH7C4 +PT_2YT37G8P BS_ZJZFT0AJ PT_2Z7GVDTM BS_QYWGB52C PT_2ZXR2PDN BS_93B38HPS PT_32J909WM BS_JDMM2XG4 @@ -92,7 +92,7 @@ PT_3A87PCQK BS_AQECMDPP PT_3AWKWXEV BS_E42SSQGJ PT_3CHB9PK5 BS_20TBZG09 PT_3CVMBGD7 BS_49JD1V3S -PT_3D74J8RZ BS_HGP0PV0D +PT_3D74J8RZ BS_VMZMGB7B PT_3J0ASVHN BS_R9V82BC1 PT_3KK1F95W BS_03SSN1N2 PT_3KM9W8S8 BS_859AV1DB @@ -168,7 +168,7 @@ PT_6DW5NFKX BS_KT9H4B1N PT_6E8JYRXM BS_3R0KN6Z4 PT_6GDPNFA6 BS_XGVSX8BX PT_6MB6RED3 BS_K14VJ1E3 -PT_6MWPJ96F BS_6GV08HTE +PT_6MWPJ96F BS_M8EBKZDG PT_6N1QWCXE BS_D2BZ25FW PT_6N825561 BS_E0S2Y0TS PT_6PFFSB6D BS_4Z6F1HJZ @@ -213,11 +213,11 @@ PT_8CZ6ANE0 BS_4G9Y2VC6 PT_8ECE2D92 BS_GXACEYKB PT_8FWP7BR3 BS_0QEBZX3M PT_8GBF5MTD BS_S7S6YEHA -PT_8GN3TQRM BS_RXSBJ929 +PT_8GN3TQRM BS_S791VC80 PT_8GW4J4TD BS_V8G6BZRR PT_8R00BMHH BS_H50HR85Y PT_8RB3EKNP BS_5KFAEMQJ -PT_8RB7TPS2 BS_8SETK1J4 +PT_8RB7TPS2 BS_ZS1QRMXS PT_8SDJXNFR BS_6Z4WHYDG PT_8V3360DR BS_JVTQD8HH PT_8WNA6M94 BS_090GV72Q @@ -238,10 +238,10 @@ PT_9BZETM0M BS_STNH7YSX PT_9C2G356W BS_1VMBA3BN PT_9DER14KH BS_TNQKJZCP PT_9DMMZ08D BS_FVYBGMG1 -PT_9GKVQ9QS BS_JRFVST47 +PT_9GKVQ9QS BS_3Z40EZHD PT_9HMVHQEH BS_H2K7XX4X PT_9M4CQX3M BS_ZAH4FHV2 -PT_9PJR0ZK7 BS_A1DV9T7G +PT_9PJR0ZK7 BS_WH8KWW5J PT_9S6WMQ92 BS_WY5KYSHJ PT_9XAA8PF6 BS_A9S5HT6P PT_9YMRNZHH BS_F8KR1QWE @@ -329,7 +329,7 @@ PT_DEYCW197 BS_6XP91JM2 PT_DFCZAG9T BS_4NPEMNAD PT_DFQAH7RS BS_ZKFEMJZ8 PT_DFXQFYPV BS_DJEVCH34 -PT_DH8A0SNQ BS_B5Z2XV03 +PT_DH8A0SNQ BS_BYJDRXMK PT_DJ106XYS BS_WJF6ZXWN PT_DMHFS0HX BS_GCQEB05M PT_DMMKT7X1 BS_QMG7XNEW @@ -337,7 +337,7 @@ PT_DNAJYFZT BS_EJ1H9PZY PT_DPVW4M1W BS_SQSH5G7A PT_DQ3ZCHB6 BS_PMSZKZP7 PT_DQT78GS5 BS_69VS8PS1 -PT_DTP4MMRA BS_KH3859M5 +PT_DTP4MMRA BS_NASADC3P PT_DV8XECKA BS_10HD18B8 PT_DW6V5V8E BS_F4D169Q7 PT_DXF7ZZQZ BS_KVYCH9PB @@ -372,7 +372,7 @@ PT_EV71W1JW BS_YETTZ1NC PT_EW604JB3 BS_N8D9FH6M PT_EXJAEW1M BS_4XPPZTGG PT_EYHJQQ8E BS_HW4J7JM8 -PT_EYWDFKA7 BS_5S8VXASX +PT_EYWDFKA7 BS_DAEM3WRX PT_EYX2CP9F BS_8JFMP1T1 PT_EYZ25B99 BS_9E6Q11G2 PT_EZEMVRVT BS_32HAVF6S @@ -399,7 +399,7 @@ PT_FWD7NZQ0 BS_797V83YM PT_FXPJM0MW BS_WQ19Z6MD PT_FYECBRPP BS_WCNPE0AC PT_FYPWZBH0 BS_ZCY4ECNV -PT_FZHGKJ0H BS_NHMPQ8Q1 +PT_FZHGKJ0H BS_5J5VH3X0 PT_G16WS1MW BS_2W200YK5 PT_G1QNGVCZ BS_JK5GTHVG PT_G3AVDN4E BS_RQ5Z7KNW @@ -486,7 +486,7 @@ PT_K63972GG BS_EQE19CB0 PT_K6G6BE6G BS_3108RS7G PT_K8ZV7APT BS_EXTEGB51 PT_K94ZVZMX BS_W3R2DQ86 -PT_KBFM551M BS_9P4NDTKJ +PT_KBFM551M BS_M5FM63EB PT_KCTZZA3G BS_TX2WGF8K PT_KDW5HHWQ BS_QE7WAAKC PT_KEQ53KRH BS_R1G6SG0K @@ -511,10 +511,10 @@ PT_M5HDHQNQ BS_GKN0B47F PT_M9XXJ4GR BS_682Z7WH6 PT_MA0J8DSN BS_T99M7842 PT_MBAXTJET BS_C6GBYR17 -PT_MDWPRDBT BS_1M63B97V +PT_MDWPRDBT BS_D368BNRD PT_MNHMAH0S BS_MJJZJMTK PT_MNR94DEV BS_ZP89F1JY -PT_MNSEJCDM BS_ZSH09N84 +PT_MNSEJCDM BS_CBMAWSAR PT_MPRBGGEJ BS_KYG3H6C6 PT_MQHST8YC BS_2VSN5YC5 PT_MSBPMJ56 BS_40FX713C @@ -541,7 +541,7 @@ PT_NCDHZ8H8 BS_DGG7YE8R PT_ND34A6PR BS_QMHND3QK PT_NDVJE438 BS_FT95T4YP PT_NEB4WEAT BS_0SFXXBQ5 -PT_NESAQHB1 BS_6TMPZKSZ +PT_NESAQHB1 BS_KJTW1RBN PT_NFDHYPGT BS_6KEYD1S4 PT_NGDW8WVP BS_154FP4ZQ PT_NH8CJ84W BS_AM2TZPNS @@ -584,7 +584,7 @@ PT_Q3EP24V1 BS_235QEYMQ PT_Q90R6M3E BS_XGMXJKFX PT_QA9WJ679 BS_7PF3C1P7 PT_QAX38GM7 BS_QD22MJJ5 -PT_QD6KKKJH BS_B91XGSA5 +PT_QD6KKKJH BS_9BN45DFK PT_QDGVJKE0 BS_EP25TTAG PT_QEMT1845 BS_TPX7YY57 PT_QEP13FH4 BS_Y5DA59M3 @@ -612,7 +612,7 @@ PT_RDJ40M73 BS_928HWFFM PT_RFB07MZS BS_N4B3WB8W PT_RFF7MKTC BS_PP4WJBNR PT_RFGZ2JGP BS_9CMJ3QF6 -PT_RGX23JFP BS_SYGKQD8M +PT_RGX23JFP BS_XW26N96W PT_RH59ET3M BS_KRYYDC2X PT_RJ1TJ2KH BS_6GN1FGTB PT_RJ98S3KZ BS_MEPW36WF @@ -637,7 +637,7 @@ PT_S2SQJVGK BS_8S2CZBA6 PT_S3FJSBJT BS_X9PJ715R PT_S4A0R1PM BS_1S2BHJ8K PT_S4H6KA09 BS_K6A9Z04J -PT_S4YNE17X BS_3MYQP7P5 +PT_S4YNE17X BS_CRKBDAYZ PT_S7WJ99PC BS_W9P0PFDH PT_S7YHNHSS BS_KSRYKCDE PT_S8E3281G BS_55N7KFHW @@ -748,7 +748,7 @@ PT_XX2VW3D9 BS_0J5GC803 PT_XXZHRPNM BS_SMCPASF0 PT_XY404K0D BS_6SA5B35V PT_Y32AQSEY BS_MDVMT75X -PT_Y572BRC1 BS_JA3XXP1Y +PT_Y572BRC1 BS_042DVDQM PT_Y5KY6KN9 BS_AYPBAHJ6 PT_Y660CKCB BS_FKQ7F6D1 PT_Y76A7PBA BS_M4E4H6NG diff --git a/analyses/independent-samples/results/independent-specimens.wgs.primary.tsv b/analyses/independent-samples/results/independent-specimens.wgs.primary.tsv index ccf59346ae..62acedffc8 100644 --- a/analyses/independent-samples/results/independent-specimens.wgs.primary.tsv +++ b/analyses/independent-samples/results/independent-specimens.wgs.primary.tsv @@ -40,7 +40,6 @@ PT_1NN9AW39 BS_8D52JK1Q PT_1T7WF5S1 BS_HSYF7G2D PT_1TB2V1PH BS_JM979K1M PT_1TGKS073 BS_CGCNC41M -PT_1VQWQ0TC BS_QXZTRMWM PT_1Z015H6V BS_A3EV6FXK PT_1ZAWNGWT BS_4DTX295Z PT_203ZY782 BS_BVD7PWP5 @@ -53,7 +52,7 @@ PT_2BTC5TEN BS_AQQY8HMR PT_2C63FJAM BS_F48RA7QF PT_2CJ31SBX BS_JC2187NA PT_2D1KGV99 BS_CFEWVDG1 -PT_2E552BAR BS_6Z213H2V +PT_2E552BAR BS_E8MC6R2K PT_2FK75B27 BS_B3RH9V17 PT_2FVTD0WR BS_8TFBNHT0 PT_2GPH62JS BS_2VHFP7M8 @@ -113,7 +112,7 @@ PT_4XWYZYJS BS_VHD4ARSG PT_4Z34K4XB BS_P36C0ABE PT_50ZFWMZE BS_4P25NNZD PT_54MH6Q46 BS_AXM96K20 -PT_59D00MBQ BS_3E5C1PN1 +PT_59D00MBQ BS_QG6V29H7 PT_59FJRPVX BS_WJB33V17 PT_5ABCFCSK BS_APAQ2X2S PT_5BWZA0NT BS_BFDEZK1C @@ -140,7 +139,7 @@ PT_6DW5NFKX BS_KT9H4B1N PT_6E8JYRXM BS_3R0KN6Z4 PT_6GDPNFA6 BS_XGVSX8BX PT_6MB6RED3 BS_K14VJ1E3 -PT_6MWPJ96F BS_M8EBKZDG +PT_6MWPJ96F BS_6GV08HTE PT_6N1QWCXE BS_D2BZ25FW PT_6PFFSB6D BS_4Z6F1HJZ PT_6Q0NPVP3 BS_E5H6CFYT @@ -160,7 +159,7 @@ PT_7F3ZPZB7 BS_FXDY881S PT_7F485CXV BS_1RF75MK2 PT_7FQ6VECA BS_Y7CA8B5R PT_7FZ8SE69 BS_KHSYAB3J -PT_7JQ24F35 BS_1135HC0V +PT_7JQ24F35 BS_WD7AQV83 PT_7KBMN6C2 BS_HZHEF797 PT_7KTAH3RD BS_ZJT1REVB PT_7M2PGCBV BS_QRH793AV @@ -185,7 +184,7 @@ PT_8GBF5MTD BS_S7S6YEHA PT_8GW4J4TD BS_V8G6BZRR PT_8R00BMHH BS_H50HR85Y PT_8RB3EKNP BS_5KFAEMQJ -PT_8RB7TPS2 BS_8SETK1J4 +PT_8RB7TPS2 BS_ZS1QRMXS PT_8V3360DR BS_JVTQD8HH PT_8WNA6M94 BS_090GV72Q PT_8XZY6MM1 BS_WB8P21ED @@ -281,7 +280,7 @@ PT_DMHFS0HX BS_GCQEB05M PT_DMMKT7X1 BS_QMG7XNEW PT_DQ3ZCHB6 BS_PMSZKZP7 PT_DQT78GS5 BS_69VS8PS1 -PT_DTP4MMRA BS_NASADC3P +PT_DTP4MMRA BS_KH3859M5 PT_DV8XECKA BS_10HD18B8 PT_DW6V5V8E BS_F4D169Q7 PT_DXF7ZZQZ BS_KVYCH9PB @@ -311,7 +310,7 @@ PT_EV71W1JW BS_YETTZ1NC PT_EW604JB3 BS_N8D9FH6M PT_EXJAEW1M BS_4XPPZTGG PT_EYHJQQ8E BS_HW4J7JM8 -PT_EYWDFKA7 BS_5S8VXASX +PT_EYWDFKA7 BS_DAEM3WRX PT_EYZ25B99 BS_9E6Q11G2 PT_EZEMVRVT BS_32HAVF6S PT_EZS4SRH6 BS_X1R0N8QS @@ -334,7 +333,7 @@ PT_FWD7NZQ0 BS_797V83YM PT_FXPJM0MW BS_WQ19Z6MD PT_FYECBRPP BS_WCNPE0AC PT_FYPWZBH0 BS_ZCY4ECNV -PT_FZHGKJ0H BS_NHMPQ8Q1 +PT_FZHGKJ0H BS_5J5VH3X0 PT_G1QNGVCZ BS_JK5GTHVG PT_G3AVDN4E BS_RQ5Z7KNW PT_G5RA8E3N BS_BAVWP5JG @@ -418,7 +417,7 @@ PT_KHX1WQ4H BS_BNFCXVYZ PT_KMHGNCNR BS_E7HEQZ1K PT_KN25EYMG BS_PVYMDM18 PT_KQK98ZVP BS_YMDPFK0V -PT_KTRJ8TFY BS_3VKW5988 +PT_KTRJ8TFY BS_BQ81D2BP PT_KVFS3Z2Q BS_9JVGXA2W PT_KVMF5TFW BS_8FSJDG2T PT_KXB1PJV0 BS_6Q9PMNWY @@ -532,7 +531,7 @@ PT_S2ASFBP7 BS_969K7ZM1 PT_S2CXXZCF BS_KVV3G6NP PT_S4A0R1PM BS_1S2BHJ8K PT_S4H6KA09 BS_K6A9Z04J -PT_S4YNE17X BS_93BV8AY9 +PT_S4YNE17X BS_3MYQP7P5 PT_S7WJ99PC BS_W9P0PFDH PT_S7YHNHSS BS_KSRYKCDE PT_S8E3281G BS_55N7KFHW @@ -593,7 +592,7 @@ PT_VTF65Y63 BS_MSGYZ69T PT_VVCN8DXT BS_MSB1RDAJ PT_VY45XTT7 BS_ZV21J6YW PT_VZTTTP3Q BS_16FT8V4B -PT_W17NV5YG BS_FVPMPMRJ +PT_W17NV5YG BS_B4DY7ET3 PT_W6AWJJK7 BS_9HEMB7RK PT_W6CW60K9 BS_ZX1YPQ88 PT_W7FK539G BS_25VZM81R diff --git a/analyses/independent-samples/results/independent-specimens.wgswxs.primary-plus.tsv b/analyses/independent-samples/results/independent-specimens.wgswxs.primary-plus.tsv index df235df31d..fd9eafb4f8 100644 --- a/analyses/independent-samples/results/independent-specimens.wgswxs.primary-plus.tsv +++ b/analyses/independent-samples/results/independent-specimens.wgswxs.primary-plus.tsv @@ -37,7 +37,7 @@ PT_1DSX4VJM BS_KYPMZZSY PT_1DY2TP9N BS_376Q9QKG PT_1E3E6GMF BS_7GKF6M85 PT_1EB5KHZX BS_C0YDDQKB -PT_1H2REHT2 BS_96S0VQBN +PT_1H2REHT2 BS_79SYEHY3 PT_1J2DT6MM BS_THH0CE5A PT_1KEER2Q1 BS_F1B71HTZ PT_1MW98VR1 BS_007JTNB8 @@ -65,7 +65,7 @@ PT_2C63FJAM BS_F48RA7QF PT_2CJ31SBX BS_JC2187NA PT_2D1KGV99 BS_CFEWVDG1 PT_2E552BAR BS_6Z213H2V -PT_2ECVKTTQ BS_DW1CYEXP +PT_2ECVKTTQ BS_ERMGD2N5 PT_2FK75B27 BS_B3RH9V17 PT_2FVTD0WR BS_8TFBNHT0 PT_2GPH62JS BS_2VHFP7M8 @@ -75,10 +75,10 @@ PT_2PRV78FX BS_17AXPP1Y PT_2SCVQ2N6 BS_ST3Z2B9B PT_2VSDT9CK BS_CQ8C6X4X PT_2WA5PM32 BS_AJFG2QDD -PT_2WVW55DA BS_NYVVN7SD +PT_2WVW55DA BS_M28HG0NT PT_2Y3R515E BS_5RD8KEED PT_2YCHME6S BS_MZB884N9 -PT_2YT37G8P BS_4QFSH7C4 +PT_2YT37G8P BS_ZJZFT0AJ PT_2Z7GVDTM BS_QYWGB52C PT_2ZXR2PDN BS_93B38HPS PT_32J909WM BS_JDMM2XG4 @@ -92,7 +92,7 @@ PT_3A87PCQK BS_AQECMDPP PT_3AWKWXEV BS_E42SSQGJ PT_3CHB9PK5 BS_20TBZG09 PT_3CVMBGD7 BS_49JD1V3S -PT_3D74J8RZ BS_HGP0PV0D +PT_3D74J8RZ BS_VMZMGB7B PT_3J0ASVHN BS_R9V82BC1 PT_3KK1F95W BS_03SSN1N2 PT_3KM9W8S8 BS_859AV1DB @@ -168,7 +168,7 @@ PT_6DW5NFKX BS_KT9H4B1N PT_6E8JYRXM BS_3R0KN6Z4 PT_6GDPNFA6 BS_XGVSX8BX PT_6MB6RED3 BS_K14VJ1E3 -PT_6MWPJ96F BS_6GV08HTE +PT_6MWPJ96F BS_M8EBKZDG PT_6N1QWCXE BS_D2BZ25FW PT_6N825561 BS_E0S2Y0TS PT_6PFFSB6D BS_4Z6F1HJZ @@ -213,11 +213,11 @@ PT_8CZ6ANE0 BS_4G9Y2VC6 PT_8ECE2D92 BS_GXACEYKB PT_8FWP7BR3 BS_0QEBZX3M PT_8GBF5MTD BS_S7S6YEHA -PT_8GN3TQRM BS_RXSBJ929 +PT_8GN3TQRM BS_S791VC80 PT_8GW4J4TD BS_V8G6BZRR PT_8R00BMHH BS_H50HR85Y PT_8RB3EKNP BS_5KFAEMQJ -PT_8RB7TPS2 BS_8SETK1J4 +PT_8RB7TPS2 BS_ZS1QRMXS PT_8SDJXNFR BS_6Z4WHYDG PT_8V3360DR BS_JVTQD8HH PT_8WNA6M94 BS_090GV72Q @@ -238,10 +238,10 @@ PT_9BZETM0M BS_STNH7YSX PT_9C2G356W BS_1VMBA3BN PT_9DER14KH BS_TNQKJZCP PT_9DMMZ08D BS_FVYBGMG1 -PT_9GKVQ9QS BS_JRFVST47 +PT_9GKVQ9QS BS_3Z40EZHD PT_9HMVHQEH BS_H2K7XX4X PT_9M4CQX3M BS_ZAH4FHV2 -PT_9PJR0ZK7 BS_A1DV9T7G +PT_9PJR0ZK7 BS_WH8KWW5J PT_9S6WMQ92 BS_WY5KYSHJ PT_9XAA8PF6 BS_A9S5HT6P PT_9YMRNZHH BS_F8KR1QWE @@ -329,7 +329,7 @@ PT_DEYCW197 BS_6XP91JM2 PT_DFCZAG9T BS_4NPEMNAD PT_DFQAH7RS BS_ZKFEMJZ8 PT_DFXQFYPV BS_DJEVCH34 -PT_DH8A0SNQ BS_B5Z2XV03 +PT_DH8A0SNQ BS_BYJDRXMK PT_DJ106XYS BS_WJF6ZXWN PT_DMHFS0HX BS_GCQEB05M PT_DMMKT7X1 BS_QMG7XNEW @@ -337,7 +337,7 @@ PT_DNAJYFZT BS_EJ1H9PZY PT_DPVW4M1W BS_SQSH5G7A PT_DQ3ZCHB6 BS_PMSZKZP7 PT_DQT78GS5 BS_69VS8PS1 -PT_DTP4MMRA BS_KH3859M5 +PT_DTP4MMRA BS_NASADC3P PT_DV8XECKA BS_10HD18B8 PT_DW6V5V8E BS_F4D169Q7 PT_DXF7ZZQZ BS_KVYCH9PB @@ -372,7 +372,7 @@ PT_EV71W1JW BS_YETTZ1NC PT_EW604JB3 BS_N8D9FH6M PT_EXJAEW1M BS_4XPPZTGG PT_EYHJQQ8E BS_HW4J7JM8 -PT_EYWDFKA7 BS_5S8VXASX +PT_EYWDFKA7 BS_DAEM3WRX PT_EYX2CP9F BS_8JFMP1T1 PT_EYZ25B99 BS_9E6Q11G2 PT_EZEMVRVT BS_32HAVF6S @@ -399,7 +399,7 @@ PT_FWD7NZQ0 BS_797V83YM PT_FXPJM0MW BS_WQ19Z6MD PT_FYECBRPP BS_WCNPE0AC PT_FYPWZBH0 BS_ZCY4ECNV -PT_FZHGKJ0H BS_NHMPQ8Q1 +PT_FZHGKJ0H BS_5J5VH3X0 PT_G16WS1MW BS_2W200YK5 PT_G1QNGVCZ BS_JK5GTHVG PT_G3AVDN4E BS_RQ5Z7KNW @@ -486,7 +486,7 @@ PT_K63972GG BS_EQE19CB0 PT_K6G6BE6G BS_3108RS7G PT_K8ZV7APT BS_EXTEGB51 PT_K94ZVZMX BS_W3R2DQ86 -PT_KBFM551M BS_9P4NDTKJ +PT_KBFM551M BS_M5FM63EB PT_KCTZZA3G BS_TX2WGF8K PT_KDW5HHWQ BS_QE7WAAKC PT_KEQ53KRH BS_R1G6SG0K @@ -511,10 +511,10 @@ PT_M5HDHQNQ BS_GKN0B47F PT_M9XXJ4GR BS_682Z7WH6 PT_MA0J8DSN BS_T99M7842 PT_MBAXTJET BS_C6GBYR17 -PT_MDWPRDBT BS_1M63B97V +PT_MDWPRDBT BS_D368BNRD PT_MNHMAH0S BS_MJJZJMTK PT_MNR94DEV BS_ZP89F1JY -PT_MNSEJCDM BS_ZSH09N84 +PT_MNSEJCDM BS_CBMAWSAR PT_MPRBGGEJ BS_KYG3H6C6 PT_MQHST8YC BS_2VSN5YC5 PT_MSBPMJ56 BS_40FX713C @@ -541,7 +541,7 @@ PT_NCDHZ8H8 BS_DGG7YE8R PT_ND34A6PR BS_QMHND3QK PT_NDVJE438 BS_FT95T4YP PT_NEB4WEAT BS_0SFXXBQ5 -PT_NESAQHB1 BS_6TMPZKSZ +PT_NESAQHB1 BS_KJTW1RBN PT_NFDHYPGT BS_6KEYD1S4 PT_NGDW8WVP BS_154FP4ZQ PT_NH8CJ84W BS_AM2TZPNS @@ -584,7 +584,7 @@ PT_Q3EP24V1 BS_235QEYMQ PT_Q90R6M3E BS_XGMXJKFX PT_QA9WJ679 BS_7PF3C1P7 PT_QAX38GM7 BS_QD22MJJ5 -PT_QD6KKKJH BS_B91XGSA5 +PT_QD6KKKJH BS_9BN45DFK PT_QDGVJKE0 BS_EP25TTAG PT_QEMT1845 BS_TPX7YY57 PT_QEP13FH4 BS_Y5DA59M3 @@ -612,7 +612,7 @@ PT_RDJ40M73 BS_928HWFFM PT_RFB07MZS BS_N4B3WB8W PT_RFF7MKTC BS_PP4WJBNR PT_RFGZ2JGP BS_9CMJ3QF6 -PT_RGX23JFP BS_SYGKQD8M +PT_RGX23JFP BS_XW26N96W PT_RH59ET3M BS_KRYYDC2X PT_RJ1TJ2KH BS_6GN1FGTB PT_RJ98S3KZ BS_MEPW36WF @@ -637,7 +637,7 @@ PT_S2SQJVGK BS_8S2CZBA6 PT_S3FJSBJT BS_X9PJ715R PT_S4A0R1PM BS_1S2BHJ8K PT_S4H6KA09 BS_K6A9Z04J -PT_S4YNE17X BS_3MYQP7P5 +PT_S4YNE17X BS_CRKBDAYZ PT_S7WJ99PC BS_W9P0PFDH PT_S7YHNHSS BS_KSRYKCDE PT_S8E3281G BS_55N7KFHW @@ -748,7 +748,7 @@ PT_XX2VW3D9 BS_0J5GC803 PT_XXZHRPNM BS_SMCPASF0 PT_XY404K0D BS_6SA5B35V PT_Y32AQSEY BS_MDVMT75X -PT_Y572BRC1 BS_JA3XXP1Y +PT_Y572BRC1 BS_042DVDQM PT_Y5KY6KN9 BS_AYPBAHJ6 PT_Y660CKCB BS_FKQ7F6D1 PT_Y76A7PBA BS_M4E4H6NG diff --git a/analyses/independent-samples/results/independent-specimens.wgswxs.primary.tsv b/analyses/independent-samples/results/independent-specimens.wgswxs.primary.tsv index 7b93c5ed57..ed136f1e09 100644 --- a/analyses/independent-samples/results/independent-specimens.wgswxs.primary.tsv +++ b/analyses/independent-samples/results/independent-specimens.wgswxs.primary.tsv @@ -40,7 +40,6 @@ PT_1NN9AW39 BS_8D52JK1Q PT_1T7WF5S1 BS_HSYF7G2D PT_1TB2V1PH BS_JM979K1M PT_1TGKS073 BS_CGCNC41M -PT_1VQWQ0TC BS_QXZTRMWM PT_1Z015H6V BS_A3EV6FXK PT_1ZAWNGWT BS_4DTX295Z PT_203ZY782 BS_BVD7PWP5 @@ -53,7 +52,7 @@ PT_2BTC5TEN BS_AQQY8HMR PT_2C63FJAM BS_F48RA7QF PT_2CJ31SBX BS_JC2187NA PT_2D1KGV99 BS_CFEWVDG1 -PT_2E552BAR BS_6Z213H2V +PT_2E552BAR BS_E8MC6R2K PT_2FK75B27 BS_B3RH9V17 PT_2FVTD0WR BS_8TFBNHT0 PT_2GPH62JS BS_2VHFP7M8 @@ -113,7 +112,7 @@ PT_4XWYZYJS BS_VHD4ARSG PT_4Z34K4XB BS_P36C0ABE PT_50ZFWMZE BS_4P25NNZD PT_54MH6Q46 BS_AXM96K20 -PT_59D00MBQ BS_3E5C1PN1 +PT_59D00MBQ BS_QG6V29H7 PT_59FJRPVX BS_WJB33V17 PT_5ABCFCSK BS_APAQ2X2S PT_5BWZA0NT BS_BFDEZK1C @@ -140,7 +139,7 @@ PT_6DW5NFKX BS_KT9H4B1N PT_6E8JYRXM BS_3R0KN6Z4 PT_6GDPNFA6 BS_XGVSX8BX PT_6MB6RED3 BS_K14VJ1E3 -PT_6MWPJ96F BS_M8EBKZDG +PT_6MWPJ96F BS_6GV08HTE PT_6N1QWCXE BS_D2BZ25FW PT_6PFFSB6D BS_4Z6F1HJZ PT_6Q0NPVP3 BS_E5H6CFYT @@ -160,7 +159,7 @@ PT_7F3ZPZB7 BS_FXDY881S PT_7F485CXV BS_1RF75MK2 PT_7FQ6VECA BS_Y7CA8B5R PT_7FZ8SE69 BS_KHSYAB3J -PT_7JQ24F35 BS_1135HC0V +PT_7JQ24F35 BS_WD7AQV83 PT_7KBMN6C2 BS_HZHEF797 PT_7KTAH3RD BS_ZJT1REVB PT_7M2PGCBV BS_QRH793AV @@ -185,7 +184,7 @@ PT_8GBF5MTD BS_S7S6YEHA PT_8GW4J4TD BS_V8G6BZRR PT_8R00BMHH BS_H50HR85Y PT_8RB3EKNP BS_5KFAEMQJ -PT_8RB7TPS2 BS_8SETK1J4 +PT_8RB7TPS2 BS_ZS1QRMXS PT_8V3360DR BS_JVTQD8HH PT_8WNA6M94 BS_090GV72Q PT_8XZY6MM1 BS_WB8P21ED @@ -281,7 +280,7 @@ PT_DMHFS0HX BS_GCQEB05M PT_DMMKT7X1 BS_QMG7XNEW PT_DQ3ZCHB6 BS_PMSZKZP7 PT_DQT78GS5 BS_69VS8PS1 -PT_DTP4MMRA BS_NASADC3P +PT_DTP4MMRA BS_KH3859M5 PT_DV8XECKA BS_10HD18B8 PT_DW6V5V8E BS_F4D169Q7 PT_DXF7ZZQZ BS_KVYCH9PB @@ -311,7 +310,7 @@ PT_EV71W1JW BS_YETTZ1NC PT_EW604JB3 BS_N8D9FH6M PT_EXJAEW1M BS_4XPPZTGG PT_EYHJQQ8E BS_HW4J7JM8 -PT_EYWDFKA7 BS_5S8VXASX +PT_EYWDFKA7 BS_DAEM3WRX PT_EYZ25B99 BS_9E6Q11G2 PT_EZEMVRVT BS_32HAVF6S PT_EZS4SRH6 BS_X1R0N8QS @@ -334,7 +333,7 @@ PT_FWD7NZQ0 BS_797V83YM PT_FXPJM0MW BS_WQ19Z6MD PT_FYECBRPP BS_WCNPE0AC PT_FYPWZBH0 BS_ZCY4ECNV -PT_FZHGKJ0H BS_NHMPQ8Q1 +PT_FZHGKJ0H BS_5J5VH3X0 PT_G1QNGVCZ BS_JK5GTHVG PT_G3AVDN4E BS_RQ5Z7KNW PT_G5RA8E3N BS_BAVWP5JG @@ -418,7 +417,7 @@ PT_KHX1WQ4H BS_BNFCXVYZ PT_KMHGNCNR BS_E7HEQZ1K PT_KN25EYMG BS_PVYMDM18 PT_KQK98ZVP BS_YMDPFK0V -PT_KTRJ8TFY BS_3VKW5988 +PT_KTRJ8TFY BS_BQ81D2BP PT_KVFS3Z2Q BS_9JVGXA2W PT_KVMF5TFW BS_8FSJDG2T PT_KXB1PJV0 BS_6Q9PMNWY @@ -532,7 +531,7 @@ PT_S2ASFBP7 BS_969K7ZM1 PT_S2CXXZCF BS_KVV3G6NP PT_S4A0R1PM BS_1S2BHJ8K PT_S4H6KA09 BS_K6A9Z04J -PT_S4YNE17X BS_93BV8AY9 +PT_S4YNE17X BS_3MYQP7P5 PT_S7WJ99PC BS_W9P0PFDH PT_S7YHNHSS BS_KSRYKCDE PT_S8E3281G BS_55N7KFHW @@ -593,7 +592,7 @@ PT_VTF65Y63 BS_MSGYZ69T PT_VVCN8DXT BS_MSB1RDAJ PT_VY45XTT7 BS_ZV21J6YW PT_VZTTTP3Q BS_16FT8V4B -PT_W17NV5YG BS_FVPMPMRJ +PT_W17NV5YG BS_B4DY7ET3 PT_W6AWJJK7 BS_9HEMB7RK PT_W6CW60K9 BS_ZX1YPQ88 PT_W7FK539G BS_25VZM81R diff --git a/analyses/independent-samples/run-independent-samples.sh b/analyses/independent-samples/run-independent-samples.sh old mode 100644 new mode 100755 index 188b1946f7..1ae0a389dd --- a/analyses/independent-samples/run-independent-samples.sh +++ b/analyses/independent-samples/run-independent-samples.sh @@ -3,15 +3,21 @@ # Josh Shapiro for CCDL 2019 # # Runs 01-generate-independent-specimens.R with default settings. +# Takes one environment variable, `BASE_SUBTYPING`, if value is 1 then +# uses pbta-histologies-base.tsv for subtyping if value is 0 runs all modules with pbta-histologies.tsv(Default) set -e set -o pipefail +RUN_FOR_SUBTYPING=${BASE_SUBTYPING:-0} + # Set the working directory to the directory of this file cd "$(dirname "${BASH_SOURCE[0]}")" -Rscript -e "rmarkdown::render('00-repeated-samples.Rmd', clean = TRUE)" +Rscript -e "rmarkdown::render('00-repeated-samples.Rmd',params=list(base_run = ${RUN_FOR_SUBTYPING}), clean = TRUE)" +if [[ RUN_FOR_SUBTYPING == "0" ]] +then Rscript 01-generate-independent-specimens.R \ -f ../../data/pbta-histologies.tsv \ -o results @@ -22,3 +28,14 @@ Rscript 02-generate-independent-rnaseq.R \ --output_directory results \ --independent_dna_sample_df ../../data/independent-specimens.wgswxs.primary-plus.tsv +else +Rscript 01-generate-independent-specimens.R \ + -f ../../data/pbta-histologies-base.tsv \ + -o results + +# adding indepedent list of rnaseq samples +Rscript 02-generate-independent-rnaseq.R \ + --histology_file ../../data/pbta-histologies-base.tsv \ + --output_directory results \ + --independent_dna_sample_df ../../data/independent-specimens.wgswxs.primary-plus.tsv +fi From 2bbca44bb85bc0da37cff99761296a5a832b1638 Mon Sep 17 00:00:00 2001 From: Krutika Gaonkar <34580719+kgaonkar6@users.noreply.github.com> Date: Wed, 9 Dec 2020 09:36:51 -0500 Subject: [PATCH 3/9] Update README.md --- analyses/independent-samples/README.md | 7 +++++++ 1 file changed, 7 insertions(+) diff --git a/analyses/independent-samples/README.md b/analyses/independent-samples/README.md index aa7db4e8c9..8c975e8a17 100644 --- a/analyses/independent-samples/README.md +++ b/analyses/independent-samples/README.md @@ -25,11 +25,18 @@ independent-specimens.rnaseq.primary-plus-stranded.tsv To generate the independent sample lists and associated analysis of redundancies in the overall data set, run the following script from the project root directory: +use BASE_SUBTYPING=1 to run this module using the pbta-histologies-base.tsv from data folder while running molecular-subtyping modules for release. +```sh +BASE_SUBTYPING=1 ../analyses/independent-samples/run-independent-samples.sh +``` + +Default uses pbta-histologies.tsv from data folder ```sh bash analyses/independent-samples/run-independent-samples.sh ``` + ## Methods When presented with more than one specimen from a given individual, the script randomly selects one specimen to include, with preference for primary tumors and whole genome sequences where available. From aacff84b8efabb447ebde969d22e67ae8d19a150 Mon Sep 17 00:00:00 2001 From: Krutika Gaonkar <34580719+kgaonkar6@users.noreply.github.com> Date: Wed, 9 Dec 2020 09:40:56 -0500 Subject: [PATCH 4/9] Update README.md --- analyses/independent-samples/README.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/analyses/independent-samples/README.md b/analyses/independent-samples/README.md index 8c975e8a17..67fcb58e1c 100644 --- a/analyses/independent-samples/README.md +++ b/analyses/independent-samples/README.md @@ -30,7 +30,7 @@ use BASE_SUBTYPING=1 to run this module using the pbta-histologies-base.tsv from BASE_SUBTYPING=1 ../analyses/independent-samples/run-independent-samples.sh ``` -Default uses pbta-histologies.tsv from data folder +OR by default uses pbta-histologies.tsv from data folder ```sh bash analyses/independent-samples/run-independent-samples.sh ``` From 191f036ce4378f7d4c3043a72443489c113232e6 Mon Sep 17 00:00:00 2001 From: Krutika Gaonkar Date: Tue, 15 Dec 2020 17:05:37 -0500 Subject: [PATCH 5/9] re-run with udpated pbta-histologies-base.tsv --- analyses/independent-samples/00-repeated-samples.nb.html | 7 ++++--- 1 file changed, 4 insertions(+), 3 deletions(-) diff --git a/analyses/independent-samples/00-repeated-samples.nb.html b/analyses/independent-samples/00-repeated-samples.nb.html index 4ed6a695ce..c2a21bce2d 100644 --- a/analyses/independent-samples/00-repeated-samples.nb.html +++ b/analyses/independent-samples/00-repeated-samples.nb.html @@ -2976,10 +2976,11 @@

Purpose

sample_df <- readr::read_tsv(file.path(root_dir, "data", "pbta-histologies-base.tsv"), guess_max = 10000) } - + 
Parsed with column specification:
 cols(
   .default = col_character(),
+  integrated_diagnosis = col_logical(),
   Notes = col_logical(),
   OS_days = col_double(),
   age_last_update_days = col_double(),
@@ -3088,7 +3089,7 @@ 
Derived cell lines

 
 

 
 

 
@@ -3111,7 +3112,7 @@ 
Unlabeled composition samples

 
 

 
 

 

From aeca2443fe3c684000083d4d4ed6cc0898a4d9f6 Mon Sep 17 00:00:00 2001
From: Krutika Gaonkar 
Date: Tue, 15 Dec 2020 17:19:24 -0500
Subject: [PATCH 6/9] re-run with udpated pbta-histologies-base.tsv

---
 .../run-independent-samples.sh                | 21 +++++++------------
 1 file changed, 7 insertions(+), 14 deletions(-)

diff --git a/analyses/independent-samples/run-independent-samples.sh b/analyses/independent-samples/run-independent-samples.sh
index 1ae0a389dd..59d892db1a 100755
--- a/analyses/independent-samples/run-independent-samples.sh
+++ b/analyses/independent-samples/run-independent-samples.sh
@@ -18,24 +18,17 @@ Rscript -e "rmarkdown::render('00-repeated-samples.Rmd',params=list(base_run = $
 
 if [[ RUN_FOR_SUBTYPING == "0" ]]
 then
-Rscript 01-generate-independent-specimens.R \
-  -f ../../data/pbta-histologies.tsv \
-  -o results
-
-# adding indepedent list of rnaseq samples
-Rscript 02-generate-independent-rnaseq.R \
-  --histology_file ../../data/pbta-histologies.tsv \
-  --output_directory results \
-  --independent_dna_sample_df ../../data/independent-specimens.wgswxs.primary-plus.tsv  
-
+   HISTOLOGY_FILE="../../data/pbta-histologies.tsv" 
 else 
+   HISTOLOGY_FILE="../../data/pbta-histologies-base.tsv"  
+fi
+
 Rscript 01-generate-independent-specimens.R \
-  -f ../../data/pbta-histologies-base.tsv \
+  -f $HISTOLOGY_FILE \
   -o results
 
 # adding indepedent list of rnaseq samples
 Rscript 02-generate-independent-rnaseq.R \
-  --histology_file ../../data/pbta-histologies-base.tsv \
+  --histology_file $HISTOLOGY_FILE \
   --output_directory results \
-  --independent_dna_sample_df ../../data/independent-specimens.wgswxs.primary-plus.tsv
-fi
+  --independent_dna_sample_df results/independent-specimens.wgswxs.primary-plus.tsv

From 8f07b4f0c877ea730df1b27f51bb3aa44d4bce75 Mon Sep 17 00:00:00 2001
From: Krutika Gaonkar 
Date: Thu, 17 Dec 2020 15:18:15 -0500
Subject: [PATCH 7/9] updating BASE_SUBTYPING to OPENPBTA_BASE_SUBTYPING

---
 analyses/independent-samples/README.md                  | 4 ++--
 analyses/independent-samples/run-independent-samples.sh | 4 ++--
 2 files changed, 4 insertions(+), 4 deletions(-)

diff --git a/analyses/independent-samples/README.md b/analyses/independent-samples/README.md
index 67fcb58e1c..3b5c7039ad 100644
--- a/analyses/independent-samples/README.md
+++ b/analyses/independent-samples/README.md
@@ -25,9 +25,9 @@ independent-specimens.rnaseq.primary-plus-stranded.tsv
 
 To generate the independent sample lists and associated analysis of redundancies in the overall data set, run the following script from the project root directory:
 
-use BASE_SUBTYPING=1 to run this module using the pbta-histologies-base.tsv from data folder while running molecular-subtyping modules for release.
+use OPENPBTA_BASE_SUBTYPING=1 to run this module using the pbta-histologies-base.tsv from data folder while running molecular-subtyping modules for release.
 ```sh
-BASE_SUBTYPING=1 ../analyses/independent-samples/run-independent-samples.sh 
+OPENPBTA_BASE_SUBTYPING=1 ../analyses/independent-samples/run-independent-samples.sh 
 ```
 
 OR by default uses pbta-histologies.tsv from data folder
diff --git a/analyses/independent-samples/run-independent-samples.sh b/analyses/independent-samples/run-independent-samples.sh
index 59d892db1a..4023b7f1c0 100755
--- a/analyses/independent-samples/run-independent-samples.sh
+++ b/analyses/independent-samples/run-independent-samples.sh
@@ -3,13 +3,13 @@
 # Josh Shapiro for CCDL 2019
 #
 # Runs 01-generate-independent-specimens.R with default settings.
-# Takes one environment variable, `BASE_SUBTYPING`, if value is 1 then
+# Takes one environment variable, `OPENPBTA_BASE_SUBTYPING`, if value is 1 then
 # uses pbta-histologies-base.tsv for subtyping if value is 0 runs all modules with pbta-histologies.tsv(Default)
 
 set -e
 set -o pipefail
 
-RUN_FOR_SUBTYPING=${BASE_SUBTYPING:-0}
+RUN_FOR_SUBTYPING=${OPENPBTA_BASE_SUBTYPING:-0}
 
 # Set the working directory to the directory of this file
 cd "$(dirname "${BASH_SOURCE[0]}")"

From 08c86177be75b74fa1fb5bdd7b4ecaded01d26a0 Mon Sep 17 00:00:00 2001
From: Krutika Gaonkar <34580719+kgaonkar6@users.noreply.github.com>
Date: Thu, 17 Dec 2020 15:36:52 -0500
Subject: [PATCH 8/9] Update config.yml

---
 .circleci/config.yml | 4 ++++
 1 file changed, 4 insertions(+)

diff --git a/.circleci/config.yml b/.circleci/config.yml
index 26232e3b7a..3d5292f5b1 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -131,6 +131,10 @@ jobs:
       - run:
           name: Independent samples
           command: ./scripts/run_in_ci.sh bash analyses/independent-samples/run-independent-samples.sh
+      
+      - run:
+          name: Independent sample for base subtyping
+          command: ./scripts/run_in_ci.sh OPENPBTA_BASE_SUBTYPING=1 analyses/independent-samples/run-independent-samples.sh 
 
       - run:
           name: Interaction plot

From bc2b92343eb10486bc0777c6e7d45fd78262652f Mon Sep 17 00:00:00 2001
From: Krutika Gaonkar <34580719+kgaonkar6@users.noreply.github.com>
Date: Thu, 17 Dec 2020 15:48:09 -0500
Subject: [PATCH 9/9] Update config.yml

---
 .circleci/config.yml | 2 +-
 1 file changed, 1 insertion(+), 1 deletion(-)

diff --git a/.circleci/config.yml b/.circleci/config.yml
index 3d5292f5b1..bdf9248a1a 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -134,7 +134,7 @@ jobs:
       
       - run:
           name: Independent sample for base subtyping
-          command: ./scripts/run_in_ci.sh OPENPBTA_BASE_SUBTYPING=1 analyses/independent-samples/run-independent-samples.sh 
+          command: OPENPBTA_BASE_SUBTYPING=1 ./scripts/run_in_ci.sh bash analyses/independent-samples/run-independent-samples.sh 
 
       - run:
           name: Interaction plot