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Fluvoxamine-Model.json
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Fluvoxamine-Model.json
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{
"Version": 78,
"Individuals": [
{
"Name": "Caucasian, mean male individuum",
"Seed": 1756794562,
"OriginData": {
"CalculationMethods": [
"SurfaceAreaPlsInt_VAR1",
"Body surface area - Mosteller"
],
"Species": "Human",
"Population": "European_ICRP_2002",
"Gender": "MALE",
"Age": {
"Value": 30.0,
"Unit": "year(s)"
}
},
"Parameters": [
{
"Path": "CYP1A2|Reference concentration",
"Value": 1.8,
"Unit": "µmol/l"
},
{
"Path": "CYP1A2|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP1A2|t1/2 (liver)",
"Value": 39.0,
"Unit": "h"
},
{
"Path": "CYP2D6|Reference concentration",
"Value": 0.4,
"Unit": "µmol/l"
},
{
"Path": "CYP2D6|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP2D6|t1/2 (liver)",
"Value": 51.0,
"Unit": "h"
},
{
"Path": "CYP3A4|Reference concentration",
"Value": 4.32,
"Unit": "µmol/l"
},
{
"Path": "CYP3A4|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP3A4|t1/2 (liver)",
"Value": 36.0,
"Unit": "h",
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Brain|Intracellular|CYP2D6|Relative expression",
"Value": 0.00768702814
},
{
"Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
"Value": 0.0041682898325
},
{
"Path": "Organism|Gonads|Intracellular|CYP1A2|Relative expression",
"Value": 0.00029559748428
},
{
"Path": "Organism|Gonads|Intracellular|CYP2D6|Relative expression",
"Value": 0.768702814
},
{
"Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
"Value": 0.00078691079081
},
{
"Path": "Organism|Kidney|Intracellular|CYP1A2|Relative expression",
"Value": 4.4025157233E-06
},
{
"Path": "Organism|Kidney|Intracellular|CYP2D6|Relative expression",
"Value": 0.0208304736
},
{
"Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
"Value": 0.0053603428126
},
{
"Path": "Organism|Liver|EHC continuous fraction",
"Value": 1.0,
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Lung|Intracellular|CYP1A2|Relative expression",
"Value": 2.4947589099E-05
},
{
"Path": "Organism|Lung|Intracellular|CYP2D6|Relative expression",
"Value": 0.0223404255
},
{
"Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
"Value": 0.00042695753798
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
}
],
"Molecules": [
{
"Name": "CYP2D6",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP2D6"
}
},
{
"Name": "CYP1A2",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP1A2"
}
},
{
"Name": "CYP3A4",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP3A4"
}
}
]
},
{
"Name": "Bahrami 2007, male, 27 y, 68 kg",
"Seed": 1757104250,
"OriginData": {
"CalculationMethods": [
"SurfaceAreaPlsInt_VAR1",
"Body surface area - Mosteller"
],
"Species": "Human",
"Population": "European_ICRP_2002",
"Gender": "MALE",
"Age": {
"Value": 27.0,
"Unit": "year(s)"
},
"Weight": {
"Value": 68.0,
"Unit": "kg"
}
},
"Parameters": [
{
"Path": "CYP1A2|Reference concentration",
"Value": 1.8,
"Unit": "µmol/l"
},
{
"Path": "CYP1A2|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP1A2|t1/2 (liver)",
"Value": 39.0,
"Unit": "h"
},
{
"Path": "CYP2D6|Reference concentration",
"Value": 0.4,
"Unit": "µmol/l"
},
{
"Path": "CYP2D6|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP2D6|t1/2 (liver)",
"Value": 51.0,
"Unit": "h"
},
{
"Path": "CYP3A4|Reference concentration",
"Value": 4.32,
"Unit": "µmol/l"
},
{
"Path": "CYP3A4|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP3A4|t1/2 (liver)",
"Value": 36.0,
"Unit": "h",
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Brain|Intracellular|CYP2D6|Relative expression",
"Value": 0.00768702814
},
{
"Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
"Value": 0.0041682898325
},
{
"Path": "Organism|Gonads|Intracellular|CYP1A2|Relative expression",
"Value": 0.00029559748428
},
{
"Path": "Organism|Gonads|Intracellular|CYP2D6|Relative expression",
"Value": 0.768702814
},
{
"Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
"Value": 0.00078691079081
},
{
"Path": "Organism|Kidney|Intracellular|CYP1A2|Relative expression",
"Value": 4.4025157233E-06
},
{
"Path": "Organism|Kidney|Intracellular|CYP2D6|Relative expression",
"Value": 0.0208304736
},
{
"Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
"Value": 0.0053603428126
},
{
"Path": "Organism|Liver|EHC continuous fraction",
"Value": 1.0,
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Lung|Intracellular|CYP1A2|Relative expression",
"Value": 2.4947589099E-05
},
{
"Path": "Organism|Lung|Intracellular|CYP2D6|Relative expression",
"Value": 0.0223404255
},
{
"Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
"Value": 0.00042695753798
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
}
],
"Molecules": [
{
"Name": "CYP2D6",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP2D6"
}
},
{
"Name": "CYP1A2",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP1A2"
}
},
{
"Name": "CYP3A4",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP3A4"
}
}
]
},
{
"Name": "Christensen 2002, female, 30 y, 69 kg",
"Seed": 1757214734,
"OriginData": {
"CalculationMethods": [
"SurfaceAreaPlsInt_VAR1",
"Body surface area - Mosteller"
],
"Species": "Human",
"Population": "European_ICRP_2002",
"Gender": "FEMALE",
"Age": {
"Value": 30.0,
"Unit": "year(s)"
},
"Weight": {
"Value": 69.0,
"Unit": "kg"
}
},
"Parameters": [
{
"Path": "CYP1A2|Reference concentration",
"Value": 1.8,
"Unit": "µmol/l"
},
{
"Path": "CYP1A2|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP1A2|t1/2 (liver)",
"Value": 39.0,
"Unit": "h"
},
{
"Path": "CYP2D6|Reference concentration",
"Value": 0.4,
"Unit": "µmol/l"
},
{
"Path": "CYP2D6|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP2D6|t1/2 (liver)",
"Value": 51.0,
"Unit": "h"
},
{
"Path": "CYP3A4|Reference concentration",
"Value": 4.32,
"Unit": "µmol/l"
},
{
"Path": "CYP3A4|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP3A4|t1/2 (liver)",
"Value": 36.0,
"Unit": "h",
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Brain|Intracellular|CYP2D6|Relative expression",
"Value": 0.00768702814
},
{
"Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
"Value": 0.0041682898325
},
{
"Path": "Organism|Gonads|Intracellular|CYP1A2|Relative expression",
"Value": 0.00029559748428
},
{
"Path": "Organism|Gonads|Intracellular|CYP2D6|Relative expression",
"Value": 0.768702814
},
{
"Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
"Value": 0.00078691079081
},
{
"Path": "Organism|Kidney|Intracellular|CYP1A2|Relative expression",
"Value": 4.4025157233E-06
},
{
"Path": "Organism|Kidney|Intracellular|CYP2D6|Relative expression",
"Value": 0.0208304736
},
{
"Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
"Value": 0.0053603428126
},
{
"Path": "Organism|Liver|EHC continuous fraction",
"Value": 1.0,
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Lung|Intracellular|CYP1A2|Relative expression",
"Value": 2.4947589099E-05
},
{
"Path": "Organism|Lung|Intracellular|CYP2D6|Relative expression",
"Value": 0.0223404255
},
{
"Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
"Value": 0.00042695753798
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
}
],
"Molecules": [
{
"Name": "CYP2D6",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP2D6"
}
},
{
"Name": "CYP1A2",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP1A2"
}
},
{
"Name": "CYP3A4",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP3A4"
}
}
]
},
{
"Name": "Christensen 2002, male, 30 y, 81 kg",
"Seed": 1757304203,
"OriginData": {
"CalculationMethods": [
"SurfaceAreaPlsInt_VAR1",
"Body surface area - Mosteller"
],
"Species": "Human",
"Population": "European_ICRP_2002",
"Gender": "MALE",
"Age": {
"Value": 30.0,
"Unit": "year(s)"
},
"Weight": {
"Value": 81.0,
"Unit": "kg"
}
},
"Parameters": [
{
"Path": "CYP1A2|Reference concentration",
"Value": 1.8,
"Unit": "µmol/l"
},
{
"Path": "CYP1A2|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP1A2|t1/2 (liver)",
"Value": 39.0,
"Unit": "h"
},
{
"Path": "CYP2D6|Reference concentration",
"Value": 0.4,
"Unit": "µmol/l"
},
{
"Path": "CYP2D6|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP2D6|t1/2 (liver)",
"Value": 51.0,
"Unit": "h"
},
{
"Path": "CYP3A4|Reference concentration",
"Value": 4.32,
"Unit": "µmol/l"
},
{
"Path": "CYP3A4|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP3A4|t1/2 (liver)",
"Value": 36.0,
"Unit": "h",
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Brain|Intracellular|CYP2D6|Relative expression",
"Value": 0.00768702814
},
{
"Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
"Value": 0.0041682898325
},
{
"Path": "Organism|Gonads|Intracellular|CYP1A2|Relative expression",
"Value": 0.00029559748428
},
{
"Path": "Organism|Gonads|Intracellular|CYP2D6|Relative expression",
"Value": 0.768702814
},
{
"Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
"Value": 0.00078691079081
},
{
"Path": "Organism|Kidney|Intracellular|CYP1A2|Relative expression",
"Value": 4.4025157233E-06
},
{
"Path": "Organism|Kidney|Intracellular|CYP2D6|Relative expression",
"Value": 0.0208304736
},
{
"Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
"Value": 0.0053603428126
},
{
"Path": "Organism|Liver|EHC continuous fraction",
"Value": 1.0,
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Lung|Intracellular|CYP1A2|Relative expression",
"Value": 2.4947589099E-05
},
{
"Path": "Organism|Lung|Intracellular|CYP2D6|Relative expression",
"Value": 0.0223404255
},
{
"Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
"Value": 0.00042695753798
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2D6|Relative expression",
"Value": 0.0909402883
},
{
"Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
"Value": 0.0727697702
}
],
"Molecules": [
{
"Name": "CYP2D6",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP2D6"
}
},
{
"Name": "CYP1A2",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP1A2"
}
},
{
"Name": "CYP3A4",
"Type": "Enzyme",
"Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
"Ontogeny": {
"Name": "CYP3A4"
}
}
]
},
{
"Name": "de Bree 1983, female, 21 y, 55.5 kg, 158 cm",
"Seed": 1757667578,
"OriginData": {
"CalculationMethods": [
"SurfaceAreaPlsInt_VAR1",
"Body surface area - Mosteller"
],
"Species": "Human",
"Population": "European_ICRP_2002",
"Gender": "MALE",
"Age": {
"Value": 21.0,
"Unit": "year(s)"
},
"Weight": {
"Value": 55.5,
"Unit": "kg"
},
"Height": {
"Value": 158.0,
"Unit": "cm"
}
},
"Parameters": [
{
"Path": "CYP1A2|Reference concentration",
"Value": 1.8,
"Unit": "µmol/l"
},
{
"Path": "CYP1A2|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP1A2|t1/2 (liver)",
"Value": 39.0,
"Unit": "h"
},
{
"Path": "CYP2D6|Reference concentration",
"Value": 0.4,
"Unit": "µmol/l"
},
{
"Path": "CYP2D6|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP2D6|t1/2 (liver)",
"Value": 51.0,
"Unit": "h"
},
{
"Path": "CYP3A4|Reference concentration",
"Value": 4.32,
"Unit": "µmol/l"
},
{
"Path": "CYP3A4|t1/2 (intestine)",
"Value": 23.0,
"Unit": "h"
},
{
"Path": "CYP3A4|t1/2 (liver)",
"Value": 36.0,
"Unit": "h",
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Brain|Intracellular|CYP2D6|Relative expression",
"Value": 0.00768702814
},
{
"Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
"Value": 0.0041682898325
},
{
"Path": "Organism|Gonads|Intracellular|CYP1A2|Relative expression",
"Value": 0.00029559748428
},
{
"Path": "Organism|Gonads|Intracellular|CYP2D6|Relative expression",
"Value": 0.768702814
},
{
"Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
"Value": 0.00078691079081
},
{
"Path": "Organism|Kidney|Intracellular|CYP1A2|Relative expression",
"Value": 4.4025157233E-06
},
{
"Path": "Organism|Kidney|Intracellular|CYP2D6|Relative expression",
"Value": 0.0208304736
},
{
"Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
"Value": 0.0053603428126
},
{
"Path": "Organism|Liver|EHC continuous fraction",
"Value": 1.0,
"ValueOrigin": {
"Source": "Unknown"
}
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP1A2|Relative expression",
"Value": 1.0
},
{
"Path": "Organism|Liver|Pericentral|Intracellular|CYP2D6|Relative expression",
"Value": 1.0
},
{