diff --git a/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs b/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs
index 726d2c596c2..e361e7b736a 100644
--- a/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs
+++ b/src/Avalonia.Controls/Platform/DefaultMenuInteractionHandler.cs
@@ -275,7 +275,7 @@ protected internal virtual void AccessKeyPressed(object sender, RoutedEventArgs
                 return;
             }
 
-            if (item.HasSubMenu)
+            if (item.HasSubMenu && item.IsEffectivelyEnabled)
             {
                 Open(item, true);
             }