diff --git a/src/Avalonia.Controls/ComboBox.cs b/src/Avalonia.Controls/ComboBox.cs
index 57c07916dbb..274696d5010 100644
--- a/src/Avalonia.Controls/ComboBox.cs
+++ b/src/Avalonia.Controls/ComboBox.cs
@@ -1,6 +1,8 @@
 using System;
 using System.Linq;
+using System.Reactive.Disposables;
 using Avalonia.Controls.Generators;
+using Avalonia.Controls.Mixins;
 using Avalonia.Controls.Presenters;
 using Avalonia.Controls.Primitives;
 using Avalonia.Controls.Shapes;
@@ -80,7 +82,7 @@ public class ComboBox : SelectingItemsControl
         private bool _isDropDownOpen;
         private Popup _popup;
         private object _selectionBoxItem;
-        private IDisposable _subscriptionsOnOpen;
+        private readonly CompositeDisposable _subscriptionsOnOpen = new CompositeDisposable();
 
         /// <summary>
         /// Initializes static members of the <see cref="ComboBox"/> class.
@@ -291,6 +293,7 @@ protected override void OnApplyTemplate(TemplateAppliedEventArgs e)
 
             _popup = e.NameScope.Get<Popup>("PART_Popup");
             _popup.Opened += PopupOpened;
+            _popup.Closed += PopupClosed;
         }
 
         internal void ItemFocused(ComboBoxItem dropDownItem)
@@ -303,8 +306,7 @@ internal void ItemFocused(ComboBoxItem dropDownItem)
 
         private void PopupClosed(object sender, EventArgs e)
         {
-            _subscriptionsOnOpen?.Dispose();
-            _subscriptionsOnOpen = null;
+            _subscriptionsOnOpen.Clear();
 
             if (CanFocus(this))
             {
@@ -316,20 +318,34 @@ private void PopupOpened(object sender, EventArgs e)
         {
             TryFocusSelectedItem();
 
-            _subscriptionsOnOpen?.Dispose();
-            _subscriptionsOnOpen = null;
+            _subscriptionsOnOpen.Clear();
 
             var toplevel = this.GetVisualRoot() as TopLevel;
             if (toplevel != null)
             {
-                _subscriptionsOnOpen = toplevel.AddDisposableHandler(PointerWheelChangedEvent, (s, ev) =>
+                toplevel.AddDisposableHandler(PointerWheelChangedEvent, (s, ev) =>
                 {
                     //eat wheel scroll event outside dropdown popup while it's open
                     if (IsDropDownOpen && (ev.Source as IVisual).GetVisualRoot() == toplevel)
                     {
                         ev.Handled = true;
                     }
-                }, Interactivity.RoutingStrategies.Tunnel);
+                }, Interactivity.RoutingStrategies.Tunnel).DisposeWith(_subscriptionsOnOpen);
+            }
+
+            this.GetObservable(IsVisibleProperty).Subscribe(IsVisibleChanged).DisposeWith(_subscriptionsOnOpen);
+
+            foreach (var parent in this.GetVisualAncestors().OfType<IControl>())
+            {
+                parent.GetObservable(IsVisibleProperty).Subscribe(IsVisibleChanged).DisposeWith(_subscriptionsOnOpen);
+            }
+        }
+
+        private void IsVisibleChanged(bool isVisible)
+        {
+            if (!isVisible && IsDropDownOpen)
+            {
+                IsDropDownOpen = false;
             }
         }
 
diff --git a/src/Avalonia.Controls/Mixins/DisposableMixin.cs b/src/Avalonia.Controls/Mixins/DisposableMixin.cs
new file mode 100644
index 00000000000..9b30b4ba4c9
--- /dev/null
+++ b/src/Avalonia.Controls/Mixins/DisposableMixin.cs
@@ -0,0 +1,38 @@
+using System;
+using System.Reactive.Disposables;
+
+namespace Avalonia.Controls.Mixins
+{
+    /// <summary>
+    /// Extension methods associated with the IDisposable interface.
+    /// </summary>
+    public static class DisposableMixin
+    {
+        /// <summary>
+        /// Ensures the provided disposable is disposed with the specified <see cref="CompositeDisposable"/>.
+        /// </summary>
+        /// <typeparam name="T">
+        /// The type of the disposable.
+        /// </typeparam>
+        /// <param name="item">
+        /// The disposable we are going to want to be disposed by the CompositeDisposable.
+        /// </param>
+        /// <param name="compositeDisposable">
+        /// The <see cref="CompositeDisposable"/> to which <paramref name="item"/> will be added.
+        /// </param>
+        /// <returns>
+        /// The disposable.
+        /// </returns>
+        public static T DisposeWith<T>(this T item, CompositeDisposable compositeDisposable)
+            where T : IDisposable
+        {
+            if (compositeDisposable is null)
+            {
+                throw new ArgumentNullException(nameof(compositeDisposable));
+            }
+
+            compositeDisposable.Add(item);
+            return item;
+        }
+    }
+}
diff --git a/src/Avalonia.Controls/Primitives/Popup.cs b/src/Avalonia.Controls/Primitives/Popup.cs
index d5fb69a6729..e804c4b4a9c 100644
--- a/src/Avalonia.Controls/Primitives/Popup.cs
+++ b/src/Avalonia.Controls/Primitives/Popup.cs
@@ -2,6 +2,7 @@
 using System.ComponentModel;
 using System.Linq;
 using System.Reactive.Disposables;
+using Avalonia.Controls.Mixins;
 using Avalonia.Controls.Diagnostics;
 using Avalonia.Controls.Presenters;
 using Avalonia.Controls.Primitives.PopupPositioning;
@@ -393,18 +394,8 @@ public void Open()
 
             var handlerCleanup = new CompositeDisposable(5);
 
-            void DeferCleanup(IDisposable? disposable)
-            {
-                if (disposable is null)
-                {
-                    return;
-                }
-
-                handlerCleanup.Add(disposable);
-            }
-
-            DeferCleanup(popupHost.BindConstraints(this, WidthProperty, MinWidthProperty, MaxWidthProperty,
-                HeightProperty, MinHeightProperty, MaxHeightProperty, TopmostProperty));
+            popupHost.BindConstraints(this, WidthProperty, MinWidthProperty, MaxWidthProperty,
+                HeightProperty, MinHeightProperty, MaxHeightProperty, TopmostProperty).DisposeWith(handlerCleanup);
 
             popupHost.SetChild(Child);
             ((ISetLogicalParent)popupHost).SetParent(this);
@@ -418,19 +409,19 @@ void DeferCleanup(IDisposable? disposable)
                 PlacementConstraintAdjustment,
                 PlacementRect);
 
-            DeferCleanup(SubscribeToEventHandler<IPopupHost, EventHandler<TemplateAppliedEventArgs>>(popupHost, RootTemplateApplied,
+            SubscribeToEventHandler<IPopupHost, EventHandler<TemplateAppliedEventArgs>>(popupHost, RootTemplateApplied,
                 (x, handler) => x.TemplateApplied += handler,
-                (x, handler) => x.TemplateApplied -= handler));
+                (x, handler) => x.TemplateApplied -= handler).DisposeWith(handlerCleanup);
 
             if (topLevel is Window window)
             {
-                DeferCleanup(SubscribeToEventHandler<Window, EventHandler>(window, WindowDeactivated,
+                SubscribeToEventHandler<Window, EventHandler>(window, WindowDeactivated,
                     (x, handler) => x.Deactivated += handler,
-                    (x, handler) => x.Deactivated -= handler));
+                    (x, handler) => x.Deactivated -= handler).DisposeWith(handlerCleanup);
                 
-                DeferCleanup(SubscribeToEventHandler<IWindowImpl, Action>(window.PlatformImpl, WindowLostFocus,
+                SubscribeToEventHandler<IWindowImpl, Action>(window.PlatformImpl, WindowLostFocus,
                         (x, handler) => x.LostFocus += handler,
-                        (x, handler) => x.LostFocus -= handler));
+                        (x, handler) => x.LostFocus -= handler).DisposeWith(handlerCleanup);
             }
             else
             {
@@ -438,13 +429,13 @@ void DeferCleanup(IDisposable? disposable)
 
                 if (parentPopupRoot?.Parent is Popup popup)
                 {
-                    DeferCleanup(SubscribeToEventHandler<Popup, EventHandler<EventArgs>>(popup, ParentClosed,
+                    SubscribeToEventHandler<Popup, EventHandler<EventArgs>>(popup, ParentClosed,
                         (x, handler) => x.Closed += handler,
-                        (x, handler) => x.Closed -= handler));
+                        (x, handler) => x.Closed -= handler).DisposeWith(handlerCleanup);
                 }
             }
 
-            DeferCleanup(InputManager.Instance?.Process.Subscribe(ListenForNonClientClick));
+            InputManager.Instance?.Process.Subscribe(ListenForNonClientClick).DisposeWith(handlerCleanup);
 
             var cleanupPopup = Disposable.Create((popupHost, handlerCleanup), state =>
             {
@@ -466,17 +457,17 @@ void DeferCleanup(IDisposable? disposable)
                     dismissLayer.IsVisible = true;
                     dismissLayer.InputPassThroughElement = _overlayInputPassThroughElement;
                     
-                    DeferCleanup(Disposable.Create(() =>
+                    Disposable.Create(() =>
                     {
                         dismissLayer.IsVisible = false;
                         dismissLayer.InputPassThroughElement = null;
-                    }));
+                    }).DisposeWith(handlerCleanup);
                     
-                    DeferCleanup(SubscribeToEventHandler<LightDismissOverlayLayer, EventHandler<PointerPressedEventArgs>>(
+                    SubscribeToEventHandler<LightDismissOverlayLayer, EventHandler<PointerPressedEventArgs>>(
                         dismissLayer,
                         PointerPressedDismissOverlay,
                         (x, handler) => x.PointerPressed += handler,
-                        (x, handler) => x.PointerPressed -= handler));
+                        (x, handler) => x.PointerPressed -= handler).DisposeWith(handlerCleanup);
                 }
             }