diff --git a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/AzureMonitorAspNetCoreEventSource.cs b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/AzureMonitorAspNetCoreEventSource.cs
index f13de811e8b9f..11aa7d65bd1a1 100644
--- a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/AzureMonitorAspNetCoreEventSource.cs
+++ b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/AzureMonitorAspNetCoreEventSource.cs
@@ -53,5 +53,14 @@ public void ConfigureFailed(Exception ex)
 
         [Event(1, Message = "Failed to configure AzureMonitorOptions using the connection string from environment variables due to an exception: {0}", Level = EventLevel.Error)]
         public void ConfigureFailed(string exceptionMessage) => WriteEvent(1, exceptionMessage);
+
+        [Event(2, Message = "Package reference for {0} found. Backing off from default included instrumentation. Action Required: You must manually configure this instrumentation.", Level = EventLevel.Warning)]
+        public void FoundInstrumentationPackageReference(string packageName) => WriteEvent(2, packageName);
+
+        [Event(3, Message = "No instrumentation package found with name: {0}.", Level = EventLevel.Verbose)]
+        public void NoInstrumentationPackageReference(string packageName) => WriteEvent(3, packageName);
+
+        [Event(4, Message = "Vendor instrumentation added for: {0}.", Level = EventLevel.Verbose)]
+        public void VendorInstrumentationAdded(string packageName) => WriteEvent(4, packageName);
     }
 }
diff --git a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/OpenTelemetryBuilderExtensions.cs b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/OpenTelemetryBuilderExtensions.cs
index f557a1c4c7a06..7864054779c7b 100644
--- a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/OpenTelemetryBuilderExtensions.cs
+++ b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/OpenTelemetryBuilderExtensions.cs
@@ -1,9 +1,12 @@
 // Copyright (c) Microsoft Corporation. All rights reserved.
 // Licensed under the MIT License.
 
+#nullable enable
+
 using System;
 using System.Collections.Generic;
 using System.Diagnostics;
+using System.Reflection;
 using Azure.Monitor.OpenTelemetry.Exporter;
 using Microsoft.Extensions.DependencyInjection;
 using Microsoft.Extensions.DependencyInjection.Extensions;
@@ -23,6 +26,10 @@ namespace Azure.Monitor.OpenTelemetry.AspNetCore
     /// </summary>
     public static class OpenTelemetryBuilderExtensions
     {
+        private const string AspNetCoreInstrumentationPackageName = "OpenTelemetry.Instrumentation.AspNetCore";
+        private const string HttpClientInstrumentationPackageName = "OpenTelemetry.Instrumentation.Http";
+        private const string SqlClientInstrumentationPackageName = "OpenTelemetry.Instrumentation.SqlClient";
+
         /// <summary>
         /// Configures Azure Monitor for logging, distributed tracing, and metrics.
         /// </summary>
@@ -102,23 +109,7 @@ public static OpenTelemetryBuilder UseAzureMonitor(this OpenTelemetryBuilder bui
 
             builder.WithTracing(b => b
                             .AddSource("Azure.*")
-                            .AddAspNetCoreInstrumentation()
-                            .AddHttpClientInstrumentation(o => o.FilterHttpRequestMessage = (_) =>
-                            {
-                                // Azure SDKs create their own client span before calling the service using HttpClient
-                                // In this case, we would see two spans corresponding to the same operation
-                                // 1) created by Azure SDK 2) created by HttpClient
-                                // To prevent this duplication we are filtering the span from HttpClient
-                                // as span from Azure SDK contains all relevant information needed.
-                                var parentActivity = Activity.Current?.Parent;
-                                if (parentActivity != null && parentActivity.Source.Name.Equals("Azure.Core.Http"))
-                                {
-                                    return false;
-                                }
-
-                                return true;
-                            })
-                            .AddSqlClientInstrumentation()
+                            .AddVendorInstrumentationIfPackageNotReferenced()
                             .AddAzureMonitorTraceExporter());
 
             builder.WithMetrics(b => b
@@ -158,5 +149,55 @@ public static OpenTelemetryBuilder UseAzureMonitor(this OpenTelemetryBuilder bui
 
             return builder;
         }
+
+        private static TracerProviderBuilder AddVendorInstrumentationIfPackageNotReferenced(this TracerProviderBuilder tracerProviderBuilder)
+        {
+            var vendorInstrumentationActions = new Dictionary<string, Action>
+            {
+                { AspNetCoreInstrumentationPackageName, () => tracerProviderBuilder.AddAspNetCoreInstrumentation() },
+                { SqlClientInstrumentationPackageName, () => tracerProviderBuilder.AddSqlClientInstrumentation() },
+                {
+                    HttpClientInstrumentationPackageName,
+                        () => tracerProviderBuilder.AddHttpClientInstrumentation(o => o.FilterHttpRequestMessage = (_) =>
+                            {
+                            // Azure SDKs create their own client span before calling the service using HttpClient
+                            // In this case, we would see two spans corresponding to the same operation
+                            // 1) created by Azure SDK 2) created by HttpClient
+                            // To prevent this duplication we are filtering the span from HttpClient
+                            // as span from Azure SDK contains all relevant information needed.
+                            var parentActivity = Activity.Current?.Parent;
+                            if (parentActivity != null && parentActivity.Source.Name.Equals("Azure.Core.Http"))
+                            {
+                                return false;
+                            }
+
+                            return true;
+                            })
+                },
+            };
+
+            foreach (var packageActionPair in vendorInstrumentationActions)
+            {
+                Assembly? instrumentationAssembly = null;
+
+                try
+                {
+                    instrumentationAssembly = Assembly.Load(packageActionPair.Key + ".dll");
+                    AzureMonitorAspNetCoreEventSource.Log.FoundInstrumentationPackageReference(packageActionPair.Key);
+                }
+                catch
+                {
+                    AzureMonitorAspNetCoreEventSource.Log.NoInstrumentationPackageReference(packageActionPair.Key);
+                }
+
+                if (instrumentationAssembly == null)
+                {
+                    packageActionPair.Value.Invoke();
+                    AzureMonitorAspNetCoreEventSource.Log.VendorInstrumentationAdded(packageActionPair.Key);
+                }
+            }
+
+            return tracerProviderBuilder;
+        }
     }
 }
diff --git a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/OpenTelemetry.Instrumentation.AspNetCore/GrpcTagHelper.cs b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/OpenTelemetry.Instrumentation.AspNetCore/GrpcTagHelper.cs
new file mode 100644
index 0000000000000..14f5d7b6164d0
--- /dev/null
+++ b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/OpenTelemetry.Instrumentation.AspNetCore/GrpcTagHelper.cs
@@ -0,0 +1,89 @@
+// <copyright file="GrpcTagHelper.cs" company="OpenTelemetry Authors">
+// Copyright The OpenTelemetry Authors
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+// </copyright>
+
+using System.Diagnostics;
+using System.Text.RegularExpressions;
+using OpenTelemetry.Trace;
+
+namespace OpenTelemetry.Instrumentation.GrpcNetClient;
+
+internal static class GrpcTagHelper
+{
+    public const string RpcSystemGrpc = "grpc";
+
+    // The Grpc.Net.Client library adds its own tags to the activity.
+    // These tags are used to source the tags added by the OpenTelemetry instrumentation.
+    public const string GrpcMethodTagName = "grpc.method";
+    public const string GrpcStatusCodeTagName = "grpc.status_code";
+
+    private static readonly Regex GrpcMethodRegex = new(@"^/?(?<service>.*)/(?<method>.*)$", RegexOptions.Compiled);
+
+    public static string GetGrpcMethodFromActivity(Activity activity)
+    {
+        return activity.GetTagValue(GrpcMethodTagName) as string;
+    }
+
+    public static bool TryGetGrpcStatusCodeFromActivity(Activity activity, out int statusCode)
+    {
+        statusCode = -1;
+        var grpcStatusCodeTag = activity.GetTagValue(GrpcStatusCodeTagName);
+        if (grpcStatusCodeTag == null)
+        {
+            return false;
+        }
+
+        return int.TryParse(grpcStatusCodeTag as string, out statusCode);
+    }
+
+    public static bool TryParseRpcServiceAndRpcMethod(string grpcMethod, out string rpcService, out string rpcMethod)
+    {
+        var match = GrpcMethodRegex.Match(grpcMethod);
+        if (match.Success)
+        {
+            rpcService = match.Groups["service"].Value;
+            rpcMethod = match.Groups["method"].Value;
+            return true;
+        }
+        else
+        {
+            rpcService = string.Empty;
+            rpcMethod = string.Empty;
+            return false;
+        }
+    }
+
+    /// <summary>
+    /// Helper method that populates span properties from RPC status code according
+    /// to https://github.com/open-telemetry/opentelemetry-specification/blob/main/specification/trace/semantic_conventions/rpc.md#status.
+    /// </summary>
+    /// <param name="statusCode">RPC status code.</param>
+    /// <returns>Resolved span <see cref="Status"/> for the Grpc status code.</returns>
+    public static ActivityStatusCode ResolveSpanStatusForGrpcStatusCode(int statusCode)
+    {
+        var status = ActivityStatusCode.Error;
+
+        if (typeof(StatusCanonicalCode).IsEnumDefined(statusCode))
+        {
+            status = ((StatusCanonicalCode)statusCode) switch
+            {
+                StatusCanonicalCode.Ok => ActivityStatusCode.Unset,
+                _ => ActivityStatusCode.Error,
+            };
+        }
+
+        return status;
+    }
+}
diff --git a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/OpenTelemetry.Instrumentation.AspNetCore/StatusCanonicalCode.cs b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/OpenTelemetry.Instrumentation.AspNetCore/StatusCanonicalCode.cs
new file mode 100644
index 0000000000000..bd8be72a74a95
--- /dev/null
+++ b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/OpenTelemetry.Instrumentation.AspNetCore/StatusCanonicalCode.cs
@@ -0,0 +1,148 @@
+// <copyright file="StatusCanonicalCode.cs" company="OpenTelemetry Authors">
+// Copyright The OpenTelemetry Authors
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+// </copyright>
+
+namespace OpenTelemetry.Instrumentation.GrpcNetClient;
+
+/// <summary>
+/// Canonical result code of span execution.
+/// </summary>
+/// <remarks>
+/// This follows the standard GRPC codes.
+/// https://github.com/grpc/grpc/blob/master/doc/statuscodes.md.
+/// </remarks>
+internal enum StatusCanonicalCode
+{
+    /// <summary>
+    /// The operation completed successfully.
+    /// </summary>
+    Ok = 0,
+
+    /// <summary>
+    /// The operation was cancelled (typically by the caller).
+    /// </summary>
+    Cancelled = 1,
+
+    /// <summary>
+    /// Unknown error. An example of where this error may be returned is if a Status value received
+    /// from another address space belongs to an error-space that is not known in this address space.
+    /// Also errors raised by APIs that do not return enough error information may be converted to
+    /// this error.
+    /// </summary>
+    Unknown = 2,
+
+    /// <summary>
+    /// Client specified an invalid argument. Note that this differs from FAILED_PRECONDITION.
+    /// INVALID_ARGUMENT indicates arguments that are problematic regardless of the state of the
+    /// system (e.g., a malformed file name).
+    /// </summary>
+    InvalidArgument = 3,
+
+    /// <summary>
+    /// Deadline expired before operation could complete. For operations that change the state of the
+    /// system, this error may be returned even if the operation has completed successfully. For
+    /// example, a successful response from a server could have been delayed long enough for the
+    /// deadline to expire.
+    /// </summary>
+    DeadlineExceeded = 4,
+
+    /// <summary>
+    /// Some requested entity (e.g., file or directory) was not found.
+    /// </summary>
+    NotFound = 5,
+
+    /// <summary>
+    /// Some entity that we attempted to create (e.g., file or directory) already exists.
+    /// </summary>
+    AlreadyExists = 6,
+
+    /// <summary>
+    /// The caller does not have permission to execute the specified operation. PERMISSION_DENIED
+    /// must not be used for rejections caused by exhausting some resource (use RESOURCE_EXHAUSTED
+    /// instead for those errors). PERMISSION_DENIED must not be used if the caller cannot be
+    /// identified (use UNAUTHENTICATED instead for those errors).
+    /// </summary>
+    PermissionDenied = 7,
+
+    /// <summary>
+    /// Some resource has been exhausted, perhaps a per-user quota, or perhaps the entire file system
+    /// is out of space.
+    /// </summary>
+    ResourceExhausted = 8,
+
+    /// <summary>
+    /// Operation was rejected because the system is not in a state required for the operation's
+    /// execution. For example, directory to be deleted may be non-empty, an rmdir operation is
+    /// applied to a non-directory, etc.
+    /// A litmus test that may help a service implementor in deciding between FAILED_PRECONDITION,
+    /// ABORTED, and UNAVAILABLE: (a) Use UNAVAILABLE if the client can retry just the failing call.
+    /// (b) Use ABORTED if the client should retry at a higher-level (e.g., restarting a
+    /// read-modify-write sequence). (c) Use FAILED_PRECONDITION if the client should not retry until
+    /// the system state has been explicitly fixed. E.g., if an "rmdir" fails because the directory
+    /// is non-empty, FAILED_PRECONDITION should be returned since the client should not retry unless
+    /// they have first fixed up the directory by deleting files from it.
+    /// </summary>
+    FailedPrecondition = 9,
+
+    /// <summary>
+    /// The operation was aborted, typically due to a concurrency issue like sequencer check
+    /// failures, transaction aborts, etc.
+    /// </summary>
+    Aborted = 10,
+
+    /// <summary>
+    /// Operation was attempted past the valid range. E.g., seeking or reading past end of file.
+    ///
+    /// Unlike INVALID_ARGUMENT, this error indicates a problem that may be fixed if the system
+    /// state changes. For example, a 32-bit file system will generate INVALID_ARGUMENT if asked to
+    /// read at an offset that is not in the range [0,2^32-1], but it will generate OUT_OF_RANGE if
+    /// asked to read from an offset past the current file size.
+    ///
+    /// There is a fair bit of overlap between FAILED_PRECONDITION and OUT_OF_RANGE. We recommend
+    /// using OUT_OF_RANGE (the more specific error) when it applies so that callers who are
+    /// iterating through a space can easily look for an OUT_OF_RANGE error to detect when they are
+    /// done.
+    /// </summary>
+    OutOfRange = 11,
+
+    /// <summary>
+    /// Operation is not implemented or not supported/enabled in this service.
+    /// </summary>
+    Unimplemented = 12,
+
+    /// <summary>
+    /// Internal errors. Means some invariants expected by underlying system has been broken. If you
+    /// see one of these errors, something is very broken.
+    /// </summary>
+    Internal = 13,
+
+    /// <summary>
+    /// The service is currently unavailable. This is a most likely a transient condition and may be
+    /// corrected by retrying with a backoff.
+    ///
+    /// See litmus test above for deciding between FAILED_PRECONDITION, ABORTED, and UNAVAILABLE.
+    /// </summary>
+    Unavailable = 14,
+
+    /// <summary>
+    /// Unrecoverable data loss or corruption.
+    /// </summary>
+    DataLoss = 15,
+
+    /// <summary>
+    /// The request does not have valid authentication credentials for the operation.
+    /// </summary>
+    Unauthenticated = 16,
+}
diff --git a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationProvider.cs b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationProvider.cs
index 8d58d64180206..f1a1c35f4a66e 100644
--- a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationProvider.cs
+++ b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationProvider.cs
@@ -2,6 +2,7 @@
 // Licensed to the .NET Foundation under one or more agreements.
 // The .NET Foundation licenses this file to you under the MIT license.
 
+#if NETSTANDARD2_0
 #nullable enable
 
 using System;
@@ -83,3 +84,4 @@ private void AddIfNormalizedKeyMatchesPrefix(Dictionary<string, string?> data, s
         private static string Normalize(string key) => key.Replace("__", ConfigurationPath.KeyDelimiter);
     }
 }
+#endif
diff --git a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationSource.cs b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationSource.cs
index 2785b2174756e..23fcdd3e0e09c 100644
--- a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationSource.cs
+++ b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesConfigurationSource.cs
@@ -2,6 +2,7 @@
 // Licensed to the .NET Foundation under one or more agreements.
 // The .NET Foundation licenses this file to you under the MIT license.
 
+#if NETSTANDARD2_0
 #nullable enable
 
 namespace Microsoft.Extensions.Configuration.EnvironmentVariables
@@ -27,3 +28,4 @@ public IConfigurationProvider Build(IConfigurationBuilder builder)
         }
     }
 }
+#endif
diff --git a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesExtensions.cs b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesExtensions.cs
index 5b97e90ce7743..0b651f5d94823 100644
--- a/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesExtensions.cs
+++ b/sdk/monitor/Azure.Monitor.OpenTelemetry.AspNetCore/src/Vendoring/Shared/EnvironmentVariables/EnvironmentVariablesExtensions.cs
@@ -2,6 +2,7 @@
 // Licensed to the .NET Foundation under one or more agreements.
 // The .NET Foundation licenses this file to you under the MIT license.
 
+#if NETSTANDARD2_0
 #nullable enable
 
 using System;
@@ -50,3 +51,4 @@ public static IConfigurationBuilder AddEnvironmentVariables(this IConfigurationB
             => builder.Add(configureSource);
     }
 }
+#endif