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If you can't open Bio7 after download even after the changes of the security settings try the following command-line recipe:
https://stackoverflow.com/questions/64842819/cant-run-app-because-of-permission-in-big-sur
Solution which worked in the terminal:
sudo chmod -R 755 /Applications/Bio7.app
sudo xattr -dr com.apple.quarantine /Applications/Bio7.app
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