diff --git a/lighthouse-cli/test/fixtures/a11y/a11y_tester.html b/lighthouse-cli/test/fixtures/a11y/a11y_tester.html
index e4e81027b4de..9e997fcb3e90 100644
--- a/lighthouse-cli/test/fixtures/a11y/a11y_tester.html
+++ b/lighthouse-cli/test/fixtures/a11y/a11y_tester.html
@@ -133,7 +133,7 @@
     <section>
       <div id="duplicate-id-aria" class="duplicate-id-aria"></span>
       <div id="duplicate-id-aria"></div>
-      <div aria-labelledby="duplicate-id-aria"></div>
+      <input type="text" aria-labelledby="duplicate-id-aria"/>
     </section>
     <p>form-field-multiple-labels</p>
     <section>
diff --git a/lighthouse-cli/test/smokehouse/test-definitions/a11y/expectations.js b/lighthouse-cli/test/smokehouse/test-definitions/a11y/expectations.js
index edca5fe3ce6c..fe4b0e31269b 100644
--- a/lighthouse-cli/test/smokehouse/test-definitions/a11y/expectations.js
+++ b/lighthouse-cli/test/smokehouse/test-definitions/a11y/expectations.js
@@ -134,7 +134,7 @@ const expectations = [
                   },
                   'selector': 'body > section > div > div#aria-treeitem-name',
                   'snippet': '<div id="aria-treeitem-name" role="treeitem">',
-                  'explanation': 'Fix any of the following:\n  Element does not have text that is visible to screen readers\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  aria-label attribute does not exist or is empty\n  Element has no title attribute',
+                  'explanation': 'Fix any of the following:\n  Element does not have text that is visible to screen readers\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute',
                   'nodeLabel': 'div',
                 },
               },
@@ -154,7 +154,7 @@ const expectations = [
                   },
                   'selector': 'body > section > div#aria-command-name',
                   'snippet': '<div id="aria-command-name" role="button">',
-                  'explanation': 'Fix any of the following:\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute\n  Element does not have text that is visible to screen readers',
+                  'explanation': 'Fix any of the following:\n  Element does not have text that is visible to screen readers\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute',
                   'nodeLabel': 'div',
                 },
               },
@@ -174,7 +174,7 @@ const expectations = [
                   },
                   'selector': 'body > section > div#aria-tooltip-name',
                   'snippet': '<div id="aria-tooltip-name" role="tooltip">',
-                  'explanation': 'Fix any of the following:\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute\n  Element does not have text that is visible to screen readers',
+                  'explanation': 'Fix any of the following:\n  Element does not have text that is visible to screen readers\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute',
                   'nodeLabel': 'div',
                 },
               },
@@ -239,7 +239,7 @@ const expectations = [
                   'selector': 'body > section > div#aria-required-attr',
                   'path': '2,HTML,1,BODY,19,SECTION,0,DIV',
                   'snippet': '<div id="aria-required-attr" role="checkbox">',
-                  'explanation': 'Fix any of the following:\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute\n  Element does not have text that is visible to screen readers',
+                  'explanation': 'Fix any of the following:\n  Element does not have text that is visible to screen readers\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute',
                   'nodeLabel': 'div',
                 },
               },
@@ -314,7 +314,7 @@ const expectations = [
                   'type': 'node',
                   'selector': 'body > section > button#button-name',
                   'snippet': '<button id="button-name">',
-                  'explanation': 'Fix any of the following:\n  Element does not have inner text that is visible to screen readers\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element\'s default semantics were not overridden with role="none" or role="presentation"\n  Element has no title attribute',
+                  'explanation': 'Fix any of the following:\n  Element does not have inner text that is visible to screen readers\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute\n  Element\'s default semantics were not overridden with role="none" or role="presentation"',
                   'nodeLabel': 'button',
                 },
               },
@@ -456,7 +456,7 @@ const expectations = [
                   'type': 'node',
                   'selector': 'body > section > iframe#frame-title',
                   'snippet': '<iframe id="frame-title">',
-                  'explanation': 'Fix any of the following:\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element has no title attribute\n  Element\'s default semantics were not overridden with role="none" or role="presentation"',
+                  'explanation': 'Fix any of the following:\n  Element has no title attribute\n  aria-label attribute does not exist or is empty\n  aria-labelledby attribute does not exist, references elements that do not exist or references elements that are empty\n  Element\'s default semantics were not overridden with role="none" or role="presentation"',
                   'nodeLabel': 'iframe',
                 },
               },
diff --git a/lighthouse-core/gather/gatherers/accessibility.js b/lighthouse-core/gather/gatherers/accessibility.js
index 4eff360cc805..48168a414c7d 100644
--- a/lighthouse-core/gather/gatherers/accessibility.js
+++ b/lighthouse-core/gather/gatherers/accessibility.js
@@ -57,6 +57,9 @@ async function runA11yChecks() {
       'svg-img-alt': {enabled: false},
       'audio-caption': {enabled: false},
       'aria-treeitem-name': {enabled: true},
+      // https://github.com/dequelabs/axe-core/issues/2958
+      'nested-interactive': {enabled: false},
+      'frame-focusable-content': {enabled: false},
     },
   });
 
diff --git a/lighthouse-core/test/report/html/renderer/report-renderer-test.js b/lighthouse-core/test/report/html/renderer/report-renderer-test.js
index 11d9e6f3ba5b..08928fde75f3 100644
--- a/lighthouse-core/test/report/html/renderer/report-renderer-test.js
+++ b/lighthouse-core/test/report/html/renderer/report-renderer-test.js
@@ -293,7 +293,7 @@ describe('ReportRenderer', () => {
       global.Element = undefined;
     });
 
-    it('renders without axe violations', (done) => {
+    it('renders without axe violations', () => {
       const container = renderer._dom._document.createElement('main');
       const output = renderer.renderReport(sampleResults, container);
       renderer._dom._document.body.appendChild(container);
@@ -311,15 +311,18 @@ describe('ReportRenderer', () => {
           'link-in-text-block': {enabled: false},
           // Report has empty links prior to i18n-ing.
           'link-name': {enabled: false},
+          // May not be a real issue. https://github.com/dequelabs/axe-core/issues/2958
+          'nested-interactive': {enabled: false},
         },
       };
 
-      axe.run(output, config, (error, {violations}) => {
-        assert.ifError(error);
-        assert.ok(violations.length === 0, JSON.stringify(violations, null, 1));
-        done();
+      return new Promise(resolve => {
+        axe.run(output, config, (error, {violations}) => {
+          expect(error).toBeNull();
+          expect(violations).toEqual([]);
+          resolve();
+        });
       });
-
     // Set timeout to 10s to give axe-core enough time to complete
     // https://github.com/dequelabs/axe-core/tree/b573b1c1/doc/examples/jest_react#timeout-issues
     }, /* timeout= */ 10 * 1000);
diff --git a/package.json b/package.json
index eaa958fa73e7..3af3d026aff7 100644
--- a/package.json
+++ b/package.json
@@ -158,7 +158,7 @@
     "webtreemap-cdt": "^3.2.0"
   },
   "dependencies": {
-    "axe-core": "4.1.3",
+    "axe-core": "4.2.1",
     "chrome-launcher": "^0.14.0",
     "configstore": "^5.0.1",
     "csp_evaluator": "^1.0.1",
diff --git a/yarn.lock b/yarn.lock
index 5a697c4cebd2..bb710bc28e61 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -1370,10 +1370,10 @@ aws4@^1.8.0:
   resolved "https://registry.yarnpkg.com/aws4/-/aws4-1.8.0.tgz#f0e003d9ca9e7f59c7a508945d7b2ef9a04a542f"
   integrity sha512-ReZxvNHIOv88FlT7rxcXIIC0fPt4KZqZbOlivyWtXLt8ESx84zd3kMC6iK5jVeS2qt+g7ftS7ye4fi06X5rtRQ==
 
-axe-core@4.1.3:
-  version "4.1.3"
-  resolved "https://registry.yarnpkg.com/axe-core/-/axe-core-4.1.3.tgz#64a4c85509e0991f5168340edc4bedd1ceea6966"
-  integrity sha512-vwPpH4Aj4122EW38mxO/fxhGKtwWTMLDIJfZ1He0Edbtjcfna/R3YB67yVhezUMzqc3Jr3+Ii50KRntlENL4xQ==
+axe-core@4.2.1:
+  version "4.2.1"
+  resolved "https://registry.yarnpkg.com/axe-core/-/axe-core-4.2.1.tgz#2e50bcf10ee5b819014f6e342e41e45096239e34"
+  integrity sha512-evY7DN8qSIbsW2H/TWQ1bX3sXN1d4MNb5Vb4n7BzPuCwRHdkZ1H2eNLuSh73EoQqkGKUtju2G2HCcjCfhvZIAA==
 
 babel-jest@^26.6.3:
   version "26.6.3"