diff --git a/packages/image-io/.gitignore b/packages/image-io/.gitignore
index 625d51c2e..54d9f904c 100644
--- a/packages/image-io/.gitignore
+++ b/packages/image-io/.gitignore
@@ -1,3 +1,6 @@
 ImageIOIndex.ts.in
 dist
-emscripten-build
+emscripten-build/
+wasi-build/
+package-lock.json
+test/data/
diff --git a/packages/image-io/CMakeLists.txt b/packages/image-io/CMakeLists.txt
index ee43ac0b1..34be93caf 100644
--- a/packages/image-io/CMakeLists.txt
+++ b/packages/image-io/CMakeLists.txt
@@ -206,3 +206,21 @@ if(EMSCRIPTEN)
   configure_file(${CMAKE_CURRENT_SOURCE_DIR}/image-io-index.ts.in
     ${CMAKE_CURRENT_SOURCE_DIR}/typescript/src/image-io-index.ts @ONLY)
 endif()
+
+enable_testing()
+
+set(input_dir ${CMAKE_CURRENT_SOURCE_DIR}/test/data/input)
+set(baseline_dir ${CMAKE_CURRENT_SOURCE_DIR}/test/data/baseline)
+set(output_dir ${CMAKE_CURRENT_BINARY_DIR})
+
+add_test(NAME bio-rad-read-image-test
+  COMMAND bio-rad-read-image
+  ${input_dir}/biorad.pic
+  ${output_dir}/bio-rad-read-image-test.could-read.json
+  ${output_dir}/bio-rad-read-image-test.iwi.cbor)
+
+add_test(NAME bio-rad-write-image-test
+  COMMAND bio-rad-write-image
+  ${baseline_dir}/bio-rad-read-image-test.iwi.cbor
+  ${output_dir}/bio-rad-write-image-test.could-write.json
+  ${output_dir}/bio-rad-write-image-test.pic)
\ No newline at end of file
diff --git a/packages/image-io/typescript/package.json b/packages/image-io/typescript/package.json
index 7ecdc2cc6..a19d4e3c3 100644
--- a/packages/image-io/typescript/package.json
+++ b/packages/image-io/typescript/package.json
@@ -14,7 +14,8 @@
   },
   "scripts": {
     "start": "npm run copyShoelaceAssets && vite -c build/vite.config.js",
-    "test": "echo \"Error: no test specified\" && exit 1",
+    "test": "npm run test:node",
+    "test:node": "ava test/node/*.js",
     "build": "npm run build:tsc && npm run build:node && npm run build:browser && npm run build:demo",
     "build:node": "rollup -c ./build/rollup.node.config.js",
     "build:browser": "rollup -c ./build/rollup.browser.config.js",
@@ -41,6 +42,7 @@
     "@rollup/plugin-typescript": "^11.1.1",
     "@shoelace-style/shoelace": "^2.5.2",
     "@types/node": "^20.2.5",
+    "ava": "^5.3.1",
     "debug": "^4.3.4",
     "rollup": "^3.9.0",
     "rollup-plugin-copy": "^3.4.0",
diff --git a/packages/image-io/typescript/test/node/bio-rad-test.js b/packages/image-io/typescript/test/node/bio-rad-test.js
new file mode 100644
index 000000000..00a65aae4
--- /dev/null
+++ b/packages/image-io/typescript/test/node/bio-rad-test.js
@@ -0,0 +1,62 @@
+import test from 'ava'
+import path from 'path'
+import fs from 'fs'
+
+function mkdirP(dir) {
+  try {
+    fs.mkdirSync(dir, { recursive: true })
+  } catch (err) {
+    if (err.code !== 'EEXIST') throw err
+  }
+}
+
+import { bioRadReadImageNode, bioRadWriteImageNode } from '../../dist/bundles/image-io-node.js'
+import { IntTypes, PixelTypes, getMatrixElement } from 'itk-wasm'
+
+const testInputFilePath = path.resolve('..', 'test', 'data', 'input', 'biorad.pic')
+const testOutputPath = path.resolve('..', 'test', 'output', 'typescript')
+const testOutputFilePath = path.join(testOutputPath, 'biorad.pic')
+
+const verifyImage = (t, image) => {
+  t.is(image.imageType.dimension, 2, 'dimension')
+  t.is(image.imageType.componentType, IntTypes.UInt8, 'componentType')
+  t.is(image.imageType.pixelType, PixelTypes.Scalar, 'pixelType')
+  t.is(image.imageType.components, 1, 'components')
+  t.is(image.origin[0], 0.0, 'origin[0]')
+  t.is(image.origin[1], 0.0, 'origin[1]')
+  t.is(image.spacing[0], 0.06000000238418579, 'spacing[0]')
+  t.is(image.spacing[1], 0.06000000238418579, 'spacing[1]')
+  t.is(getMatrixElement(image.direction, 2, 0, 0), 1.0, 'direction (0, 0)')
+  t.is(getMatrixElement(image.direction, 2, 0, 1), 0.0, 'direction (0, 1)')
+  t.is(getMatrixElement(image.direction, 2, 1, 0), 0.0, 'direction (1, 0)')
+  t.is(getMatrixElement(image.direction, 2, 1, 1), 1.0, 'direction (1, 1)')
+  t.is(image.size[0], 768, 'size[0]')
+  t.is(image.size[1], 512, 'size[1]')
+  t.is(image.data.length, 393216, 'data.length')
+  t.is(image.data[1000], 27, 'data[1000]')
+}
+
+test('Test reading a BioRad file', async t => {
+  const { couldRead, image } = await bioRadReadImageNode(testInputFilePath)
+  t.true(couldRead)
+  verifyImage(t, image)
+})
+
+test('Test writing a BioRad file', async t => {
+  const { couldRead, image } = await bioRadReadImageNode(testInputFilePath)
+  t.true(couldRead)
+  const useCompression = false
+  const { couldWrite, serializedImage } = await bioRadWriteImageNode(image,  { useCompression })
+  console.log(couldWrite, serializedImage)
+
+  // verifyImage(t, image)
+  // return readImageLocalFile(testInputFilePath).then(function (image) {
+  //   const useCompression = false
+  //   return writeImageLocalFile(image, testOutputFilePath, useCompression)
+  // })
+  //   .then(function () {
+  //     return readImageLocalFile(testOutputFilePath).then(function (image) {
+  //       verifyImage(t, image)
+  //     })
+    // })
+})