diff --git a/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/compress_stringify.py b/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/compress_stringify.py
index ca4a2c3e1..a40ff9753 100644
--- a/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/compress_stringify.py
+++ b/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/compress_stringify.py
@@ -6,6 +6,8 @@
 
 from importlib_resources import files as file_resources
 
+_pipeline = None
+
 from itkwasm import (
     InterfaceTypes,
     PipelineOutput,
@@ -37,7 +39,9 @@ def compress_stringify(
     :return: Output compressed binary
     :rtype:  bytes
     """
-    pipeline = Pipeline(file_resources('itkwasm_compress_stringify_wasi').joinpath(Path('wasm_modules') / Path('compress-stringify.wasi.wasm')))
+    global _pipeline
+    if _pipeline is None:
+        _pipeline = Pipeline(file_resources('itkwasm_compress_stringify_wasi').joinpath(Path('wasm_modules') / Path('compress-stringify.wasi.wasm')))
 
     pipeline_outputs: List[PipelineOutput] = [
         PipelineOutput(InterfaceTypes.BinaryStream),
@@ -65,9 +69,7 @@ def compress_stringify(
         args.append(str(data_url_prefix))
 
 
-    outputs = pipeline.run(args, pipeline_outputs, pipeline_inputs)
-
-    del pipeline
+    outputs = _pipeline.run(args, pipeline_outputs, pipeline_inputs)
 
     result = outputs[0].data.data
     return result
diff --git a/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/parse_string_decompress.py b/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/parse_string_decompress.py
index f4c2b93a7..592484386 100644
--- a/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/parse_string_decompress.py
+++ b/packages/compress-stringify/python/itkwasm-compress-stringify-wasi/itkwasm_compress_stringify_wasi/parse_string_decompress.py
@@ -6,6 +6,8 @@
 
 from importlib_resources import files as file_resources
 
+_pipeline = None
+
 from itkwasm import (
     InterfaceTypes,
     PipelineOutput,
@@ -29,7 +31,9 @@ def parse_string_decompress(
     :return: Output decompressed binary
     :rtype:  bytes
     """
-    pipeline = Pipeline(file_resources('itkwasm_compress_stringify_wasi').joinpath(Path('wasm_modules') / Path('parse-string-decompress.wasi.wasm')))
+    global _pipeline
+    if _pipeline is None:
+        _pipeline = Pipeline(file_resources('itkwasm_compress_stringify_wasi').joinpath(Path('wasm_modules') / Path('parse-string-decompress.wasi.wasm')))
 
     pipeline_outputs: List[PipelineOutput] = [
         PipelineOutput(InterfaceTypes.BinaryStream),
@@ -49,9 +53,7 @@ def parse_string_decompress(
         args.append('--parse-string')
 
 
-    outputs = pipeline.run(args, pipeline_outputs, pipeline_inputs)
-
-    del pipeline
+    outputs = _pipeline.run(args, pipeline_outputs, pipeline_inputs)
 
     result = outputs[0].data.data
     return result
diff --git a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/apply_presentation_state_to_image.py b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/apply_presentation_state_to_image.py
index 18e1e96c1..fc96ce686 100644
--- a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/apply_presentation_state_to_image.py
+++ b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/apply_presentation_state_to_image.py
@@ -6,6 +6,8 @@
 
 from importlib_resources import files as file_resources
 
+_pipeline = None
+
 from itkwasm import (
     InterfaceTypes,
     PipelineOutput,
@@ -49,7 +51,9 @@ def apply_presentation_state_to_image(
     :return: Output image
     :rtype:  Image
     """
-    pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('apply-presentation-state-to-image.wasi.wasm')))
+    global _pipeline
+    if _pipeline is None:
+        _pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('apply-presentation-state-to-image.wasi.wasm')))
 
     pipeline_outputs: List[PipelineOutput] = [
         PipelineOutput(InterfaceTypes.JsonObject),
@@ -84,9 +88,7 @@ def apply_presentation_state_to_image(
         args.append('--no-bitmap-output')
 
 
-    outputs = pipeline.run(args, pipeline_outputs, pipeline_inputs)
-
-    del pipeline
+    outputs = _pipeline.run(args, pipeline_outputs, pipeline_inputs)
 
     result = (
         outputs[0].data.data,
diff --git a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/read_dicom_encapsulated_pdf.py b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/read_dicom_encapsulated_pdf.py
index a106aaa3b..bcdc163ab 100644
--- a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/read_dicom_encapsulated_pdf.py
+++ b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/read_dicom_encapsulated_pdf.py
@@ -6,6 +6,8 @@
 
 from importlib_resources import files as file_resources
 
+_pipeline = None
+
 from itkwasm import (
     InterfaceTypes,
     PipelineOutput,
@@ -86,7 +88,9 @@ def read_dicom_encapsulated_pdf(
     :return: Output pdf file
     :rtype:  bytes
     """
-    pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('read-dicom-encapsulated-pdf.wasi.wasm')))
+    global _pipeline
+    if _pipeline is None:
+        _pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('read-dicom-encapsulated-pdf.wasi.wasm')))
 
     pipeline_outputs: List[PipelineOutput] = [
         PipelineOutput(InterfaceTypes.BinaryStream),
@@ -148,9 +152,7 @@ def read_dicom_encapsulated_pdf(
         args.append('--disable-correction')
 
 
-    outputs = pipeline.run(args, pipeline_outputs, pipeline_inputs)
-
-    del pipeline
+    outputs = _pipeline.run(args, pipeline_outputs, pipeline_inputs)
 
     result = outputs[0].data.data
     return result
diff --git a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_html.py b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_html.py
index 4a594c8ac..04b0d99e3 100644
--- a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_html.py
+++ b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_html.py
@@ -6,6 +6,8 @@
 
 from importlib_resources import files as file_resources
 
+_pipeline = None
+
 from itkwasm import (
     InterfaceTypes,
     PipelineOutput,
@@ -187,7 +189,9 @@ def structured_report_to_html(
     :return: Output text file
     :rtype:  str
     """
-    pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('structured-report-to-html.wasi.wasm')))
+    global _pipeline
+    if _pipeline is None:
+        _pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('structured-report-to-html.wasi.wasm')))
 
     pipeline_outputs: List[PipelineOutput] = [
         PipelineOutput(InterfaceTypes.TextStream),
@@ -332,9 +336,7 @@ def structured_report_to_html(
         args.append('--code-details-tooltip')
 
 
-    outputs = pipeline.run(args, pipeline_outputs, pipeline_inputs)
-
-    del pipeline
+    outputs = _pipeline.run(args, pipeline_outputs, pipeline_inputs)
 
     result = outputs[0].data.data
     return result
diff --git a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_text.py b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_text.py
index 23b688d8a..9917fa3ae 100644
--- a/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_text.py
+++ b/packages/dicom/python/itkwasm-dicom-wasi/itkwasm_dicom_wasi/structured_report_to_text.py
@@ -6,6 +6,8 @@
 
 from importlib_resources import files as file_resources
 
+_pipeline = None
+
 from itkwasm import (
     InterfaceTypes,
     PipelineOutput,
@@ -94,7 +96,9 @@ def structured_report_to_text(
     :return: Output text file
     :rtype:  str
     """
-    pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('structured-report-to-text.wasi.wasm')))
+    global _pipeline
+    if _pipeline is None:
+        _pipeline = Pipeline(file_resources('itkwasm_dicom_wasi').joinpath(Path('wasm_modules') / Path('structured-report-to-text.wasi.wasm')))
 
     pipeline_outputs: List[PipelineOutput] = [
         PipelineOutput(InterfaceTypes.TextStream),
@@ -162,9 +166,7 @@ def structured_report_to_text(
         args.append('--print-color')
 
 
-    outputs = pipeline.run(args, pipeline_outputs, pipeline_inputs)
-
-    del pipeline
+    outputs = _pipeline.run(args, pipeline_outputs, pipeline_inputs)
 
     result = outputs[0].data.data
     return result
diff --git a/src/bindgen/python.js b/src/bindgen/python.js
index 6b53b186c..11813ef76 100644
--- a/src/bindgen/python.js
+++ b/src/bindgen/python.js
@@ -278,6 +278,8 @@ from typing import Dict, Tuple, Optional, List
 
 from importlib_resources import files as file_resources
 
+_pipeline = None
+
 from itkwasm import (
     InterfaceTypes,
     PipelineOutput,
@@ -465,7 +467,9 @@ from itkwasm import (
   moduleContent += `def ${functionName}(
 ${functionArgs}) -> ${returnType}:
     ${docstring}
-    pipeline = Pipeline(file_resources('${pypackage}').joinpath(Path('wasm_modules') / Path('${interfaceJson.name}.wasi.wasm')))
+    global _pipeline
+    if _pipeline is None:
+        _pipeline = Pipeline(file_resources('${pypackage}').joinpath(Path('wasm_modules') / Path('${interfaceJson.name}.wasi.wasm')))
 
     pipeline_outputs: List[PipelineOutput] = [
 ${pipelineOutputs}    ]
@@ -474,9 +478,7 @@ ${pipelineOutputs}    ]
 ${pipelineInputs}    ]
 
 ${args}
-    outputs = pipeline.run(args, pipeline_outputs, pipeline_inputs)
-
-    del pipeline
+    outputs = _pipeline.run(args, pipeline_outputs, pipeline_inputs)
 
 ${postOutput}
 `