diff --git a/src/itk-wasm-cli.js b/src/itk-wasm-cli.js
index f5cba430a..349222aaa 100755
--- a/src/itk-wasm-cli.js
+++ b/src/itk-wasm-cli.js
@@ -284,6 +284,9 @@ function typescriptBindings(outputDir, buildDir, wasmBinaries, options, forNode=
     if (err.code !== 'EEXIST') throw err
   }
 
+  let readmeInterface = ''
+  let readmePipelines = ''
+
   if (options.packageName) {
     const packageName = options.packageName
     const packageJsonPath = path.join(outputDir, 'package.json')
@@ -299,15 +302,6 @@ function typescriptBindings(outputDir, buildDir, wasmBinaries, options, forNode=
       packageJson.exports['.'].default = `./dist/${packageName}.js`
       fs.writeFileSync(packageJsonPath, JSON.stringify(packageJson, null, 2))
 
-      const readmePath = path.join(outputDir, 'README.md')
-      if (!fs.existsSync(readmePath)) {
-        let readme = `# ${packageName}\n`
-        readme += `\n[![npm version](https://badge.fury.io/js/${packageName}.svg)](https://www.npmjs.com/package/${packageName})\n`
-        if (options.packageDescription) {
-          readme += `\n${options.packageDescription}\n`
-        }
-        fs.writeFileSync(readmePath, readme)
-      }
     }
 
     if (!forNode) {
@@ -384,10 +378,16 @@ function typescriptBindings(outputDir, buildDir, wasmBinaries, options, forNode=
     const moduleCamelCase = camelCase(parsedPath.name)
     const modulePascalCase = `${moduleCamelCase[0].toUpperCase()}${moduleCamelCase.substring(1)}`
 
+    readmeInterface += `  ${moduleCamelCase}${nodeText},\n`
+    let readmeResult = ''
+    let readmeOptions = ''
+
     // Result module
     let resultContent = `interface ${modulePascalCase}${nodeText}Result {\n`
+    readmeResult += `\n\`${modulePascalCase}${nodeText}Result\` interface:\n\n| Property | Type | Description |\n| -------- | ---- | ----------- |\n`
     if (!forNode) {
       resultContent += `  /** WebWorker used for computation */\n  webWorker: Worker | null\n\n`
+      readmeResult += `| webWorker | Worker | WebWorker used for computation |\n`
     }
 
     // track unique output types in this set
@@ -405,6 +405,7 @@ function typescriptBindings(outputDir, buildDir, wasmBinaries, options, forNode=
         importTypes.add(outputType)
       }
       resultContent += `  ${camelCase(output.name)}: ${outputType}\n\n`
+      readmeResult += `| ${camelCase(output.name)} | ${outputType} | ${output.description} |\n`
     })
 
     // Insert the import statement in the beginning for the file.
@@ -617,8 +618,17 @@ function typescriptBindings(outputDir, buildDir, wasmBinaries, options, forNode=
     indexContent += `import ${moduleCamelCase}${nodeText} from './${moduleCamelCase}${nodeText}.js'\n`
     indexContent += `export { ${moduleCamelCase}${nodeText} }\n`
 
+    readmePipelines += readmeOptions
+    readmePipelines += readmeResult
   })
+
+  if (options.packageName) {
+    const packageName = options.packageName
+    readmeInterface += `} from "${packageName}"\n\`\`\`\n`
+    readmeInterface += readmePipelines
+  }
   fs.writeFileSync(path.join(srcOutputDir, `index${nodeText}.ts`), indexContent)
+  return readmeInterface
 }
 
 
@@ -639,8 +649,37 @@ function bindgen(wasmBinaries, options) {
 
   switch (language) {
     case 'typescript': {
-      typescriptBindings(outputDir, buildDir, filteredWasmBinaries, options, false)
-      typescriptBindings(outputDir, buildDir, filteredWasmBinaries, options, true)
+      let readme = ''
+      if (options.packageName) {
+        const packageName = options.packageName
+        readme += `# ${packageName}\n`
+        readme += `\n[![npm version](https://badge.fury.io/js/${packageName}.svg)](https://www.npmjs.com/package/${packageName})\n`
+        if (options.packageDescription) {
+          readme += `\n${options.packageDescription}\n`
+        }
+        readme += `\n## Installation\n
+  \`\`\`sh
+  npm install ${packageName}
+  \`\`\`
+`
+      }
+
+      let readmeUsage = '\n## Usage\n'
+      let readmeBrowserInterface = '\n### Browser interface\n\nImport desired functions from the package:\n\n```js\nimport {\n'
+      let readmeNodeInterface = '\n### Node interface\n\nImport desired functions from the package:\n\n```js\nimport {\n'
+
+      readmeBrowserInterface += typescriptBindings(outputDir, buildDir, filteredWasmBinaries, options, false)
+      readmeNodeInterface += typescriptBindings(outputDir, buildDir, filteredWasmBinaries, options, true)
+      if (options.packageName) {
+        readme += readmeUsage
+        readme += readmeBrowserInterface
+        readme += readmeNodeInterface
+
+        const readmePath = path.join(outputDir, 'README.md')
+        if (!fs.existsSync(readmePath)) {
+          fs.writeFileSync(readmePath, readme)
+        }
+      }
     }
     break
   }