diff --git a/packages/core/python/itkwasm/.gitattributes b/packages/core/python/itkwasm/.gitattributes
new file mode 100644
index 000000000..07fe41c52
--- /dev/null
+++ b/packages/core/python/itkwasm/.gitattributes
@@ -0,0 +1,2 @@
+# GitHub syntax highlighting
+pixi.lock linguist-language=YAML linguist-generated=true
diff --git a/packages/core/python/itkwasm/.gitignore b/packages/core/python/itkwasm/.gitignore
index 849ddff3b..69dec31d7 100644
--- a/packages/core/python/itkwasm/.gitignore
+++ b/packages/core/python/itkwasm/.gitignore
@@ -1 +1,5 @@
 dist/
+# pixi environments
+.pixi
+*.egg-info
+pyodide.tar.bz2
diff --git a/packages/core/python/itkwasm/pixi.lock b/packages/core/python/itkwasm/pixi.lock
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index 000000000..262a334c4
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+  requires_dist:
+  - cffi>=1.11 ; platform_python_implementation == 'PyPy'
+  - cffi>=1.11 ; extra == 'cffi'
+  requires_python: '>=3.8'
diff --git a/packages/core/python/itkwasm/pyproject.toml b/packages/core/python/itkwasm/pyproject.toml
index 62a183ed1..212ba0598 100644
--- a/packages/core/python/itkwasm/pyproject.toml
+++ b/packages/core/python/itkwasm/pyproject.toml
@@ -42,6 +42,9 @@ Home = "https://itkwasm.readthedocs.io"
 Source = "https://github.com/InsightSoftwareConsortium/ITK-Wasm"
 Issues = "https://github.com/InsightSoftwareConsortium/ITK-Wasm/issues"
 
+[project.optional-dependencies]
+test = ["itk", "pytest", "pytest-pyodide", "dask[array]", "hatch>=1.12.0,<2", "pyodide-py>=0.26.2,<0.27"]
+
 [tool.hatch.envs.default]
 dependencies = [
     "itk>=5.4.0",
@@ -68,3 +71,22 @@ path = "itkwasm/__init__.py"
 
 [tool.black]
 line-length = 120
+
+[tool.pixi.project]
+channels = ["conda-forge"]
+platforms = ["linux-aarch64"]
+
+[tool.pixi.pypi-dependencies]
+itkwasm = { path = ".", editable = true }
+test-accelerator = { path = "test/test-accelerator", editable = true }
+
+[tool.pixi.tasks]
+
+[tool.pixi.feature.test.tasks]
+download-pyodide = { cmd = "curl -L https://github.com/pyodide/pyodide/releases/download/0.26.2/pyodide-0.26.2.tar.bz2 -o pyodide.tar.bz2 && tar xjf pyodide.tar.bz2 && rm -rf dist/pyodide && mkdir -p dist && mv pyodide dist", description = "Download Pyodide", outputs = ["pyodide.tar.bz2"] }
+serve = { cmd = 'hatch build -t wheel ./dist/pyodide/ && echo "Visit http://localhost:8877/console.html" && python -m http.server --directory=./dist/pyodide 8877', description = "Serve the Pyodide distribution", depends-on = ["download-pyodide"] }
+test = { cmd = "hatch build -t wheel ./dist/pyodide/ && pytest --dist-dir=./dist/pyodide --rt=chrome", description = "Run the test suite", depends-on = ["download-pyodide"] }
+
+[tool.pixi.environments]
+default = {features = [], solve-group = "default"}
+test = {features = ["test"], solve-group = "default"}
\ No newline at end of file