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variables.json
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variables.json
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{
"code": "root",
"groups": [
{
"code": "genetic",
"groups": [
{
"code": "polymorphism",
"label": "polymorphism",
"variables": [
{
"code": "apoe4",
"description": "Apolipoprotein E (APOE) e4 allele: is the strongest risk factor for Late Onset Alzheimer Disease (LOAD). At least one copy of APOE-e4 ",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "ApoE4",
"methodology": "adni-merge",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs3818361_t",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs3818361_T",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs744373_c",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs744373_C",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs190982_g",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs190982_G",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs1476679_c",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs1476679_C",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs11767557_c",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs11767557_C",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs11136000_t",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs11136000_T",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs610932_a",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs610932_A",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs3851179_a",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs3851179_A",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs17125944_c",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs17125944_C",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs10498633_t",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs10498633_T",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs3764650_g",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs3764650_G",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs3865444_t",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs3865444_T",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
},
{
"code": "rs2718058_g",
"description": "",
"enumerations": [
{
"code": 0,
"label": 0
},
{
"code": 1,
"label": 1
},
{
"code": 2,
"label": 2
}
],
"label": "rs2718058_G",
"methodology": "lren-nmm-volumes",
"sql_type": "int",
"type": "polynominal"
}
]
}
],
"label": "Genetic"
},
{
"code": "pet",
"label": "PET - Positron Emission Tomography",
"variables": [
{
"code": "fdg",
"description": " Average FDG-PET of angular, temporal, and posterior cingulate. Most important hypometabolic regions that are indicative of pathological metabolic change in MCI and AD.",
"label": "FDG-PET",
"methodology": "adni-merge",
"type": "real"
},
{
"code": "pib",
"description": "Average PIB SUVR of frontal cortex, anterior cingulate, precuneus cortex, and parietal cortex.",
"label": "PIB",
"methodology": "adni-merge",
"type": "real"
},
{
"code": "av45",
"description": "AV45 Average AV45 SUVR of frontal, anterior cingulate, precuneus, and parietal cortex relative to the cerebellum",
"label": "AV45",
"methodology": "adni-merge",
"type": "real"
}
]
},
{
"code": "proteome",
"description": "Protein biology as detected using routine lab chemistries in blood and cerebrospinal fluid specimens as well as in biopsy, measurement of protein-protein interactions, level of antibodies, auto-antibodies, etc.",
"groups": [
{
"code": "csf_proteome",
"description": "Protein content of the cerebrospinal fluid",
"label": "Cerebrospinal fluid",
"variables": [
{
"code": "ab1_42",
"description": "A\u03b2 is the main component of amyloid plaques (extracellular deposits found in the brains of patients with Alzheimer''s disease). Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis (a muscle disease), while A\u03b2 can also form the aggregates that coat cerebral blood vessels in cerebral amyloid angiopathy. The plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as the prions associated with protein misfolding diseases.",
"label": "Level of amyloid beta 1-42 peptides in cerebrospinal fluid",
"methodology": "mip-cde",
"type": "real",
"units": ""
},
{
"code": "ab1_40",
"description": "A\u03b2 is the main component of amyloid plaques (extracellular deposits found in the brains of patients with Alzheimer''s disease). Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis (a muscle disease), while A\u03b2 can also form the aggregates that coat cerebral blood vessels in cerebral amyloid angiopathy. The plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as the prions associated with protein misfolding diseases.",
"label": "Level od amyloid beta 1-40 peptides ion cerebrospinal fluid",
"methodology": "mip-cde",
"type": "real",
"units": ""
},
{
"code": "t_tau",
"description": "Tau proteins (or \u03c4 proteins) are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer''s disease and Parkinson''s disease are associated with tau proteins that have become defective and no longer stabilize microtubules properly.",
"label": "Total level of tau proteins in cerebrospinal fluid",
"methodology": "mip-cde",
"type": "real",
"units": ""
},
{
"code": "p_tau",
"description": "Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer''s disease, frontotemporal dementia, and other tauopathies.",
"label": "Level of phosphorylated tau proteins in cerebrospinal fluid ",
"methodology": "mip-cde",
"type": "real",
"units": ""
}
]
}
],
"label": "Entire set of proteins expressed by the patient''s organism at the time of the medical workup"
},
{
"code": "brain_anatomy",
"groups": [
{
"code": "csf_volume",
"label": "CSF volume",
"variables": [
{
"code": "rightinflatvent",
"description": "",
"label": "Right inferior lateral ventricle",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftinflatvent",
"description": "",
"label": "Left inferior lateral ventricle",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightlateralventricle",
"description": "",
"label": "Right lateral ventricle",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftlateralventricle",
"description": "",
"label": "Left lateral ventricle",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "_3rdventricle",
"description": "",
"label": "3rd Ventricle",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "_4thventricle",
"description": "",
"label": "4th Ventricle",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "csfglobal",
"description": "",
"label": "CSF global",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
}
]
},
{
"code": "white_matter_volume",
"label": "White matter volume",
"variables": [
{
"code": "rightcerebellumwhitematter",
"description": "",
"label": "Right Cerebellum White Matter",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftcerebellumwhitematter",
"description": "",
"label": "Left Cerebellum White Matter",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightcerebralwhitematter",
"description": "",
"label": "Right Cerebral White Matter",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftcerebralwhitematter",
"description": "",
"label": "Left Cerebral White Matter",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "opticchiasm",
"description": "",
"label": "Optic chiasm",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
}
]
},
{
"code": "grey_matter_volume",
"groups": [
{
"code": "cerebellum",
"label": "Cerebellum",
"variables": [
{
"code": "cerebellarvermallobulesviiix",
"description": "",
"label": "Cerebellar Vermal Lobules VIII-X",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "cerebellarvermallobulesvivii",
"description": "",
"label": "Cerebellar Vermal Lobules VI-VII",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "cerebellarvermallobulesiv",
"description": "",
"label": "Cerebellar Vermal Lobules I-V",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftcerebellumexterior",
"description": "",
"label": "Left Cerebellum Exterior",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightcerebellumexterior",
"description": "",
"label": "Right Cerebellum Exterior",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
}
]
},
{
"code": "cerebral_nuclei",
"groups": [
{
"code": "basal_ganglia",
"label": "Basal Ganglia",
"variables": [
{
"code": "rightbasalforebrain",
"description": "",
"label": "Right Basal Forebrain",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftbasalforebrain",
"description": "",
"label": "Left Basal Forebrain",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightaccumbensarea",
"description": "",
"label": "Right Accumbens Area",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftaccumbensarea",
"description": "",
"label": "Left Accumbens Area",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightcaudate",
"description": "",
"label": "Right Caudate",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftcaudate",
"description": "",
"label": "Left Caudate",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightpallidum",
"description": "",
"label": "Right Pallidum",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftpallidum",
"description": "",
"label": "Left Pallidum",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightputamen",
"description": "",
"label": "Right Putamen",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftputamen",
"description": "",
"label": "Left Putamen",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
}
]
},
{
"code": "amygdala",
"label": "Amygdala",
"variables": [
{
"code": "rightamygdala",
"description": "",
"label": "Right Amygdala",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftamygdala",
"description": "",
"label": "Left Amygdala",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
}
]
}
],
"label": "Cerebral nuclei"
},
{
"code": "limbic",
"label": "Limbic",
"variables": [
{
"code": "righthippocampus",
"description": "",
"label": "Right Hippocampus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "lefthippocampus",
"description": "",
"label": "Left Hippocampus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightthalamusproper",
"description": "",
"label": "Right Thalamus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftthalamusproper",
"description": "",
"label": "Left Thalamus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightacgganteriorcingulategyrus",
"description": "",
"label": "Right anterior cingulate gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftacgganteriorcingulategyrus",
"description": "",
"label": "Left anterior cingulate gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightententorhinalarea",
"description": "",
"label": "Right entorhinal area",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftententorhinalarea",
"description": "",
"label": "Left entorhinal area",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightmcggmiddlecingulategyrus",
"description": "",
"label": "Right middle cingulate gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftmcggmiddlecingulategyrus",
"description": "",
"label": "Left middle cingulate gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightpcggposteriorcingulategyrus",
"description": "",
"label": "Right posterior cingulate gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftpcggposteriorcingulategyrus",
"description": "",
"label": "Left posterior cingulate gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightphgparahippocampalgyrus",
"description": "",
"label": "Right parahippocampal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftphgparahippocampalgyrus",
"description": "",
"label": "Left parahippocampal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
}
]
},
{
"code": "temporal",
"label": "Temporal",
"variables": [
{
"code": "rightfugfusiformgyrus",
"description": "",
"label": "Right fusiform gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftfugfusiformgyrus",
"description": "",
"label": "Left fusiform gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightitginferiortemporalgyrus",
"description": "",
"label": "Right inferior temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftitginferiortemporalgyrus",
"description": "",
"label": "Left inferior temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightmtgmiddletemporalgyrus",
"description": "",
"label": "Right middle temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftmtgmiddletemporalgyrus",
"description": "",
"label": "Left middle temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightppplanumpolare",
"description": "",
"label": "Right planum polare",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftppplanumpolare",
"description": "",
"label": "Left planum polare",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightptplanumtemporale",
"description": "",
"label": "Right planum temporale",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftptplanumtemporale",
"description": "",
"label": "Left planum temporale",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightstgsuperiortemporalgyrus",
"description": "",
"label": "Right superior temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftstgsuperiortemporalgyrus",
"description": "",
"label": "Left superior temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "righttmptemporalpole",
"description": "",
"label": "Right temporal pole",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "lefttmptemporalpole",
"description": "",
"label": "Left temporal pole",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightttgtransversetemporalgyrus",
"description": "",
"label": "Right transverse temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftttgtransversetemporalgyrus",
"description": "",
"label": "Left transverse temporal gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
}
]
},
{
"code": "occipital",
"label": "Occipital",
"variables": [
{
"code": "rightcalccalcarinecortex",
"description": "",
"label": "Right calcarine cortex",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftcalccalcarinecortex",
"description": "",
"label": "Left calcarine cortex",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightcuncuneus",
"description": "",
"label": "Right cuneus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftcuncuneus",
"description": "",
"label": "Left cuneus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightioginferioroccipitalgyrus",
"description": "",
"label": "Right inferior occipital gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftioginferioroccipitalgyrus",
"description": "",
"label": "Left inferior occipital gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightliglingualgyrus",
"description": "",
"label": "Right lingual gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftliglingualgyrus",
"description": "",
"label": "Left lingual gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "rightmogmiddleoccipitalgyrus",
"description": "",
"label": "Right middle occipital gyrus",
"methodology": "lren-nmm-volumes",
"type": "real",
"units": "cm3"
},
{
"code": "leftmogmiddleoccipitalgyrus",