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STRING and Wikipathways Nodes #237

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reductiveminded opened this issue Jul 8, 2024 · 4 comments
Open

STRING and Wikipathways Nodes #237

reductiveminded opened this issue Jul 8, 2024 · 4 comments
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@reductiveminded
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Description:
After uploading a gene counts matrix and corresponding metadata file, I performed DE analysis, then created a list of up and down scored genes. For each list I performed STRING and Wikipathways analysis to see which genes were connected / enriched pathways. For some reason every time I do this it returns 0 values. If I take the same list and perform the enrichment analysis online at the respective websites it shows me a totally different output (with many connections, that of which are highly connected)

@reductiveminded
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If I instead upload a gene list (from say another publication) it works totally fine. It seems to be only from the particular counts and metadata files I uploaded.

@u8sand
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u8sand commented Jul 8, 2024

Are you able to share the link to your playbook with us so we can investigate?

@reductiveminded
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@u8sand u8sand added the ExRNA label Jul 11, 2024
@reductiveminded
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Hello,
Is there any update regarding this yet? My final presentation is in 2 weeks and I am really hoping that the STRING outputs will work :)
Thanks!

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