diff --git a/.github/scripts/check-bitrise-e2e-smoke/check-e2e-smoke-trigger.ts b/.github/scripts/check-bitrise-e2e-smoke/check-e2e-smoke-trigger.ts
new file mode 100644
index 00000000000..c26fdb23d00
--- /dev/null
+++ b/.github/scripts/check-bitrise-e2e-smoke/check-e2e-smoke-trigger.ts
@@ -0,0 +1,100 @@
+import * as core from '@actions/core';
+import { context, getOctokit } from '@actions/github';
+import { GitHub } from '@actions/github/lib/utils';
+
+enum PullRequestTriggerType {
+  Opened = 'opened',
+  Reopened = 'reopened',
+  ReadyForReview = 'ready_for_review',
+  Labeled = 'labeled',
+}
+
+main().catch((error: Error): void => {
+  console.error(error);
+  process.exit(1);
+});
+
+async function main(): Promise<void> {
+  const githubToken = process.env.GITHUB_TOKEN;
+  const e2eLabel = process.env.E2E_LABEL;
+  const triggerAction = context.payload.action as PullRequestTriggerType;
+  const pullRequestLink = `https://github.com/MetaMask/metamask-mobile/pull/${context.issue.number}`;
+  let shouldTriggerE2E = false;
+
+  if (!githubToken) {
+    core.setFailed('GITHUB_TOKEN not found');
+    process.exit(1);
+  }
+
+  if (!e2eLabel) {
+    core.setFailed('E2E_LABEL not found');
+    process.exit(1);
+  }
+
+  console.log(`Workflow triggered by the event (${triggerAction})`);
+
+  switch (triggerAction) {
+    case PullRequestTriggerType.Opened:
+      shouldTriggerE2E = !context.payload.pull_request?.draft;
+      if (!shouldTriggerE2E) {
+        console.log(`Skipping E2E smoke since opened PR is in draft.`);
+      } else {
+        console.log(`Starting E2E smoke since opened PR is ready for review.`);
+      }
+      break;
+    case PullRequestTriggerType.Reopened:
+      shouldTriggerE2E = !context.payload.pull_request?.draft;
+      if (!shouldTriggerE2E) {
+        console.log(`Skipping E2E smoke since reopened PR is in draft.`);
+      } else {
+        console.log(`Starting E2E smoke since reopened PR is ready for review.`);
+      }
+      break;
+    case PullRequestTriggerType.ReadyForReview:
+      shouldTriggerE2E = true;
+      console.log(
+        `Starting E2E smoke since PR has changed to ready for review.`,
+      );
+      break;
+    case PullRequestTriggerType.Labeled:
+      shouldTriggerE2E = e2eLabel === context.payload.label.name;
+      if (!shouldTriggerE2E) {
+        console.log(
+          `Skipping E2E smoke since (${e2eLabel}) is not the label that triggered this workflow.`,
+        );
+      } else {
+        console.log(
+          `Starting E2E smoke since (${e2eLabel}) is the label that triggered this workflow.`,
+        );
+      }
+      break;
+  }
+
+  if (shouldTriggerE2E) {
+    // Apply the E2E smoke label
+    const { owner, repo, number: issue_number } = context.issue;
+    const octokit: InstanceType<typeof GitHub> = getOctokit(githubToken);
+    try {
+      const applyLabelResponse = await octokit.rest.issues.addLabels({
+        owner,
+        repo,
+        issue_number,
+        labels: [e2eLabel],
+      });
+      if (applyLabelResponse.status === 200) {
+        console.log(`Applied (${e2eLabel}) label to PR ${pullRequestLink}`);
+      } else {
+        core.setFailed(
+          `Failed to apply (${e2eLabel}) label to ${pullRequestLink}`,
+        );
+        process.exit(1);
+      }
+    } catch (error) {
+      console.log(`Error occured when applying label: ${error}`);
+      process.exit(1);
+    }
+  }
+
+  // Set the output for the next step to use.
+  core.setOutput("shouldTriggerE2E", shouldTriggerE2E);
+}
diff --git a/.github/scripts/check-bitrise-e2e-smoke/run-bitrise-e2e-smoke.ts b/.github/scripts/check-bitrise-e2e-smoke/run-bitrise-e2e-smoke.ts
new file mode 100644
index 00000000000..ba41e29745b
--- /dev/null
+++ b/.github/scripts/check-bitrise-e2e-smoke/run-bitrise-e2e-smoke.ts
@@ -0,0 +1,108 @@
+import * as core from '@actions/core';
+import { context, getOctokit } from '@actions/github';
+import { GitHub } from '@actions/github/lib/utils';
+import axios from 'axios';
+
+main().catch((error: Error): void => {
+  console.error(error);
+  process.exit(1);
+});
+
+async function main(): Promise<void> {
+  const e2eLabel = process.env.E2E_LABEL;
+  const githubToken = process.env.GITHUB_TOKEN;
+  const e2ePipeline = process.env.E2E_PIPELINE;
+  const workflowName = process.env.WORKFLOW_NAME;
+  const pullRequestNumber = context.issue.number;
+  const repoOwner = context.repo.owner;
+  const repo = context.repo.repo;
+  const pullRequestLink = `https://github.com/MetaMask/metamask-mobile/pull/${pullRequestNumber}`;
+
+  if (!githubToken) {
+    core.setFailed('GITHUB_TOKEN not found');
+    process.exit(1);
+  }
+
+  if (!e2ePipeline) {
+    core.setFailed('E2E_PIPELINE not found');
+    process.exit(1);
+  }
+
+  const octokit: InstanceType<typeof GitHub> = getOctokit(githubToken);
+
+  const data = {
+    hook_info: {
+      type: 'bitrise',
+      build_trigger_token: process.env.BITRISE_BUILD_TRIGGER_TOKEN,
+    },
+    build_params: {
+      branch: process.env.GITHUB_HEAD_REF,
+      pipeline_id: e2ePipeline,
+      commit_message: `Triggered by (${workflowName}) workflow in ${pullRequestLink}`,
+    },
+    triggered_by: workflowName,
+  };
+
+  const bitriseProjectUrl = `https://app.bitrise.io/app/${process.env.BITRISE_APP_ID}`;
+
+  // Start Bitrise build.
+  const bitriseBuildResponse = await axios.post(
+    `${bitriseProjectUrl}/build/start.json`,
+    data,
+    {
+      headers: {
+        'Content-Type': 'application/json',
+      },
+    },
+  );
+
+  if (!bitriseBuildResponse.data.build_slug) {
+    core.setFailed(`Bitrise build slug not found`);
+    process.exit(1);
+  }
+
+  const buildLink = `${bitriseProjectUrl}/pipelines/${bitriseBuildResponse.data.build_slug}`;
+  const message = `E2E test started on Bitrise: ${buildLink}\nYou can also kick off another Bitrise E2E smoke test by removing and re-applying the (${e2eLabel}) label`;
+
+  if (bitriseBuildResponse.status === 201) {
+    console.log(message);
+  } else {
+    core.setFailed(
+      `Bitrise build request returned with status code ${bitriseBuildResponse.status}`,
+    );
+    process.exit(1);
+  }
+
+  // Reopen conversation in case it's locked
+  const unlockConvoResponse = await octokit.rest.issues.unlock({
+    owner: repoOwner,
+    repo,
+    issue_number: pullRequestNumber,
+  });
+
+  if (unlockConvoResponse.status === 204) {
+    console.log(`Unlocked conversation for PR ${pullRequestLink}`);
+  } else {
+    core.setFailed(
+      `Unlock conversation request returned with status code ${unlockConvoResponse.status}`,
+    );
+    process.exit(1);
+  }
+
+  // Post build link in PR comments.
+  const postCommentResponse = await octokit.rest.issues.createComment({
+    owner: repoOwner,
+    repo,
+    issue_number: pullRequestNumber,
+    body: message,
+  });
+
+  if (postCommentResponse.status === 201) {
+    console.log(`Posting comment in pull request ${pullRequestLink}`);
+  } else {
+    core.setFailed(
+      `Post comment request returned with status code ${postCommentResponse.status}`,
+    );
+    process.exit(1);
+  }
+}
diff --git a/.github/workflows/check-bitrise-e2e-smoke.yml b/.github/workflows/check-bitrise-e2e-smoke.yml
new file mode 100644
index 00000000000..86502729829
--- /dev/null
+++ b/.github/workflows/check-bitrise-e2e-smoke.yml
@@ -0,0 +1,46 @@
+name: Check Bitrise E2E Smoke Tests
+
+on:
+  pull_request:
+    types: [opened, reopened, ready_for_review, labeled]
+
+env:
+  E2E_LABEL: 'Run Smoke E2E'
+  E2E_PIPELINE: 'pr_smoke_e2e_pipeline'
+  WORKFLOW_NAME: 'check-bitrise-e2e-smoke'
+
+jobs:
+  check-bitrise-e2e-smoke:
+    runs-on: ubuntu-latest
+    permissions:
+      pull-requests: write
+      contents: write
+    steps:
+      - name: Checkout code
+        uses: actions/checkout@v3
+
+      - name: Set up Node.js
+        uses: actions/setup-node@v3
+        with:
+          node-version-file: '.nvmrc'
+          cache: yarn
+
+      - name: Install Axios
+        run: yarn add axios
+
+      - name: Install dependencies
+        run: yarn --immutable
+
+      - name: Check E2E trigger
+        id: check-trigger
+        env:
+          GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
+        run: yarn run check-e2e-smoke-trigger
+
+      - name: Run Bitrise E2E
+        if: steps.check-trigger.outputs.shouldTriggerE2E == 'true'
+        env:
+          BITRISE_BUILD_TRIGGER_TOKEN: ${{ secrets.BITRISE_BUILD_TRIGGER_TOKEN }}
+          BITRISE_APP_ID: 'be69d4368ee7e86d'
+          GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
+        run: yarn run run-bitrise-e2e-smoke
diff --git a/package.json b/package.json
index ee341643d5d..c25cbaf0270 100644
--- a/package.json
+++ b/package.json
@@ -78,6 +78,8 @@
     "deduplicate": "yarn yarn-deduplicate",
     "create-release": "./scripts/set-versions.sh && yarn update-changelog",
     "add-release-label-to-pr-and-linked-issues": "ts-node ./.github/scripts/add-release-label-to-pr-and-linked-issues.ts",
+    "check-e2e-smoke-trigger": "ts-node ./.github/scripts/check-bitrise-e2e-smoke/check-e2e-smoke-trigger.ts",
+    "run-bitrise-e2e-smoke": "ts-node ./.github/scripts/check-bitrise-e2e-smoke/run-bitrise-e2e-smoke.ts",
     "check-pr-has-required-labels": "ts-node ./.github/scripts/check-pr-has-required-labels.ts",
     "close-release-bug-report-issue": "ts-node ./.github/scripts/close-release-bug-report-issue.ts",
     "check-template-and-add-labels": "ts-node ./.github/scripts/check-template-and-add-labels.ts",