GitHub - ModelDBRepository/123623: Hodgkin-Huxley models of different classes of cortical neurons (Pospischil et al. 2008)

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Hodgkin-Huxley models of different classes of cortical neurons (Pospischil et al. 2008)

modeldb.science/123623

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Name		Name	Last commit message	Last commit date
Latest commit History 4 Commits
HH_traub.mod		HH_traub.mod
IL_gutnick.mod		IL_gutnick.mod
IM_cortex.mod		IM_cortex.mod
IT_huguenard.mod		IT_huguenard.mod
README.html		README.html
cadecay_destexhe.mod		cadecay_destexhe.mod
demo_IN_FS.hoc		demo_IN_FS.hoc
demo_PY_IB.hoc		demo_PY_IB.hoc
demo_PY_IBR.hoc		demo_PY_IBR.hoc
demo_PY_LTS.hoc		demo_PY_LTS.hoc
demo_PY_RS.hoc		demo_PY_RS.hoc
fig5b.jpg		fig5b.jpg
mosinit.hoc		mosinit.hoc
rundemo.hoc		rundemo.hoc
sIN_template		sIN_template
sPY_template		sPY_template
sPYb_template		sPYb_template
sPYbr_template		sPYbr_template
sPYr_template		sPYr_template

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<html><pre>
Simulation of single-compartment Hodgkin-Huxley models for different
classes of cortical neurons

The models are described in:

   Pospischil, M., Toledo-Rodriguez, M., Monier, C., Piwkowska, Z., 
   Bal, T., Fregnac, Y., Markram, H. and Destexhe, A.
   Minimal Hodgkin-Huxley type models for different classes of
   cortical and thalamic neurons.
   Biological Cybernetics 99: 427-441, 2008.

Intrinsic currents: INa, IKd for action potentials, IM for
spike-frequency adaptation, ICaL for high-threshold calcium current,
ICaT for the low-threshold calcium current, intracellular calcium
dynamics.  

demo_PY_RS.oc : simplified model of the "regular-spiking" neuron
demo_IN_FS.oc : simplified model of the "fast-spiking" interneuron
demo_PY_IB.oc : simplified model of the "intrinsically bursting" neuron
demo_PY_IBR.oc : simplified model of the "repetive bursting" neuron
demo_PY_LTS.oc : simplified model of the "low-threshold spike" neurons

Usage:
------

Simply auto-launch from ModelDB (after NEURON is installed) or
download and extract the archive.  Then under

linux/unix:
-----------

cd to the extracted folder.  Type at the shell prompt:

nrnivmodl
nrngui mosinit.hoc

MAC OS X:
---------

Drag and drop the extracted folder onto the mknrndll icon.  Drag and
drop the mosinit.hoc file onto the nrngui icon.

mswin:
------

Run mknrndll and cd to the extracted folder. Select to make the
nrnmech.dll.  Use windows explorer to view the contents of the
expanded folder from the archive. Double click on the mosinit.hoc
file.

Once the simulation is started:
-------------------------------

Click on a button to select a cell.  Reposition the windows and press
the Init & Run button.

For example selecting Bursting Pyramidal Cell and then Init & Run
should produce a figure like figure 5B from the paper:

<img src="./fig5b.jpg" alt="fig 5B appears here">

20111102 The file IL_gutnick.mod was updated to use derivimplicit in the
solver.  See http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
for details.

20120216 the files IM_cortex.mod, IT_huguenard.mod, and
cadecay_destexhe.mod had solver methods updated from euler to cnexp,
cnexp, and derivimplicit respectively.  The IL_gutnick.mod was changed
from derivimplicit to cnexp. See www.neuron.yale.edu phpBB link above.
</pre></html>