diff --git a/Documentation/source/devel/initGui.py b/Documentation/source/devel/initGui.py
index a9d7510656..4fb910243c 100644
--- a/Documentation/source/devel/initGui.py
+++ b/Documentation/source/devel/initGui.py
@@ -3,9 +3,8 @@
 #file, You can obtain one at http://mozilla.org/MPL/2.0/. */
 #Created by Alexandre GAUTHIER-FOICHAT on 01/27/2015.
 
-#PySide is already imported by Natron, but we remove the cumbersome PySide.QtGui and PySide.QtCore prefix
-from PySide.QtGui import *
-from PySide.QtCore import *
+from qtpy.QtGui import *
+from qtpy.QtCore import *
 
 #To import the variable "natron"
 from NatronGui import *
diff --git a/Engine/AppManager.cpp b/Engine/AppManager.cpp
index 4e8b45cb3d..974ea47bb1 100644
--- a/Engine/AppManager.cpp
+++ b/Engine/AppManager.cpp
@@ -1954,37 +1954,28 @@ AppManager::loadPythonGroups()
         operateOnPathRecursive(&addToPythonPathFunctor, d);
     }
 
-    ///Also import Pyside.QtCore and Pyside.QtGui (the later only in non background mode)
+    ///Also import qtpy.QtCore and qtpy.QtGui (the later only in non background mode)
     {
         std::string s;
-#     if (SHIBOKEN_MAJOR_VERSION == 2)
-        s = "import PySide2\nimport PySide2.QtCore as QtCore";
-#     else
-        s = "import PySide\nimport PySide.QtCore as QtCore";
-#     endif
+        s = "import qtpy\nfrom qtpy import QtCore";
         bool ok  = NATRON_PYTHON_NAMESPACE::interpretPythonScript(s, &err, 0);
         if (!ok) {
-            QString message = tr("Failed to import PySide.QtCore, make sure it is bundled with your Natron installation "
+            QString message = tr("Failed to import qtpy.QtCore, make sure it is bundled with your Natron installation "
                                      "or reachable through the Python path. "
                                      "Note that Natron disables usage "
                                  "of site-packages).");
             std::cerr << message.toStdString() << std::endl;
-            appPTR->writeToErrorLog_mt_safe(QLatin1String("PySide.QtCore"), QDateTime::currentDateTime(), message);
+            appPTR->writeToErrorLog_mt_safe(QLatin1String("qtpy.QtCore"), QDateTime::currentDateTime(), message);
         }
     }
 
     if ( !isBackground() ) {
-        std::string s;
-#     if (SHIBOKEN_MAJOR_VERSION == 2)
-        s = "import PySide2.QtGui as QtGui";
-#     else
-        s = "import PySide.QtGui as QtGui";
-#     endif
+        std::string s = "from qtpy import QtGui";
         bool ok  = NATRON_PYTHON_NAMESPACE::interpretPythonScript(s, &err, 0);
         if (!ok) {
-            QString message = tr("Failed to import PySide.QtGui");
+            QString message = tr("Failed to import qtpy.QtGui");
             std::cerr << message.toStdString() << std::endl;
-            appPTR->writeToErrorLog_mt_safe(QLatin1String("PySide.QtGui"), QDateTime::currentDateTime(), message);
+            appPTR->writeToErrorLog_mt_safe(QLatin1String("qtpy.QtGui"), QDateTime::currentDateTime(), message);
         }
     }
 
@@ -3402,6 +3393,13 @@ AppManager::initPython()
             throw std::runtime_error( tr("Error while loading StreamCatcher: %1").arg( QString::fromUtf8( err.c_str() ) ).toStdString() );
         }
     }
+    // Set QT_API for QtPy
+    // https://github.com/spyder-ide/qtpy
+#if QT_VERSION < QT_VERSION_CHECK(5, 0, 0)
+    qputenv("QT_API", "pyside");
+#else
+    qputenv("QT_API", "pyside2");
+#endif
 } // AppManager::initPython
 
 void
diff --git a/INSTALL_LINUX.md b/INSTALL_LINUX.md
index 798329e5f5..9cb1823fde 100644
--- a/INSTALL_LINUX.md
+++ b/INSTALL_LINUX.md
@@ -14,6 +14,7 @@ Natron on GNU/Linux.
     - [Cairo](#cairo)
     - [Pyside](#pyside)
     - [Shiboken](#shiboken)
+    - [QtPy](#qtpy)
 2. [Configuration](#configuration)
     - [OpenFX](#openfx)
     - [OpenColorIO-Configs](#download-opencolorio-configs)
@@ -106,6 +107,13 @@ Natron uses pyside for python 2
 
 Natron uses shiboken for python 2
 
+### QtPy
+
+Abstraction layer for PyQt5/PyQt4/PySide2/PySide.
+
+```
+pip install qtpy
+```
 
 # Configuration
 
diff --git a/tools/jenkins/build-Linux-installer.sh b/tools/jenkins/build-Linux-installer.sh
index 7380b12cd5..5262ef0927 100755
--- a/tools/jenkins/build-Linux-installer.sh
+++ b/tools/jenkins/build-Linux-installer.sh
@@ -584,6 +584,9 @@ if [ -x "${TMP_PORTABLE_DIR}"/bin/natron-python ]; then
     rm get-pip.py
 fi
 
+# Install qtpy
+"${TMP_PORTABLE_DIR}"/bin/natron-python -m pip install qtpy
+
 # Run extra user provided pip install scripts
 if [ -f "${EXTRA_PYTHON_MODULES_SCRIPT:-}" ]; then
     "${TMP_PORTABLE_DIR}"/bin/natron-python "$EXTRA_PYTHON_MODULES_SCRIPT" || true
diff --git a/tools/jenkins/build-OSX-installer.sh b/tools/jenkins/build-OSX-installer.sh
index 75fc7510c3..abf2a2c150 100755
--- a/tools/jenkins/build-OSX-installer.sh
+++ b/tools/jenkins/build-OSX-installer.sh
@@ -908,6 +908,9 @@ if [ -x "${TMP_PORTABLE_DIR}.app/Contents/MacOS"/natron-python ]; then
     rm get-pip.py
 fi
 
+# Install qtpy
+"${TMP_PORTABLE_DIR}"/bin/natron-python -m pip install qtpy
+
 # Run extra user provided pip install scripts
 if [ -f "${EXTRA_PYTHON_MODULES_SCRIPT:-}" ]; then
     "${TMP_PORTABLE_DIR}.app/Contents/MacOS"/natron-python "$EXTRA_PYTHON_MODULES_SCRIPT" || true
diff --git a/tools/jenkins/build-Windows-installer.sh b/tools/jenkins/build-Windows-installer.sh
index 60791793b0..6a80a49030 100755
--- a/tools/jenkins/build-Windows-installer.sh
+++ b/tools/jenkins/build-Windows-installer.sh
@@ -435,6 +435,9 @@ if [ -x "${TMP_PORTABLE_DIR}"/bin/natron-python ]; then
     rm get-pip.py
 fi
 
+# Install qtpy
+"${TMP_PORTABLE_DIR}"/bin/natron-python -m pip install qtpy
+
 # Run extra user provided pip install scripts
 if [ -f "${EXTRA_PYTHON_MODULES_SCRIPT:-}" ]; then
     "${TMP_PORTABLE_DIR}"/bin/natron-python "$EXTRA_PYTHON_MODULES_SCRIPT" || true