diff --git a/pkgs/applications/gis/qgis/unwrapped-ltr.nix b/pkgs/applications/gis/qgis/unwrapped-ltr.nix
index 0ad11bc630bf9..1d59ee220c4b0 100644
--- a/pkgs/applications/gis/qgis/unwrapped-ltr.nix
+++ b/pkgs/applications/gis/qgis/unwrapped-ltr.nix
@@ -128,7 +128,6 @@ in mkDerivation rec {
   '';
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DWITH_3D=True"
     "-DWITH_PDAL=TRUE"
     "-DPYQT5_SIP_DIR=${py.pkgs.pyqt5}/${py.pkgs.python.sitePackages}/PyQt5/bindings"
diff --git a/pkgs/applications/gis/qgis/unwrapped.nix b/pkgs/applications/gis/qgis/unwrapped.nix
index 1c46cd81f65ab..31e2159cd18f1 100644
--- a/pkgs/applications/gis/qgis/unwrapped.nix
+++ b/pkgs/applications/gis/qgis/unwrapped.nix
@@ -128,7 +128,6 @@ in mkDerivation rec {
   '';
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DWITH_3D=True"
     "-DWITH_PDAL=TRUE"
     "-DPYQT5_SIP_DIR=${py.pkgs.pyqt5}/${py.pkgs.python.sitePackages}/PyQt5/bindings"
diff --git a/pkgs/applications/graphics/paraview/default.nix b/pkgs/applications/graphics/paraview/default.nix
index cd16fe1de0892..1087bba9705e8 100644
--- a/pkgs/applications/graphics/paraview/default.nix
+++ b/pkgs/applications/graphics/paraview/default.nix
@@ -44,13 +44,6 @@ in mkDerivation rec {
     export QT_PLUGIN_PATH=${qtbase.bin}/${qtbase.qtPluginPrefix}
   '';
 
-  # During build, binaries are called that rely on freshly built
-  # libraries.  These reside in build/lib, and are not found by
-  # default.
-  preBuild = ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD/lib:$PWD/VTK/ThirdParty/vtkm/vtk-m/lib
-  '';
-
   cmakeFlags = [
     "-DCMAKE_BUILD_TYPE=Release"
     "-DPARAVIEW_ENABLE_FFMPEG=ON"
diff --git a/pkgs/applications/kde/dolphin.nix b/pkgs/applications/kde/dolphin.nix
index 92d256f477090..b70f4977f587b 100644
--- a/pkgs/applications/kde/dolphin.nix
+++ b/pkgs/applications/kde/dolphin.nix
@@ -27,8 +27,4 @@ mkDerivation {
     wayland qtwayland
   ];
   outputs = [ "out" "dev" ];
-  # We need the RPATH for linking, because the `libkdeinit5_dolphin.so` links
-  # private against its dependencies and without the correct RPATH, these
-  # dependencies are not found.
-  cmakeFlags = [ "-DCMAKE_SKIP_BUILD_RPATH=OFF" ];
 }
diff --git a/pkgs/applications/misc/audio/soxr/default.nix b/pkgs/applications/misc/audio/soxr/default.nix
index f7c01ce464940..e90ac480eb19f 100644
--- a/pkgs/applications/misc/audio/soxr/default.nix
+++ b/pkgs/applications/misc/audio/soxr/default.nix
@@ -16,13 +16,6 @@ stdenv.mkDerivation rec {
 
   outputs = [ "out" "doc" ]; # headers are just two and very small
 
-  preConfigure =
-    if stdenv.isDarwin then ''
-      export DYLD_LIBRARY_PATH="$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}"`pwd`/build/src
-    '' else ''
-      export LD_LIBRARY_PATH="$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}"`pwd`/build/src
-    '';
-
   nativeBuildInputs = [ cmake ];
 
   meta = with lib; {
diff --git a/pkgs/applications/networking/sniffers/wireshark/default.nix b/pkgs/applications/networking/sniffers/wireshark/default.nix
index b74905586192d..2f41d0ec55ff8 100644
--- a/pkgs/applications/networking/sniffers/wireshark/default.nix
+++ b/pkgs/applications/networking/sniffers/wireshark/default.nix
@@ -59,10 +59,6 @@ in stdenv.mkDerivation {
     sed -i -e '1i cmake_policy(SET CMP0025 NEW)' CMakeLists.txt
   '';
 
-  preBuild = ''
-    export LD_LIBRARY_PATH="$PWD/run"
-  '';
-
   postInstall = ''
     # to remove "cycle detected in the references"
     mkdir -p $dev/lib/wireshark
diff --git a/pkgs/applications/office/gnucash/default.nix b/pkgs/applications/office/gnucash/default.nix
index 1c6fe68480d72..e33ef517088ae 100644
--- a/pkgs/applications/office/gnucash/default.nix
+++ b/pkgs/applications/office/gnucash/default.nix
@@ -154,8 +154,6 @@ stdenv.mkDerivation rec {
       test-xml-pricedb \
       test-xml-transaction \
       test-xml2-is-file
-
-      export LD_LIBRARY_PATH="$PWD/lib:$PWD/lib/gnucash:$PWD/lib/gnucash/test:$PWD/lib/gnucash/test/future"
   '';
 
   preFixup = ''
diff --git a/pkgs/applications/radio/dsd/default.nix b/pkgs/applications/radio/dsd/default.nix
index e885270370eca..c98974740667d 100644
--- a/pkgs/applications/radio/dsd/default.nix
+++ b/pkgs/applications/radio/dsd/default.nix
@@ -22,10 +22,6 @@ stdenv.mkDerivation rec {
   ] ++ lib.optionals portaudioSupport [ portaudio ];
 
   doCheck = true;
-  preCheck = ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$PWD
-  '';
 
   meta = with lib; {
     description = "Digital Speech Decoder";
diff --git a/pkgs/applications/science/machine-learning/shogun/default.nix b/pkgs/applications/science/machine-learning/shogun/default.nix
index b715c2fc33b34..c7209d00af515 100644
--- a/pkgs/applications/science/machine-learning/shogun/default.nix
+++ b/pkgs/applications/science/machine-learning/shogun/default.nix
@@ -134,7 +134,6 @@ stdenv.mkDerivation rec {
     "-DCMAKE_DISABLE_FIND_PACKAGE_Mosek=ON"
     "-DCMAKE_DISABLE_FIND_PACKAGE_TFLogger=ON"
     "-DCMAKE_DISABLE_FIND_PACKAGE_ViennaCL=ON"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DCMAKE_CTEST_ARGUMENTS='--exclude-regex;TrainedModelSerialization'"  # Sporadic segfault
     "-DENABLE_TESTING=${enableIf doCheck}"
     "-DDISABLE_META_INTEGRATION_TESTS=ON"
diff --git a/pkgs/applications/science/misc/simgrid/default.nix b/pkgs/applications/science/misc/simgrid/default.nix
index 4867e6c9ed552..3afd997f70ff0 100644
--- a/pkgs/applications/science/misc/simgrid/default.nix
+++ b/pkgs/applications/science/misc/simgrid/default.nix
@@ -73,11 +73,6 @@ stdenv.mkDerivation rec {
     patchShebangs ..
   '';
 
-  # needed by tests (so libsimgrid.so is found)
-  preConfigure = ''
-    export LD_LIBRARY_PATH="$PWD/build/lib"
-  '';
-
   doCheck = true;
   preCheck = ''
     # prevent the execution of tests known to fail
diff --git a/pkgs/applications/video/avidemux/default.nix b/pkgs/applications/video/avidemux/default.nix
index d6b0467fb7295..35c628f8a59d8 100644
--- a/pkgs/applications/video/avidemux/default.nix
+++ b/pkgs/applications/video/avidemux/default.nix
@@ -66,7 +66,6 @@ stdenv.mkDerivation rec {
     cd "$sourceRoot"
     patchPhase
 
-    export LD_LIBRARY_PATH="$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}${libXext}/lib"
     ${stdenv.shell} bootStrap.bash \
       --with-core \
       ${if withQT then "--with-qt" else "--without-qt"} \
diff --git a/pkgs/desktops/gnome/core/evolution-data-server/default.nix b/pkgs/desktops/gnome/core/evolution-data-server/default.nix
index 0a8d46157a6e9..c4a12cd5ca867 100644
--- a/pkgs/desktops/gnome/core/evolution-data-server/default.nix
+++ b/pkgs/desktops/gnome/core/evolution-data-server/default.nix
@@ -119,7 +119,6 @@ stdenv.mkDerivation rec {
     "-DENABLE_UOA=OFF"
     "-DENABLE_VALA_BINDINGS=ON"
     "-DENABLE_INTROSPECTION=ON"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DINCLUDE_INSTALL_DIR=${placeholder "dev"}/include"
     "-DWITH_PHONENUMBER=ON"
     "-DWITH_GWEATHER4=ON"
diff --git a/pkgs/desktops/plasma-5/kwin/default.nix b/pkgs/desktops/plasma-5/kwin/default.nix
index 847ef41ee88b7..74c6b1b7faa5e 100644
--- a/pkgs/desktops/plasma-5/kwin/default.nix
+++ b/pkgs/desktops/plasma-5/kwin/default.nix
@@ -61,7 +61,6 @@ mkDerivation {
   CXXFLAGS = [
     ''-DNIXPKGS_XWAYLAND=\"${lib.getBin xwayland}/bin/Xwayland\"''
   ];
-  cmakeFlags = [ "-DCMAKE_SKIP_BUILD_RPATH=OFF" ];
   postInstall = ''
     # Some package(s) refer to these service types by the wrong name.
     # I would prefer to patch those packages, but I cannot find them!
diff --git a/pkgs/development/compilers/halide/default.nix b/pkgs/development/compilers/halide/default.nix
index 916d8fa56f75d..853cf1a663e95 100644
--- a/pkgs/development/compilers/halide/default.nix
+++ b/pkgs/development/compilers/halide/default.nix
@@ -32,12 +32,6 @@ llvmPackages.stdenv.mkDerivation rec {
 
   cmakeFlags = [ "-DWARNINGS_AS_ERRORS=OFF" "-DWITH_PYTHON_BINDINGS=OFF" ];
 
-  # To handle the lack of 'local' RPATH; required, as they call one of
-  # their built binaries requiring their libs, in the build process.
-  preBuild = ''
-    export LD_LIBRARY_PATH="$(pwd)/src''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
-  '';
-
   # Note: only openblas and not atlas part of this Nix expression
   # see pkgs/development/libraries/science/math/liblapack/3.5.0.nix
   # to get a hint howto setup atlas instead of openblas
diff --git a/pkgs/development/compilers/solc/default.nix b/pkgs/development/compilers/solc/default.nix
index 6594872a258f7..d00a354be187b 100644
--- a/pkgs/development/compilers/solc/default.nix
+++ b/pkgs/development/compilers/solc/default.nix
@@ -90,12 +90,6 @@ let
     doCheck = false;
 
     checkPhase = ''
-      while IFS= read -r -d ''' dir
-      do
-        LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$(pwd)/$dir
-        export LD_LIBRARY_PATH
-      done <   <(find . -type d -print0)
-
       pushd ..
       # IPC tests need aleth avaliable, so we disable it
       sed -i "s/IPC_ENABLED=true/IPC_ENABLED=false\nIPC_FLAGS=\"--no-ipc\"/" ./scripts/tests.sh
diff --git a/pkgs/development/libraries/arrow-cpp/default.nix b/pkgs/development/libraries/arrow-cpp/default.nix
index a69d161c9268f..c88afbe6a0fcf 100644
--- a/pkgs/development/libraries/arrow-cpp/default.nix
+++ b/pkgs/development/libraries/arrow-cpp/default.nix
@@ -204,7 +204,6 @@ stdenv.mkDerivation rec {
   ] ++ lib.optionals (!enableShared) [
     "-DARROW_TEST_LINKAGE=static"
   ] ++ lib.optionals stdenv.isDarwin [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # needed for tests
     "-DCMAKE_INSTALL_RPATH=@loader_path/../lib" # needed for tools executables
   ] ++ lib.optional (!stdenv.isx86_64) "-DARROW_USE_SIMD=OFF"
   ++ lib.optional enableS3 "-DAWSSDK_CORE_HEADER_FILE=${aws-sdk-cpp}/include/aws/core/Aws.h";
diff --git a/pkgs/development/libraries/audio/libkeyfinder/default.nix b/pkgs/development/libraries/audio/libkeyfinder/default.nix
index cb34f24ced8d8..65e4d0fb15eeb 100644
--- a/pkgs/development/libraries/audio/libkeyfinder/default.nix
+++ b/pkgs/development/libraries/audio/libkeyfinder/default.nix
@@ -11,9 +11,6 @@ stdenv.mkDerivation rec {
     sha256 = "sha256-7w/Wc9ncLinbnM2q3yv5DBtFoJFAM2e9xAUTsqvE9mg=";
   };
 
-  # needed for finding libkeyfinder.so to link it into keyfinder-tests executable
-  cmakeFlags = [ "-DCMAKE_SKIP_BUILD_RPATH=OFF" ];
-
   nativeBuildInputs = [ cmake ];
 
   buildInputs = [ fftw ];
diff --git a/pkgs/development/libraries/audio/mbelib/default.nix b/pkgs/development/libraries/audio/mbelib/default.nix
index dc01027c46932..dccb738a30f4f 100644
--- a/pkgs/development/libraries/audio/mbelib/default.nix
+++ b/pkgs/development/libraries/audio/mbelib/default.nix
@@ -14,10 +14,6 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake ];
 
   doCheck = true;
-  preCheck = ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$PWD
-  '';
 
   meta = with lib; {
     description = "P25 Phase 1 and ProVoice vocoder";
diff --git a/pkgs/development/libraries/aws-c-auth/default.nix b/pkgs/development/libraries/aws-c-auth/default.nix
index 5b8590750178d..2c70c3e8acba5 100644
--- a/pkgs/development/libraries/aws-c-auth/default.nix
+++ b/pkgs/development/libraries/aws-c-auth/default.nix
@@ -39,7 +39,6 @@ stdenv.mkDerivation rec {
   ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DBUILD_SHARED_LIBS=ON"
   ];
 
diff --git a/pkgs/development/libraries/aws-c-common/default.nix b/pkgs/development/libraries/aws-c-common/default.nix
index 1b8f7e73e822b..b20371f5dd29a 100644
--- a/pkgs/development/libraries/aws-c-common/default.nix
+++ b/pkgs/development/libraries/aws-c-common/default.nix
@@ -20,7 +20,6 @@ stdenv.mkDerivation rec {
 
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=ON"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # for tests
   ] ++ lib.optionals stdenv.hostPlatform.isRiscV [
     "-DCMAKE_C_FLAGS=-fasynchronous-unwind-tables"
   ];
diff --git a/pkgs/development/libraries/aws-c-compression/default.nix b/pkgs/development/libraries/aws-c-compression/default.nix
index 9d885278ff06c..5d13c0653b223 100644
--- a/pkgs/development/libraries/aws-c-compression/default.nix
+++ b/pkgs/development/libraries/aws-c-compression/default.nix
@@ -24,7 +24,6 @@ stdenv.mkDerivation rec {
   ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DBUILD_SHARED_LIBS=ON"
   ];
 
diff --git a/pkgs/development/libraries/aws-c-http/default.nix b/pkgs/development/libraries/aws-c-http/default.nix
index 0eee407f989a4..86ab4f4230e69 100644
--- a/pkgs/development/libraries/aws-c-http/default.nix
+++ b/pkgs/development/libraries/aws-c-http/default.nix
@@ -32,7 +32,6 @@ stdenv.mkDerivation rec {
   ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DBUILD_SHARED_LIBS=ON"
   ];
 
diff --git a/pkgs/development/libraries/aws-c-mqtt/default.nix b/pkgs/development/libraries/aws-c-mqtt/default.nix
index 11ba67fe6f5a5..6700b4e6a13e1 100644
--- a/pkgs/development/libraries/aws-c-mqtt/default.nix
+++ b/pkgs/development/libraries/aws-c-mqtt/default.nix
@@ -34,7 +34,6 @@ stdenv.mkDerivation rec {
   ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DBUILD_SHARED_LIBS=ON"
   ];
 
diff --git a/pkgs/development/libraries/aws-c-s3/default.nix b/pkgs/development/libraries/aws-c-s3/default.nix
index 398a36019f544..881bec9c2805c 100644
--- a/pkgs/development/libraries/aws-c-s3/default.nix
+++ b/pkgs/development/libraries/aws-c-s3/default.nix
@@ -38,7 +38,6 @@ stdenv.mkDerivation rec {
   ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DBUILD_SHARED_LIBS=ON"
   ];
 
diff --git a/pkgs/development/libraries/aws-c-sdkutils/default.nix b/pkgs/development/libraries/aws-c-sdkutils/default.nix
index 6fb04fbb3a23c..919b3229d7ea5 100644
--- a/pkgs/development/libraries/aws-c-sdkutils/default.nix
+++ b/pkgs/development/libraries/aws-c-sdkutils/default.nix
@@ -24,7 +24,6 @@ stdenv.mkDerivation rec {
   ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DBUILD_SHARED_LIBS=ON"
   ];
 
diff --git a/pkgs/development/libraries/aws-crt-cpp/default.nix b/pkgs/development/libraries/aws-crt-cpp/default.nix
index 201837eb53639..28bb15f2a7453 100644
--- a/pkgs/development/libraries/aws-crt-cpp/default.nix
+++ b/pkgs/development/libraries/aws-crt-cpp/default.nix
@@ -67,7 +67,6 @@ stdenv.mkDerivation rec {
 
   cmakeFlags = [
     "-DBUILD_DEPS=OFF"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DBUILD_SHARED_LIBS=ON"
   ];
 
diff --git a/pkgs/development/libraries/aws-sdk-cpp/default.nix b/pkgs/development/libraries/aws-sdk-cpp/default.nix
index 8bf009ddacba5..889c03676c103 100644
--- a/pkgs/development/libraries/aws-sdk-cpp/default.nix
+++ b/pkgs/development/libraries/aws-sdk-cpp/default.nix
@@ -85,7 +85,6 @@ stdenv.mkDerivation rec {
 
   cmakeFlags = [
     "-DBUILD_DEPS=OFF"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
   ] ++ lib.optional (!customMemoryManagement) "-DCUSTOM_MEMORY_MANAGEMENT=0"
   ++ lib.optionals (stdenv.buildPlatform != stdenv.hostPlatform) [
     "-DENABLE_TESTING=OFF"
diff --git a/pkgs/development/libraries/caf/default.nix b/pkgs/development/libraries/caf/default.nix
index 045595a84fde7..8640fb6b5c9c9 100644
--- a/pkgs/development/libraries/caf/default.nix
+++ b/pkgs/development/libraries/caf/default.nix
@@ -21,10 +21,6 @@ stdenv.mkDerivation rec {
 
   doCheck = true;
   checkTarget = "test";
-  preCheck = ''
-    export LD_LIBRARY_PATH=$PWD/libcaf_core:$PWD/libcaf_io
-    export DYLD_LIBRARY_PATH=$PWD/libcaf_core:$PWD/libcaf_io
-  '';
 
   meta = with lib; {
     description = "An open source implementation of the actor model in C++";
diff --git a/pkgs/development/libraries/cpp-netlib/default.nix b/pkgs/development/libraries/cpp-netlib/default.nix
index 6085a3c849cc2..1effce915515b 100644
--- a/pkgs/development/libraries/cpp-netlib/default.nix
+++ b/pkgs/development/libraries/cpp-netlib/default.nix
@@ -19,11 +19,6 @@ stdenv.mkDerivation rec {
     "-DCPP-NETLIB_BUILD_SHARED_LIBS=ON"
   ];
 
-  # The test driver binary lacks an RPath to the library's libs
-  preCheck = ''
-    export LD_LIBRARY_PATH=$PWD/libs/network/src
-  '';
-
   # Most tests make network GET requests to various websites
   doCheck = false;
 
diff --git a/pkgs/development/libraries/crc32c/default.nix b/pkgs/development/libraries/crc32c/default.nix
index bfd7bee94b658..2ba0c4e65b8ba 100644
--- a/pkgs/development/libraries/crc32c/default.nix
+++ b/pkgs/development/libraries/crc32c/default.nix
@@ -29,8 +29,6 @@ stdenv.mkDerivation rec {
     "-DCRC32C_BUILD_BENCHMARKS=0"
     "-DCRC32C_USE_GLOG=0"
     "-DBUILD_SHARED_LIBS=${if staticOnly then "0" else "1"}"
-  ] ++ lib.optionals stdenv.isDarwin [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # for tests
   ];
 
   doCheck = false;
diff --git a/pkgs/development/libraries/criterion/default.nix b/pkgs/development/libraries/criterion/default.nix
index a1e7137d92ab6..723865ab11d3a 100644
--- a/pkgs/development/libraries/criterion/default.nix
+++ b/pkgs/development/libraries/criterion/default.nix
@@ -27,9 +27,6 @@ stdenv.mkDerivation rec {
 
   cmakeFlags = [ "-DCTESTS=ON" ];
   doCheck = true;
-  preCheck = ''
-    export LD_LIBRARY_PATH=`pwd`''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH
-  '';
   checkTarget = "criterion_tests test";
 
   outputs = [ "dev" "out" ];
diff --git a/pkgs/development/libraries/cutelyst/default.nix b/pkgs/development/libraries/cutelyst/default.nix
index d7fe4e92802b2..51336a9e1a55b 100644
--- a/pkgs/development/libraries/cutelyst/default.nix
+++ b/pkgs/development/libraries/cutelyst/default.nix
@@ -31,14 +31,6 @@ stdenv.mkDerivation rec {
     "-DPLUGIN_VIEW_GRANTLEE=ON"
   ];
 
-  preBuild = lib.optionalString stdenv.isLinux ''
-    export LD_LIBRARY_PATH="$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}`pwd`/Cutelyst:`pwd`/EventLoopEPoll"
-  '';
-
-  postBuild = lib.optionalString stdenv.isLinux ''
-    unset LD_LIBRARY_PATH
-  '';
-
   meta = with lib; {
     description = "C++ Web Framework built on top of Qt";
     homepage = "https://cutelyst.org/";
diff --git a/pkgs/development/libraries/docopt_cpp/default.nix b/pkgs/development/libraries/docopt_cpp/default.nix
index 4fae1db9ba3c3..2e37e073fb656 100644
--- a/pkgs/development/libraries/docopt_cpp/default.nix
+++ b/pkgs/development/libraries/docopt_cpp/default.nix
@@ -33,7 +33,7 @@ stdenv.mkDerivation rec {
                 "@CMAKE_INSTALL_LIBDIR@"
   '';
 
-  checkPhase = "LD_LIBRARY_PATH=$(pwd) python ./run_tests";
+  checkPhase = "python ./run_tests";
 
   meta = with lib; {
     description = "C++11 port of docopt";
diff --git a/pkgs/development/libraries/fcppt/default.nix b/pkgs/development/libraries/fcppt/default.nix
index 380fdcce29f33..46237505ff312 100644
--- a/pkgs/development/libraries/fcppt/default.nix
+++ b/pkgs/development/libraries/fcppt/default.nix
@@ -13,7 +13,12 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake ];
   buildInputs = [ boost catch2 metal ];
 
-  cmakeFlags = [ "-DCMAKE_SKIP_BUILD_RPATH=false" "-DENABLE_BOOST=true" "-DENABLE_EXAMPLES=true" "-DENABLE_CATCH=true" "-DENABLE_TEST=true" ];
+  cmakeFlags = [
+    "-DENABLE_BOOST=true"
+    "-DENABLE_EXAMPLES=true"
+    "-DENABLE_CATCH=true"
+    "-DENABLE_TEST=true"
+  ];
 
   meta = with lib; {
     description = "Freundlich's C++ toolkit";
diff --git a/pkgs/development/libraries/fmt/default.nix b/pkgs/development/libraries/fmt/default.nix
index 3fee016175bc2..f22d505e3a502 100644
--- a/pkgs/development/libraries/fmt/default.nix
+++ b/pkgs/development/libraries/fmt/default.nix
@@ -23,7 +23,6 @@ let
 
       cmakeFlags = [
         "-DBUILD_SHARED_LIBS=${if enableShared then "ON" else "OFF"}"
-        "-DCMAKE_SKIP_BUILD_RPATH=OFF" # for tests
       ];
 
       doCheck = true;
diff --git a/pkgs/development/libraries/galario/default.nix b/pkgs/development/libraries/galario/default.nix
index 7fb93a61a0feb..8454bcfc219f8 100644
--- a/pkgs/development/libraries/galario/default.nix
+++ b/pkgs/development/libraries/galario/default.nix
@@ -49,7 +49,6 @@ stdenv.mkDerivation rec {
   '';
 
   preCheck = ''
-    ${if stdenv.isDarwin then "export DYLD_LIBRARY_PATH=$(pwd)/src/" else "export LD_LIBRARY_PATH=$(pwd)/src/"}
     ${if enablePython then "sed -i -e 's|^#!.*|#!${stdenv.shell}|' python/py.test.sh" else ""}
   '';
 
diff --git a/pkgs/development/libraries/glog/default.nix b/pkgs/development/libraries/glog/default.nix
index 98ae294c48023..f49c8b982993d 100644
--- a/pkgs/development/libraries/glog/default.nix
+++ b/pkgs/development/libraries/glog/default.nix
@@ -17,9 +17,6 @@ stdenv.mkDerivation rec {
 
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=ON"
-    # Mak CMake place RPATHs such that tests will find the built libraries.
-    # See https://github.com/NixOS/nixpkgs/pull/144561#discussion_r742468811 and https://github.com/NixOS/nixpkgs/pull/108496
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
   ];
 
   # TODO: Re-enable Darwin tests once we're on a release that has https://github.com/google/glog/issues/709#issuecomment-960381653 fixed
diff --git a/pkgs/development/libraries/grpc/default.nix b/pkgs/development/libraries/grpc/default.nix
index bb98ca6eea158..9ba791e073ca0 100644
--- a/pkgs/development/libraries/grpc/default.nix
+++ b/pkgs/development/libraries/grpc/default.nix
@@ -61,7 +61,6 @@ stdenv.mkDerivation rec {
     "-DgRPC_PROTOBUF_PROVIDER=package"
     "-DgRPC_ABSL_PROVIDER=package"
     "-DBUILD_SHARED_LIBS=ON"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
   ] ++ lib.optionals (stdenv.hostPlatform != stdenv.buildPlatform) [
     "-D_gRPC_PROTOBUF_PROTOC_EXECUTABLE=${buildPackages.protobuf}/bin/protoc"
   ] ++ lib.optionals ((stdenv.hostPlatform.useLLVM or false) && lib.versionOlder stdenv.cc.cc.version "11.0") [
diff --git a/pkgs/development/libraries/igraph/default.nix b/pkgs/development/libraries/igraph/default.nix
index b598d846f9e2e..e36793debdff8 100644
--- a/pkgs/development/libraries/igraph/default.nix
+++ b/pkgs/development/libraries/igraph/default.nix
@@ -87,13 +87,6 @@ stdenv.mkDerivation rec {
 
   doCheck = true;
 
-  # needed to find libigraph, and liblas on darwin
-  preCheck = if stdenv.isDarwin then ''
-    export DYLD_LIBRARY_PATH="${lib.makeLibraryPath [ blas ]}:$PWD/src"
-  '' else ''
-    export LD_LIBRARY_PATH="$PWD/src"
-  '';
-
   postInstall = ''
     mkdir -p "$out/share"
     cp -r doc "$out/share"
diff --git a/pkgs/development/libraries/jsoncpp/default.nix b/pkgs/development/libraries/jsoncpp/default.nix
index 77d49c700030c..d9cf9a6c43464 100644
--- a/pkgs/development/libraries/jsoncpp/default.nix
+++ b/pkgs/development/libraries/jsoncpp/default.nix
@@ -43,14 +43,6 @@ stdenv.mkDerivation rec {
     sed -i 's/#define JSONCPP_USING_SECURE_MEMORY 0/#define JSONCPP_USING_SECURE_MEMORY 1/' include/json/version.h
   '';
 
-  # Hack to be able to run the test, broken because we use
-  # CMAKE_SKIP_BUILD_RPATH to avoid cmake resetting rpath on install
-  preBuild = if stdenv.isDarwin then ''
-    export DYLD_LIBRARY_PATH="$PWD/lib''${DYLD_LIBRARY_PATH:+:}$DYLD_LIBRARY_PATH"
-  '' else ''
-    export LD_LIBRARY_PATH="$PWD/lib''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
-  '';
-
   nativeBuildInputs = [ cmake python3 validatePkgConfig ];
 
   cmakeFlags = [
diff --git a/pkgs/development/libraries/leveldb/default.nix b/pkgs/development/libraries/leveldb/default.nix
index a6f75413c91e7..8cac5df55ea20 100644
--- a/pkgs/development/libraries/leveldb/default.nix
+++ b/pkgs/development/libraries/leveldb/default.nix
@@ -36,7 +36,6 @@ stdenv.mkDerivation rec {
   # NOTE: disabling tests due to gtest issue
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=${if static then "OFF" else "ON"}"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DLEVELDB_BUILD_TESTS=OFF"
     "-DLEVELDB_BUILD_BENCHMARKS=OFF"
   ];
diff --git a/pkgs/development/libraries/lib2geom/default.nix b/pkgs/development/libraries/lib2geom/default.nix
index 755ed6b814e6e..92cc1424af9fa 100644
--- a/pkgs/development/libraries/lib2geom/default.nix
+++ b/pkgs/development/libraries/lib2geom/default.nix
@@ -44,7 +44,6 @@ stdenv.mkDerivation rec {
   ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # for tests
     "-D2GEOM_BUILD_SHARED=ON"
   ];
 
diff --git a/pkgs/development/libraries/libjxl/default.nix b/pkgs/development/libraries/libjxl/default.nix
index 352c810e81a6e..be0a4fb915499 100644
--- a/pkgs/development/libraries/libjxl/default.nix
+++ b/pkgs/development/libraries/libjxl/default.nix
@@ -129,16 +129,6 @@ stdenv.mkDerivation rec {
 
   doCheck = !stdenv.hostPlatform.isi686;
 
-  # The test driver runs a test `LibraryCLinkageTest` which without
-  # LD_LIBRARY_PATH setting errors with:
-  #     /build/source/build/tools/tests/libjxl_test: error while loading shared libraries: libjxl.so.0
-  # The required file is in the build directory (`$PWD`).
-  preCheck = if stdenv.isDarwin then ''
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$PWD
-  '' else ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD
-  '';
-
   meta = with lib; {
     homepage = "https://github.com/libjxl/libjxl";
     description = "JPEG XL image format reference implementation.";
diff --git a/pkgs/development/libraries/libminc/default.nix b/pkgs/development/libraries/libminc/default.nix
index 2440082cce9d7..f1f6dc1b374f1 100644
--- a/pkgs/development/libraries/libminc/default.nix
+++ b/pkgs/development/libraries/libminc/default.nix
@@ -29,7 +29,6 @@ stdenv.mkDerivation rec {
 
   doCheck = !stdenv.isDarwin;
   checkPhase = ''
-    export LD_LIBRARY_PATH="$(pwd)"  # see #22060
     ctest -j1 -E 'ezminc_rw_test' --output-on-failure
     # -j1: see https://github.com/BIC-MNI/libminc/issues/110
     # ezminc_rw_test: can't find libminc_io.so.5.2.0
diff --git a/pkgs/development/libraries/libpointmatcher/default.nix b/pkgs/development/libraries/libpointmatcher/default.nix
index 31fb5cb05ba79..01c3e3e87e43f 100644
--- a/pkgs/development/libraries/libpointmatcher/default.nix
+++ b/pkgs/development/libraries/libpointmatcher/default.nix
@@ -20,7 +20,6 @@ stdenv.mkDerivation rec {
 
   doCheck = true;
   checkPhase = ''
-    export LD_LIBRARY_PATH=$PWD
     ./utest/utest --path ../examples/data/
   '';
 
diff --git a/pkgs/development/libraries/libtiff/aarch64-darwin.nix b/pkgs/development/libraries/libtiff/aarch64-darwin.nix
index 5de481066f67d..521db8ff7993c 100644
--- a/pkgs/development/libraries/libtiff/aarch64-darwin.nix
+++ b/pkgs/development/libraries/libtiff/aarch64-darwin.nix
@@ -19,8 +19,6 @@ stdenv.mkDerivation rec {
     sha256 = "1jrkjv0xya9radddn8idxvs2gqzp3l2b1s8knlizmn7ad3jq817b";
   };
 
-  cmakeFlags = lib.optional stdenv.isDarwin "-DCMAKE_SKIP_BUILD_RPATH=OFF";
-
   # FreeImage needs this patch
   patches = [ ./headers-cmake.patch ];
 
diff --git a/pkgs/development/libraries/libtins/default.nix b/pkgs/development/libraries/libtins/default.nix
index b7e02a62fa996..b96c02a35bfd4 100644
--- a/pkgs/development/libraries/libtins/default.nix
+++ b/pkgs/development/libraries/libtins/default.nix
@@ -30,10 +30,6 @@ stdenv.mkDerivation rec {
   ];
 
   doCheck = true;
-  preCheck = ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD${placeholder "out"}/lib
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$PWD${placeholder "out"}/lib
-  '';
   checkTarget = "tests test";
 
   meta = with lib; {
diff --git a/pkgs/development/libraries/libuchardet/default.nix b/pkgs/development/libraries/libuchardet/default.nix
index 8bf2e2acff9f9..6b39995f39b9c 100644
--- a/pkgs/development/libraries/libuchardet/default.nix
+++ b/pkgs/development/libraries/libuchardet/default.nix
@@ -13,10 +13,6 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ cmake ];
 
-  cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # for tests
-  ];
-
   doCheck = !stdenv.isi686; # tests fail on i686
 
   meta = with lib; {
diff --git a/pkgs/development/libraries/libversion/default.nix b/pkgs/development/libraries/libversion/default.nix
index 98ad4ef7feec8..c8af82d04917f 100644
--- a/pkgs/development/libraries/libversion/default.nix
+++ b/pkgs/development/libraries/libversion/default.nix
@@ -13,13 +13,6 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ cmake ];
 
-  cmakeFlags = lib.optional stdenv.isDarwin [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # needed for tests
-  ];
-
-  preCheck = ''
-    export LD_LIBRARY_PATH=/build/source/build/libversion/''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH
-  '';
   doCheck = true;
   checkTarget = "test";
 
diff --git a/pkgs/development/libraries/libxc/default.nix b/pkgs/development/libraries/libxc/default.nix
index f28420229ab99..5091489ba72a5 100644
--- a/pkgs/development/libraries/libxc/default.nix
+++ b/pkgs/development/libraries/libxc/default.nix
@@ -20,8 +20,6 @@ stdenv.mkDerivation rec {
   cmakeFlags = [
     "-DENABLE_FORTRAN=ON"
     "-DBUILD_SHARED_LIBS=ON"
-    # needed for tests to link
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     # Force compilation of higher derivatives
     "-DDISABLE_VXC=0"
     "-DDISABLE_FXC=0"
diff --git a/pkgs/development/libraries/mailcore2/default.nix b/pkgs/development/libraries/mailcore2/default.nix
index 4e5a5fdbcdbca..65e35217f80a2 100644
--- a/pkgs/development/libraries/mailcore2/default.nix
+++ b/pkgs/development/libraries/mailcore2/default.nix
@@ -46,7 +46,7 @@ stdenv.mkDerivation rec {
   checkPhase = ''
     (
       cd unittest
-      LD_LIBRARY_PATH="$(cd ../src; pwd)" TZ=PST8PDT ./unittestcpp ../../unittest/data
+      TZ=PST8PDT ./unittestcpp ../../unittest/data
     )
   '';
 
diff --git a/pkgs/development/libraries/oneDNN/default.nix b/pkgs/development/libraries/oneDNN/default.nix
index 42f05a6561632..a4c4bb057251a 100644
--- a/pkgs/development/libraries/oneDNN/default.nix
+++ b/pkgs/development/libraries/oneDNN/default.nix
@@ -21,12 +21,6 @@ stdenv.mkDerivation rec {
   # Tests fail on some Hydra builders, because they do not support SSE4.2.
   doCheck = false;
 
-  # The test driver doesn't add an RPath to the build libdir
-  preCheck = ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD/src
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$PWD/src
-  '';
-
   # The cmake install gets tripped up and installs a nix tree into $out, in
   # addition to the correct install; clean it up.
   postInstall = ''
diff --git a/pkgs/development/libraries/orcania/default.nix b/pkgs/development/libraries/orcania/default.nix
index 2c43cfb4cc90e..158bc9f405fc4 100644
--- a/pkgs/development/libraries/orcania/default.nix
+++ b/pkgs/development/libraries/orcania/default.nix
@@ -18,11 +18,6 @@ stdenv.mkDerivation rec {
 
   doCheck = true;
 
-  preCheck = ''
-    export LD_LIBRARY_PATH="$(pwd)''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
-    export DYLD_FALLBACK_LIBRARY_PATH="$(pwd):$DYLD_FALLBACK_LIBRARY_PATH"
-  '';
-
   meta = with lib; {
     description = "Potluck with different functions for different purposes that can be shared among C programs";
     homepage = "https://github.com/babelouest/orcania";
diff --git a/pkgs/development/libraries/plplot/default.nix b/pkgs/development/libraries/plplot/default.nix
index dca1248b8b6b4..f3a703ce18785 100644
--- a/pkgs/development/libraries/plplot/default.nix
+++ b/pkgs/development/libraries/plplot/default.nix
@@ -33,7 +33,9 @@ in stdenv.mkDerivation rec {
     ;
   };
 
-  cmakeFlags = [ "-DCMAKE_SKIP_BUILD_RPATH=OFF" "-DBUILD_TEST=ON" ];
+  cmakeFlags = [
+    "-DBUILD_TEST=ON"
+  ];
 
   doCheck = true;
 
diff --git a/pkgs/development/libraries/pugixml/default.nix b/pkgs/development/libraries/pugixml/default.nix
index c976db8822571..73d890e03a41f 100644
--- a/pkgs/development/libraries/pugixml/default.nix
+++ b/pkgs/development/libraries/pugixml/default.nix
@@ -22,14 +22,6 @@ stdenv.mkDerivation rec {
 
   checkInputs = [ check ];
 
-  # Hack to be able to run the test, broken because we use
-  # CMAKE_SKIP_BUILD_RPATH to avoid cmake resetting rpath on install
-  preCheck = if stdenv.isDarwin then ''
-    export DYLD_LIBRARY_PATH="$(pwd)''${DYLD_LIBRARY_PATH:+:}$DYLD_LIBRARY_PATH"
-  '' else ''
-    export LD_LIBRARY_PATH="$(pwd)''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
-  '';
-
   preConfigure = ''
     # Enable long long support (required for filezilla)
     sed -ire '/PUGIXML_HAS_LONG_LONG/ s/^\/\///' src/pugiconfig.hpp
diff --git a/pkgs/development/libraries/s2n-tls/default.nix b/pkgs/development/libraries/s2n-tls/default.nix
index 918626d04c9de..3d3193f7e1081 100644
--- a/pkgs/development/libraries/s2n-tls/default.nix
+++ b/pkgs/development/libraries/s2n-tls/default.nix
@@ -23,7 +23,6 @@ stdenv.mkDerivation rec {
 
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=ON"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DUNSAFE_TREAT_WARNINGS_AS_ERRORS=OFF" # disable -Werror
   ] ++ lib.optionals stdenv.hostPlatform.isMips64 [
     # See https://github.com/aws/s2n-tls/issues/1592 and https://github.com/aws/s2n-tls/pull/1609
diff --git a/pkgs/development/libraries/science/biology/bpp-core/default.nix b/pkgs/development/libraries/science/biology/bpp-core/default.nix
index d1eb096e08e61..102cae24adb94 100644
--- a/pkgs/development/libraries/science/biology/bpp-core/default.nix
+++ b/pkgs/development/libraries/science/biology/bpp-core/default.nix
@@ -12,10 +12,6 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ cmake ];
 
-  preCheck = ''
-    export LD_LIBRARY_PATH=$(pwd)/src
-  '';
-
   postFixup = ''
     substituteInPlace $out/lib/cmake/bpp-core/bpp-core-targets.cmake  \
       --replace 'set(_IMPORT_PREFIX' '#set(_IMPORT_PREFIX'
diff --git a/pkgs/development/libraries/science/biology/bpp-phyl/default.nix b/pkgs/development/libraries/science/biology/bpp-phyl/default.nix
index 8ff6ad433fb51..c11b49aa57eb3 100644
--- a/pkgs/development/libraries/science/biology/bpp-phyl/default.nix
+++ b/pkgs/development/libraries/science/biology/bpp-phyl/default.nix
@@ -15,10 +15,6 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake ];
   buildInputs = [ bpp-core bpp-seq ];
 
-  preCheck = ''
-    export LD_LIBRARY_PATH=$(pwd)/src
-  '';
-
   postFixup = ''
     substituteInPlace $out/lib/cmake/${pname}/${pname}-targets.cmake  \
       --replace 'set(_IMPORT_PREFIX' '#set(_IMPORT_PREFIX'
diff --git a/pkgs/development/libraries/science/biology/bpp-popgen/default.nix b/pkgs/development/libraries/science/biology/bpp-popgen/default.nix
index af5d1d00d4d91..4b9a62eb762bc 100644
--- a/pkgs/development/libraries/science/biology/bpp-popgen/default.nix
+++ b/pkgs/development/libraries/science/biology/bpp-popgen/default.nix
@@ -15,10 +15,6 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake ];
   buildInputs = [ bpp-core bpp-seq ];
 
-  preCheck = ''
-    export LD_LIBRARY_PATH=$(pwd)/src
-  '';
-
   postFixup = ''
     substituteInPlace $out/lib/cmake/${pname}/${pname}-targets.cmake  \
       --replace 'set(_IMPORT_PREFIX' '#set(_IMPORT_PREFIX'
diff --git a/pkgs/development/libraries/science/biology/bpp-seq/default.nix b/pkgs/development/libraries/science/biology/bpp-seq/default.nix
index ef3f3d5756e90..7981fb28ac098 100644
--- a/pkgs/development/libraries/science/biology/bpp-seq/default.nix
+++ b/pkgs/development/libraries/science/biology/bpp-seq/default.nix
@@ -15,10 +15,6 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake ];
   buildInputs = [ bpp-core ];
 
-  preCheck = ''
-    export LD_LIBRARY_PATH=$(pwd)/src
-  '';
-
   postFixup = ''
     substituteInPlace $out/lib/cmake/${pname}/${pname}-targets.cmake  \
       --replace 'set(_IMPORT_PREFIX' '#set(_IMPORT_PREFIX'
diff --git a/pkgs/development/libraries/science/biology/elastix/default.nix b/pkgs/development/libraries/science/biology/elastix/default.nix
index 15465c501b43f..84762414fef93 100644
--- a/pkgs/development/libraries/science/biology/elastix/default.nix
+++ b/pkgs/development/libraries/science/biology/elastix/default.nix
@@ -24,10 +24,6 @@ stdenv.mkDerivation rec {
 
   doCheck = !stdenv.isDarwin;  # usual dynamic linker issues
 
-  preCheck = "
-    export LD_LIBRARY_PATH=$(pwd)/bin
-  ";
-
   meta = with lib; {
     homepage = "https://elastix.lumc.nl";
     description = "Image registration toolkit based on ITK";
diff --git a/pkgs/development/libraries/science/math/arpack/default.nix b/pkgs/development/libraries/science/math/arpack/default.nix
index 88336f21ed27b..9d96368a4cda7 100644
--- a/pkgs/development/libraries/science/math/arpack/default.nix
+++ b/pkgs/development/libraries/science/math/arpack/default.nix
@@ -36,11 +36,7 @@ stdenv.mkDerivation rec {
     "-DINTERFACE64=${if blas.isILP64 then "1" else "0"}"
   ];
 
-  preCheck = if stdenv.isDarwin then ''
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}`pwd`/lib:${blas}/lib:${lapack}/lib
-  '' else ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}`pwd`/lib
-  '' + ''
+  preCheck = ''
     # Prevent tests from using all cores
     export OMP_NUM_THREADS=2
   '';
diff --git a/pkgs/development/libraries/science/math/itpp/default.nix b/pkgs/development/libraries/science/math/itpp/default.nix
index b2acbe761b3bc..c3ff2aeebfb40 100644
--- a/pkgs/development/libraries/science/math/itpp/default.nix
+++ b/pkgs/development/libraries/science/math/itpp/default.nix
@@ -39,8 +39,6 @@ stdenv.mkDerivation rec {
   doCheck = true;
 
   checkPhase = ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD/itpp
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$PWD/itpp
     ./gtests/itpp_gtests
   '';
 
diff --git a/pkgs/development/libraries/science/math/scalapack/default.nix b/pkgs/development/libraries/science/math/scalapack/default.nix
index 7620844f8d1cd..ebf167de8d9d6 100644
--- a/pkgs/development/libraries/science/math/scalapack/default.nix
+++ b/pkgs/development/libraries/science/math/scalapack/default.nix
@@ -67,8 +67,6 @@ stdenv.mkDerivation rec {
 
     # Run single threaded
     export OMP_NUM_THREADS=1
-
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}`pwd`/lib
   '';
 
   meta = with lib; {
diff --git a/pkgs/development/libraries/silgraphite/graphite2.nix b/pkgs/development/libraries/silgraphite/graphite2.nix
index 9255889c6943c..a29706aefc483 100644
--- a/pkgs/development/libraries/silgraphite/graphite2.nix
+++ b/pkgs/development/libraries/silgraphite/graphite2.nix
@@ -35,11 +35,6 @@ stdenv.mkDerivation rec {
     sed -e '/freetype freetype.c/d' -i ../tests/examples/CMakeLists.txt
   '';
 
-  preCheck = ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$PWD/src/
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$PWD/src/
-  '';
-
   doCheck = true;
 
   meta = with lib; {
diff --git a/pkgs/development/libraries/snappy/default.nix b/pkgs/development/libraries/snappy/default.nix
index 797db5b69b0c3..7d70c500dfac0 100644
--- a/pkgs/development/libraries/snappy/default.nix
+++ b/pkgs/development/libraries/snappy/default.nix
@@ -36,7 +36,6 @@ stdenv.mkDerivation rec {
 
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=${if static then "OFF" else "ON"}"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
     "-DSNAPPY_BUILD_TESTS=OFF"
     "-DSNAPPY_BUILD_BENCHMARKS=OFF"
   ];
diff --git a/pkgs/development/libraries/spdlog/default.nix b/pkgs/development/libraries/spdlog/default.nix
index 5a21af12e33ca..523fe798168cb 100644
--- a/pkgs/development/libraries/spdlog/default.nix
+++ b/pkgs/development/libraries/spdlog/default.nix
@@ -36,11 +36,6 @@ let
       '';
 
       doCheck = true;
-      preCheck =  if stdenv.isDarwin then ''
-        export DYLD_LIBRARY_PATH="$(pwd)''${DYLD_LIBRARY_PATH:+:}$DYLD_LIBRARY_PATH"
-      '' else ''
-        export LD_LIBRARY_PATH="$(pwd)''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
-      '';
 
       meta = with lib; {
         description    = "Very fast, header only, C++ logging library";
diff --git a/pkgs/development/libraries/utf8proc/default.nix b/pkgs/development/libraries/utf8proc/default.nix
index ec8dab3f90c76..7e3471eefa016 100644
--- a/pkgs/development/libraries/utf8proc/default.nix
+++ b/pkgs/development/libraries/utf8proc/default.nix
@@ -16,7 +16,6 @@ stdenv.mkDerivation rec {
   cmakeFlags = [
     "-DBUILD_SHARED_LIBS=ON"
     "-DUTF8PROC_ENABLE_TESTING=ON"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
   ];
 
   doCheck = true;
diff --git a/pkgs/development/libraries/vtk/generic.nix b/pkgs/development/libraries/vtk/generic.nix
index eb58e0d54fdb5..43c6ded8a5d02 100644
--- a/pkgs/development/libraries/vtk/generic.nix
+++ b/pkgs/development/libraries/vtk/generic.nix
@@ -53,10 +53,6 @@ in stdenv.mkDerivation rec {
 
   patches = map fetchpatch patchesToFetch;
 
-  preBuild = ''
-    export LD_LIBRARY_PATH="$(pwd)/lib";
-  '';
-
   dontWrapQtApps = true;
 
   # Shared libraries don't work, because of rpath troubles with the current
diff --git a/pkgs/development/libraries/yder/default.nix b/pkgs/development/libraries/yder/default.nix
index 9dd55482300cf..b5667f9cfe6a6 100644
--- a/pkgs/development/libraries/yder/default.nix
+++ b/pkgs/development/libraries/yder/default.nix
@@ -39,11 +39,6 @@ stdenv.mkDerivation rec {
 
   doCheck = true;
 
-  preCheck = ''
-    export LD_LIBRARY_PATH="$(pwd)''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
-    export DYLD_FALLBACK_LIBRARY_PATH="$(pwd):$DYLD_FALLBACK_LIBRARY_PATH"
-  '';
-
   meta = with lib; {
     description = "Logging library for C applications";
     homepage = "https://github.com/babelouest/yder";
diff --git a/pkgs/development/tools/build-managers/cmake/setup-hook.sh b/pkgs/development/tools/build-managers/cmake/setup-hook.sh
index 89e8e0e197a0b..50f23f1bb7b11 100755
--- a/pkgs/development/tools/build-managers/cmake/setup-hook.sh
+++ b/pkgs/development/tools/build-managers/cmake/setup-hook.sh
@@ -102,9 +102,8 @@ cmakeConfigurePhase() {
         cmakeFlags="-DBUILD_TESTING=OFF $cmakeFlags"
     fi
 
-    # Avoid cmake resetting the rpath of binaries, on make install
-    # And build always Release, to ensure optimisation flags
-    cmakeFlags="-DCMAKE_BUILD_TYPE=${cmakeBuildType:-Release} -DCMAKE_SKIP_BUILD_RPATH=ON $cmakeFlags"
+    # Always build Release, to ensure optimisation flags
+    cmakeFlags="-DCMAKE_BUILD_TYPE=${cmakeBuildType:-Release} $cmakeFlags"
 
     # Disable user package registry to avoid potential side effects
     # and unecessary attempts to access non-existent home folder
diff --git a/pkgs/games/dwarf-fortress/dfhack/default.nix b/pkgs/games/dwarf-fortress/dfhack/default.nix
index 2064aa0199b4d..49e8fabd45e42 100644
--- a/pkgs/games/dwarf-fortress/dfhack/default.nix
+++ b/pkgs/games/dwarf-fortress/dfhack/default.nix
@@ -157,10 +157,6 @@ let
       touch .git/index .git/modules/library/xml/index
     '';
 
-    preBuild = ''
-      export LD_LIBRARY_PATH="$PWD/depends/protobuf''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
-    '';
-
     cmakeFlags = [ "-DDFHACK_BUILD_ARCH=${arch}" "-DDOWNLOAD_RUBY=OFF" ]
       ++ lib.optionals enableStoneSense [ "-DBUILD_STONESENSE=ON" "-DSTONESENSE_INTERNAL_SO=OFF" ];
 
diff --git a/pkgs/os-specific/linux/tiscamera/default.nix b/pkgs/os-specific/linux/tiscamera/default.nix
index e16c2dffe50aa..5ef0b0b0ea7f4 100644
--- a/pkgs/os-specific/linux/tiscamera/default.nix
+++ b/pkgs/os-specific/linux/tiscamera/default.nix
@@ -108,10 +108,6 @@ stdenv.mkDerivation rec {
     "-DTCAM_INTERNAL_ARAVIS=OFF"
     "-DTCAM_ARAVIS_USB_VISION=${if withAravis && withAravisUsbVision then "ON" else "OFF"}"
     "-DTCAM_INSTALL_FORCE_PREFIX=ON"
-    # There are gobject introspection commands launched as part of the build. Those have a runtime
-    # dependency on `libtcam` (which itself is built as part of this build). In order to allow
-    # that, we set the dynamic linker's path to point on the build time location of the library.
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
   ];
 
   doCheck = true;
diff --git a/pkgs/servers/sql/mysql/5.7.x.nix b/pkgs/servers/sql/mysql/5.7.x.nix
index 5f876b455e3ff..2b86df4f9d065 100644
--- a/pkgs/servers/sql/mysql/5.7.x.nix
+++ b/pkgs/servers/sql/mysql/5.7.x.nix
@@ -31,7 +31,6 @@ self = stdenv.mkDerivation rec {
   outputs = [ "out" "static" ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # To run libmysql/libmysql_api_test during build.
     "-DWITH_SSL=yes"
     "-DWITH_EMBEDDED_SERVER=yes"
     "-DWITH_UNIT_TESTS=no"
diff --git a/pkgs/servers/sql/mysql/8.0.x.nix b/pkgs/servers/sql/mysql/8.0.x.nix
index f7611d253e5bb..25115eafeb8c8 100644
--- a/pkgs/servers/sql/mysql/8.0.x.nix
+++ b/pkgs/servers/sql/mysql/8.0.x.nix
@@ -34,7 +34,6 @@ self = stdenv.mkDerivation rec {
   outputs = [ "out" "static" ];
 
   cmakeFlags = [
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # To run libmysql/libmysql_api_test during build.
     "-DFORCE_UNSUPPORTED_COMPILER=1" # To configure on Darwin.
     "-DWITH_ROUTER=OFF" # It may be packaged separately.
     "-DWITH_SYSTEM_LIBS=ON"
diff --git a/pkgs/tools/backup/percona-xtrabackup/generic.nix b/pkgs/tools/backup/percona-xtrabackup/generic.nix
index 85e9ac6f364ba..4caafcae679be 100644
--- a/pkgs/tools/backup/percona-xtrabackup/generic.nix
+++ b/pkgs/tools/backup/percona-xtrabackup/generic.nix
@@ -45,7 +45,6 @@ stdenv.mkDerivation rec {
     "-DWITH_ZLIB=system"
     "-DWITH_VALGRIND=ON"
     "-DWITH_MAN_PAGES=OFF"
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF" # To run libmysql/libmysql_api_test during build.
   ];
 
   postInstall = ''
diff --git a/pkgs/tools/filesystems/ceph/default.nix b/pkgs/tools/filesystems/ceph/default.nix
index db02bedf7f940..73e9dd1f01fa1 100644
--- a/pkgs/tools/filesystems/ceph/default.nix
+++ b/pkgs/tools/filesystems/ceph/default.nix
@@ -184,8 +184,6 @@ in rec {
       substituteInPlace src/common/module.c --replace "/sbin/modprobe" "modprobe"
       substituteInPlace src/common/module.c --replace "/bin/grep" "grep"
 
-      # for pybind/rgw to find internal dep
-      export LD_LIBRARY_PATH="$PWD/build/lib''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH"
       # install target needs to be in PYTHONPATH for "*.pth support" check to succeed
       # set PYTHONPATH, so the build system doesn't silently skip installing ceph-volume and others
       export PYTHONPATH=${ceph-python-env}/${sitePackages}:$lib/${sitePackages}:$out/${sitePackages}
diff --git a/pkgs/tools/misc/hdf4/default.nix b/pkgs/tools/misc/hdf4/default.nix
index 606f06d3405c3..051e98862bd2a 100644
--- a/pkgs/tools/misc/hdf4/default.nix
+++ b/pkgs/tools/misc/hdf4/default.nix
@@ -88,12 +88,6 @@ stdenv.mkDerivation rec {
 
   doCheck = true;
 
-  preCheck = ''
-    export LD_LIBRARY_PATH=$(pwd)/bin
-  '' + lib.optionalString (stdenv.isDarwin) ''
-    export DYLD_LIBRARY_PATH=$(pwd)/bin
-  '';
-
   excludedTests = lib.optionals stdenv.isDarwin [
     "MFHDF_TEST-hdftest"
     "MFHDF_TEST-hdftest-shared"
diff --git a/pkgs/tools/security/yubihsm-shell/default.nix b/pkgs/tools/security/yubihsm-shell/default.nix
index 06a1452400de5..2533e0c787092 100644
--- a/pkgs/tools/security/yubihsm-shell/default.nix
+++ b/pkgs/tools/security/yubihsm-shell/default.nix
@@ -38,11 +38,6 @@ stdenv.mkDerivation rec {
     openssl
   ];
 
-  cmakeFlags = [
-    # help2man fails without this
-    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
-  ];
-
   postPatch = ''
     # Can't find libyubihsm at runtime because of dlopen() in C code
     substituteInPlace lib/yubihsm.c \
diff --git a/pkgs/tools/text/opencc/default.nix b/pkgs/tools/text/opencc/default.nix
index fbff68abb692c..193c541cfab02 100644
--- a/pkgs/tools/text/opencc/default.nix
+++ b/pkgs/tools/text/opencc/default.nix
@@ -13,13 +13,6 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ cmake python3 ];
 
-  # let intermediate tools find intermediate library
-  preBuild = lib.optionalString stdenv.isLinux ''
-    export LD_LIBRARY_PATH=$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}$(pwd)/src
-  '' + lib.optionalString stdenv.isDarwin ''
-    export DYLD_LIBRARY_PATH=$DYLD_LIBRARY_PATH''${DYLD_LIBRARY_PATH:+:}$(pwd)/src
-  '';
-
   meta = with lib; {
     homepage = "https://github.com/BYVoid/OpenCC";
     license = licenses.asl20;