diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index 739b7dc2..1aed7bc8 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -229,6 +229,7 @@ jobs:
             || (python${{ matrix.python-version }} -m pip install virtualenv && python${{ matrix.python-version }} -m virtualenv .venv)
           source .venv/bin/activate
           sudo -E pytest --ignore=test/cunit --pastebin=failed --no-flaky-report -sr a
+          pytest --ignore=test/cunit --pastebin=failed --no-flaky-report -sr a -k _darwin
           deactivate
 
   wheels-osx:
diff --git a/src/austin.c b/src/austin.c
index a584243b..f607dc1e 100644
--- a/src/austin.c
+++ b/src/austin.c
@@ -219,6 +219,14 @@ int main(int argc, char ** argv) {
   py_proc_t * py_proc        = NULL;
   int         exec_arg       = parse_args(argc, argv);
 
+#if defined PL_MACOS
+  // On MacOS, we need to be root to use Austin.
+  if (geteuid() != 0) {
+    _msg(MPERM);
+    return EPROCPERM;
+  }
+#endif
+
   logger_init();
   if (!pargs.pipe)
     log_header();
diff --git a/test/test_cli.py b/test/test_cli.py
index 733ceded..40067dde 100644
--- a/test/test_cli.py
+++ b/test/test_cli.py
@@ -70,3 +70,14 @@ def test_cli_permissions():
         result = austin("-i", "1ms", "-p", str(p.pid))
         assert result.returncode == 37, result.stderr
         assert "Insufficient permissions" in result.stderr, result.stderr
+
+
+@pytest.mark.skipif(
+    platform.system() != "Darwin",
+    reason="Only Darwin requires sudo in all cases",
+)
+@no_sudo
+def test_cli_permissions_darwin():
+    result = austin("-i", "1ms", "python3.10", "-c", "from time import sleep; sleep(1)")
+    assert result.returncode == 37, result.stderr
+    assert "Insufficient permissions" in result.stderr, result.stderr