diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index b5f5a982ce04..4d2acfecbf69 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -16,10 +16,10 @@ The format is based on `Keep a Changelog`_.
   - **Fixed**: for any bug fixes.
   - **Security**: in case of vulnerabilities.
 
-
 `UNRELEASED`_
 =============
 
+
 Added
 -----
 
@@ -87,6 +87,7 @@ Deprecated
 Fixed
 -----
 
+- Fixed #1892, whereby inheriting from QuantumRegister or ClassicalRegister would cause a QiskitError in instruction.py
 - Fixed #829 by removing dependence on scipy unitary_group (#1857).
 - Fixed a bug with measurement sampling optimization in BasicAer
   qasm_simulator (#1624).
diff --git a/qiskit/circuit/instruction.py b/qiskit/circuit/instruction.py
index 8e9e9aeafcf1..b5def64db347 100644
--- a/qiskit/circuit/instruction.py
+++ b/qiskit/circuit/instruction.py
@@ -48,9 +48,9 @@ def __init__(self, name, params, qargs, cargs, circuit=None):
         Raises:
             QiskitError: when the register is not in the correct format.
         """
-        if not all((type(i[0]), type(i[1])) == (QuantumRegister, int) for i in qargs):
+        if not all(isinstance(i[0], QuantumRegister) and isinstance(i[1], int) for i in qargs):
             raise QiskitError("qarg not (QuantumRegister, int) tuple")
-        if not all((type(i[0]), type(i[1])) == (ClassicalRegister, int) for i in cargs):
+        if not all(isinstance(i[0], ClassicalRegister) and isinstance(i[1], int) for i in cargs):
             raise QiskitError("carg not (ClassicalRegister, int) tuple")
         self.name = name
         self.params = []  # a list of gate params stored