diff --git a/pkg/libcose/Makefile.dep b/pkg/libcose/Makefile.dep
index bab895a6489b7..fa4af01a8a899 100644
--- a/pkg/libcose/Makefile.dep
+++ b/pkg/libcose/Makefile.dep
@@ -8,3 +8,9 @@ endif
 ifneq (,$(filter libcose_crypt_hacl,$(USEMODULE)))
   USEPKG += hacl
 endif
+ifneq (,$(filter libcose_crypt_monocypher,$(USEMODULE)))
+  USEPKG += monocypher
+endif
+ifneq (,$(filter libcose_crypt_c25519,$(USEMODULE)))
+  USEPKG += c25519
+endif
diff --git a/pkg/libcose/Makefile.include b/pkg/libcose/Makefile.include
index 744210a85393a..5013541e6fbd2 100644
--- a/pkg/libcose/Makefile.include
+++ b/pkg/libcose/Makefile.include
@@ -7,6 +7,12 @@ endif
 ifneq (,$(filter libcose_crypt_hacl,$(USEMODULE)))
   CFLAGS += -DCRYPTO_HACL
 endif
+ifneq (,$(filter libcose_crypt_monocypher,$(USEMODULE)))
+  CFLAGS += -DCRYPTO_MONOCYPHER
+endif
+ifneq (,$(filter libcose_crypt_c25519,$(USEMODULE)))
+  CFLAGS += -DCRYPTO_C25519
+endif
 
 # Declare pseudomodules here to be selfcontained
 PSEUDOMODULES += libcose_crypt_%