diff --git a/cmd/stackdriver-prometheus-sidecar/main.go b/cmd/stackdriver-prometheus-sidecar/main.go
index 767864be..48d200bb 100644
--- a/cmd/stackdriver-prometheus-sidecar/main.go
+++ b/cmd/stackdriver-prometheus-sidecar/main.go
@@ -24,6 +24,7 @@ import (
 	"os/signal"
 	"path"
 	"path/filepath"
+	"regexp"
 	"runtime"
 	"syscall"
 	"time"
@@ -155,6 +156,7 @@ func main() {
 		walDirectory       string
 		prometheusURL      *url.URL
 		listenAddress      string
+		filters            []string
 
 		logLevel promlog.AllowedLevel
 	}{}
@@ -190,6 +192,9 @@ func main() {
 	a.Flag("web.listen-address", "Address to listen on for UI, API, and telemetry.").
 		Default("0.0.0.0:9091").StringVar(&cfg.listenAddress)
 
+	a.Flag("filter", "Label matcher which must pass for a series to be forwarded to Stackdriver,").
+		StringsVar(&cfg.filters)
+
 	promlogflag.AddFlags(a, &cfg.logLevel)
 
 	_, err := a.Parse(os.Args[1:])
@@ -226,6 +231,12 @@ func main() {
 		staticLabels["_debug"] = "debug"
 	}
 
+	filters, err := parseFilters(cfg.filters)
+	if err != nil {
+		fmt.Fprintln(os.Stderr, "Error parsing filters:", err)
+		os.Exit(2)
+	}
+
 	cfg.projectIdResource = fmt.Sprintf("projects/%v", *projectId)
 	targetsURL, err := cfg.prometheusURL.Parse(targets.DefaultAPIEndpoint)
 	if err != nil {
@@ -279,6 +290,7 @@ func main() {
 		log.With(logger, "component", "Prometheus reader"),
 		cfg.walDirectory,
 		tailer,
+		filters,
 		retrieval.TargetsWithDiscoveredLabels(targetCache, labels.FromMap(staticLabels)),
 		metadataCache,
 		queueManager,
@@ -456,3 +468,31 @@ func waitForPrometheus(ctx context.Context, logger log.Logger, promURL *url.URL)
 		}
 	}
 }
+
+func parseFilters(strs []string) (matchers []*labels.Matcher, err error) {
+	pattern := regexp.MustCompile(`^([a-zA-Z0-9_]+)(=|!=|=~|!~)"(.+)"$`)
+
+	for _, s := range strs {
+		parts := pattern.FindStringSubmatch(s)
+		if len(parts) != 4 {
+			return nil, fmt.Errorf("invalid filter %q", s)
+		}
+		var matcherType labels.MatchType
+		switch parts[2] {
+		case "=":
+			matcherType = labels.MatchEqual
+		case "!=":
+			matcherType = labels.MatchNotEqual
+		case "=~":
+			matcherType = labels.MatchRegexp
+		case "!~":
+			matcherType = labels.MatchNotRegexp
+		}
+		matcher, err := labels.NewMatcher(matcherType, parts[1], parts[3])
+		if err != nil {
+			return nil, fmt.Errorf("invalid filter %q: %s", s, err)
+		}
+		matchers = append(matchers, matcher)
+	}
+	return matchers, nil
+}
diff --git a/retrieval/manager.go b/retrieval/manager.go
index 982c3578..5be4972f 100644
--- a/retrieval/manager.go
+++ b/retrieval/manager.go
@@ -81,6 +81,7 @@ func NewPrometheusReader(
 	logger log.Logger,
 	walDirectory string,
 	tailer *tail.Tailer,
+	filters []*labels.Matcher,
 	targetGetter TargetGetter,
 	metadataGetter MetadataGetter,
 	appender Appender,
@@ -92,6 +93,7 @@ func NewPrometheusReader(
 		appender:             appender,
 		logger:               logger,
 		tailer:               tailer,
+		filters:              filters,
 		walDirectory:         walDirectory,
 		targetGetter:         targetGetter,
 		metadataGetter:       metadataGetter,
@@ -103,6 +105,7 @@ type PrometheusReader struct {
 	logger               log.Logger
 	walDirectory         string
 	tailer               *tail.Tailer
+	filters              []*labels.Matcher
 	targetGetter         TargetGetter
 	metadataGetter       MetadataGetter
 	appender             Appender
@@ -138,7 +141,14 @@ func init() {
 func (r *PrometheusReader) Run(ctx context.Context, startOffset int) error {
 	level.Info(r.logger).Log("msg", "Starting Prometheus reader...")
 
-	seriesCache := newSeriesCache(r.logger, r.walDirectory, r.targetGetter, r.metadataGetter, ResourceMappings)
+	seriesCache := newSeriesCache(
+		r.logger,
+		r.walDirectory,
+		r.filters,
+		r.targetGetter,
+		r.metadataGetter,
+		ResourceMappings,
+	)
 	go seriesCache.run(ctx)
 
 	builder := &sampleBuilder{series: seriesCache}
diff --git a/retrieval/manager_test.go b/retrieval/manager_test.go
index 39760d48..48b5aa25 100644
--- a/retrieval/manager_test.go
+++ b/retrieval/manager_test.go
@@ -81,7 +81,7 @@ func TestReader_Progress(t *testing.T) {
 		"job1/inst1/metric1": &scrape.MetricMetadata{Type: textparse.MetricTypeGauge, Metric: "metric1"},
 	}
 
-	r := NewPrometheusReader(nil, dir, tailer, targetMap, metadataMap, &nopAppender{})
+	r := NewPrometheusReader(nil, dir, tailer, nil, targetMap, metadataMap, &nopAppender{})
 	r.progressSaveInterval = 200 * time.Millisecond
 
 	// Populate sample data
@@ -136,7 +136,7 @@ func TestReader_Progress(t *testing.T) {
 	}
 
 	recorder := &nopAppender{}
-	r = NewPrometheusReader(nil, dir, tailer, targetMap, metadataMap, recorder)
+	r = NewPrometheusReader(nil, dir, tailer, nil, targetMap, metadataMap, recorder)
 	go r.Run(ctx, progressOffset)
 
 	// Wait for reader to process until the end.
diff --git a/retrieval/series_cache.go b/retrieval/series_cache.go
index 568a5e51..9d182015 100644
--- a/retrieval/series_cache.go
+++ b/retrieval/series_cache.go
@@ -75,6 +75,7 @@ type seriesGetter interface {
 type seriesCache struct {
 	logger       log.Logger
 	dir          string
+	filters      []*promlabels.Matcher
 	targets      TargetGetter
 	metadata     MetadataGetter
 	resourceMaps []ResourceMap
@@ -122,13 +123,21 @@ func (e *seriesCacheEntry) shouldRefresh() bool {
 	return !e.populated() && time.Since(e.lastRefresh) > refreshInterval
 }
 
-func newSeriesCache(logger log.Logger, dir string, targets TargetGetter, metadata MetadataGetter, resourceMaps []ResourceMap) *seriesCache {
+func newSeriesCache(
+	logger log.Logger,
+	dir string,
+	filters []*promlabels.Matcher,
+	targets TargetGetter,
+	metadata MetadataGetter,
+	resourceMaps []ResourceMap,
+) *seriesCache {
 	if logger == nil {
 		logger = log.NewNopLogger()
 	}
 	return &seriesCache{
 		logger:       logger,
 		dir:          dir,
+		filters:      filters,
 		targets:      targets,
 		metadata:     metadata,
 		resourceMaps: resourceMaps,
@@ -285,6 +294,11 @@ func (c *seriesCache) getResetAdjusted(ref uint64, t int64, v float64) (int64, f
 // set the label set for the given reference.
 // maxSegment indicates the the highest segment at which the series was possibly defined.
 func (c *seriesCache) set(ctx context.Context, ref uint64, lset labels.Labels, maxSegment int) error {
+	for _, m := range c.filters {
+		if v := lset.Get(m.Name); !m.Matches(v) {
+			return nil
+		}
+	}
 	c.mtx.Lock()
 	c.entries[ref] = &seriesCacheEntry{
 		maxSegment: maxSegment,
diff --git a/retrieval/series_cache_test.go b/retrieval/series_cache_test.go
index b22b5c88..0ba441e2 100644
--- a/retrieval/series_cache_test.go
+++ b/retrieval/series_cache_test.go
@@ -43,7 +43,7 @@ func TestScrapeCache_GarbageCollect(t *testing.T) {
 	// Initialize the series cache with "empty" target and metadata maps.
 	// The series we use below have no job, instance, and __name__ labels set, which
 	// will result in those empty lookup keys.
-	c := newSeriesCache(nil, dir,
+	c := newSeriesCache(nil, dir, nil,
 		targetMap{"/": &targets.Target{}},
 		metadataMap{"//": &scrape.MetricMetadata{Type: textparse.MetricTypeGauge}},
 		[]ResourceMap{
@@ -181,7 +181,7 @@ func TestSeriesCache_Refresh(t *testing.T) {
 	}
 	targetMap := targetMap{}
 	metadataMap := metadataMap{}
-	c := newSeriesCache(nil, "", targetMap, metadataMap, resourceMaps)
+	c := newSeriesCache(nil, "", nil, targetMap, metadataMap, resourceMaps)
 
 	ctx, cancel := context.WithCancel(context.Background())
 	defer cancel()
@@ -225,3 +225,50 @@ func TestSeriesCache_Refresh(t *testing.T) {
 		t.Errorf("expected metadata but got none, error: %s", err)
 	}
 }
+
+func TestSeriesCache_Filter(t *testing.T) {
+	resourceMaps := []ResourceMap{
+		{
+			Type:     "resource2",
+			LabelMap: map[string]labelTranslation{"__resource_a": constValue("resource_a")},
+		},
+	}
+	// Populate the getters with data.
+	targetMap := targetMap{
+		"job1/inst1": &targets.Target{
+			Labels:           promlabels.FromStrings("job", "job1", "instance", "inst1"),
+			DiscoveredLabels: promlabels.FromStrings("__resource_a", "resource2_a"),
+		},
+	}
+	metadataMap := metadataMap{
+		"job1/inst1/metric1": &scrape.MetricMetadata{Type: textparse.MetricTypeGauge, Metric: "metric1"},
+	}
+	c := newSeriesCache(nil, "", []*promlabels.Matcher{
+		&promlabels.Matcher{Type: promlabels.MatchEqual, Name: "a", Value: "a1"},
+		&promlabels.Matcher{Type: promlabels.MatchEqual, Name: "b", Value: "b1"},
+	}, targetMap, metadataMap, resourceMaps)
+
+	ctx, cancel := context.WithCancel(context.Background())
+	defer cancel()
+
+	// Test base case of metric that passes all filters. This primarily
+	// ensures that our setup is correct and metrics aren't dropped for reasons
+	// other than the filter.
+	err := c.set(ctx, 1, labels.FromStrings("__name__", "metric1", "job", "job1", "instance", "inst1", "a", "a1", "b", "b1"), 1)
+	if err != nil {
+		t.Fatal(err)
+	}
+	if _, ok, err := c.get(ctx, 1); !ok || err != nil {
+		t.Fatalf("metric not found: %s", err)
+	}
+	// Test filtered metric.
+	err = c.set(ctx, 2, labels.FromStrings("__name__", "metric1", "job", "job1", "instance", "inst1", "a", "a1", "b", "b2"), 1)
+	if err != nil {
+		t.Fatal(err)
+	}
+	if _, ok, err := c.get(ctx, 2); err != nil {
+		t.Fatalf("error retrieving metric: %s", err)
+	} else if ok {
+		t.Fatalf("metric was not filtered")
+	}
+}
diff --git a/retrieval/transform_test.go b/retrieval/transform_test.go
index 9a04f177..c5581017 100644
--- a/retrieval/transform_test.go
+++ b/retrieval/transform_test.go
@@ -594,7 +594,7 @@ func TestSampleBuilder(t *testing.T) {
 		var err error
 		var result []*monitoring_pb.TimeSeries
 
-		series := newSeriesCache(nil, "", c.targets, c.metadata, resourceMaps)
+		series := newSeriesCache(nil, "", nil, c.targets, c.metadata, resourceMaps)
 		for ref, s := range c.series {
 			series.set(ctx, ref, s, 0)
 		}