diff --git a/data/deprecatedIdentifiers/deprecatedMetabolites.tsv b/data/deprecatedIdentifiers/deprecatedMetabolites.tsv
index a9673a29..0e73b4c0 100644
--- a/data/deprecatedIdentifiers/deprecatedMetabolites.tsv
+++ b/data/deprecatedIdentifiers/deprecatedMetabolites.tsv
@@ -2191,3 +2191,6 @@ mets	metsNoComp	metBiGGID	metKEGGID	metHMDBID	metChEBIID	metPubChemID	metLipidMa
 "MAM00156c"	"MAM00156"	""	""	""	""	"53481438"	""	"CE2196"	""	"CE2196"	"MNXM31535"	"m00156c"	"m00156c"
 "MAM02045c"	"MAM02045"	""	"C09209"	""	"CHEBI:5623"	"5281404"	""	""	""	"C09209"	"MNXM11747"	"m02045c"	"m02045c"
 "MAM00077x"	"MAM00077"	"CE2416"	""	""	""	""	""	"CE2416"	""	""	"MNXM165274"	"m00077p"	"m00077p"
+"MAM01703m"	"MAM01703"	"dhlpro"	"C02972"	""	"CHEBI:16194"	""	""	""	""	"dhlpro"	"MNXM1663"	"m01703m"	"m01703m"
+"MAM02400m"	"MAM02400"	"lpro"	"C02051"	""	"CHEBI:15804"	""	""	""	""	"lpro"	"MNXM998"	"m02400m"	"m02400m"
+"MAM02879m"	"MAM02879"	"alpro"	"C01242"	""	"CHEBI:16882"	""	""	""	""	"alpro"	"MNXM81221"	"m02879m"	"m02879m"
diff --git a/data/deprecatedIdentifiers/deprecatedReactions.tsv b/data/deprecatedIdentifiers/deprecatedReactions.tsv
index 062aa08c..b512d9fc 100644
--- a/data/deprecatedIdentifiers/deprecatedReactions.tsv
+++ b/data/deprecatedIdentifiers/deprecatedReactions.tsv
@@ -72,3 +72,8 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR04588"	""	""	""	"r0425"	""	"r0425"	"MNXR105341"	"HMR_4588"	"RCR11669"	""	0	""	""	"HMR_4588"
 "MAR03488"	""	""	"RE3073X"	""	""	""	"MNXR95747"	"HMR_3488"	"RCR12589"	""	0	""	""	"HMR_3488"
 "MAR03489"	""	""	"RE3079X"	""	""	""	""	"HMR_3489"	"RCR12590"	""	0	""	""	"HMR_3489"
+"MAR04456"	"R01324"	"ACONTm"	"R01324C"	"r0316"	""	"ACONTm"	"MNXR95384"	"HMR_4456"	"RCR10351"	""	0	""	"RHEA:10336"	"HMR_4456"
+"MAR08435"	"R03425"	"GCCcm"	""	""	""	"GCCam"	"MNXR100067;MNXR100069"	"HMR_8435"	"RCR10246"	""	0	""	"RHEA:24304"	"HMR_8435"
+"MAR08436"	"R04125"	"GCHOLAt"	""	""	""	"GCCbim"	"MNXR100068;MNXR100070"	"HMR_8436"	"RCR11319"	""	0	""	"RHEA:16945"	"HMR_8436"
+"MAR08437"	"R03815"	"GCHOLAt2"	""	""	""	"GCCcm"	"MNXR100069;MNXR100071"	"HMR_8437"	"RCR11320"	""	0	""	""	"HMR_8437"
+"MAR03923"	"R01221"	"GLYCLm"	"R01221C"	"r0295"	""	"r0295"	"MNXR100330"	"HMR_3923"	"RCR10962"	""	0	""	"RHEA:27758"	"HMR_3923"
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index 338f86b3..7ca031ae 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -23044,14 +23044,6 @@
       - charge: -1
       - inchis: ""
       - metFrom: "HMRdatabase"
-    - !!omap
-      - id: "MAM01703m"
-      - name: "dihydrolipoylprotein"
-      - compartment: "m"
-      - formula: "H2S2X"
-      - charge: 0
-      - inchis: ""
-      - metFrom: "HMRdatabase"
     - !!omap
       - id: "MAM01704c"
       - name: "dihydroneopterin"
@@ -32860,14 +32852,6 @@
       - charge: 0
       - inchis: ""
       - metFrom: "HMRdatabase"
-    - !!omap
-      - id: "MAM02400m"
-      - name: "lipoylprotein"
-      - compartment: "m"
-      - formula: "S2X"
-      - charge: 0
-      - inchis: ""
-      - metFrom: "HMRdatabase"
     - !!omap
       - id: "MAM02401c"
       - name: "L-isoleucyl-tRNA(ile)"
@@ -39812,14 +39796,6 @@
       - charge: 1
       - inchis: ""
       - metFrom: "HMRdatabase"
-    - !!omap
-      - id: "MAM02879m"
-      - name: "S-aminomethyldihydrolipoylprotein"
-      - compartment: "m"
-      - formula: "CH6NS2X"
-      - charge: 1
-      - inchis: ""
-      - metFrom: "HMRdatabase"
     - !!omap
       - id: "MAM02880c"
       - name: "sarcosine"
@@ -80422,7 +80398,7 @@
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.4.19.9"
-      - references: "PMID:12909365;PMID:16859665"
+      - references: "PMID:12909365;PMID:16859665;PMID:17171578"
       - subsystem:
           - "Glycine, serine and threonine metabolism"
       - confidence_score: 0
@@ -80437,7 +80413,7 @@
           - MAM02553m: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"
+      - gene_reaction_rule: "ENSG00000091140"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.8.1.4;2.1.2.10"
@@ -80493,11 +80469,11 @@
           - MAM02878m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"
+      - gene_reaction_rule: "ENSG00000140905 and ENSG00000178445"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.8.1.4;2.1.2.10"
-      - references: ""
+      - references: "PMID:24798336"
       - subsystem:
           - "Glycine, serine and threonine metabolism"
       - confidence_score: 0
@@ -80513,69 +80489,11 @@
           - MAM02980m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.8.1.4;2.1.2.10"
-      - references: ""
-      - subsystem:
-          - "Glycine, serine and threonine metabolism"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR08435"
-      - name: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)"
-      - metabolites: !!omap
-          - MAM01596m: 1
-          - MAM01986m: -1
-          - MAM02039m: -1
-          - MAM02400m: -1
-          - MAM02879m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.4.4.2"
-      - references: ""
-      - subsystem:
-          - "Glycine, serine and threonine metabolism"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR08436"
-      - name: "[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)"
-      - metabolites: !!omap
-          - MAM01045m: 1
-          - MAM01703m: 1
-          - MAM02039m: 1
-          - MAM02578m: 1
-          - MAM02879m: -1
-          - MAM02980m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"
+      - gene_reaction_rule: "ENSG00000140905 and ENSG00000145020"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.8.1.4;2.1.2.10"
-      - references: ""
-      - subsystem:
-          - "Glycine, serine and threonine metabolism"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR08437"
-      - name: "dihydrolipoylprotein:NAD+ oxidoreductase"
-      - metabolites: !!omap
-          - MAM01703m: 1
-          - MAM02039m: -1
-          - MAM02400m: -1
-          - MAM02552m: 1
-          - MAM02553m: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.8.1.4;2.1.2.10"
-      - references: ""
+      - references: "PMID:24798336"
       - subsystem:
           - "Glycine, serine and threonine metabolism"
       - confidence_score: 0
@@ -94538,23 +94456,7 @@
           - MAM02183c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000122729 or ENSG00000136381"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "4.2.1.3"
-      - references: "PMID:15263083;PMID:16511074"
-      - subsystem:
-          - "Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR04456"
-      - name: "citrate hydroxymutase"
-      - metabolites: !!omap
-          - MAM01587m: -1
-          - MAM02183m: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100412 or ENSG00000122729"
+      - gene_reaction_rule: "ENSG00000122729"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.2.1.3"
@@ -94571,7 +94473,7 @@
           - MAM02040m: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100412 or ENSG00000122729"
+      - gene_reaction_rule: "ENSG00000100412"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.2.1.3"
@@ -94607,7 +94509,7 @@
           - MAM02183m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000100412 or ENSG00000122729"
+      - gene_reaction_rule: "ENSG00000100412"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.2.1.3"
@@ -95072,7 +94974,7 @@
           - MAM02630m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000111775 and ENSG00000112695 and ENSG00000126267 and ENSG00000127184 and ENSG00000131143 and ENSG00000131174 and ENSG00000135940 and ENSG00000164919 and ENSG00000176340 and ENSG00000178741 and ENSG00000198712 and ENSG00000198804 and ENSG00000198938 and ENSG00000189043"
+      - gene_reaction_rule: "ENSG00000198804 and ENSG00000198712 and ENSG00000198938 and (ENSG00000131143 or ENSG00000131055) and ENSG00000178741 and ENSG00000135940 and (ENSG00000111775 or ENSG00000156885) and (ENSG00000126267 or ENSG00000160471) and ENSG00000164919 and (ENSG00000161281 or ENSG00000112695) and ENSG00000131174 and ENSG00000170516 and ENSG00000127184 and ENSG00000176340 and ENSG00000189043"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.9.3.1"
@@ -153357,28 +153259,6 @@
       - subsystem:
           - "Inositol phosphate metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03923"
-      - name: "glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding)"
-      - metabolites: !!omap
-          - MAM01045m: 1
-          - MAM01596m: 1
-          - MAM01986m: -1
-          - MAM02039m: 1
-          - MAM02552m: -1
-          - MAM02553m: 1
-          - MAM02578m: 1
-          - MAM02980m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"
-      - rxnNotes: ""
-      - rxnFrom: "HMRdatabase"
-      - eccodes: "1.8.1.4;2.1.2.10"
-      - references: "PMID:7916605"
-      - subsystem:
-          - "Folate metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03925"
       - name: "5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase"
@@ -210078,7 +209958,7 @@
           - MAM01968r: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000105220 or ENSG00000137700"
+      - gene_reaction_rule: "ENSG00000281500"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: ""
@@ -210574,7 +210454,7 @@
           - MAM02751r: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000137700"
+      - gene_reaction_rule: "ENSG00000281500"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: ""
@@ -226875,7 +226755,7 @@
           - MAM02751r: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000137700"
+      - gene_reaction_rule: "ENSG00000281500"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: ""
@@ -302937,9 +302817,9 @@
           - MAM02630m: -1
           - MAM02631m: 0.02
       - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000111775 and ENSG00000112695 and ENSG00000126267 and ENSG00000127184 and ENSG00000131055 and ENSG00000131143 and ENSG00000131174 and ENSG00000135940 and ENSG00000156885 and ENSG00000160471 and ENSG00000161281 and ENSG00000164919 and ENSG00000170516 and ENSG00000176340 and ENSG00000178741 and ENSG00000187581 and ENSG00000198712 and ENSG00000198804 and ENSG00000198938"
-      - rxnNotes: ""
+      - upper_bound: 0
+      - gene_reaction_rule: "ENSG00000198804 and ENSG00000198712 and ENSG00000198938 and (ENSG00000131143 or ENSG00000131055) and ENSG00000178741 and ENSG00000135940 and (ENSG00000111775 or ENSG00000156885) and (ENSG00000126267 or ENSG00000160471) and ENSG00000164919 and (ENSG00000161281 or ENSG00000112695) and ENSG00000131174 and ENSG00000170516 and ENSG00000127184 and ENSG00000176340 and ENSG00000189043"
+      - rxnNotes: "This is ROS version of Complex IV, and blocked by default"
       - rxnFrom: "Recon3D"
       - eccodes: ""
       - references: ""
@@ -309398,8 +309278,6 @@
       - id: "ENSG00000136267"
     - !!omap
       - id: "ENSG00000136371"
-    - !!omap
-      - id: "ENSG00000136381"
     - !!omap
       - id: "ENSG00000136448"
     - !!omap
@@ -309470,8 +309348,6 @@
       - id: "ENSG00000137563"
     - !!omap
       - id: "ENSG00000137574"
-    - !!omap
-      - id: "ENSG00000137700"
     - !!omap
       - id: "ENSG00000137731"
     - !!omap
@@ -311934,8 +311810,6 @@
       - id: "ENSG00000187555"
     - !!omap
       - id: "ENSG00000187566"
-    - !!omap
-      - id: "ENSG00000187581"
     - !!omap
       - id: "ENSG00000187630"
     - !!omap
@@ -312586,6 +312460,8 @@
       - id: "ENSG00000277893"
     - !!omap
       - id: "ENSG00000278540"
+    - !!omap
+      - id: "ENSG00000281500"
     - !!omap
       - id: "ENSG00000288702"
     - !!omap
diff --git a/model/genes.tsv b/model/genes.tsv
index fd2bf656..46782211 100644
--- a/model/genes.tsv
+++ b/model/genes.tsv
@@ -1302,7 +1302,6 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000136250"	"ENST00000617537;ENST00000621510;ENST00000617267;ENST00000614254;ENST00000491444;ENST00000487014;ENST00000495942;ENST00000480201;ENST00000543742;ENST00000435386;ENST00000414637;ENST00000612871"	"ENSP00000483783;ENSP00000479664;ENSP00000416051;ENSP00000416472;ENSP00000484305"	"P28039"	"AOAH"	"313"	"acyloxyacyl hydrolase"	""	"Cytosol"	"SwissProt"
 "ENSG00000136267"	"ENST00000403951;ENST00000402815;ENST00000407950;ENST00000493142;ENST00000406247;ENST00000403963;ENST00000471732;ENST00000477401;ENST00000464065;ENST00000467449;ENST00000437998;ENST00000463981;ENST00000399322"	"ENSP00000385780;ENSP00000384909;ENSP00000385031;ENSP00000386066;ENSP00000405569;ENSP00000382260"	"Q9Y6T7"	"DGKB"	"1607"	"diacylglycerol kinase beta"	"DAGK2;DGK;DGK-BETA;KIAA0718"	"Cytosol"	"SwissProt"
 "ENSG00000136371"	"ENST00000560261;ENST00000258874;ENST00000559722;ENST00000560919"	"ENSP00000454318;ENSP00000258874;ENSP00000489076;ENSP00000454626"	"P49914"	"MTHFS"	"10588"	"methenyltetrahydrofolate synthetase"	"HsT19268"	"Cytosol"	"SwissProt;CellAtlas"
-"ENSG00000136381"	"ENST00000560840;ENST00000559215;ENST00000258886;ENST00000558525;ENST00000560440;ENST00000558570;ENST00000560454;ENST00000559427;ENST00000559676;ENST00000559091"	"ENSP00000453172;ENSP00000453532;ENSP00000258886;ENSP00000453058;ENSP00000452938;ENSP00000454063;ENSP00000453863"	"P48200"	"IREB2"	"3658"	"iron responsive element binding protein 2"	"IRP2"	"Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000136448"	"ENST00000678938;ENST00000592782;ENST00000676828;ENST00000590310;ENST00000677949;ENST00000591931;ENST00000678606;ENST00000587014;ENST00000587670;ENST00000258960;ENST00000678576;ENST00000543908;ENST00000676753;ENST00000678332;ENST00000590114;ENST00000585561;ENST00000592654;ENST00000588455;ENST00000587120"	"ENSP00000503621;ENSP00000468424;ENSP00000504192;ENSP00000503657;ENSP00000504048;ENSP00000504365;ENSP00000258960;ENSP00000503635;ENSP00000439263;ENSP00000503505;ENSP00000504484;ENSP00000504284;ENSP00000466777;ENSP00000466827"	"P30419"	"NMT1"	"4836"	"N-myristoyltransferase 1"	"NMT"	"Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000136504"	"ENST00000675278;ENST00000454930;ENST00000259021;ENST00000509773;ENST00000510819;ENST00000424009;ENST00000509124;ENST00000506533;ENST00000435742;ENST00000513171;ENST00000514540;ENST00000513980;ENST00000512616;ENST00000508594;ENST00000509794;ENST00000510426;ENST00000513075;ENST00000503101;ENST00000503635"	"ENSP00000502732;ENSP00000413415;ENSP00000259021;ENSP00000424577;ENSP00000423385;ENSP00000398961;ENSP00000421368;ENSP00000409477"	"O95251"	"KAT7"	"11143"	"lysine acetyltransferase 7"	"HBO1;HBOA;MYST2;ZC2HC7"	"Nucleus;Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000136521"	"ENST00000488002;ENST00000611971;ENST00000493866;ENST00000259037;ENST00000472629;ENST00000468210;ENST00000359944;ENST00000477177;ENST00000482604;ENST00000480374;ENST00000496904;ENST00000473500;ENST00000491054;ENST00000471112;ENST00000476587;ENST00000493716"	"ENSP00000481703;ENSP00000419656;ENSP00000259037;ENSP00000419248;ENSP00000420538;ENSP00000353026;ENSP00000418354;ENSP00000419099;ENSP00000419501"	"O43674"	"NDUFB5"	"4711"	"NADH:ubiquinone oxidoreductase subunit B5"	"CI-SGDH;MGC12314;SGDH"	"Nucleus;Inner mitochondria"	"SwissProt;CellAtlas"
@@ -1338,7 +1337,6 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000137491"	"ENST00000526660;ENST00000531713;ENST00000289575;ENST00000532236;ENST00000531756;ENST00000531457;ENST00000525650;ENST00000454962;ENST00000530556;ENST00000534004;ENST00000527180;ENST00000525845;ENST00000534186;ENST00000428359;ENST00000526839;ENST00000530012;ENST00000528108;ENST00000530015;ENST00000341411"	"ENSP00000432889;ENSP00000289575;ENSP00000434112;ENSP00000436324;ENSP00000389653;ENSP00000435384;ENSP00000431192;ENSP00000436513;ENSP00000431324;ENSP00000433872;ENSP00000388912;ENSP00000434742"	"O94956"	"SLCO2B1"	"11309"	"solute carrier organic anion transporter family member 2B1"	"OATP-B;OATP2B1;SLC21A9"	"Cell membrane"	"DeepLoc2"
 "ENSG00000137563"	"ENST00000518466;ENST00000523788;ENST00000678069;ENST00000677459;ENST00000677482;ENST00000677919;ENST00000260118;ENST00000677327;ENST00000679326;ENST00000522852;ENST00000520609;ENST00000678045;ENST00000518113;ENST00000518966;ENST00000523479"	"ENSP00000503731;ENSP00000504590;ENSP00000504579;ENSP00000260118;ENSP00000504262;ENSP00000504520"	"Q92820"	"GGH"	"8836"	"gamma-glutamyl hydrolase"	""	"Lysosome"	"SwissProt"
 "ENSG00000137574"	"ENST00000260129;ENST00000523948;ENST00000519494"	"ENSP00000260129;ENSP00000430467"	"Q96RS0"	"TGS1"	"96764"	"trimethylguanosine synthase 1"	"NCOA6IP;PIMT"	"Nucleus;Cytosol"	"SwissProt;CellAtlas"
-"ENSG00000137700"	"ENST00000525102;ENST00000330775;ENST00000357590;ENST00000538950;ENST00000545985;ENST00000526275;ENST00000532085;ENST00000650539;ENST00000527992;ENST00000638925;ENST00000638360;ENST00000638186;ENST00000530407;ENST00000524428;ENST00000525372;ENST00000525039;ENST00000529510;ENST00000532888;ENST00000526626;ENST00000525787;ENST00000534384"	"ENSP00000476242;ENSP00000476176;ENSP00000475991;ENSP00000475241"	""	"SLC37A4"	"2542"	"solute carrier family 37 member 4"	"G6PT1;G6PT2;G6PT3;GSD1b;GSD1c;GSD1d"	"Mitochondria"	"CellAtlas"
 "ENSG00000137731"	"ENST00000514385;ENST00000532119;ENST00000528014;ENST00000292079;ENST00000260287;ENST00000534383;ENST00000533281;ENST00000317594"	"ENSP00000436414;ENSP00000432430;ENSP00000292079;ENSP00000260287"	"P54710"	"FXYD2"	"486"	"FXYD domain containing ion transport regulator 2"	"ATP1G1;HOMG2;MGC12372"	"Mitochondria"	"CellAtlas"
 "ENSG00000137770"	"ENST00000260327;ENST00000558791;ENST00000560834;ENST00000558966;ENST00000559793;ENST00000558968;ENST00000558373;ENST00000561189;ENST00000560620;ENST00000559738;ENST00000559175"	"ENSP00000260327;ENSP00000453612;ENSP00000452837;ENSP00000454187;ENSP00000454154;ENSP00000453051;ENSP00000453538"	"Q05D32"	"CTDSPL2"	"51496"	"CTD small phosphatase like 2"	"FLJ10523;HSPC129"	"Nucleus"	"CellAtlas"
 "ENSG00000137817"	"ENST00000569173;ENST00000569795;ENST00000260376;ENST00000616176;ENST00000413097;ENST00000287196;ENST00000569972;ENST00000564610;ENST00000567974;ENST00000544520;ENST00000565443;ENST00000566991;ENST00000567440;ENST00000567263;ENST00000566831;ENST00000419739;ENST00000567042;ENST00000569890;ENST00000568213;ENST00000565999;ENST00000568360;ENST00000566844;ENST00000567633"	"ENSP00000456749;ENSP00000456348;ENSP00000260376;ENSP00000484561;ENSP00000287196;ENSP00000456468;ENSP00000455815;ENSP00000456370;ENSP00000454298;ENSP00000457752;ENSP00000403265;ENSP00000455637;ENSP00000455847;ENSP00000457134;ENSP00000457862;ENSP00000457187"	"Q2NL67"	"PARP6"	"56965"	"poly(ADP-ribose) polymerase family member 6"	"ARTD17;pART17"	"Cytosol;Nucleus"	"DeepLoc2"
@@ -1405,7 +1403,7 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000139266"	"ENST00000266643;ENST00000552279;ENST00000548358"	"ENSP00000266643;ENSP00000446758"	"Q86YJ5"	"MARCHF9"	"92979"	"membrane associated ring-CH-type finger 9"	"FLJ36578;MARCH9;RNF179"	"Lysosome;Golgi apparatus"	"SwissProt"
 "ENSG00000139278"	"ENST00000536703;ENST00000266659;ENST00000456650;ENST00000550491"	"ENSP00000440595;ENSP00000266659;ENSP00000391144;ENSP00000448008"	"P48060"	"GLIPR1"	"11010"	"GLI pathogenesis related 1"	"GliPR;RTVP1"	"Extracellular"	"DeepLoc2"
 "ENSG00000139287"	"ENST00000333850;ENST00000546576;ENST00000550403;ENST00000547348;ENST00000551074;ENST00000547278"	"ENSP00000329093"	"Q8IWU9"	"TPH2"	"121278"	"tryptophan hydroxylase 2"	"FLJ37295;NTPH"	"Mitochondria"	"DeepLoc2"
-"ENSG00000139304"	"ENST00000623635;ENST00000551042;ENST00000547376;ENST00000551573;ENST00000616559;ENST00000644991;ENST00000547485;ENST00000551624;ENST00000547881;ENST00000549355"	"ENSP00000447522;ENSP00000448844;ENSP00000449133;ENSP00000483259;ENSP00000495607;ENSP00000449526"	""	"PTPRQ"	"374462"	"protein tyrosine phosphatase receptor type Q"	"DFNB84"	"Cytosol"	"CellAtlas"
+"ENSG00000139304"	"ENST00000623635;ENST00000551042;ENST00000547376;ENST00000551573;ENST00000616559;ENST00000644991;ENST00000547485;ENST00000551624;ENST00000547881;ENST00000549355"	"ENSP00000447522;ENSP00000448844;ENSP00000449133;ENSP00000483259;ENSP00000495607;ENSP00000449526"	"A0A087WZU1"	"PTPRQ"	"374462"	"protein tyrosine phosphatase receptor type Q"	"DFNB84"	"Cytosol"	"CellAtlas"
 "ENSG00000139344"	"ENST00000266736;ENST00000548310;ENST00000553023;ENST00000549171"	"ENSP00000266736;ENSP00000448632;ENSP00000448918"	"Q96NU7"	"AMDHD1"	"144193"	"amidohydrolase domain containing 1"	"MGC35366"	"Cytosol;Nucleus"	"CellAtlas"
 "ENSG00000139370"	"ENST00000266771;ENST00000376744;ENST00000545031;ENST00000544112;ENST00000366292;ENST00000376740;ENST00000539703;ENST00000535272"	"ENSP00000266771;ENSP00000365935;ENSP00000365930"	"Q8N697"	"SLC15A4"	"121260"	"solute carrier family 15 member 4"	"PHT1;PTR4"	"Lysosome"	"SwissProt"
 "ENSG00000139410"	"ENST00000403593;ENST00000553248;ENST00000345635;ENST00000547802;ENST00000546672;ENST00000551760"	"ENSP00000385790;ENSP00000448868;ENSP00000341117;ENSP00000446867;ENSP00000449136;ENSP00000448950"	"Q96GA7"	"SDSL"	"113675"	"serine dehydratase like"	"cSDH;SDS-RS1"	"Cytosol"	"CellAtlas"
@@ -1870,7 +1868,7 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000160883"	"ENST00000506834;ENST00000292432;ENST00000514666;ENST00000514058;ENST00000509717;ENST00000504910"	"ENSP00000292432;ENSP00000424632;ENSP00000422169;ENSP00000427000"	"P52790"	"HK3"	"3101"	"hexokinase 3"	""	"Cytosol;Mitochondria"	"DeepLoc2"
 "ENSG00000161013"	"ENST00000518778;ENST00000337755;ENST00000292591;ENST00000519836;ENST00000520969;ENST00000522293;ENST00000518980;ENST00000522451;ENST00000520875;ENST00000523382;ENST00000518867;ENST00000518702;ENST00000520822;ENST00000523108;ENST00000521855;ENST00000520918;ENST00000521305;ENST00000523329;ENST00000518168;ENST00000520134;ENST00000519616;ENST00000520019;ENST00000519965"	"ENSP00000428906;ENSP00000338487;ENSP00000292591;ENSP00000430721;ENSP00000428960;ENSP00000431093;ENSP00000430723;ENSP00000428764;ENSP00000427995;ENSP00000430376;ENSP00000430964"	"Q9UQ53"	"MGAT4B"	"11282"	"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B"	"GnT-Ivb"	"Golgi apparatus;Nucleus;Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000161031"	"ENST00000292609;ENST00000340880;ENST00000601792;ENST00000594637"	"ENSP00000292609;ENSP00000345968;ENSP00000472856;ENSP00000470112"	"Q96PD5"	"PGLYRP2"	"114770"	"peptidoglycan recognition protein 2"	"PGLYRPL;PGRP-L;PGRPL;tagL;tagL-alpha;tagl-beta;TAGL-like"	"Extracellular"	"DeepLoc2"
-"ENSG00000161133"	"ENST00000486536;ENST00000292729;ENST00000470202"	"ENSP00000292729"	""	"USP41"	"373856"	"ubiquitin specific peptidase 41"	""	""	""
+"ENSG00000161133"	"ENST00000486536;ENST00000292729;ENST00000470202"	"ENSP00000292729"	"Q3LFD5"	"USP41"	"373856"	"ubiquitin specific peptidase 41"	""	""	""
 "ENSG00000161217"	"ENST00000441879;ENST00000419333;ENST00000292823;ENST00000431016;ENST00000460827;ENST00000411591;ENST00000433733;ENST00000430755;ENST00000473978;ENST00000488235;ENST00000460677;ENST00000444822;ENST00000412869;ENST00000438634;ENST00000491544;ENST00000443555"	"ENSP00000392397;ENSP00000390968;ENSP00000292823;ENSP00000394617;ENSP00000400430;ENSP00000390458;ENSP00000402283;ENSP00000397888;ENSP00000402015;ENSP00000391405;ENSP00000393341"	"P49585"	"PCYT1A"	"5130"	"phosphate cytidylyltransferase 1, choline, alpha"	"CT;CTPCT;PCYT1"	"Endoplasmic reticulum;Nucleus;Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000161267"	"ENST00000392378;ENST00000651856;ENST00000441275;ENST00000479425;ENST00000446746;ENST00000455876;ENST00000477015;ENST00000483920;ENST00000434143;ENST00000432819;ENST00000495285;ENST00000431056;ENST00000445160;ENST00000468710;ENST00000492681;ENST00000476764;ENST00000392379;ENST00000358186"	"ENSP00000376183;ENSP00000498996;ENSP00000411014;ENSP00000387648;ENSP00000408016;ENSP00000408685;ENSP00000409849;ENSP00000396149;ENSP00000405462;ENSP00000376184;ENSP00000350914"	"Q02338"	"BDH1"	"622"	"3-hydroxybutyrate dehydrogenase 1"	"BDH;SDR9C1"	"Mitochondria"	"CellAtlas"
 "ENSG00000161281"	"ENST00000437291;ENST00000481297;ENST00000292907;ENST00000589154"	"ENSP00000475885;ENSP00000292907;ENSP00000468063"	"P24310"	"COX7A1"	"1346"	"cytochrome c oxidase subunit 7A1"	"COX7A;COX7AH"	"Inner mitochondria"	"SwissProt"
@@ -2329,7 +2327,7 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000175048"	"ENST00000414563;ENST00000359775;ENST00000518214;ENST00000523468;ENST00000341375;ENST00000340347;ENST00000523706;ENST00000517432;ENST00000422910"	"ENSP00000410713;ENSP00000352821;ENSP00000428211;ENSP00000345721"	"Q8IZN3"	"ZDHHC14"	"79683"	"zinc finger DHHC-type palmitoyltransferase 14"	"FLJ20984;NEW1CP"	"Endoplasmic reticulum;Golgi apparatus"	"SwissProt"
 "ENSG00000175063"	"ENST00000405520;ENST00000617055;ENST00000335046;ENST00000356455;ENST00000243893;ENST00000352551;ENST00000372568;ENST00000496085"	"ENSP00000385878;ENSP00000479486;ENSP00000335674;ENSP00000348838;ENSP00000243893;ENSP00000333975;ENSP00000361649"	"O00762"	"UBE2C"	"11065"	"ubiquitin conjugating enzyme E2 C"	"UBCH10"	"Cytosol"	"CellAtlas"
 "ENSG00000175066"	"ENST00000392993;ENST00000492097;ENST00000480757;ENST00000460515;ENST00000463349;ENST00000486459;ENST00000460630;ENST00000460544;ENST00000487672;ENST00000466685;ENST00000472759;ENST00000489085"	"ENSP00000418001;ENSP00000420312;ENSP00000419031;ENSP00000417153;ENSP00000420593;ENSP00000418239"	"Q6ZS86"	"GK5"	"256356"	"glycerol kinase 5"	"MGC40579"	"Cytosol;Nucleus"	"CellAtlas"
-"ENSG00000175164"	"ENST00000679909;ENST00000680600;ENST00000453660;ENST00000647353;ENST00000611156;ENST00000538324;ENST00000651471"	"ENSP00000506089;ENSP00000483265;ENSP00000483018"	""	"ABO"	"28"	"ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase"	"A3GALNT;A3GALT1"	"Golgi apparatus"	"DeepLoc2"
+"ENSG00000175164"	"ENST00000679909;ENST00000680600;ENST00000453660;ENST00000647353;ENST00000611156;ENST00000538324;ENST00000651471"	"ENSP00000506089;ENSP00000483265;ENSP00000483018"	"A0A087X009"	"ABO"	"28"	"ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase"	"A3GALNT;A3GALT1"	"Golgi apparatus"	"DeepLoc2"
 "ENSG00000175198"	"ENST00000376285;ENST00000647303;ENST00000637358;ENST00000636420;ENST00000636366;ENST00000636475;ENST00000637657;ENST00000485946;ENST00000424527;ENST00000443601;ENST00000458283;ENST00000413170;ENST00000621936;ENST00000428969;ENST00000376286;ENST00000376279"	"ENSP00000365462;ENSP00000495663;ENSP00000489804;ENSP00000490290;ENSP00000490939;ENSP00000490843;ENSP00000489974;ENSP00000396050;ENSP00000400740;ENSP00000390850;ENSP00000411194;ENSP00000399413;ENSP00000365463;ENSP00000365456"	"P05165"	"PCCA"	"5095"	"propionyl-CoA carboxylase subunit alpha"	""	"Mitochondria"	"SwissProt;CellAtlas"
 "ENSG00000175229"	"ENST00000312006;ENST00000527878;ENST00000527048"	"ENSP00000308591;ENSP00000434829"	"Q96A11"	"GAL3ST3"	"89792"	"galactose-3-O-sulfotransferase 3"	"GAL3ST2"	"Golgi apparatus"	"SwissProt"
 "ENSG00000175264"	"ENST00000308064;ENST00000533673;ENST00000531322"	"ENSP00000309270"	"O43916"	"CHST1"	"8534"	"carbohydrate sulfotransferase 1"	"C6ST;KSGal6ST"	"Golgi apparatus"	"SwissProt"
@@ -2435,7 +2433,7 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000181090"	"ENST00000460843;ENST00000462484;ENST00000371394;ENST00000630754;ENST00000626216;ENST00000637593;ENST00000629335;ENST00000637335;ENST00000636376;ENST00000637655;ENST00000636027;ENST00000492232;ENST00000460486;ENST00000636081;ENST00000637161;ENST00000629417;ENST00000637662;ENST00000636186;ENST00000637261;ENST00000637977;ENST00000626066;ENST00000638071;ENST00000495657;ENST00000637318;ENST00000478940;ENST00000640639;ENST00000629808;ENST00000462942;ENST00000465566;ENST00000637891;ENST00000637949;ENST00000493484;ENST00000482340;ENST00000636565;ENST00000486164;ENST00000637277;ENST00000635783;ENST00000488242;ENST00000483653;ENST00000637407;ENST00000636463;ENST00000494249;ENST00000635987;ENST00000637748;ENST00000635741;ENST00000475564;ENST00000637784;ENST00000636472;ENST00000636526;ENST00000472849;ENST00000637287;ENST00000475704"	"ENSP00000417980;ENSP00000417328;ENSP00000485945;ENSP00000485933;ENSP00000485878;ENSP00000490056;ENSP00000489961;ENSP00000486580;ENSP00000486969;ENSP00000490328;ENSP00000486857;ENSP00000490815;ENSP00000490714;ENSP00000485900;ENSP00000490417;ENSP00000490611;ENSP00000490732;ENSP00000491823;ENSP00000485947;ENSP00000436107;ENSP00000486261;ENSP00000490907;ENSP00000489786;ENSP00000486503;ENSP00000486748;ENSP00000486127"	"Q9H9B1"	"EHMT1"	"79813"	"euchromatic histone lysine methyltransferase 1"	"bA188C12.1;EHMT1-IT1;Eu-HMTase1;FLJ12879;FLJ40292;KIAA1876;KMT1D"	"Nucleus"	"SwissProt;CellAtlas"
 "ENSG00000181191"	"ENST00000471141;ENST00000374583;ENST00000374584;ENST00000361478;ENST00000374571;ENST00000477231;ENST00000590146"	"ENSP00000467564;ENSP00000363711;ENSP00000363712;ENSP00000355014;ENSP00000363699;ENSP00000467404"	"Q8NG27"	"PJA1"	"64219"	"praja ring finger ubiquitin ligase 1"	"FLJ11830;RNF70"	"Nucleus"	"CellAtlas"
 "ENSG00000181192"	"ENST00000263035;ENST00000437298;ENST00000465617;ENST00000415935;ENST00000448829;ENST00000479283"	"ENSP00000263035;ENSP00000388163;ENSP00000400625;ENSP00000398482"	"Q96HY7"	"DHTKD1"	"55526"	"dehydrogenase E1 and transketolase domain containing 1"	"CMT2Q;DKFZP762M115;KIAA1630;MGC3090"	"Mitochondria"	"SwissProt;CellAtlas"
-"ENSG00000181222"	"ENST00000674977;ENST00000617998;ENST00000572844;ENST00000576952;ENST00000575547;ENST00000576114;ENST00000576718;ENST00000574158;ENST00000573603;ENST00000576553"	"ENSP00000502190"	""	"POLR2A"	"5430"	"RNA polymerase II subunit A"	"POLR2;POLRA;RPB1"	"Cytosol;Nucleus"	"CellAtlas"
+"ENSG00000181222"	"ENST00000674977;ENST00000617998;ENST00000572844;ENST00000576952;ENST00000575547;ENST00000576114;ENST00000576718;ENST00000574158;ENST00000573603;ENST00000576553"	"ENSP00000502190"	"A0A6Q8PGB0"	"POLR2A"	"5430"	"RNA polymerase II subunit A"	"POLR2;POLRA;RPB1"	"Cytosol;Nucleus"	"CellAtlas"
 "ENSG00000181523"	"ENST00000575484;ENST00000571156;ENST00000572257;ENST00000326317;ENST00000575282;ENST00000573150;ENST00000576856;ENST00000570923;ENST00000576941;ENST00000574505;ENST00000572208;ENST00000571051;ENST00000576707;ENST00000570427;ENST00000571675;ENST00000575188;ENST00000571075"	"ENSP00000461827;ENSP00000314606;ENSP00000459280;ENSP00000460720;ENSP00000458200;ENSP00000461160;ENSP00000459708;ENSP00000461128;ENSP00000459765"	"P51688"	"SGSH"	"6448"	"N-sulfoglucosamine sulfohydrolase"	"HSS;MPS3A;SFMD"	"Lysosome"	"SwissProt"
 "ENSG00000181555"	"ENST00000431180;ENST00000330022;ENST00000409792;ENST00000445387;ENST00000479832;ENST00000492397;ENST00000638947;ENST00000484689;ENST00000412450"	"ENSP00000388349;ENSP00000332415;ENSP00000386759;ENSP00000411901;ENSP00000491413;ENSP00000416401"	"Q9BYW2"	"SETD2"	"29072"	"SET domain containing 2, histone lysine methyltransferase"	"FLJ23184;HIF-1;HYPB;KIAA1732;KMT3A"	"Nucleus;Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000181652"	"ENST00000498521;ENST00000605952;ENST00000639579;ENST00000617967;ENST00000404733;ENST00000476282;ENST00000471797;ENST00000611177;ENST00000469530;ENST00000473409;ENST00000473134;ENST00000466157"	"ENSP00000475737;ENSP00000491504;ENSP00000479879"	"Q674R7"	"ATG9B"	"285973"	"autophagy related 9B"	"APG9L2;FLJ14885;NOS3AS;SONE"	"Cytosol"	"SwissProt"
@@ -2570,7 +2568,6 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000187531"	"ENST00000574992;ENST00000572976;ENST00000571832;ENST00000328666;ENST00000536038;ENST00000574153;ENST00000576156;ENST00000571233;ENST00000572902;ENST00000572350;ENST00000577065;ENST00000574495;ENST00000573367;ENST00000571915;ENST00000575360;ENST00000575244;ENST00000570367;ENST00000572671;ENST00000571213;ENST00000573576;ENST00000574915"	"ENSP00000329466;ENSP00000461044;ENSP00000459524"	"Q9NRC8"	"SIRT7"	"51547"	"sirtuin 7"	""	"Nucleus;Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000187555"	"ENST00000344836;ENST00000673704;ENST00000563961;ENST00000381886;ENST00000565455;ENST00000563085;ENST00000567113;ENST00000565883;ENST00000562615;ENST00000563043;ENST00000562051;ENST00000567692;ENST00000569448;ENST00000566131;ENST00000570256;ENST00000567329;ENST00000542333;ENST00000566004;ENST00000569230;ENST00000566273;ENST00000564117;ENST00000566224"	"ENSP00000343535;ENSP00000501290;ENSP00000454362;ENSP00000371310;ENSP00000456258;ENSP00000454795;ENSP00000459594;ENSP00000458027;ENSP00000439272;ENSP00000456150;ENSP00000457237;ENSP00000455719;ENSP00000457815"	"Q93009"	"USP7"	"7874"	"ubiquitin specific peptidase 7"	"HAUSP"	"Nucleus;Cytosol"	"SwissProt;CellAtlas"
 "ENSG00000187566"	"ENST00000340650"	"ENSP00000345464"	"Q6VVB1"	"NHLRC1"	"378884"	"NHL repeat containing E3 ubiquitin protein ligase 1"	"bA204B7.2;EPM2B"	"Endoplasmic reticulum;Nucleus"	"SwissProt"
-"ENSG00000187581"	"ENST00000342144"	"ENSP00000340568"	"Q7Z4L0"	"COX8C"	"341947"	"cytochrome c oxidase subunit 8C"	"COX8-3"	"Mitochondria"	"DeepLoc2"
 "ENSG00000187630"	"ENST00000534993;ENST00000543805;ENST00000621761;ENST00000397071;ENST00000559411;ENST00000558753;ENST00000537912;ENST00000335125;ENST00000559387;ENST00000557812;ENST00000560276"	"ENSP00000441095;ENSP00000441433;ENSP00000481066;ENSP00000380261;ENSP00000453889;ENSP00000453845;ENSP00000439942;ENSP00000334801;ENSP00000453173;ENSP00000452875"	"Q6PKH6"	"DHRS4L2"	"317749"	"dehydrogenase/reductase 4 like 2"	"SDR25C3"	"Nucleus"	"CellAtlas"
 "ENSG00000187676"	"ENST00000343307;ENST00000461652"	"ENSP00000343002"	"Q6Y288"	"B3GLCT"	"145173"	"beta 3-glucosyltransferase"	"B3GALTL;B3Glc-T;B3GTL"	"Endoplasmic reticulum"	"SwissProt"
 "ENSG00000187714"	"ENST00000374115"	"ENSP00000363229"	"Q16572"	"SLC18A3"	"6572"	"solute carrier family 18 member A3"	"VACHT"	"Cell membrane;Lysosome"	"DeepLoc2"
@@ -2857,7 +2854,7 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000248933"	"ENST00000511280"	"ENSP00000423115"	"D6RA61"	"USP17L22"	"100287513"	"ubiquitin specific peptidase 17 like family member 22"	""	"Cytosol;Nucleus"	"DeepLoc2"
 "ENSG00000249222"	"ENST00000505920"	"ENSP00000421076"	"Q7Z4Y8"	"ATP5MGL"	"267020"	"ATP synthase membrane subunit g like"	"ATP5K2;ATP5L2"	"Inner mitochondria"	"SwissProt"
 "ENSG00000249853"	"ENST00000312719;ENST00000441954"	"ENSP00000427888"	"Q8IZT8"	"HS3ST5"	"222537"	"heparan sulfate-glucosamine 3-sulfotransferase 5"	"3-OST-5"	"Golgi apparatus"	"SwissProt"
-"ENSG00000249948"	"ENST00000508166;ENST00000503442;ENST00000511446;ENST00000504802;ENST00000508264;ENST00000613293;ENST00000610628"	"ENSP00000427458;ENSP00000422220;ENSP00000423754;ENSP00000480447;ENSP00000478226"	""	"GBA3"	"57733"	"glucosylceramidase beta 3 (gene/pseudogene)"	"GLUC;KLrP"	""	""
+"ENSG00000249948"	"ENST00000508166;ENST00000503442;ENST00000511446;ENST00000504802;ENST00000508264;ENST00000613293;ENST00000610628"	"ENSP00000427458;ENSP00000422220;ENSP00000423754;ENSP00000480447;ENSP00000478226"	"Q9H227"	"GBA3"	"57733"	"glucosylceramidase beta 3 (gene/pseudogene)"	"GLUC;KLrP"	""	""
 "ENSG00000250565"	"ENST00000524249;ENST00000306448;ENST00000522587;ENST00000524188;ENST00000505245;ENST00000522219"	"ENSP00000304891;ENSP00000428141"	"Q96A05"	"ATP6V1E2"	"90423"	"ATPase H+ transporting V1 subunit E2"	"ATP6E1;ATP6EL2;ATP6V1EL2;MGC9341;VMA4"	"Cytosol"	"DeepLoc2"
 "ENSG00000250799"	"ENST00000587808;ENST00000653904;ENST00000588266;ENST00000587695;ENST00000301175;ENST00000589835;ENST00000591694"	"ENSP00000499779;ENSP00000465214;ENSP00000301175;ENSP00000474199"	"Q9UF12"	"PRODH2"	"58510"	"proline dehydrogenase 2"	"HSPOX1"	"Cytosol;Nucleus"	"CellAtlas"
 "ENSG00000251287"	"ENST00000425059;ENST00000507643;ENST00000511726"	"ENSP00000479850"	"C9J202"	"ALG1L2"	"644974"	"ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2"	""	"Endoplasmic reticulum;Nucleus"	"CellAtlas"
@@ -2896,5 +2893,6 @@ genes	geneENSTID	geneENSPID	geneUniProtID	geneSymbols	geneEntrezID	geneNames	gen
 "ENSG00000277494"	"ENST00000622500"	"ENSP00000480053"	"Q8IV16"	"GPIHBP1"	"338328"	"glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1"	"GPI-HBP1;LOC338328"	"Cell membrane"	"DeepLoc2"
 "ENSG00000277893"	"ENST00000622030"	"ENSP00000477587"	"P31213"	"SRD5A2"	"6716"	"steroid 5 alpha-reductase 2"	""	"Endoplasmic reticulum"	"SwissProt"
 "ENSG00000278540"	"ENST00000616317;ENST00000612895;ENST00000614428;ENST00000619546;ENST00000617649;ENST00000614482;ENST00000618053;ENST00000613776;ENST00000618575;ENST00000619245;ENST00000614450;ENST00000612120;ENST00000613146;ENST00000612926;ENST00000615229;ENST00000621960;ENST00000614789;ENST00000617548;ENST00000616352;ENST00000614438;ENST00000612007;ENST00000614333;ENST00000618351"	"ENSP00000483300;ENSP00000482269;ENSP00000478547;ENSP00000483969;ENSP00000482368;ENSP00000480371;ENSP00000482064;ENSP00000482498;ENSP00000483696;ENSP00000479621;ENSP00000481900;ENSP00000477912;ENSP00000483852;ENSP00000484948"	"Q13085"	"ACACA"	"31"	"acetyl-CoA carboxylase alpha"	"ACAC;ACC;ACC1"	"Nucleus;Cytosol"	"SwissProt;CellAtlas"
+"ENSG00000281500"	"ENST00000525102;ENST00000330775;ENST00000357590;ENST00000538950;ENST00000545985;ENST00000526275;ENST00000532085;ENST00000650539;ENST00000527992;ENST00000638925;ENST00000638360;ENST00000638186;ENST00000530407;ENST00000524428;ENST00000525372;ENST00000525039;ENST00000529510;ENST00000532888;ENST00000526626;ENST00000525787;ENST00000534384"	"ENSP00000476242;ENSP00000476176;ENSP00000475991;ENSP00000475241"	"O43826"	"SLC37A4"	""	"Glucose-6-phosphate exchanger"	"G6PT,G6PT1"	"Endoplasmic reticulum"	"SwissProt"
 "ENSG00000288702"	"ENST00000482026"	"ENSP00000418532"	"P35503"	"UGT1A3"	"54659"	"UDP glucuronosyltransferase family 1 member A3"	"UGT1C"	"Endoplasmic reticulum"	"SwissProt"
 "ENSG00000288705"	"ENST00000373414"	"ENSP00000362513"	"P35504"	"UGT1A5"	"54579"	"UDP glucuronosyltransferase family 1 member A5"	"UGT1E"	"Endoplasmic reticulum"	"SwissProt"
diff --git a/model/metabolites.tsv b/model/metabolites.tsv
index 243418f5..811d21b3 100644
--- a/model/metabolites.tsv
+++ b/model/metabolites.tsv
@@ -2878,7 +2878,6 @@ mets	metsNoComp	metBiGGID	metKEGGID	metHMDBID	metChEBIID	metPubChemID	metLipidMa
 "MAM01701c"	"MAM01701"	"dhlam"	"C00579"	"HMDB0000985"	"CHEBI:17694"	"663"	""	""	"HC00437"	"dhlam"	"MNXM1277"	"m01701c"	"m01701c"
 "MAM01701m"	"MAM01701"	"dhlam"	"C00579"	"HMDB0000985"	"CHEBI:17694"	"663"	""	""	"HC00437"	"dhlam"	"MNXM1277"	"m01701m"	"m01701m"
 "MAM01702c"	"MAM01702"	""	"C02147"	"HMDB0012210"	"CHEBI:18047"	"421"	"LMFA01130003"	""	""	"C02147"	"MNXM3585"	"m01702c"	"m01702c"
-"MAM01703m"	"MAM01703"	"dhlpro"	"C02972"	""	"CHEBI:16194"	""	""	""	""	"dhlpro"	"MNXM1663"	"m01703m"	"m01703m"
 "MAM01704c"	"MAM01704"	""	"C04874"	""	"CHEBI:17001"	"65074"	""	""	"HC01361"	"HC01361"	"MNXM993"	"m01704c"	"m01704c"
 "MAM01704e"	"MAM01704"	""	"C04874"	""	"CHEBI:17001"	"65074"	""	""	"HC01361"	"HC01361"	"MNXM993"	"m01704s"	"m01704s"
 "MAM01705c"	"MAM01705"	"56dthm"	"C00906"	"HMDB0000079"	"CHEBI:27468"	"93556"	""	""	"HC00582"	"56dthm"	"MNXM772"	"m01705c"	"m01705c"
@@ -4105,7 +4104,6 @@ mets	metsNoComp	metBiGGID	metKEGGID	metHMDBID	metChEBIID	metPubChemID	metLipidMa
 "MAM02397c"	"MAM02397"	""	"C16239"	""	""	""	""	""	""	"M02397"	"MNXM19093"	"m02397c"	"m02397c"
 "MAM02398c"	"MAM02398"	""	"C16238"	""	""	"23724672"	""	"CE5656"	""	"CE5656"	"MNXM2392"	"m02398c"	"m02398c"
 "MAM02399c"	"MAM02399"	""	""	""	""	"53481572"	""	"CE2102"	""	"CE2102"	"MNXM60228"	"m02399c"	"m02399c"
-"MAM02400m"	"MAM02400"	"lpro"	"C02051"	""	"CHEBI:15804"	""	""	""	""	"lpro"	"MNXM998"	"m02400m"	"m02400m"
 "MAM02401c"	"MAM02401"	""	"C03127"	""	"CHEBI:29160"	""	""	""	""	"M02401"	"MNXM89832"	"m02401c"	"m02401c"
 "MAM02402c"	"MAM02402"	""	"C03990"	"HMDB0000761"	"CHEBI:16325"	"11740284"	"LMST04010003"	""	"HC02191"	"HC02191"	"MNXM886"	"m02402c"	"m02402c"
 "MAM02402x"	"MAM02402"	""	"C03990"	"HMDB0000761"	"CHEBI:16325"	"11740284"	"LMST04010003"	""	"HC02191"	"HC02191"	"MNXM886"	"m02402p"	"m02402p"
@@ -4974,7 +4972,6 @@ mets	metsNoComp	metBiGGID	metKEGGID	metHMDBID	metChEBIID	metPubChemID	metLipidMa
 "MAM02877n"	"MAM02877"	"amet"	"C00019"	"HMDB0001185"	"CHEBI:15414"	"16757548"	""	""	"HC00029"	"amet"	"MNXM16"	"m02877n"	"m02877n"
 "MAM02877r"	"MAM02877"	"amet"	"C00019"	"HMDB0001185"	"CHEBI:15414"	"16757548"	""	""	"HC00029"	"amet"	"MNXM16"	"m02877r"	"m02877r"
 "MAM02878m"	"MAM02878"	"alpam"	""	"HMDB0006239"	"CHEBI:50622"	"24906333"	""	""	""	"alpam"	"MNXM81220"	"m02878m"	"m02878m"
-"MAM02879m"	"MAM02879"	"alpro"	"C01242"	""	"CHEBI:16882"	""	""	""	""	"alpro"	"MNXM81221"	"m02879m"	"m02879m"
 "MAM02880c"	"MAM02880"	"sarcs"	"C00213"	"HMDB0000271"	"CHEBI:15611"	"1088"	""	""	"HC00197"	"sarcs"	"MNXM300"	"m02880c"	"m02880c"
 "MAM02880m"	"MAM02880"	"sarcs"	"C00213"	"HMDB0000271"	"CHEBI:15611"	"1088"	""	""	"HC00197"	"sarcs"	"MNXM300"	"m02880m"	"m02880m"
 "MAM02880x"	"MAM02880"	"sarcs"	"C00213"	"HMDB0000271"	"CHEBI:15611"	"1088"	""	""	"HC00197"	"sarcs"	"MNXM300"	"m02880p"	"m02880p"
diff --git a/model/reactions.tsv b/model/reactions.tsv
index fc63cc03..9324c619 100644
--- a/model/reactions.tsv
+++ b/model/reactions.tsv
@@ -689,11 +689,8 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR06409"	"R01698"	"GCC2cm"	"R01698C"	"r0382"	""	"GCC2cm"	"MNXR100066"	"HMR_6409"	"RCR14321"	""	0	""	"RHEA:33059"	"HMR_6409"
 "MAR07702"	"R00465"	""	""	""	""	"GLYCLTDy"	"MNXR100332"	"HMR_7702"	"RCR11317"	""	0	""	"RHEA:10992"	"HMR_7702"
 "MAR07703"	"R00475"	""	""	""	""	"HMR_7703"	"MNXR100338"	"HMR_7703"	"RCR10524"	""	0	""	"RHEA:25311"	"HMR_7703"
-"MAR08433"	""	"GCC2cm"	""	""	""	"GCC2am"	"MNXR100066"	"HMR_8433"	"RCR11318"	""	0	""	""	"HMR_8433"
-"MAR08434"	""	"GCCam"	""	""	""	"GCC2bim"	"MNXR100067"	"HMR_8434"	"RCR14322"	""	0	""	""	"HMR_8434"
-"MAR08435"	"R03425"	"GCCcm"	""	""	""	"GCCam"	"MNXR100067;MNXR100069"	"HMR_8435"	"RCR10246"	""	0	""	"RHEA:24304"	"HMR_8435"
-"MAR08436"	"R04125"	"GCHOLAt"	""	""	""	"GCCbim"	"MNXR100068;MNXR100070"	"HMR_8436"	"RCR11319"	""	0	""	"RHEA:16945"	"HMR_8436"
-"MAR08437"	"R03815"	"GCHOLAt2"	""	""	""	"GCCcm"	"MNXR100069;MNXR100071"	"HMR_8437"	"RCR11320"	""	0	""	""	"HMR_8437"
+"MAR08433"	""	"GCC2cm"	""	""	""	"GCC2am"	"MNXR100066"	"HMR_8433"	"RCR11318"	""	0	""	"RHEA:24304"	"HMR_8433"
+"MAR08434"	""	"GCCam"	""	""	""	"GCC2bim"	"MNXR100067"	"HMR_8434"	"RCR14322"	""	0	""	"RHEA:16945"	"HMR_8434"
 "MAR08439"	""	"DMHPTCRNCPT2"	""	""	""	"DMGDHm"	"MNXR97521"	"HMR_8439"	"RCR11321"	""	0	""	""	"HMR_8439"
 "MAR08440"	"R02565"	"BETALDHxm"	""	""	""	"BETALDHxm"	"MNXR96237"	"HMR_8440"	"RCR11322"	""	0	""	"RHEA:15305"	"HMR_8440"
 "MAR08441"	""	"CHOLK"	""	""	""	"CHOLD2m"	"MNXR96702"	"HMR_8441"	"RCR11323"	""	0	""	""	"HMR_8441"
@@ -1347,7 +1344,6 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR04408"	"R01082"	"FUM"	"R01082C"	"r0258"	""	"FUM"	"MNXR99705"	"HMR_4408"	"RCR10105"	""	0	""	"RHEA:12460"	"HMR_4408"
 "MAR04410"	"R01082"	"FUMm"	"R01082C"	"r0259"	""	"FUMm"	"MNXR99705"	"HMR_4410"	"RCR11665"	""	0	""	"RHEA:12460"	"HMR_4410"
 "MAR04454"	"R01324"	"ACONT"	"R01324C"	"r0315"	""	"ACONT"	"MNXR95384"	"HMR_4454"	"RCR10028"	""	0	""	"RHEA:10336"	"HMR_4454"
-"MAR04456"	"R01324"	"ACONTm"	"R01324C"	"r0316"	""	"ACONTm"	"MNXR95384"	"HMR_4456"	"RCR10351"	""	0	""	"RHEA:10336"	"HMR_4456"
 "MAR04458"	"R01325"	""	"R01325C"	"r0317"	""	"r0317"	"MNXR105321;MNXR95386"	"HMR_4458"	"RCR10106"	""	0	"RHEA:10231"	"RHEA:10228"	"HMR_4458"
 "MAR04465"	"R01392"	"HPYRRy"	"R01392C"	"r0327"	""	"HPYRRy"	"MNXR100336"	"HMR_4465"	"RCR11666"	""	0	""	"RHEA:18657"	"HMR_4465"
 "MAR04589"	"R01900"	""	"R01900C"	"r0426"	""	"r0426"	"MNXR105342;MNXR95387"	"HMR_4589"	"RCR10352"	""	0	""	"RHEA:22144"	"HMR_4589"
@@ -4481,7 +4477,6 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR08833"	""	"PIPLCn"	""	""	""	"PIPLCn"	"MNXR102851"	"HMR_8833"	"RCR10417"	""	0	""	""	"HMR_8833"
 "MAR08835"	""	"PMI1346PH"	""	""	""	"PMI1346PH"	"MNXR101556"	"HMR_8835"	"RCR10961"	""	0	""	""	"HMR_8835"
 "MAR08836"	""	"PMI1346PHn"	""	""	""	"PMI1346PHn"	"MNXR101556"	"HMR_8836"	"RCR13801"	""	0	""	""	"HMR_8836"
-"MAR03923"	"R01221"	"GLYCLm"	"R01221C"	"r0295"	""	"r0295"	"MNXR100330"	"HMR_3923"	"RCR10962"	""	0	""	"RHEA:27758"	"HMR_3923"
 "MAR03925"	"R01793"	"DHPR"	"R01793C"	"r0397"	""	"DHPR"	"MNXR107172;MNXR97436"	"HMR_3925"	"RCR13802"	""	0	""	"RHEA:32251"	"HMR_3925"
 "MAR03929"	"R02302"	"FTCD"	"R02302C"	"r0524"	""	"FORTHFC"	"MNXR99667"	"HMR_3929"	"RCR13803"	""	0	""	"RHEA:22736"	"HMR_3929"
 "MAR03972"	"R09093"	"FldAct"	""	""	""	"FldAct"	""	"HMR_3972"	"RCR13804"	""	0	""	"RHEA:68264"	"HMR_3972"