diff --git a/packages/components/src/mobile/image/index.native.js b/packages/components/src/mobile/image/index.native.js
index abd4d86f9a166..7260fc5f7abb0 100644
--- a/packages/components/src/mobile/image/index.native.js
+++ b/packages/components/src/mobile/image/index.native.js
@@ -1,7 +1,12 @@
 /**
  * External dependencies
  */
-import { Image as RNImage, Text, View } from 'react-native';
+import {
+	Image as RNImage,
+	Text,
+	View,
+	useWindowDimensions,
+} from 'react-native';
 import FastImage from 'react-native-fast-image';
 
 /**
@@ -11,7 +16,7 @@ import { __ } from '@wordpress/i18n';
 import { Icon } from '@wordpress/components';
 import { image as icon } from '@wordpress/icons';
 import { usePreferredColorSchemeStyle } from '@wordpress/compose';
-import { useEffect, useState } from '@wordpress/element';
+import { useEffect, useState, useRef, Platform } from '@wordpress/element';
 
 /**
  * Internal dependencies
@@ -54,6 +59,10 @@ const ImageComponent = ( {
 } ) => {
 	const [ imageData, setImageData ] = useState( null );
 	const [ containerSize, setContainerSize ] = useState( null );
+	const [ shouldUseFallback, setShouldUseFallback ] = useState( false );
+	const { height: windowHeight, width: windowWidth } = useWindowDimensions();
+	const isLandscape = useRef( windowWidth > windowHeight );
+
 	const Image = ! shouldUseFastImage ? RNImage : FastImage;
 	const imageResizeMode = ! shouldUseFastImage
 		? resizeMode
@@ -80,6 +89,21 @@ const ImageComponent = ( {
 		return () => ( isCurrent = false );
 	}, [ url ] );
 
+	// Workaround for Android where changing the orientation breaks FastImage
+	// for now if there's any orientation changes, it will use the fallback
+	// prop to use the default Image component.
+	// https://github.com/WordPress/gutenberg/issues/42869
+	useEffect( () => {
+		if ( Platform.isAndroid && shouldUseFastImage ) {
+			const isCurrentOrientationLandscape = windowWidth > windowHeight;
+
+			if ( isLandscape.current !== isCurrentOrientationLandscape ) {
+				setShouldUseFallback( true );
+				isLandscape.current = isCurrentOrientationLandscape;
+			}
+		}
+	}, [ windowHeight, windowWidth ] );
+
 	const onContainerLayout = ( event ) => {
 		const { height, width } = event.nativeEvent.layout;
 
@@ -226,6 +250,7 @@ const ImageComponent = ( {
 								resizeMethod: 'scale',
 							} ) }
 							resizeMode={ imageResizeMode }
+							fallback={ shouldUseFallback }
 						/>
 					</View>
 				) }