diff --git a/packages/interface/src/components/interface-skeleton/style.scss b/packages/interface/src/components/interface-skeleton/style.scss
index a45239b529ddd0..d7ce996226ba59 100644
--- a/packages/interface/src/components/interface-skeleton/style.scss
+++ b/packages/interface/src/components/interface-skeleton/style.scss
@@ -88,6 +88,12 @@ html.interface-interface-skeleton__html-container {
 	// to "bleed" through the header.
 	// See https://github.com/WordPress/gutenberg/issues/32631
 	z-index: z-index(".interface-interface-skeleton__content");
+
+	// On Safari the z-index is not respected when the element is fixed.
+	// Setting it to auto fixes the problem
+	@include break-medium() {
+		z-index: auto;
+	}
 }
 
 .interface-interface-skeleton__secondary-sidebar,