TumorInvasion_summary.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/markdown": [
       "This notebook has been executed using the docker image `colomoto/colomoto-docker:2020-07-01`"
      ],
      "text/plain": [
       "<IPython.core.display.Markdown object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "import actonet\n",
    "import biolqm\n",
    "from colomoto.minibn import BooleanNetwork\n",
    "from colomoto_jupyter import tabulate\n",
    "import cabean # for attractor computation"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "In this notebook we compare the results obtained with actonet, stable motifs and caspo-control on the tumor invasion model"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Definition of targets "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "targets = {\"CellCycleArrest\": 1,\"EMT\":1,\"Invasion\":1,\"Migration\":1,\"Metastasis\":1,\"Apoptosis\":0}"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Computation of wild-type model attractors"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/markdown": [
       "Downloading http://ginsim.org/sites/default/files/SuppMat_Model_Master_Model.zginml"
      ],
      "text/plain": [
       "<IPython.core.display.Markdown object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     0          0     1     0       0                0     0   \n",
       "1     0     0          1     1     0       0                1     0   \n",
       "2     0     0          1     1     0       0                1     0   \n",
       "3     0     0          1     1     0       0                1     0   \n",
       "4     0     0          1     1     0       0                1     0   \n",
       "5     0     1          0     0     1       0                1     0   \n",
       "6     0     1          0     0     1       0                1     0   \n",
       "7     0     1          0     0     1       0                1     1   \n",
       "8     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    0    0   0         0           0          0     0   \n",
       "1          1           0    0    0   0         0           0          0     0   \n",
       "2          1           0    0    0   0         0           0          0     0   \n",
       "3          1           1    0    0   0         0           0          0     0   \n",
       "4          1           1    0    0   0         0           0          0     0   \n",
       "5          0           0    1    1   1         0           0          0     0   \n",
       "6          1           0    1    1   1         0           0          0     0   \n",
       "7          0           1    1    1   1         1           1          1     1   \n",
       "8          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     0      0      0        0       0    0     0     0       0       0   \n",
       "1     0      0      0        0       0    0     0     0       1       0   \n",
       "2     0      0      0        0       0    0     0     0       1       1   \n",
       "3     0      0      0        1       0    0     0     0       1       0   \n",
       "4     0      0      0        1       0    0     0     0       1       1   \n",
       "5     0      1      1        0       1    1     1     1       0       0   \n",
       "6     0      1      1        0       1    1     1     1       0       0   \n",
       "7     1      1      1        1       1    1     1     1       0       0   \n",
       "8     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    1    0    1    1  \n",
       "2      0    1    1    0    0  \n",
       "3      0    1    0    1    1  \n",
       "4      0    1    1    0    0  \n",
       "5      0    0    0    0    0  \n",
       "6      0    0    0    0    0  \n",
       "7      0    0    0    0    0  \n",
       "8      0    0    0    0    0  "
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "model = biolqm.load(\"http://ginsim.org/sites/default/files/SuppMat_Model_Master_Model.zginml\")\n",
    "test = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "att=cabean.attractors(test)\n",
    "tabulate(att)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# without sources"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## caspo-control solutions\n",
    "The solution set computed by caspo-control for the target previously defined with no sources is an={(NICD=1, SNAI2=1),(AKT2=1, ECMicroenv=1),(NICD=1, SNAI2=1),(AKT2=1, NICD=1)}"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "1     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           1    1    1   1         1           1          1     1   \n",
       "1          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "1     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    0    0    0    0  "
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_cc1 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_cc1[\"AKT2\"] = 1\n",
    "nos_cc1[\"ECMicroenv\"] = 1\n",
    "nos_att1=cabean.attractors(nos_cc1)\n",
    "tabulate(nos_att1)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Both stable states are attractors of of the wild-type model : "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, True, False],\n",
       " [False, False, False, False, False, False, False, False, True]]"
      ]
     },
     "execution_count": 5,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att1_t=[[a==b for a in list(att)] for b in list(nos_att1)]\n",
    "nos_att1_t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "1     0     1          0     0     1       0                1     1   \n",
       "2     0     1          0     0     1       0                1     1   \n",
       "3     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    1    1   1         1           1          1     1   \n",
       "1          0           1    1    1   1         1           1          1     1   \n",
       "2          1           0    1    1   1         1           1          1     1   \n",
       "3          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "1     1      1      1        1       1    1     1     1       0       0   \n",
       "2     1      1      1        1       1    1     1     1       0       0   \n",
       "3     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    0    0    0    0  \n",
       "2      0    0    0    0    0  \n",
       "3      0    0    0    0    0  "
      ]
     },
     "execution_count": 6,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_cc2 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_cc2[\"AKT2\"] = 1\n",
    "nos_cc2[\"NICD\"] = 1\n",
    "nos_att2=cabean.attractors(nos_cc2)\n",
    "tabulate(nos_att2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, True, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, True]]"
      ]
     },
     "execution_count": 7,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att2_t=[[a==b for a in list(att)] for b in list(nos_att2)]\n",
    "nos_att2_t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "1     0     1          0     0     1       0                1     1   \n",
       "2     0     1          0     0     1       0                1     1   \n",
       "3     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    1    1   1         1           1          1     1   \n",
       "1          0           1    1    1   1         1           1          1     1   \n",
       "2          1           0    1    1   1         1           1          1     1   \n",
       "3          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "1     1      1      1        1       1    1     1     1       0       0   \n",
       "2     1      1      1        1       1    1     1     1       0       0   \n",
       "3     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    0    0    0    0  \n",
       "2      0    0    0    0    0  \n",
       "3      0    0    0    0    0  "
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_cc3 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_cc3[\"SNAI2\"] = 1\n",
    "nos_cc3[\"NICD\"] = 1\n",
    "nos_att3=cabean.attractors(nos_cc3)\n",
    "tabulate(nos_att3)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, True, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, True]]"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att3_t=[[a==b for a in list(att)] for b in list(nos_att3)]\n",
    "nos_att3_t"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## actonet solutions\n",
    "The solution set computed by actonet for the target previously defined with no sources is \n",
    "an={(NICD=1, p53=0),(NICD=1, p73=1),(DNAdamage=0, ECMicroenv=1),(NICD=1, SNAI2=1),(AKT2=1, ECMicroenv=1),(AKT2=1, NICD=1)(AKT2=1, SNAI1=0),(AKT2=1, TGFbeta=1),(AKT2=1, Invasion=1),(AKT2=1, SMAD=1)}"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "1     0     1          0     0     1       0                1     1   \n",
       "2     0     1          0     0     1       0                1     1   \n",
       "3     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    1    1   1         1           1          1     1   \n",
       "1          0           1    1    1   1         1           1          1     1   \n",
       "2          1           0    1    1   1         1           1          1     1   \n",
       "3          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "1     1      1      1        1       1    1     1     1       0       0   \n",
       "2     1      1      1        1       1    1     1     1       0       0   \n",
       "3     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    0    0    0    0  \n",
       "2      0    0    0    0    0  \n",
       "3      0    0    0    0    0  "
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_an4 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_an4[\"p53\"] = 0\n",
    "nos_an4[\"NICD\"] = 1\n",
    "nos_att4=cabean.attractors(nos_an4)\n",
    "tabulate(nos_att4)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, True, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, True]]"
      ]
     },
     "execution_count": 11,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att4_t=[[a==b for a in list(att)] for b in list(nos_att4)]\n",
    "nos_att4_t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "1     0     1          0     0     1       0                1     1   \n",
       "2     0     1          0     0     1       0                1     1   \n",
       "3     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    1    1   1         1           1          1     1   \n",
       "1          0           1    1    1   1         1           1          1     1   \n",
       "2          1           0    1    1   1         1           1          1     1   \n",
       "3          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "1     1      1      1        1       1    1     1     1       0       0   \n",
       "2     1      1      1        1       1    1     1     1       0       0   \n",
       "3     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    1  \n",
       "1      0    0    0    0    1  \n",
       "2      0    0    0    0    1  \n",
       "3      0    0    0    0    1  "
      ]
     },
     "execution_count": 12,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_an5 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_an5[\"p73\"] = 1\n",
    "nos_an5[\"NICD\"] = 1\n",
    "nos_att5=cabean.attractors(nos_an5)\n",
    "tabulate(nos_att5)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, False]]"
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att5_t=[[a==b for a in list(att)] for b in list(nos_att5)]\n",
    "nos_att5_t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  "
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_an6 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_an6[\"DNAdamage\"] = 0\n",
    "nos_an6[\"ECMicroenv\"] = 1\n",
    "nos_att6=cabean.attractors(nos_an6)\n",
    "tabulate(nos_att6)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, True, False]]"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att6_t=[[a==b for a in list(att)] for b in list(nos_att6)]\n",
    "nos_att6_t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [],
   "source": [
    "nos_an7=biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_an7[\"AKT2\"] = 1\n",
    "nos_an7[\"SNAI1\"] = 0"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      0      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  "
      ]
     },
     "execution_count": 17,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att7=cabean.attractors(nos_an7)\n",
    "tabulate([nos_att7[0]])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, False, False]"
      ]
     },
     "execution_count": 18,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att7_t0=[a==nos_att7[0] for a in list(att)]\n",
    "nos_att7_t0"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      0      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  "
      ]
     },
     "execution_count": 19,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "tabulate([nos_att7[1]])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, False, False]"
      ]
     },
     "execution_count": 20,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att7_t1=[a==nos_att7[1] for a in list(att)]\n",
    "nos_att7_t1"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  AKT1  AKT2  Apoptosis  CDH1 CDH2  CTNNB1 CellCycleArrest DKK1  DNAdamage  \\\n",
       "1    *     1          0     0    0       1               *    *          0   \n",
       "2    *     1          0     0    1       1               *    *          0   \n",
       "0    *     1          0     0    *       0               *    *          0   \n",
       "\n",
       "   ECMicroenv EMT ERK  GF Invasion Metastasis Migration  NICD  SMAD  SNAI1  \\\n",
       "1           0   *   *   1        *          *         *     0     0      0   \n",
       "2           0   *   *   1        *          *         *     0     0      0   \n",
       "0           0   *   *   1        *          *         *     0     0      0   \n",
       "\n",
       "  SNAI2  TGFbeta TWIST1 VIM ZEB1 ZEB2  miR200  miR203  miR34 p21  p53  p63  \\\n",
       "1     *        0      *   *    *    *       0       0      0   *    0    0   \n",
       "2     *        0      1   *    *    *       0       0      0   *    0    0   \n",
       "0     *        0      *   *    *    *       0       0      0   *    0    0   \n",
       "\n",
       "   p73  \n",
       "1    0  \n",
       "2    0  \n",
       "0    0  "
      ]
     },
     "execution_count": 21,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "tabulate(nos_att7[2])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  AKT1  AKT2  Apoptosis  CDH1 CDH2  CTNNB1 CellCycleArrest DKK1  DNAdamage  \\\n",
       "1    *     1          0     0    0       1               *    *          1   \n",
       "2    *     1          0     0    1       1               *    *          1   \n",
       "0    *     1          0     0    *       0               *    *          1   \n",
       "\n",
       "   ECMicroenv EMT ERK  GF Invasion Metastasis Migration  NICD  SMAD  SNAI1  \\\n",
       "1           0   *   *   1        *          *         *     0     0      0   \n",
       "2           0   *   *   1        *          *         *     0     0      0   \n",
       "0           0   *   *   1        *          *         *     0     0      0   \n",
       "\n",
       "  SNAI2  TGFbeta TWIST1 VIM ZEB1 ZEB2  miR200  miR203  miR34 p21  p53  p63  \\\n",
       "1     *        0      *   *    *    *       0       0      0   *    0    0   \n",
       "2     *        0      1   *    *    *       0       0      0   *    0    0   \n",
       "0     *        0      *   *    *    *       0       0      0   *    0    0   \n",
       "\n",
       "   p73  \n",
       "1    0  \n",
       "2    0  \n",
       "0    0  "
      ]
     },
     "execution_count": 22,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "tabulate(nos_att7[3])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     0   \n",
       "1     0     1          0     0     1       0                1     0   \n",
       "2     0     1          0     0     1       0                1     1   \n",
       "3     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    1    1   1         1           1          1     0   \n",
       "1          1           0    1    1   1         1           1          1     0   \n",
       "2          0           1    1    1   1         1           1          1     1   \n",
       "3          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "1     1      1      1        1       1    1     1     1       0       0   \n",
       "2     1      1      1        1       1    1     1     1       0       0   \n",
       "3     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    0    0    0    0  \n",
       "2      0    0    0    0    0  \n",
       "3      0    0    0    0    0  "
      ]
     },
     "execution_count": 23,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_an8 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_an8[\"AKT2\"] = 1\n",
    "nos_an8[\"TGFbeta\"] = 1\n",
    "nos_att8=cabean.attractors(nos_an8)\n",
    "tabulate(nos_att8)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 24,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, True, False],\n",
       " [False, False, False, False, False, False, False, False, True]]"
      ]
     },
     "execution_count": 24,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att8_t=[[a==b for a in list(att)] for b in list(nos_att8)]\n",
    "nos_att8_t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     0   \n",
       "1     0     1          0     0     1       0                1     0   \n",
       "2     0     1          0     0     1       0                1     1   \n",
       "3     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    1    1   1         1           1          1     0   \n",
       "1          1           0    1    1   1         1           1          1     0   \n",
       "2          0           1    1    1   1         1           1          1     1   \n",
       "3          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     0      1      1        0       1    1     1     1       0       0   \n",
       "1     0      1      1        0       1    1     1     1       0       0   \n",
       "2     1      1      1        1       1    1     1     1       0       0   \n",
       "3     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    0    0    0    0  \n",
       "2      0    0    0    0    0  \n",
       "3      0    0    0    0    0  "
      ]
     },
     "execution_count": 25,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_an9 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_an9[\"AKT2\"] = 1\n",
    "nos_an9[\"Invasion\"] = 1\n",
    "nos_att9=cabean.attractors(nos_an9)\n",
    "tabulate(nos_att9)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 26,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, True, False],\n",
       " [False, False, False, False, False, False, False, False, True]]"
      ]
     },
     "execution_count": 26,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att9_t=[[a==b for a in list(att)] for b in list(nos_att9)]\n",
    "nos_att9_t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     0   \n",
       "1     0     1          0     0     1       0                1     0   \n",
       "2     0     1          0     0     1       0                1     1   \n",
       "3     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           0    1    1   1         1           1          1     0   \n",
       "1          1           0    1    1   1         1           1          1     0   \n",
       "2          0           1    1    1   1         1           1          1     1   \n",
       "3          1           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        0       1    1     1     1       0       0   \n",
       "1     1      1      1        0       1    1     1     1       0       0   \n",
       "2     1      1      1        1       1    1     1     1       0       0   \n",
       "3     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  \n",
       "1      0    0    0    0    0  \n",
       "2      0    0    0    0    0  \n",
       "3      0    0    0    0    0  "
      ]
     },
     "execution_count": 27,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_an10 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "nos_an10[\"AKT2\"] = 1\n",
    "nos_an10[\"SMAD\"] = 1\n",
    "nos_att10=cabean.attractors(nos_an10)\n",
    "tabulate(nos_att10)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 28,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[[False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, False, False],\n",
       " [False, False, False, False, False, False, False, True, False],\n",
       " [False, False, False, False, False, False, False, False, True]]"
      ]
     },
     "execution_count": 28,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nos_att10_t=[[a==b for a in list(att)] for b in list(nos_att10)]\n",
    "nos_att10_t"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# with sources "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {},
   "outputs": [],
   "source": [
    "sources = {\"ECMicroenv\":1,\"DNAdamage\":0}"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## actonet solution\n",
    "The solution set computed by actonet for the source,target couple defined previsouly is : an={}\n",
    "The model with the sources fixed has a single stable state which verifies the desired values for the targets :"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 30,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  "
      ]
     },
     "execution_count": 30,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test1 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "for n, v in sources.items():\n",
    "    test1[n] = v\n",
    "att1=cabean.attractors(test1)\n",
    "tabulate(att1)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "This unique stable state is a stable state of the wild-type model : "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 31,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, True, False]"
      ]
     },
     "execution_count": 31,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "t=[a==list(att1)[0] for a in list(att)]\n",
    "t"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## stable motifs solutions\n",
    "The solution set computed by stable motifs for the source,target couple defined previsouly is :sm={(SNAI2=1),(p53=0)}\n",
    "The model with the sources and solution fixed has a single stable state which verifies the desired values for the targets :"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  "
      ]
     },
     "execution_count": 32,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test2 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "for n, v in sources.items():\n",
    "    test2[n] = v\n",
    "    test2[\"SNAI2\"] = 1\n",
    "att2=cabean.attractors(test2)\n",
    "tabulate(att2)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "This unique stable state is a stable state of the wild-type model : "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, True, False]"
      ]
     },
     "execution_count": 33,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "t=[a==list(att2)[0] for a in list(att)]\n",
    "t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>Apoptosis</th>\n",
       "      <th>CDH1</th>\n",
       "      <th>CDH2</th>\n",
       "      <th>CTNNB1</th>\n",
       "      <th>CellCycleArrest</th>\n",
       "      <th>DKK1</th>\n",
       "      <th>DNAdamage</th>\n",
       "      <th>ECMicroenv</th>\n",
       "      <th>EMT</th>\n",
       "      <th>ERK</th>\n",
       "      <th>GF</th>\n",
       "      <th>Invasion</th>\n",
       "      <th>Metastasis</th>\n",
       "      <th>Migration</th>\n",
       "      <th>NICD</th>\n",
       "      <th>SMAD</th>\n",
       "      <th>SNAI1</th>\n",
       "      <th>SNAI2</th>\n",
       "      <th>TGFbeta</th>\n",
       "      <th>TWIST1</th>\n",
       "      <th>VIM</th>\n",
       "      <th>ZEB1</th>\n",
       "      <th>ZEB2</th>\n",
       "      <th>miR200</th>\n",
       "      <th>miR203</th>\n",
       "      <th>miR34</th>\n",
       "      <th>p21</th>\n",
       "      <th>p53</th>\n",
       "      <th>p63</th>\n",
       "      <th>p73</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT1  AKT2  Apoptosis  CDH1  CDH2  CTNNB1  CellCycleArrest  DKK1  \\\n",
       "0     0     1          0     0     1       0                1     1   \n",
       "\n",
       "   DNAdamage  ECMicroenv  EMT  ERK  GF  Invasion  Metastasis  Migration  NICD  \\\n",
       "0          0           1    1    1   1         1           1          1     1   \n",
       "\n",
       "   SMAD  SNAI1  SNAI2  TGFbeta  TWIST1  VIM  ZEB1  ZEB2  miR200  miR203  \\\n",
       "0     1      1      1        1       1    1     1     1       0       0   \n",
       "\n",
       "   miR34  p21  p53  p63  p73  \n",
       "0      0    0    0    0    0  "
      ]
     },
     "execution_count": 34,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test3 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "for n, v in sources.items():\n",
    "    test3[n] = v\n",
    "    test3[\"p53\"] = 0\n",
    "att3=cabean.attractors(test3)\n",
    "tabulate(att3)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, True, False]"
      ]
     },
     "execution_count": 35,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "t=[a==list(att3)[0] for a in list(att)]\n",
    "t"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## caspo solutions\n",
    "The solution set computed by caspo-control for the source,target couple defined previsouly is :\n",
    "cc={(p53=0),(AKT2=1),(SNAI2=1),(NICD=0, SNAI1=1),(Migration=1, SNAI1=1),(SNAI1=1, p73=1)}²"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, True, False]"
      ]
     },
     "execution_count": 36,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test_cc3 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "for n, v in sources.items():\n",
    "    test_cc3[n] = v\n",
    "    test_cc3[\"AKT2\"] = 1\n",
    "att_cc3=cabean.attractors(test_cc3)\n",
    "tabulate(att_cc3)\n",
    "\n",
    "t_cc3=[a==list(att_cc3)[0] for a in list(att)]\n",
    "t_cc3\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, False, False]"
      ]
     },
     "execution_count": 37,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test_cc4 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "for n, v in sources.items():\n",
    "    test_cc4[n] = v\n",
    "    test_cc4[\"NICD\"] = 0\n",
    "    test_cc4[\"SNAI1\"] = 1\n",
    "att_cc4=cabean.attractors(test_cc4)\n",
    "tabulate(att_cc4)\n",
    "\n",
    "t_cc4=[a==list(att_cc4)[0] for a in list(att)]\n",
    "t_cc4"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, True, False]"
      ]
     },
     "execution_count": 38,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "\n",
    "test_cc5 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "for n, v in sources.items():\n",
    "    test_cc5[n] = v\n",
    "    test_cc5[\"Migration\"] = 1\n",
    "    test_cc5[\"SNAI1\"] = 1\n",
    "att_cc5=cabean.attractors(test_cc5)\n",
    "tabulate(att_cc5)\n",
    "\n",
    "t_cc5=[a==list(att_cc5)[0] for a in list(att)]\n",
    "t_cc5"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[False, False, False, False, False, False, False, False, False]"
      ]
     },
     "execution_count": 39,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test_cc6 = biolqm.to_minibn(model, ensure_boolean=True)\n",
    "for n, v in sources.items():\n",
    "    test_cc6[n] = v\n",
    "    test_cc6[\"p73\"] = 1\n",
    "    test_cc6[\"SNAI1\"] = 1\n",
    "att_cc6=cabean.attractors(test_cc6)\n",
    "tabulate(att_cc6)\n",
    "\n",
    "t_cc6=[a==list(att_cc6)[0] for a in list(att)]\n",
    "t_cc6\n"
   ]
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "Python 3",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.7.6"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 4
}