diff --git a/python/tvm/testing/utils.py b/python/tvm/testing/utils.py
index ad1e003d6e3fe..2babe442ca3c0 100644
--- a/python/tvm/testing/utils.py
+++ b/python/tvm/testing/utils.py
@@ -1752,13 +1752,13 @@ def fetch_model_from_url(
     return tvmc_model.mod, tvmc_model.params
 
 
-def xfail_parameterizations(*xfail_params, reason):
+def _mark_parameterizations(*params, marker_fn, reason):
     """
-    Mark tests with a nodeid parameters that exactly matches one in params as
-    xfail. Useful for quickly marking tests as xfail when they have a large
+    Mark tests with a nodeid parameters that exactly matches one in params.
+    Useful for quickly marking tests as xfail when they have a large
     combination of parameters.
     """
-    xfail_params = set(xfail_params)
+    params = set(params)
 
     def decorator(func):
         @functools.wraps(func)
@@ -1766,8 +1766,10 @@ def wrapper(request, *args, **kwargs):
             if "[" in request.node.name and "]" in request.node.name:
                 # Strip out the test name and the [ and ] brackets
                 params_from_name = request.node.name[len(request.node.originalname) + 1 : -1]
-                if params_from_name in xfail_params:
-                    pytest.xfail(reason=f"xfail on nodeid {request.node.nodeid}: " + reason)
+                if params_from_name in params:
+                    marker_fn(
+                        reason=f"{marker_fn.__name__} on nodeid {request.node.nodeid}: " + reason
+                    )
 
             return func(request, *args, **kwargs)
 
@@ -1776,6 +1778,14 @@ def wrapper(request, *args, **kwargs):
     return decorator
 
 
+def xfail_parameterizations(*xfail_params, reason):
+    return _mark_parameterizations(*xfail_params, marker_fn=pytest.xfail, reason=reason)
+
+
+def skip_parameterizations(*skip_params, reason):
+    return _mark_parameterizations(*skip_params, marker_fn=pytest.skip, reason=reason)
+
+
 def main():
     test_file = inspect.getsourcefile(sys._getframe(1))
     sys.exit(pytest.main([test_file] + sys.argv[1:]))
diff --git a/tests/python/contrib/test_ethosu/test_codegen.py b/tests/python/contrib/test_ethosu/test_codegen.py
index 28ea48f009321..16d2a7d44afed 100644
--- a/tests/python/contrib/test_ethosu/test_codegen.py
+++ b/tests/python/contrib/test_ethosu/test_codegen.py
@@ -368,7 +368,6 @@ def binary_elementwise(lhs, rhs):
     )
 
 
-@pytest.mark.xfail(strict=False, reason="See https://github.com/apache/tvm/issues/10487")
 @pytest.mark.parametrize(
     "accel_type",
     ACCEL_TYPES,
@@ -390,6 +389,7 @@ def binary_elementwise(lhs, rhs):
         [(8, 4), (0,), False, False],
     ],
 )
+@pytest.mark.skip(reason="See https://github.com/apache/tvm/issues/12634")
 def test_mean(accel_type, ifm_shape, axis, keep_dims, use_same_quantization):
     np.random.seed(0)
     dtype = "int8"
diff --git a/tests/python/contrib/test_ethosu/test_replace_depthwise_conv2d.py b/tests/python/contrib/test_ethosu/test_replace_depthwise_conv2d.py
index 80aa74b8434d1..6f4980d57b44d 100644
--- a/tests/python/contrib/test_ethosu/test_replace_depthwise_conv2d.py
+++ b/tests/python/contrib/test_ethosu/test_replace_depthwise_conv2d.py
@@ -75,6 +75,9 @@
         ],
     ],
 )
+@tvm.testing.skip_parameterizations(
+    "trial3", reason="See https://github.com/apache/tvm/issues/12841"
+)
 def test_depthwise_conv2d_single(trial):
     def _get_func(
         ifm_shape,
diff --git a/tests/python/unittest/test_roofline.py b/tests/python/unittest/test_roofline.py
index e37f6e085bf6c..61e6e06aa8f3f 100644
--- a/tests/python/unittest/test_roofline.py
+++ b/tests/python/unittest/test_roofline.py
@@ -35,6 +35,7 @@
 
 
 @tvm.testing.parametrize_targets("llvm", "cuda")
+@pytest.mark.skip(reason="See https://github.com/apache/tvm/issues/12955")
 def test_estimate_peak_flops(target, dev):
     server = rpc.Server(key="roofline_flops")
     remote = rpc.connect("127.0.0.1", server.port, key="roofline_flops")