diff --git a/chromium_src/chrome/browser/profiles/profile_io_data.cc b/chromium_src/chrome/browser/profiles/profile_io_data.cc
index 816e9d05886f..6c7ada50feac 100644
--- a/chromium_src/chrome/browser/profiles/profile_io_data.cc
+++ b/chromium_src/chrome/browser/profiles/profile_io_data.cc
@@ -3,6 +3,29 @@
  * License, v. 2.0. If a copy of the MPL was not distributed with this file,
  * You can obtain one at http://mozilla.org/MPL/2.0/. */
 
+#include "chrome/browser/profiles/profile_io_data.h"
 #include "brave/common/url_constants.h"
 
+#define IsHandledProtocol IsHandledProtocol_ChromiumImpl
+#define IsHandledURL IsHandledURL_ChromiumImpl
 #include "../../../../../chrome/browser/profiles/profile_io_data.cc"
+#undef IsHandledURL
+#undef IsHandledProtocol
+
+bool ProfileIOData::IsHandledProtocol(const std::string& scheme) {
+  if (scheme == kBraveUIScheme)
+    return true;
+  return IsHandledProtocol_ChromiumImpl(scheme);
+}
+
+// We need to provide our own version of IsHandledURL() as well to make sure
+// that we get our own version of IsHandledProtocol() called when invoked via
+// IsHandledURL(). Otherwise the old version will still be called since the
+// renaming of IsHandledProtocol above does also modify the call point.
+bool ProfileIOData::IsHandledURL(const GURL& url) {
+  if (!url.is_valid()) {
+    // We handle error cases.
+    return true;
+  }
+  return IsHandledProtocol(url.scheme());
+}
diff --git a/chromium_src/chrome/browser/profiles/profile_io_data.h b/chromium_src/chrome/browser/profiles/profile_io_data.h
new file mode 100644
index 000000000000..de9d9f8cac28
--- /dev/null
+++ b/chromium_src/chrome/browser/profiles/profile_io_data.h
@@ -0,0 +1,25 @@
+/* Copyright (c) 2021 The Brave Authors. All rights reserved.
+ * This Source Code Form is subject to the terms of the Mozilla Public
+ * License, v. 2.0. If a copy of the MPL was not distributed with this file,
+ * You can obtain one at http://mozilla.org/MPL/2.0/. */
+
+#ifndef BRAVE_CHROMIUM_SRC_CHROME_BROWSER_PROFILES_PROFILE_IO_DATA_H_
+#define BRAVE_CHROMIUM_SRC_CHROME_BROWSER_PROFILES_PROFILE_IO_DATA_H_
+
+#include <string>
+#include "url/gurl.h"
+
+#define IsHandledProtocol                                    \
+  IsHandledProtocol_ChromiumImpl(const std::string& scheme); \
+  static bool IsHandledProtocol
+
+#define IsHandledURL                          \
+  IsHandledURL_ChromiumImpl(const GURL& url); \
+  static bool IsHandledURL
+
+#include "../../../../../chrome/browser/profiles/profile_io_data.h"
+
+#undef IsHandledURL
+#undef IsHandledProtocol
+
+#endif  // BRAVE_CHROMIUM_SRC_CHROME_BROWSER_PROFILES_PROFILE_IO_DATA_H_
diff --git a/patches/chrome-browser-profiles-profile_io_data.cc.patch b/patches/chrome-browser-profiles-profile_io_data.cc.patch
deleted file mode 100644
index a2792530f73a..000000000000
--- a/patches/chrome-browser-profiles-profile_io_data.cc.patch
+++ /dev/null
@@ -1,12 +0,0 @@
-diff --git a/chrome/browser/profiles/profile_io_data.cc b/chrome/browser/profiles/profile_io_data.cc
-index 2f5ed4b15589ffa5bae18d7f06e6776f705f5229..a4bd6ab7ef01d4740211eff1de086fe1493f2129 100644
---- a/chrome/browser/profiles/profile_io_data.cc
-+++ b/chrome/browser/profiles/profile_io_data.cc
-@@ -248,6 +248,7 @@ bool ProfileIOData::IsHandledProtocol(const std::string& scheme) {
- #endif
-     content::kChromeUIScheme,
-     content::kChromeUIUntrustedScheme,
-+    kBraveUIScheme,
-     url::kDataScheme,
- #if BUILDFLAG(IS_CHROMEOS_ASH)
-     content::kExternalFileScheme,