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Handle unmarked duplicates where mates have MQ = 0 #5720

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davidbenjamin opened this issue Feb 26, 2019 · 3 comments
Closed

Handle unmarked duplicates where mates have MQ = 0 #5720

davidbenjamin opened this issue Feb 26, 2019 · 3 comments
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@davidbenjamin
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PCR duplicates may not be marked if their mates all have mapping quality zero and are assigned to different places. This causes false positives in Mutect2.

@davidbenjamin davidbenjamin self-assigned this Feb 26, 2019
@davidbenjamin davidbenjamin added this to the Mutect 3 milestone Feb 26, 2019
@jamesemery
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jamesemery commented Feb 28, 2019

@davidbenjamin If you aren't aware there is a proposal to handle this case better in MarkDuplicates floating around in Picard. If you haven't already expressed your opinions to the relevant people it may be worth leaving a comment on the discussion broadinstitute/picard#1285 (comment).

@davidbenjamin
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Thanks @jamesemery!

@davidbenjamin
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Closed by #5734.

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