diff --git a/crates/wasm-pkg-common/src/config.rs b/crates/wasm-pkg-common/src/config.rs
index 05e55c9..9bc8bd3 100644
--- a/crates/wasm-pkg-common/src/config.rs
+++ b/crates/wasm-pkg-common/src/config.rs
@@ -1,7 +1,7 @@
 use std::{
     collections::{hash_map::Entry, HashMap},
     io::ErrorKind,
-    path::Path,
+    path::{Path, PathBuf},
 };
 
 use serde::{Deserialize, Serialize};
@@ -102,13 +102,18 @@ impl Config {
         Ok(config)
     }
 
+    /// Returns the default global config file location
+    pub fn global_config_path() -> Option<PathBuf> {
+        dirs::config_dir().map(|path| path.join("wasm-pkg").join("config.toml"))
+    }
+
     /// Reads config from the default global config file location
     pub async fn read_global_config() -> Result<Option<Self>, Error> {
-        let Some(config_dir) = dirs::config_dir() else {
-            return Ok(None);
+        let path = match Config::global_config_path() {
+            Some(path) => path,
+            None => return Ok(None),
         };
-        let path = config_dir.join("wasm-pkg").join("config.toml");
-        let contents = match tokio::fs::read_to_string(path).await {
+        let contents = match tokio::fs::read_to_string(&path).await {
             Ok(contents) => contents,
             Err(err) if err.kind() == ErrorKind::NotFound => return Ok(None),
             Err(err) => return Err(Error::ConfigFileIoError(err)),
diff --git a/crates/wkg/src/main.rs b/crates/wkg/src/main.rs
index d86ed84..028ae7f 100644
--- a/crates/wkg/src/main.rs
+++ b/crates/wkg/src/main.rs
@@ -10,6 +10,7 @@ use wasm_pkg_client::{
     Client, PublishOpts,
 };
 use wasm_pkg_common::{
+    self,
     config::{Config, RegistryMapping},
     package::PackageSpec,
     registry::Registry,
@@ -83,6 +84,8 @@ impl Common {
 #[derive(Subcommand, Debug)]
 #[allow(clippy::large_enum_variant)]
 enum Commands {
+    /// Set registry configuration
+    Config(ConfigArgs),
     /// Download a package from a registry
     Get(GetArgs),
     /// Publish a package to a registry
@@ -95,6 +98,53 @@ enum Commands {
     Wit(WitCommands),
 }
 
+#[derive(Args, Debug)]
+struct ConfigArgs {
+    /// The default registry domain to use. Overrides configuration file(s).
+    #[arg(long = "default", value_name = "DEFAULT")]
+    default: Option<Registry>,
+
+    #[command(flatten)]
+    common: Common,
+}
+
+impl ConfigArgs {
+    pub async fn run(self) -> anyhow::Result<()> {
+        // use config path provided, otherwise global config path
+        let path = if let Some(path) = self.common.config {
+            path
+        } else {
+            Config::global_config_path()
+                .ok_or(anyhow::anyhow!("global config path not available"))?
+        };
+
+        // read file or use default config (not empty config)
+        let mut config = match tokio::fs::read_to_string(&path).await {
+            Ok(contents) => Config::from_toml(&contents)?,
+            Err(err) if err.kind() == std::io::ErrorKind::NotFound => Config::default(),
+            Err(err) => return Err(anyhow::anyhow!("error reading config file: {0}", err)),
+        };
+
+        if let Some(default) = self.default {
+            // set default registry
+            config.set_default_registry(Some(default));
+
+            // write config file
+            config.to_file(&path).await?;
+            println!("Updated config file: {path}", path = path.display());
+        }
+
+        // print config
+        if let Some(registry) = config.default_registry() {
+            println!("Default registry: {}", registry);
+        } else {
+            println!("Default registry is not set");
+        }
+
+        Ok(())
+    }
+}
+
 #[derive(Args, Debug)]
 struct GetArgs {
     /// Output path. If this ends with a '/', a filename based on the package
@@ -312,6 +362,7 @@ async fn main() -> anyhow::Result<()> {
     let cli = Cli::parse();
 
     match cli.command {
+        Commands::Config(args) => args.run().await,
         Commands::Get(args) => args.run().await,
         Commands::Publish(args) => args.run().await,
         Commands::Oci(args) => args.run().await,