diff --git a/.changeset/hot-pans-grow.md b/.changeset/hot-pans-grow.md
new file mode 100644
index 0000000000..b29be33369
--- /dev/null
+++ b/.changeset/hot-pans-grow.md
@@ -0,0 +1,7 @@
+---
+'@clerk/clerk-js': patch
+'@clerk/clerk-react': patch
+'@clerk/clerk-expo': minor
+---
+
+Support swapping the Clerk publishableKey at runtime to allow users to toggle the instance being used.
diff --git a/packages/clerk-js/src/core/clerk.ts b/packages/clerk-js/src/core/clerk.ts
index 8c7c00431a..1dc3e89512 100644
--- a/packages/clerk-js/src/core/clerk.ts
+++ b/packages/clerk-js/src/core/clerk.ts
@@ -256,6 +256,7 @@ export default class Clerk implements ClerkInterface {
 
       const { frontendApi, instanceType } = publishableKey as PublishableKey;
 
+      this.publishableKey = key;
       this.frontendApi = frontendApi;
       this.#instanceType = instanceType;
     }
diff --git a/packages/expo/src/ClerkProvider.tsx b/packages/expo/src/ClerkProvider.tsx
index 8fe2013dbf..de478b50ce 100644
--- a/packages/expo/src/ClerkProvider.tsx
+++ b/packages/expo/src/ClerkProvider.tsx
@@ -25,6 +25,8 @@ export function ClerkProvider(props: ClerkProviderProps): JSX.Element {
   return (
     //@ts-expect-error
     <ClerkReactProvider
+      // Force reset the state when the provided key changes, this ensures that the provider does not retain stale state. See JS-598 for additional context.
+      key={key}
       {...rest}
       Clerk={buildClerk({ key, tokenCache })}
       standardBrowser={!isReactNative()}
diff --git a/packages/expo/src/cache.ts b/packages/expo/src/cache.ts
index 9d9d196548..3294c34608 100644
--- a/packages/expo/src/cache.ts
+++ b/packages/expo/src/cache.ts
@@ -1,6 +1,7 @@
 export interface TokenCache {
   getToken: (key: string) => Promise<string | undefined | null>;
   saveToken: (key: string, token: string) => Promise<void>;
+  clearToken?: (key: string) => void;
 }
 
 const createMemoryTokenCache = (): TokenCache => {
@@ -13,6 +14,9 @@ const createMemoryTokenCache = (): TokenCache => {
     getToken: key => {
       return Promise.resolve(cache[key]);
     },
+    clearToken: key => {
+      delete cache[key];
+    },
   };
 };
 
diff --git a/packages/expo/src/singleton.ts b/packages/expo/src/singleton.ts
index 587e4af565..686f7a435c 100644
--- a/packages/expo/src/singleton.ts
+++ b/packages/expo/src/singleton.ts
@@ -14,7 +14,14 @@ type BuildClerkOptions = {
 };
 
 export function buildClerk({ key, tokenCache }: BuildClerkOptions): HeadlessBrowserClerk {
-  if (!clerk) {
+  // Support "hot-swapping" the Clerk instance at runtime. See JS-598 for additional details.
+  const hasKeyChanged = clerk && key !== clerk.publishableKey;
+
+  if (!clerk || hasKeyChanged) {
+    if (hasKeyChanged) {
+      tokenCache.clearToken?.(KEY);
+    }
+
     const getToken = tokenCache.getToken;
     const saveToken = tokenCache.saveToken;
     // TODO: DO NOT ACCEPT THIS
diff --git a/packages/react/src/isomorphicClerk.ts b/packages/react/src/isomorphicClerk.ts
index 8bb6c3569b..8927f0d8d6 100644
--- a/packages/react/src/isomorphicClerk.ts
+++ b/packages/react/src/isomorphicClerk.ts
@@ -87,8 +87,9 @@ export default class IsomorphicClerk {
   static getOrCreateInstance(options: IsomorphicClerkOptions) {
     // During SSR: a new instance should be created for every request
     // During CSR: use the cached instance for the whole lifetime of the app
+    // Also will recreate the instance if the provided Clerk instance changes
     // This method should be idempotent in both scenarios
-    if (!inClientSide() || !this.#instance) {
+    if (!inClientSide() || !this.#instance || (options.Clerk && this.#instance.Clerk !== options.Clerk)) {
       this.#instance = new IsomorphicClerk(options);
     }
     return this.#instance;