From 7c2d283a05c29d43337794bbe93e5c2cdab92aa0 Mon Sep 17 00:00:00 2001 From: Michael Baudis Date: Mon, 25 Mar 2024 07:34:55 +0100 Subject: [PATCH] Create 2024-03-28-zh-seminars-in-bioinformatics.md --- .../2024-03-28-zh-seminars-in-bioinformatics.md | 14 ++++++++++++++ 1 file changed, 14 insertions(+) create mode 100644 docs/news/2024-03-28-zh-seminars-in-bioinformatics.md diff --git a/docs/news/2024-03-28-zh-seminars-in-bioinformatics.md b/docs/news/2024-03-28-zh-seminars-in-bioinformatics.md new file mode 100644 index 000000000..f1ea9ec88 --- /dev/null +++ b/docs/news/2024-03-28-zh-seminars-in-bioinformatics.md @@ -0,0 +1,14 @@ +--- +template: post.html +title: "Characterizing Intestinal Fibroblast Diversity in Health and Inflammatory Bowel Disease Through Single-Cell Analysis
Master Thesis Presentation" +description: 'Zurich Seminars in Bioinformatics' +date: 2024-03-28 +authors: + - "@mbaudis" +links: + - '[Robinson lab @ UZH](https://robinsonlabuzh.github.io)' +--- + +* 12:15 UZH Irchel Y55-l-06/08 and ZOOM Call + +**Abstract** Crohn’s disease (CD), a form of inflammatory bowel disease (IBD) characterized by chronic intestinal inflammation, emerges from a complex interplay of genetic, environmental, and cellular factors. Among these, intestinal fibroblasts represent a pivotal yet underexplored component. Leveraging single-cell RNA sequencing and CITE-seq, we conducted a comprehensive analysis of 154,000 cells from the lamina propria, submucosa, and gut-associated lymphoid tissues of both the colon and small intestine derived from a cohort of 4 CD patients and 6 healthy controls. This investigation enabled the identification of four distinct fibroblast populations, each characterized by distinctive transcriptional identities, functional roles, and diverse distribution across intestinal sites. Through differential gene expression analysis and gene set enrichment analysis, we investigated changes in the predominant fibroblast population in the ileal lamina propria of CD patients, uncovering a potential involvement of these cells in disease pathogenesis. \ No newline at end of file