diff --git a/grayskull/strategy/py_base.py b/grayskull/strategy/py_base.py
index bb48f94e8..e00ec485e 100644
--- a/grayskull/strategy/py_base.py
+++ b/grayskull/strategy/py_base.py
@@ -531,9 +531,19 @@ def is_compiler_present() -> bool:
 
     if not is_compiler_present():
         return
+
+    def clean_list_pkg(pkg, list_pkgs):
+        result = []
+        for p in list_pkgs:
+            if pkg == p.strip().split(" ", 1)[0]:
+                continue
+            result.append(p)
+        return result
+
     for pkg in requirements["host"]:
         pkg_name = RE_DEPS_NAME.match(pkg).group(0)
         if pkg_name in PIN_PKG_COMPILER.keys():
+            requirements["run"] = clean_list_pkg(pkg_name, requirements["run"])
             if pkg_name in requirements["run"]:
                 requirements["run"].remove(pkg_name)
             requirements["run"].append(PIN_PKG_COMPILER[pkg_name])
diff --git a/tests/test_pypi.py b/tests/test_pypi.py
index df0ae36d1..548c6fa00 100644
--- a/tests/test_pypi.py
+++ b/tests/test_pypi.py
@@ -875,3 +875,9 @@ def test_create_recipe_from_local_sdist(pkg_pytest):
 def test_400_for_python_selector():
     recipe = create_python_recipe("pyquil", version="3.0.1")[0]
     assert recipe["build"]["skip"].selector == "py>=400 or py2k"
+
+
+def test_numpy_and_pin_compatible_mixed():
+    recipe = create_python_recipe("dimod", version="0.10.13")[0]
+    assert "<{ pin_compatible('numpy') }}" in list(recipe["requirements"]["run"])
+    assert "numpy" not in list(recipe["requirements"]["run"])