diff --git a/grayskull/strategy/py_base.py b/grayskull/strategy/py_base.py
index 76a185535..224578965 100644
--- a/grayskull/strategy/py_base.py
+++ b/grayskull/strategy/py_base.py
@@ -799,6 +799,21 @@ def ensure_pep440_in_req_list(list_req: List[str]) -> List[str]:
     return [ensure_pep440(pkg) for pkg in list_req]
 
 
+def split_deps(deps: str) -> List[str]:
+    deps = deps.split(",")
+    result = []
+    for d in deps:
+        constrain = ""
+        for val in re.split(r"([><!=~^]+)", d):
+            if not val:
+                continue
+            if {">", "<", "=", "!", "~", "^"} & set(val):
+                constrain = val.strip()
+            else:
+                result.append(f"{constrain}{val.strip()}")
+    return result
+
+
 def ensure_pep440(pkg: str) -> str:
     if not pkg:
         return pkg
@@ -813,7 +828,7 @@ def ensure_pep440(pkg: str) -> str:
         selector = f"  {' '.join(split_pkg[hash_index:])}"
         split_pkg = split_pkg[:hash_index]
     constrain_pkg = "".join(split_pkg[1:])
-    list_constrains = constrain_pkg.split(",")
+    list_constrains = split_deps(constrain_pkg)
     full_constrain = []
     for constrain in list_constrains:
         if "~=" in constrain:
diff --git a/tests/test_py_base.py b/tests/test_py_base.py
index 8e711162e..3774220f1 100644
--- a/tests/test_py_base.py
+++ b/tests/test_py_base.py
@@ -8,6 +8,7 @@
     generic_py_ver_to,
     get_sdist_metadata,
     merge_deps_toml_setup,
+    split_deps,
     update_requirements_with_pin,
 )
 from grayskull.utils import PyVer
@@ -117,3 +118,15 @@ def test_get_sdist_metadata_toml_files_BLACK():
         "typing_extensions>=3.10.0.0; python_version < '3.10'",
         "python >=3.7",
     ]
+
+
+def test_split_deps_without_comma():
+    assert split_deps(">=1.8.0<3.0.0,!=2.0.1") == [">=1.8.0", "<3.0.0", "!=2.0.1"]
+
+
+def test_split_deps():
+    assert split_deps(">=1.8.0,<3.0.0,!=2.0.1") == [">=1.8.0", "<3.0.0", "!=2.0.1"]
+
+
+def test_split_deps_space():
+    assert split_deps(">=1.8.0 <3.0.0 !=2.0.1") == [">=1.8.0", "<3.0.0", "!=2.0.1"]