diff --git a/dandiapi/api/views/asset.py b/dandiapi/api/views/asset.py
index 34d35e8f1..26c09a9dc 100644
--- a/dandiapi/api/views/asset.py
+++ b/dandiapi/api/views/asset.py
@@ -36,6 +36,7 @@
 from rest_framework.exceptions import NotAuthenticated, NotFound, PermissionDenied
 from rest_framework.generics import get_object_or_404
 from rest_framework.response import Response
+from rest_framework.throttling import AnonRateThrottle, BaseThrottle
 from rest_framework.viewsets import GenericViewSet, ReadOnlyModelViewSet
 from rest_framework_extensions.mixins import DetailSerializerMixin, NestedViewSetMixin
 
@@ -82,6 +83,13 @@ class AssetViewSet(DetailSerializerMixin, GenericViewSet):
     filter_backends = [filters.DjangoFilterBackend]
     filterset_class = AssetFilter
 
+    def get_throttles(self) -> list[BaseThrottle]:
+        # Throttle the asset list endpoint for unauthenticated users to prevent it from
+        # slowing down the rest of the system.
+        if self.action == 'list':
+            return [*self.throttle_classes, AnonRateThrottle]
+        return super().get_throttles()
+
     def raise_if_unauthorized(self):
         # We need to check the dandiset to see if it's embargoed, and if so whether or not the
         # user has ownership
diff --git a/dandiapi/settings.py b/dandiapi/settings.py
index 0ba65368f..0db248abd 100644
--- a/dandiapi/settings.py
+++ b/dandiapi/settings.py
@@ -181,6 +181,11 @@ def mutate_configuration(configuration: type[ComposedConfiguration]):
         # We're configuring sentry by hand since we need to pass custom options (traces_sampler).
         configuration.INSTALLED_APPS.remove('composed_configuration.sentry.apps.SentryConfig')
 
+        # We only want rate-limiting enabled in production
+        configuration.REST_FRAMEWORK['DEFAULT_THROTTLE_RATES'] = {
+            'anon': '60/minute',
+        }
+
     ENABLE_GITHUB_OAUTH = True
 
     # All login attempts in production should go straight to GitHub