diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7207f3f6138..bba5f8cf694 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -41,7 +41,7 @@ To learn more about our roadmap, we recommend reading [this document](ROADMAP.md
 
 ### Improvements
 
-- TODO ([#XXX](https://github.com/kedacore/keda/issue/XXX))
+- **Datadog Scaler:** Support multi-query metrics, and aggregation ([#3423](https://github.com/kedacore/keda/issues/3423))
 
 ### Fixes
 
diff --git a/pkg/scalers/datadog_scaler.go b/pkg/scalers/datadog_scaler.go
index 559e3f47198..73a3510cf32 100644
--- a/pkg/scalers/datadog_scaler.go
+++ b/pkg/scalers/datadog_scaler.go
@@ -29,6 +29,7 @@ type datadogMetadata struct {
 	datadogSite          string
 	query                string
 	queryValue           float64
+	queryAggegrator      string
 	activationQueryValue float64
 	vType                v2beta2.MetricTargetType
 	metricName           string
@@ -37,6 +38,9 @@ type datadogMetadata struct {
 	fillValue            float64
 }
 
+const maxString = "max"
+const avgString = "average"
+
 var filter *regexp.Regexp
 
 func init() {
@@ -111,6 +115,20 @@ func parseDatadogMetadata(config *ScalerConfig, logger logr.Logger) (*datadogMet
 		return nil, fmt.Errorf("no queryValue given")
 	}
 
+	allowedQueryAggregators := []string{avgString, maxString}
+
+	if val, ok := config.TriggerMetadata["queryAggregator"]; ok && val != "" {
+		queryAggregator := strings.ToLower(val)
+		_, found := FindStringInSlice(allowedQueryAggregators, queryAggregator)
+		if found {
+			meta.queryAggegrator = queryAggregator
+		} else {
+			return nil, fmt.Errorf("queryAggregator has to be one of %+q", queryAggregator)
+		}
+	} else {
+		meta.queryAggegrator = maxString
+	}
+
 	meta.activationQueryValue = 0
 	if val, ok := config.TriggerMetadata["activationQueryValue"]; ok {
 		activationQueryValue, err := strconv.ParseFloat(val, 64)
@@ -136,7 +154,7 @@ func parseDatadogMetadata(config *ScalerConfig, logger logr.Logger) (*datadogMet
 		}
 		val = strings.ToLower(val)
 		switch val {
-		case "average":
+		case avgString:
 			meta.vType = v2beta2.AverageValueMetricType
 		case "global":
 			meta.vType = v2beta2.ValueMetricType
@@ -272,10 +290,6 @@ func (s *datadogScaler) getQueryResult(ctx context.Context) (float64, error) {
 
 	series := resp.GetSeries()
 
-	if len(series) > 1 {
-		return 0, fmt.Errorf("query returned more than 1 series; modify the query to return only 1 series")
-	}
-
 	if len(series) == 0 {
 		if !s.metadata.useFiller {
 			return 0, fmt.Errorf("no Datadog metrics returned for the given time window")
@@ -283,18 +297,28 @@ func (s *datadogScaler) getQueryResult(ctx context.Context) (float64, error) {
 		return s.metadata.fillValue, nil
 	}
 
-	points := series[0].GetPointlist()
-
-	index := len(points) - 1
-	if len(points) == 0 || len(points[index]) < 2 {
-		if !s.metadata.useFiller {
-			return 0, fmt.Errorf("no Datadog metrics returned for the given time window")
+  // Collect all latest point values from any/all series
+	results := make([]float64, len(series))
+	for i := 0; i < len(series); i++ {
+		points := series[i].GetPointlist()
+		if len(points) == 0 || len(points[0]) < 2 {
+			if !s.metadata.useFiller {
+				return 0, fmt.Errorf("no Datadog metrics returned for the given time window")
+			}
+			return s.metadata.fillValue, nil
 		}
-		return s.metadata.fillValue, nil
+		// Return the last point from the series
+		index := len(points) - 1
+		results[i] = *points[index][1]
 	}
 
-	// Return the last point from the series
-	return *points[index][1], nil
+	switch s.metadata.queryAggegrator {
+	case avgString:
+		return AvgFloatFromSlice(results), nil
+	default:
+		// Aggregate Results - default Max value:
+		return MaxFloatFromSlice(results), nil
+	}
 }
 
 // GetMetricSpecForScaling returns the MetricSpec for the Horizontal Pod Autoscaler
@@ -323,3 +347,34 @@ func (s *datadogScaler) GetMetrics(ctx context.Context, metricName string, metri
 
 	return append([]external_metrics.ExternalMetricValue{}, metric), nil
 }
+
+// Takes a slice of strings, and looks for a string in it. If found it will
+// return it's key/index, otherwise it will return -1 and a bool of false.
+func FindStringInSlice(slice []string, val string) (int, bool) {
+	for i, item := range slice {
+		if item == val {
+			return i, true
+		}
+	}
+	return -1, false
+}
+
+// Find the largest value in a slice of floats
+func MaxFloatFromSlice(results []float64) float64 {
+	max := results[0]
+	for _, result := range results {
+		if result > max {
+			max = result
+		}
+	}
+	return max
+}
+
+// Find the average value in a slice of floats
+func AvgFloatFromSlice(results []float64) float64 {
+	total := 0.0
+	for _, result := range results {
+		total += result
+	}
+	return total / float64(len(results))
+}
diff --git a/pkg/scalers/datadog_scaler_test.go b/pkg/scalers/datadog_scaler_test.go
index c372c653482..422ee26829e 100644
--- a/pkg/scalers/datadog_scaler_test.go
+++ b/pkg/scalers/datadog_scaler_test.go
@@ -27,6 +27,41 @@ type datadogAuthMetadataTestData struct {
 	isError    bool
 }
 
+func assertEqual(t *testing.T, a interface{}, b interface{}) {
+	if a == b {
+		return
+	}
+	t.Errorf("%v != %v", a, b)
+}
+
+func TestFindStringInSlice(t *testing.T) {
+	inputSlice := []string{"this", "looks", "for", "strings"}
+	inputValue := "looks"
+	expectedIndex, expectedBool := int(1), bool(true)
+
+	outputIndex, outputBool := FindStringInSlice(inputSlice, inputValue)
+	assertEqual(t, outputIndex, expectedIndex)
+	assertEqual(t, outputBool, expectedBool)
+}
+
+func TestMaxFloatFromSlice(t *testing.T) {
+	input := []float64{1.0, 2.0, 3.0, 4.0}
+	expectedOutput := float64(4.0)
+
+	output := MaxFloatFromSlice(input)
+
+	assertEqual(t, output, expectedOutput)
+}
+
+func TestAvgFloatFromSlice(t *testing.T) {
+	input := []float64{1.0, 2.0, 3.0, 4.0}
+	expectedOutput := float64(2.5)
+
+	output := AvgFloatFromSlice(input)
+
+	assertEqual(t, output, expectedOutput)
+}
+
 var testParseQueries = []datadogQueries{
 	{"", false, true},
 	// All properly formed
@@ -36,6 +71,8 @@ var testParseQueries = []datadogQueries{
 	{"top(per_second(abs(sum:http.requests{service:myapp,dc:us-west-2}.rollup(max, 2))), 5, 'mean', 'desc')", true, false},
 	{"system.cpu.user{*}.rollup(sum, 30)", true, false},
 	{"min:system.cpu.user{*}", true, false},
+	// Multi-query
+	{"avg:system.cpu.user{*}.rollup(sum, 30),sum:system.cpu.user{*}.rollup(30)", true, false},
 
 	// Missing filter
 	{"min:system.cpu.user", false, true},
@@ -63,6 +100,8 @@ var testDatadogMetadata = []datadogAuthMetadataTestData{
 
 	// all properly formed
 	{"", map[string]string{"query": "sum:trace.redis.command.hits{env:none,service:redis}.as_count()", "queryValue": "7", "metricUnavailableValue": "1.5", "type": "average", "age": "60"}, map[string]string{"apiKey": "apiKey", "appKey": "appKey", "datadogSite": "datadogSite"}, false},
+	// Multi-query all properly formed
+	{"", map[string]string{"query": "sum:trace.redis.command.hits{env:none,service:redis}.as_count(),sum:trace.redis.command.hits{env:none,service:redis}.as_count()/2", "queryValue": "7", "queryAggregator": "average", "metricUnavailableValue": "1.5", "type": "average", "age": "60"}, map[string]string{"apiKey": "apiKey", "appKey": "appKey", "datadogSite": "datadogSite"}, false},
 	// default age
 	{"", map[string]string{"query": "sum:trace.redis.command.hits{env:none,service:redis}.as_count()", "queryValue": "7", "type": "average"}, map[string]string{"apiKey": "apiKey", "appKey": "appKey", "datadogSite": "datadogSite"}, false},
 	// default type
@@ -77,6 +116,8 @@ var testDatadogMetadata = []datadogAuthMetadataTestData{
 	{"", map[string]string{"query": "sum:trace.redis.command.hits{env:none,service:redis}.as_count()", "type": "average", "age": "60"}, map[string]string{"apiKey": "apiKey", "appKey": "appKey", "datadogSite": "datadogSite"}, true},
 	// wrong query value type
 	{"", map[string]string{"query": "sum:trace.redis.command.hits{env:none,service:redis}.as_count()", "queryValue": "notanint", "type": "average", "age": "60"}, map[string]string{"apiKey": "apiKey", "appKey": "appKey", "datadogSite": "datadogSite"}, true},
+	// wrong queryAggregator value
+	{"", map[string]string{"query": "sum:trace.redis.command.hits{env:none,service:redis}.as_count()", "queryValue": "notanint", "queryAggegrator": "1.0", "type": "average", "age": "60"}, map[string]string{"apiKey": "apiKey", "appKey": "appKey", "datadogSite": "datadogSite"}, true},
 	// wrong activation query value type
 	{"", map[string]string{"query": "sum:trace.redis.command.hits{env:none,service:redis}.as_count()", "queryValue": "1", "activationQueryValue": "notanint", "type": "average", "age": "60"}, map[string]string{"apiKey": "apiKey", "appKey": "appKey", "datadogSite": "datadogSite"}, true},
 	// malformed query