diff --git a/src/libraries/Native/Unix/System.Native/pal_io.c b/src/libraries/Native/Unix/System.Native/pal_io.c
index 049e44e12fcef..3541a90f1858b 100644
--- a/src/libraries/Native/Unix/System.Native/pal_io.c
+++ b/src/libraries/Native/Unix/System.Native/pal_io.c
@@ -324,6 +324,12 @@ int32_t SystemNative_Unlink(const char* path)
 
 intptr_t SystemNative_ShmOpen(const char* name, int32_t flags, int32_t mode)
 {
+#if defined(SHM_NAME_MAX) // macOS
+    assert(strlen(name) <= SHM_NAME_MAX);
+#elif defined(PATH_MAX) // other Unixes
+    assert(strlen(name) <= PATH_MAX);
+#endif
+
 #if HAVE_SHM_OPEN_THAT_WORKS_WELL_ENOUGH_WITH_MMAP
     flags = ConvertOpenFlags(flags);
     if (flags == -1)
diff --git a/src/libraries/System.IO.MemoryMappedFiles/src/System/IO/MemoryMappedFiles/MemoryMappedFile.Unix.cs b/src/libraries/System.IO.MemoryMappedFiles/src/System/IO/MemoryMappedFiles/MemoryMappedFile.Unix.cs
index 389ab072d9a6c..6882527cecc8d 100644
--- a/src/libraries/System.IO.MemoryMappedFiles/src/System/IO/MemoryMappedFiles/MemoryMappedFile.Unix.cs
+++ b/src/libraries/System.IO.MemoryMappedFiles/src/System/IO/MemoryMappedFiles/MemoryMappedFile.Unix.cs
@@ -1,6 +1,7 @@
 // Licensed to the .NET Foundation under one or more agreements.
 // The .NET Foundation licenses this file to you under the MIT license.
 
+using System.Diagnostics;
 using Microsoft.Win32.SafeHandles;
 
 namespace System.IO.MemoryMappedFiles
@@ -173,9 +174,6 @@ private static FileStream CreateSharedBackingObject(Interop.Sys.MemoryMappedProt
         private static FileStream? CreateSharedBackingObjectUsingMemory(
            Interop.Sys.MemoryMappedProtections protections, long capacity, HandleInheritability inheritability)
         {
-            // The POSIX shared memory object name must begin with '/'.  After that we just want something short and unique.
-            string mapName = string.Create(null, stackalloc char[128], $"/corefx_map_{Guid.NewGuid():N}");
-
             // Determine the flags to use when creating the shared memory object
             Interop.Sys.OpenFlags flags = (protections & Interop.Sys.MemoryMappedProtections.PROT_WRITE) != 0 ?
                 Interop.Sys.OpenFlags.O_RDWR :
@@ -191,22 +189,32 @@ private static FileStream CreateSharedBackingObject(Interop.Sys.MemoryMappedProt
             if ((protections & Interop.Sys.MemoryMappedProtections.PROT_EXEC) != 0)
                 perms |= Interop.Sys.Permissions.S_IXUSR;
 
-            // Create the shared memory object.
-            SafeFileHandle fd = Interop.Sys.ShmOpen(mapName, flags, (int)perms);
-            if (fd.IsInvalid)
+            string mapName;
+            SafeFileHandle fd;
+
+            do
             {
-                Interop.ErrorInfo errorInfo = Interop.Sys.GetLastErrorInfo();
-                if (errorInfo.Error == Interop.Error.ENOTSUP)
+                mapName = GenerateMapName();
+                fd = Interop.Sys.ShmOpen(mapName, flags, (int)perms); // Create the shared memory object.
+
+                if (fd.IsInvalid)
                 {
-                    // If ShmOpen is not supported, fall back to file backing object.
-                    // Note that the System.Native shim will force this failure on platforms where
-                    // the result of native shm_open does not work well with our subsequent call
-                    // to mmap.
-                    return null;
-                }
+                    Interop.ErrorInfo errorInfo = Interop.Sys.GetLastErrorInfo();
+                    fd.Dispose();
 
-                throw Interop.GetExceptionForIoErrno(errorInfo);
-            }
+                    if (errorInfo.Error == Interop.Error.ENOTSUP)
+                    {
+                        // If ShmOpen is not supported, fall back to file backing object.
+                        // Note that the System.Native shim will force this failure on platforms where
+                        // the result of native shm_open does not work well with our subsequent call to mmap.
+                        return null;
+                    }
+                    else if (errorInfo.Error != Interop.Error.EEXIST) // map with same name already existed
+                    {
+                        throw Interop.GetExceptionForIoErrno(errorInfo);
+                    }
+                }
+            } while (fd.IsInvalid);
 
             try
             {
@@ -236,6 +244,18 @@ private static FileStream CreateSharedBackingObject(Interop.Sys.MemoryMappedProt
                 fd.Dispose();
                 throw;
             }
+
+            static string GenerateMapName()
+            {
+                const int MaxSharedMemoryObjectNameLength = 32; // SHM_NAME_MAX on OSX ARM64, on other systems it's equal PATH_MAX (250)
+                // The POSIX shared memory object name must begin with '/'.  After that we just want something short (32) and unique.
+                return string.Create(MaxSharedMemoryObjectNameLength, 0, (span, state) =>
+                {
+                    Guid.NewGuid().TryFormat(span, out int charsWritten, "N");
+                    Debug.Assert(charsWritten == MaxSharedMemoryObjectNameLength);
+                    "/dotnet_".CopyTo(span);
+                });
+            }
         }
 
         private static FileStream CreateSharedBackingObjectUsingFile(Interop.Sys.MemoryMappedProtections protections, long capacity, HandleInheritability inheritability)
diff --git a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CreateNew.Tests.cs b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CreateNew.Tests.cs
index e7c5ee2f80c3a..70b82398301d5 100644
--- a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CreateNew.Tests.cs
+++ b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CreateNew.Tests.cs
@@ -11,7 +11,6 @@ namespace System.IO.MemoryMappedFiles.Tests
     /// <summary>
     /// Tests for MemoryMappedFile.CreateNew.
     /// </summary>
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49104", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class MemoryMappedFileTests_CreateNew : MemoryMappedFilesTestBase
     {
         /// <summary>
diff --git a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewAccessor.Tests.cs b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewAccessor.Tests.cs
index 0c8517ca4affe..8fe35396ae804 100644
--- a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewAccessor.Tests.cs
+++ b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewAccessor.Tests.cs
@@ -11,7 +11,6 @@ namespace System.IO.MemoryMappedFiles.Tests
     /// <summary>
     /// Tests for MemoryMappedViewAccessor.
     /// </summary>
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49104", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class MemoryMappedViewAccessorTests : MemoryMappedFilesTestBase
     {
         /// <summary>
diff --git a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStream.Tests.cs b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStream.Tests.cs
index a5340527df901..f279b8c33f98f 100644
--- a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStream.Tests.cs
+++ b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStream.Tests.cs
@@ -11,7 +11,6 @@ namespace System.IO.MemoryMappedFiles.Tests
     /// <summary>
     /// Tests for MemoryMappedViewStream.
     /// </summary>
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49104", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class MemoryMappedViewStreamTests : MemoryMappedFilesTestBase
     {
         /// <summary>
diff --git a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStreamConformanceTests.cs b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStreamConformanceTests.cs
index e84a86a91f20c..c190d329a00fe 100644
--- a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStreamConformanceTests.cs
+++ b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedViewStreamConformanceTests.cs
@@ -45,7 +45,6 @@ private Task<Stream> CreateStream(byte[] initialData, FileAccess access)
         }
     }
 
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49104", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class AnonymousMemoryMappedViewStreamConformanceTests : MemoryMappedViewStreamConformanceTests
     {
         protected override MemoryMappedFile CreateFile(int length) =>