diff --git a/src/libraries/System.IO.Pipes/src/Resources/Strings.resx b/src/libraries/System.IO.Pipes/src/Resources/Strings.resx
index c8193e445cdbd..e4777e219890c 100644
--- a/src/libraries/System.IO.Pipes/src/Resources/Strings.resx
+++ b/src/libraries/System.IO.Pipes/src/Resources/Strings.resx
@@ -291,4 +291,7 @@
   <data name="NotSupported_PipeSecurityIsCurrentUserOnly" xml:space="preserve">
     <value>'pipeSecurity' must be null when 'options' contains 'PipeOptions.CurrentUserOnly'. </value>
   </data>
+  <data name="Pipes_PlatformNotSupported" xml:space="preserve">
+    <value>System.IO.Pipes is not supported on this platform</value>
+  </data>
 </root>
diff --git a/src/libraries/System.IO.Pipes/src/System.IO.Pipes.csproj b/src/libraries/System.IO.Pipes/src/System.IO.Pipes.csproj
index b4411f32e4d75..becae30a11a9d 100644
--- a/src/libraries/System.IO.Pipes/src/System.IO.Pipes.csproj
+++ b/src/libraries/System.IO.Pipes/src/System.IO.Pipes.csproj
@@ -3,11 +3,14 @@
     <AssemblyName>System.IO.Pipes</AssemblyName>
     <AllowUnsafeBlocks>true</AllowUnsafeBlocks>
     <OmitTransitiveCompileReferences>true</OmitTransitiveCompileReferences>
-    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)-Browser</TargetFrameworks>
+    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)</TargetFrameworks>
     <Nullable>enable</Nullable>
   </PropertyGroup>
+  <PropertyGroup>
+    <GeneratePlatformNotSupportedAssemblyMessage Condition="'$(TargetsAnyOS)' == 'true'">SR.Pipes_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
+  </PropertyGroup>
   <!-- Compiled Source Files -->
-  <ItemGroup>
+  <ItemGroup Condition="'$(TargetsAnyOS)' != 'true'">
     <Compile Include="Microsoft\Win32\SafeHandles\SafePipeHandle.cs" />
     <Compile Include="System\IO\Error.cs" />
     <Compile Include="System\IO\Pipes\AnonymousPipeClientStream.cs" />
@@ -115,7 +118,7 @@
              Link="Common\Interop\Windows\Interop.LoadLibraryEx_IntPtr.cs" />
     <Compile Include="System\IO\Pipes\NamedPipeServerStream.Win32.cs" />
   </ItemGroup>
-  <ItemGroup Condition=" '$(TargetsUnix)' == 'true' or '$(TargetsBrowser)' == 'true' ">
+  <ItemGroup Condition=" '$(TargetsUnix)' == 'true'">
     <Compile Include="Microsoft\Win32\SafeHandles\SafePipeHandle.Unix.cs" />
     <Compile Include="System\IO\Pipes\AnonymousPipeServerStream.Unix.cs" />
     <Compile Include="System\IO\Pipes\NamedPipeClientStream.Unix.cs" />
diff --git a/src/libraries/System.IO.Pipes/tests/AssemblyInfo.cs b/src/libraries/System.IO.Pipes/tests/AssemblyInfo.cs
index f9fdcb43917c4..394d602401c8c 100644
--- a/src/libraries/System.IO.Pipes/tests/AssemblyInfo.cs
+++ b/src/libraries/System.IO.Pipes/tests/AssemblyInfo.cs
@@ -4,3 +4,4 @@
 using Xunit;
 
 [assembly: ActiveIssue("https://github.com/dotnet/runtime/issues/34582", TestPlatforms.Windows, TargetFrameworkMonikers.Netcoreapp, TestRuntimes.Mono)]
+[assembly: SkipOnMono("System.IO.Pipes is not supported on Browser", TestPlatforms.Browser)]
diff --git a/src/libraries/System.IO.Pipes/tests/System.IO.Pipes.Tests.csproj b/src/libraries/System.IO.Pipes/tests/System.IO.Pipes.Tests.csproj
index 4ae5348a1da4c..bd2aabe486355 100644
--- a/src/libraries/System.IO.Pipes/tests/System.IO.Pipes.Tests.csproj
+++ b/src/libraries/System.IO.Pipes/tests/System.IO.Pipes.Tests.csproj
@@ -2,7 +2,8 @@
   <PropertyGroup>
     <AllowUnsafeBlocks>true</AllowUnsafeBlocks>
     <IncludeRemoteExecutor>true</IncludeRemoteExecutor>
-    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)-Browser</TargetFrameworks>
+    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)</TargetFrameworks>
+    <IgnoreForCI Condition="'$(TargetOS)' == 'Browser'">true</IgnoreForCI>
   </PropertyGroup>
   <ItemGroup>
     <Compile Include="AssemblyInfo.cs" />