diff --git a/src/mono/mono/eglib/CMakeLists.txt b/src/mono/mono/eglib/CMakeLists.txt
index 1325ee6c1126c..69bf7e188696b 100644
--- a/src/mono/mono/eglib/CMakeLists.txt
+++ b/src/mono/mono/eglib/CMakeLists.txt
@@ -43,6 +43,10 @@ set(eglib_common_sources
     gunicode.c
     unicode-data.h)
 
+if(HAVE_CLOCK_NANOSLEEP)
+list(APPEND eglib_common_sources gclock-nanosleep.c)
+endif()
+
 addprefix(eglib_sources ../eglib/ "${eglib_platform_sources};${eglib_common_sources}")
 
 add_library(eglib_objects OBJECT "${eglib_sources}")
diff --git a/src/mono/mono/eglib/eglib-remap.h b/src/mono/mono/eglib/eglib-remap.h
index c3e956842dea8..3af646a8e47b2 100644
--- a/src/mono/mono/eglib/eglib-remap.h
+++ b/src/mono/mono/eglib/eglib-remap.h
@@ -318,3 +318,7 @@
 #define g_ascii_charcmp monoeg_ascii_charcmp
 #define g_ascii_charcasecmp monoeg_ascii_charcasecmp
 #define g_warning_d monoeg_warning_d
+
+#ifdef HAVE_CLOCK_NANOSLEEP
+#define g_clock_nanosleep monoeg_clock_nanosleep
+#endif
diff --git a/src/mono/mono/eglib/gclock-nanosleep.c b/src/mono/mono/eglib/gclock-nanosleep.c
new file mode 100644
index 0000000000000..f2ced8b2c07d1
--- /dev/null
+++ b/src/mono/mono/eglib/gclock-nanosleep.c
@@ -0,0 +1,31 @@
+/*
+ * gclock_nanosleep.c: Clock nanosleep on platforms that have clock_nanosleep().
+ *
+ * Copyright 2022 Microsoft
+ * Licensed under the MIT license. See LICENSE file in the project root for full license information.
+*/
+
+#include <config.h>
+#include <glib.h>
+#include <errno.h>
+
+gint
+g_clock_nanosleep (clockid_t clockid, gint flags, const struct timespec *request, struct timespec *remain)
+{
+	gint ret = 0;
+
+#if defined(HAVE_CLOCK_NANOSLEEP) && !defined(__PASE__)
+	ret = clock_nanosleep (clockid, flags, request, remain);
+#else
+	g_assert_not_reached ();
+#endif
+
+#ifdef HOST_ANDROID
+	// Workaround for incorrect implementation of clock_nanosleep return value on old Android (<=5.1)
+	// See https://github.com/xamarin/xamarin-android/issues/6600
+	if (ret == -1)
+		ret = errno;
+#endif
+
+	return ret;
+}
diff --git a/src/mono/mono/eglib/gdate-unix.c b/src/mono/mono/eglib/gdate-unix.c
index 53f4bbb3d5adc..9a98e66304576 100644
--- a/src/mono/mono/eglib/gdate-unix.c
+++ b/src/mono/mono/eglib/gdate-unix.c
@@ -64,7 +64,7 @@ g_usleep (gulong microseconds)
 	}
 
 	do {
-		ret = clock_nanosleep (CLOCK_MONOTONIC, TIMER_ABSTIME, &target, NULL);
+		ret = g_clock_nanosleep (CLOCK_MONOTONIC, TIMER_ABSTIME, &target, NULL);
 		if (ret != 0 && ret != EINTR)
 			g_error ("%s: clock_nanosleep () returned %d", __func__, ret);
 	} while (ret == EINTR);
diff --git a/src/mono/mono/eglib/glib.h b/src/mono/mono/eglib/glib.h
index 14872b9814f48..5cc269957307e 100644
--- a/src/mono/mono/eglib/glib.h
+++ b/src/mono/mono/eglib/glib.h
@@ -28,6 +28,7 @@
 #include <inttypes.h>
 #include <eglib-config.h>
 #include <minipal/utils.h>
+#include <time.h>
 
 // - Pointers should only be converted to or from pointer-sized integers.
 // - Any size integer can be converted to any other size integer.
@@ -1506,4 +1507,13 @@ mono_qsort (void* base, size_t num, size_t size, int (*compare)(const void*, con
 #define g_try_realloc(obj, size) (g_cast (monoeg_try_realloc ((obj), (size))))
 #define g_memdup(mem, size) (g_cast (monoeg_g_memdup ((mem), (size))))
 
+/*
+ * Clock Nanosleep
+ */
+
+#ifdef HAVE_CLOCK_NANOSLEEP
+gint
+g_clock_nanosleep (clockid_t clockid, gint flags, const struct timespec *request, struct timespec *remain);
+#endif
+
 #endif // __GLIB_H
diff --git a/src/mono/mono/mini/mini-posix.c b/src/mono/mono/mini/mini-posix.c
index b706de969f5ce..8bb41ee1cb9a3 100644
--- a/src/mono/mono/mini/mini-posix.c
+++ b/src/mono/mono/mini/mini-posix.c
@@ -78,6 +78,7 @@
 #include <mono/component/debugger-agent.h>
 #include "mini-runtime.h"
 #include "jit-icalls.h"
+#include <glib.h>
 
 #ifdef HOST_DARWIN
 #include <mach/mach.h>
@@ -484,7 +485,7 @@ clock_init_for_profiler (MonoProfilerSampleMode mode)
 		 * CLOCK_PROCESS_CPUTIME_ID clock but don't actually support it. For
 		 * those systems, we fall back to CLOCK_MONOTONIC if we get EINVAL.
 		 */
-		if (clock_nanosleep (CLOCK_PROCESS_CPUTIME_ID, TIMER_ABSTIME, &ts, NULL) != EINVAL) {
+		if (g_clock_nanosleep (CLOCK_PROCESS_CPUTIME_ID, TIMER_ABSTIME, &ts, NULL) != EINVAL) {
 			sampling_clock = CLOCK_PROCESS_CPUTIME_ID;
 			break;
 		}
@@ -509,7 +510,6 @@ clock_sleep_ns_abs (guint64 ns_abs)
 
 	do {
 		ret = clock_nanosleep (sampling_clock, TIMER_ABSTIME, &then, NULL);
-
 		if (ret != 0 && ret != EINTR)
 			g_error ("%s: clock_nanosleep () returned %d", __func__, ret);
 	} while (ret == EINTR && mono_atomic_load_i32 (&sampling_thread_running));
diff --git a/src/mono/mono/utils/mono-threads.c b/src/mono/mono/utils/mono-threads.c
index e3a936a1abc3c..7697ac5002240 100644
--- a/src/mono/mono/utils/mono-threads.c
+++ b/src/mono/mono/utils/mono-threads.c
@@ -33,6 +33,7 @@
 #include <mono/utils/mono-threads-debug.h>
 #include <mono/utils/os-event.h>
 #include <mono/utils/w32api.h>
+#include <glib.h>
 
 #include <errno.h>
 #include <mono/utils/mono-errno.h>
@@ -1748,7 +1749,7 @@ mono_thread_info_sleep (guint32 ms, gboolean *alerted)
 		}
 
 		do {
-			ret = clock_nanosleep (CLOCK_MONOTONIC, TIMER_ABSTIME, &target, NULL);
+			ret = g_clock_nanosleep (CLOCK_MONOTONIC, TIMER_ABSTIME, &target, NULL);
 		} while (ret != 0);
 #elif HOST_WIN32
 		Sleep (ms);