diff --git a/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml b/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml
index 97b862d23843a..6728a4ebb4100 100644
--- a/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml
+++ b/eng/pipelines/extra-platforms/runtime-extra-platforms-other.yml
@@ -112,41 +112,42 @@ jobs:
 # Mono CoreCLR runtime Test executions using live libraries and LLVM Full AOT
 # Only when Mono is changed
 #
-- template: /eng/pipelines/common/platform-matrix.yml
-  parameters:
-    jobTemplate: /eng/pipelines/common/global-build-job.yml
-    helixQueuesTemplate: /eng/pipelines/coreclr/templates/helix-queues-setup.yml
-    buildConfig: Release
-    runtimeFlavor: mono
-    platforms:
-      - linux_x64
-      - linux_arm64
-    variables:
-      - name: timeoutPerTestInMinutes
-        value: 60
-      - name: timeoutPerTestCollectionInMinutes
-        value: 180
-    jobParameters:
-      testGroup: innerloop
-      nameSuffix: AllSubsets_Mono_LLVMFullAot_RuntimeTests
-      runtimeVariant: llvmfullaot
-      buildArgs: -s mono+libs+clr.hosts+clr.iltools -c Release /p:MonoEnableLLVM=true /p:MonoBundleLLVMOptimizer=true
-      timeoutInMinutes: 300
-      isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
+# Disabled due to OOM issues https://github.com/dotnet/runtime/issues/90427
+# - template: /eng/pipelines/common/platform-matrix.yml
+#   parameters:
+#     jobTemplate: /eng/pipelines/common/global-build-job.yml
+#     helixQueuesTemplate: /eng/pipelines/coreclr/templates/helix-queues-setup.yml
+#     buildConfig: Release
+#     runtimeFlavor: mono
+#     platforms:
+#       - linux_x64
+#       - linux_arm64
+#     variables:
+#       - name: timeoutPerTestInMinutes
+#         value: 60
+#       - name: timeoutPerTestCollectionInMinutes
+#         value: 180
+#     jobParameters:
+#       testGroup: innerloop
+#       nameSuffix: AllSubsets_Mono_LLVMFullAot_RuntimeTests
+#       runtimeVariant: llvmfullaot
+#       buildArgs: -s mono+libs+clr.hosts+clr.iltools -c Release /p:MonoEnableLLVM=true /p:MonoBundleLLVMOptimizer=true
+#       timeoutInMinutes: 300
+#       isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
 
-      condition: >-
-        or(
-          eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_mono_excluding_wasm.containsChange'], true),
-          eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_runtimetests.containsChange'], true),
-          eq(variables['isRollingBuild'], true))
-      postBuildSteps:
-        - template: /eng/pipelines/common/templates/runtimes/build-runtime-tests-and-send-to-helix.yml
-          parameters:
-            creator: dotnet-bot
-            llvmAotStepContainer: linux_x64_llvmaot
-            testRunNamePrefixSuffix: Mono_Release
-      extraVariablesTemplates:
-        - template: /eng/pipelines/common/templates/runtimes/test-variables.yml
+#       condition: >-
+#         or(
+#           eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_mono_excluding_wasm.containsChange'], true),
+#           eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_runtimetests.containsChange'], true),
+#           eq(variables['isRollingBuild'], true))
+#       postBuildSteps:
+#         - template: /eng/pipelines/common/templates/runtimes/build-runtime-tests-and-send-to-helix.yml
+#           parameters:
+#             creator: dotnet-bot
+#             llvmAotStepContainer: linux_x64_llvmaot
+#             testRunNamePrefixSuffix: Mono_Release
+#       extraVariablesTemplates:
+#         - template: /eng/pipelines/common/templates/runtimes/test-variables.yml
 
 #
 # Mono CoreCLR runtime Test executions using live libraries in interpreter mode
diff --git a/src/libraries/System.Runtime/tests/System.IO.Tests/MemoryStream/MemoryStreamTests.cs b/src/libraries/System.Runtime/tests/System.IO.Tests/MemoryStream/MemoryStreamTests.cs
index 1e7eb491a3699..baa158060cfc4 100644
--- a/src/libraries/System.Runtime/tests/System.IO.Tests/MemoryStream/MemoryStreamTests.cs
+++ b/src/libraries/System.Runtime/tests/System.IO.Tests/MemoryStream/MemoryStreamTests.cs
@@ -103,6 +103,7 @@ from bufferContext in
         [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.Is64BitProcess))]
         [MemberData(nameof(MemoryStream_PositionOverflow_Throws_MemberData))]
         [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "https://github.com/dotnet/runtime/issues/92467")]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/100225", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoRuntime), nameof(PlatformDetection.IsWindows), nameof(PlatformDetection.IsX64Process))]
         public void MemoryStream_SeekOverflow_Throws(SeekMode mode, int bufferSize, int origin)
         {
             byte[] buffer = new byte[bufferSize];
diff --git a/src/libraries/System.Security.Cryptography/tests/X509Certificates/ChainTests.cs b/src/libraries/System.Security.Cryptography/tests/X509Certificates/ChainTests.cs
index 775c05b7fc7ee..210f36dcf6d57 100644
--- a/src/libraries/System.Security.Cryptography/tests/X509Certificates/ChainTests.cs
+++ b/src/libraries/System.Security.Cryptography/tests/X509Certificates/ChainTests.cs
@@ -1270,6 +1270,7 @@ public static void BuildChainForSelfSignedSha3Certificate()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/100224", typeof(PlatformDetection), nameof(PlatformDetection.IsAndroid), nameof(PlatformDetection.IsArmOrArm64Process))]
         public static void BuildChainForSelfSignedCertificate_WithSha256RsaSignature()
         {
             using (ChainHolder chainHolder = new ChainHolder())
@@ -1288,6 +1289,7 @@ public static void BuildChainForSelfSignedCertificate_WithSha256RsaSignature()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/100224", typeof(PlatformDetection), nameof(PlatformDetection.IsAndroid), nameof(PlatformDetection.IsArmOrArm64Process))]
         public static void BuildChainForSelfSignedCertificate_WithUnknownOidSignature()
         {
             using (ChainHolder chainHolder = new ChainHolder())
diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 4c668a7442dba..e0351885f87fa 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -3127,6 +3127,13 @@
         </ExcludeList>
     </ItemGroup>
 
+    <!-- Apple mobile NativeAOT -->
+    <ItemGroup Condition="'$(XunitTestBinBase)' != '' and '$(TargetsAppleMobile)' == 'true' and '$(TestBuildMode)' == 'nativeaot'">
+        <ExcludeList Include = "$(XunitTestBinBase)/nativeaot/SmokeTests/TrimmingBehaviors/**">
+            <Issue>https://github.com/dotnet/runtime/issues/100226</Issue>
+        </ExcludeList>
+    </ItemGroup>
+
     <ItemGroup Condition="'$(TargetArchitecture)' == 'wasm'">
         <ExcludeList Include = "$(XunitTestBinBase)/baseservices/exceptions/unhandled/unhandled/**">
             <Issue>System.Diagnostics.Process is not supported</Issue>