diff --git a/src/libraries/System.Text.Encodings.Web/tests/TextEncoderSettingsTests.cs b/src/libraries/System.Text.Encodings.Web/tests/TextEncoderSettingsTests.cs
index e8d39bc93ab8d..b7945bfaf00b4 100644
--- a/src/libraries/System.Text.Encodings.Web/tests/TextEncoderSettingsTests.cs
+++ b/src/libraries/System.Text.Encodings.Web/tests/TextEncoderSettingsTests.cs
@@ -31,7 +31,6 @@ public static bool IsCharacterAllowed(this TextEncoderSettings settings, char ch
         }
     }
 
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/50965", TestPlatforms.Browser)]
     public class TextEncoderSettingsTests
     {
         [Fact]
diff --git a/src/mono/mono/metadata/icall.c b/src/mono/mono/metadata/icall.c
index f9dacf654ddc2..54f1c551b3b44 100644
--- a/src/mono/mono/metadata/icall.c
+++ b/src/mono/mono/metadata/icall.c
@@ -6635,7 +6635,7 @@ ves_icall_System_Environment_get_TickCount64 (void)
 gpointer
 ves_icall_RuntimeMethodHandle_GetFunctionPointer (MonoMethod *method, MonoError *error)
 {
-	return mono_compile_method_checked (method, error);
+	return mono_get_runtime_callbacks ()->get_ftnptr (method, error);
 }
 
 MonoBoolean
diff --git a/src/mono/mono/metadata/object-internals.h b/src/mono/mono/metadata/object-internals.h
index 025f250a3d7d8..0af9ed940682c 100644
--- a/src/mono/mono/metadata/object-internals.h
+++ b/src/mono/mono/metadata/object-internals.h
@@ -641,6 +641,8 @@ typedef struct {
 	void     (*metadata_update_published) (MonoAssemblyLoadContext *alc, uint32_t generation);
 	void (*get_jit_stats)(gint64 *methods_compiled, gint64 *cil_code_size_bytes, gint64 *native_code_size_bytes);
 	void (*get_exception_stats)(guint32 *exception_count);
+	// Same as compile_method, but returns a MonoFtnDesc in llvmonly mode
+	gpointer (*get_ftnptr)(MonoMethod *method, MonoError *error);
 } MonoRuntimeCallbacks;
 
 typedef gboolean (*MonoInternalStackWalk) (MonoStackFrameInfo *frame, MonoContext *ctx, gpointer data);
diff --git a/src/mono/mono/mini/interp/interp-internals.h b/src/mono/mono/mini/interp/interp-internals.h
index 2afac6e27ddc1..465fd20240fa4 100644
--- a/src/mono/mono/mini/interp/interp-internals.h
+++ b/src/mono/mono/mini/interp/interp-internals.h
@@ -124,6 +124,7 @@ struct InterpMethod {
 	MonoType *rtype;
 	MonoType **param_types;
 	MonoJitInfo *jinfo;
+	MonoFtnDesc *ftndesc;
 
 	guint32 locals_size;
 	guint32 alloca_size;
diff --git a/src/mono/mono/mini/interp/interp.c b/src/mono/mono/mini/interp/interp.c
index da9bed4af1c5e..1c7468ba3cadc 100644
--- a/src/mono/mono/mini/interp/interp.c
+++ b/src/mono/mono/mini/interp/interp.c
@@ -1620,6 +1620,9 @@ interp_init_delegate (MonoDelegate *del, MonoError *error)
 	} if (del->method_ptr && !del->method) {
 		/* Delegate created from methodInfo.MethodHandle.GetFunctionPointer() */
 		del->interp_method = (InterpMethod *)del->method_ptr;
+		if (mono_llvm_only)
+			// FIXME:
+			g_assert_not_reached ();
 	} else if (del->method) {
 		/* Delegate created dynamically */
 		del->interp_method = mono_interp_get_imethod (del->method, error);
@@ -1659,13 +1662,57 @@ interp_init_delegate (MonoDelegate *del, MonoError *error)
 	}
 }
 
+/* Convert a function pointer for a managed method to an InterpMethod* */
+static InterpMethod*
+ftnptr_to_imethod (gpointer addr)
+{
+	InterpMethod *imethod;
+
+	if (mono_llvm_only) {
+		ERROR_DECL (error);
+		/* Function pointers are represented by a MonoFtnDesc structure */
+		MonoFtnDesc *ftndesc = (MonoFtnDesc*)addr;
+		g_assert (ftndesc);
+		g_assert (ftndesc->method);
+
+		imethod = ftndesc->interp_method;
+		if (!imethod) {
+			imethod = mono_interp_get_imethod (ftndesc->method, error);
+			mono_error_assert_ok (error);
+			mono_memory_barrier ();
+			ftndesc->interp_method = imethod;
+		}
+	} else {
+		/* Function pointers are represented by their InterpMethod */
+		imethod = (InterpMethod*)addr;
+	}
+	return imethod;
+}
+
+static gpointer
+imethod_to_ftnptr (InterpMethod *imethod)
+{
+	if (mono_llvm_only) {
+		ERROR_DECL (error);
+		/* Function pointers are represented by a MonoFtnDesc structure */
+		MonoFtnDesc *ftndesc = imethod->ftndesc;
+		if (!ftndesc) {
+			ftndesc = mini_llvmonly_load_method_ftndesc (imethod->method, FALSE, FALSE, error);
+			mono_error_assert_ok (error);
+			mono_memory_barrier ();
+			imethod->ftndesc = ftndesc;
+		}
+		return ftndesc;
+	} else {
+		return imethod;
+	}
+}
+
 static void
 interp_delegate_ctor (MonoObjectHandle this_obj, MonoObjectHandle target, gpointer addr, MonoError *error)
 {
-	/*
-	 * addr is the result of an LDFTN opcode, i.e. an InterpMethod
-	 */
-	InterpMethod *imethod = (InterpMethod*)addr;
+	/* addr is the result of an LDFTN opcode */
+	InterpMethod *imethod = ftnptr_to_imethod (addr);
 
 	if (!(imethod->method->flags & METHOD_ATTRIBUTE_STATIC)) {
 		MonoMethod *invoke = mono_get_delegate_invoke_internal (mono_handle_class (this_obj));
@@ -3420,7 +3467,9 @@ interp_exec_method (InterpFrame *frame, ThreadContext *context, FrameClauseArgs
 
 			csignature = (MonoMethodSignature*)frame->imethod->data_items [ip [4]];
 
-			cmethod = LOCAL_VAR (ip [2], InterpMethod*);
+			/* In mixed mode, stay in the interpreter for simplicity even if there is an AOT version of the callee */
+			cmethod = ftnptr_to_imethod (LOCAL_VAR (ip [2], gpointer));
+
 			if (cmethod->method->flags & METHOD_ATTRIBUTE_PINVOKE_IMPL) {
 				cmethod = mono_interp_get_imethod (mono_marshal_get_native_wrapper (cmethod->method, FALSE, FALSE), error);
 				mono_interp_error_cleanup (error); /* FIXME: don't swallow the error */
@@ -6455,25 +6504,36 @@ MINT_IN_CASE(MINT_BRTRUE_I8_SP) ZEROP_SP(gint64, !=); MINT_IN_BREAK;
 #undef RELOP_FP
 #undef RELOP_CAST
 
-		MINT_IN_CASE(MINT_LDFTN) {
+		MINT_IN_CASE(MINT_LDFTN_ADDR) {
 			LOCAL_VAR (ip [1], gpointer) = frame->imethod->data_items [ip [2]];
 			ip += 3;
 			MINT_IN_BREAK;
 		}
+		MINT_IN_CASE(MINT_LDFTN) {
+			InterpMethod *m = (InterpMethod*)frame->imethod->data_items [ip [2]];
+
+			LOCAL_VAR (ip [1], gpointer) = imethod_to_ftnptr (m);
+			ip += 3;
+			MINT_IN_BREAK;
+		}
 		MINT_IN_CASE(MINT_LDVIRTFTN) {
 			InterpMethod *m = (InterpMethod*)frame->imethod->data_items [ip [3]];
 			MonoObject *o = LOCAL_VAR (ip [2], MonoObject*);
 			NULL_CHECK (o);
-				
-			LOCAL_VAR (ip [1], gpointer) = get_virtual_method (m, o->vtable);
+
+			m = get_virtual_method (m, o->vtable);
+			LOCAL_VAR (ip [1], gpointer) = imethod_to_ftnptr (m);
 			ip += 4;
 			MINT_IN_BREAK;
 		}
 		MINT_IN_CASE(MINT_LDFTN_DYNAMIC) {
 			error_init_reuse (error);
-			InterpMethod *m = mono_interp_get_imethod (LOCAL_VAR (ip [2], MonoMethod*), error);
+
+			MonoMethod *cmethod = LOCAL_VAR (ip [2], MonoMethod*);
+
+			InterpMethod *m = mono_interp_get_imethod (cmethod, error);
 			mono_error_assert_ok (error);
-			LOCAL_VAR (ip [1], gpointer) = m;
+			LOCAL_VAR (ip [1], gpointer) = imethod_to_ftnptr (m);
 			ip += 3;
 			MINT_IN_BREAK;
 		}
@@ -6655,7 +6715,7 @@ MINT_IN_CASE(MINT_BRTRUE_I8_SP) ZEROP_SP(gint64, !=); MINT_IN_BREAK;
 				mono_error_assert_ok (error);
 			}
 			g_assert (del->interp_method);
-			LOCAL_VAR (ip [1], gpointer) = del->interp_method;
+			LOCAL_VAR (ip [1], gpointer) = imethod_to_ftnptr (del->interp_method);
 			ip += 3;
 			MINT_IN_BREAK;
 		}
diff --git a/src/mono/mono/mini/interp/mintops.def b/src/mono/mono/mini/interp/mintops.def
index 1f55c92ec5900..0de870874beca 100644
--- a/src/mono/mono/mini/interp/mintops.def
+++ b/src/mono/mono/mini/interp/mintops.def
@@ -356,6 +356,7 @@ OPDEF(MINT_BOX_NULLABLE_PTR, "box.nullable.ptr", 4, 1, 1, MintOpShortInt)
 OPDEF(MINT_UNBOX, "unbox", 4, 1, 1, MintOpClassToken)
 OPDEF(MINT_LDTOKEN, "ldtoken", 3, 1, 0, MintOpShortInt)
 OPDEF(MINT_LDFTN, "ldftn", 3, 1, 0, MintOpMethodToken)
+OPDEF(MINT_LDFTN_ADDR, "ldftn_addr", 3, 1, 0, MintOpMethodToken)
 OPDEF(MINT_LDFTN_DYNAMIC, "ldftn.dynamic", 3, 1, 1, MintOpMethodToken)
 OPDEF(MINT_LDVIRTFTN, "ldvirtftn", 4, 1, 1, MintOpMethodToken)
 OPDEF(MINT_CPOBJ, "cpobj", 4, 0, 2, MintOpClassToken)
diff --git a/src/mono/mono/mini/interp/transform.c b/src/mono/mono/mini/interp/transform.c
index 2736b645795fe..29d1dec4ca11e 100644
--- a/src/mono/mono/mini/interp/transform.c
+++ b/src/mono/mono/mini/interp/transform.c
@@ -6859,7 +6859,7 @@ generate_code (TransformData *td, MonoMethod *method, MonoMethodHeader *header,
 					td->ip += 5;
 					const gconstpointer func = mono_find_jit_icall_info ((MonoJitICallId)token)->func;
 
-					interp_add_ins (td, MINT_LDFTN);
+					interp_add_ins (td, MINT_LDFTN_ADDR);
 					push_simple_type (td, STACK_TYPE_I);
 					interp_ins_set_dreg (td->last_ins, td->sp [-1].local);
 					td->last_ins->data [0] = get_data_item_index (td, (gpointer)func);
diff --git a/src/mono/mono/mini/llvmonly-runtime.c b/src/mono/mono/mini/llvmonly-runtime.c
index 9dd899bae1b41..d457dadfb7fee 100644
--- a/src/mono/mono/mini/llvmonly-runtime.c
+++ b/src/mono/mono/mini/llvmonly-runtime.c
@@ -115,9 +115,10 @@ mini_llvmonly_get_delegate_arg (MonoMethod *method, gpointer method_ptr)
 MonoFtnDesc*
 mini_llvmonly_create_ftndesc (MonoMethod *m, gpointer addr, gpointer arg)
 {
-	MonoFtnDesc *ftndesc = (MonoFtnDesc*)m_method_alloc0 (m, 2 * sizeof (gpointer));
+	MonoFtnDesc *ftndesc = (MonoFtnDesc*)m_method_alloc0 (m, sizeof (MonoFtnDesc));
 	ftndesc->addr = addr;
 	ftndesc->arg = arg;
+	ftndesc->method = m;
 
 	return ftndesc;
 }
diff --git a/src/mono/mono/mini/method-to-ir.c b/src/mono/mono/mini/method-to-ir.c
index dc22f3e38dea4..02ca3bad3a541 100644
--- a/src/mono/mono/mini/method-to-ir.c
+++ b/src/mono/mono/mini/method-to-ir.c
@@ -7155,7 +7155,10 @@ mono_method_to_ir (MonoCompile *cfg, MonoMethod *method, MonoBasicBlock *start_b
 					goto calli_end;
 				}
 			}
-			ins = (MonoInst*)mini_emit_calli_full (cfg, fsig, sp, addr, NULL, NULL, tailcall);
+			if (cfg->llvm_only && !(cfg->method->wrapper_type && cfg->method->wrapper_type != MONO_WRAPPER_DYNAMIC_METHOD))
+				ins = mini_emit_llvmonly_calli (cfg, fsig, sp, addr);
+			else
+				ins = (MonoInst*)mini_emit_calli_full (cfg, fsig, sp, addr, NULL, NULL, tailcall);
 			goto calli_end;
 		}
 		case MONO_CEE_CALL:
diff --git a/src/mono/mono/mini/mini-runtime.c b/src/mono/mono/mini/mini-runtime.c
index 2fd03d8a3524a..09944b33a7234 100644
--- a/src/mono/mono/mini/mini-runtime.c
+++ b/src/mono/mono/mini/mini-runtime.c
@@ -2687,6 +2687,22 @@ mono_jit_compile_method_jit_only (MonoMethod *method, MonoError *error)
 	return code;
 }
 
+/*
+ * get_ftnptr_for_method:
+ *
+ *   Return a function pointer for METHOD which is indirectly callable from managed code.
+ * On llvmonly, this returns a MonoFtnDesc, otherwise it returns a normal function pointer.
+ */
+static gpointer
+get_ftnptr_for_method (MonoMethod *method, MonoError *error)
+{
+	if (!mono_llvm_only) {
+		return mono_jit_compile_method (method, error);
+	} else {
+		return mini_llvmonly_load_method_ftndesc (method, FALSE, FALSE, error);
+	}
+}
+
 #ifdef MONO_ARCH_HAVE_INVALIDATE_METHOD
 static void
 invalidated_delegate_trampoline (char *desc)
@@ -4326,6 +4342,7 @@ mini_init (const char *filename, const char *runtime_version)
 	callbacks.create_jit_trampoline = mono_create_jit_trampoline;
 	callbacks.create_delegate_trampoline = mono_create_delegate_trampoline;
 	callbacks.free_method = mono_jit_free_method;
+	callbacks.get_ftnptr = get_ftnptr_for_method;
 #endif
 	callbacks.is_interpreter_enabled = mini_is_interpreter_enabled;
 	callbacks.get_weak_field_indexes = mono_aot_get_weak_field_indexes;
diff --git a/src/mono/mono/mini/mini.h b/src/mono/mono/mini/mini.h
index ae8306b160edb..f953cd21b6472 100644
--- a/src/mono/mono/mini/mini.h
+++ b/src/mono/mono/mini/mini.h
@@ -1136,6 +1136,9 @@ typedef struct
 {
 	gpointer addr;
 	gpointer arg;
+	MonoMethod *method;
+	/* InterpMethod* */
+	gpointer interp_method;
 } MonoFtnDesc;
 
 typedef enum {