diff --git a/CHANGELOG.md b/CHANGELOG.md
index bbfb6daf648..aae3e0ce6df 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -8,6 +8,7 @@
 
 - Fixed content in `EuiFilterButton` when `numFilters` is not passed ([#5012](https://github.com/elastic/eui/pull/5012))
 - Fixed default value of `outsideClickCloses` prop of `EuiFlyout` ([#5027](https://github.com/elastic/eui/pull/5027))
+- Fixed `EuiSelectable`'s double click bug ([#5021](https://github.com/elastic/eui/pull/5021))
 
 ## [`37.2.0`](https://github.com/elastic/eui/tree/v37.2.0)
 
diff --git a/src/components/selectable/__snapshots__/selectable.test.tsx.snap b/src/components/selectable/__snapshots__/selectable.test.tsx.snap
index 96a0b54fd75..35ce39017b3 100644
--- a/src/components/selectable/__snapshots__/selectable.test.tsx.snap
+++ b/src/components/selectable/__snapshots__/selectable.test.tsx.snap
@@ -54,3 +54,43 @@ exports[`EuiSelectable props singleSelection 1`] = `
   class="euiSelectable"
 />
 `;
+
+exports[`EuiSelectable should not reset the activeOptionIndex nor isFocused when EuiSelectable is blurred in favour of its popover 1`] = `
+Object {
+  "activeOptionIndex": 0,
+  "isFocused": true,
+  "searchValue": "",
+  "visibleOptions": Array [
+    Object {
+      "data-test-subj": "titanOption",
+      "label": "Titan",
+    },
+    Object {
+      "label": "Enceladus",
+    },
+    Object {
+      "label": "Pandora is one of Saturn's moons, named for a Titaness of Greek mythology",
+    },
+  ],
+}
+`;
+
+exports[`EuiSelectable should not reset the activeOptionIndex nor isFocused when EuiSelectable is blurred in favour of its popover 2`] = `
+Object {
+  "activeOptionIndex": 0,
+  "isFocused": true,
+  "searchValue": "",
+  "visibleOptions": Array [
+    Object {
+      "data-test-subj": "titanOption",
+      "label": "Titan",
+    },
+    Object {
+      "label": "Enceladus",
+    },
+    Object {
+      "label": "Pandora is one of Saturn's moons, named for a Titaness of Greek mythology",
+    },
+  ],
+}
+`;
diff --git a/src/components/selectable/selectable.test.tsx b/src/components/selectable/selectable.test.tsx
index ef63c131616..3eda2107cb6 100644
--- a/src/components/selectable/selectable.test.tsx
+++ b/src/components/selectable/selectable.test.tsx
@@ -36,6 +36,31 @@ describe('EuiSelectable', () => {
     expect(component).toMatchSnapshot();
   });
 
+  test('should not reset the activeOptionIndex nor isFocused when EuiSelectable is blurred in favour of its popover', () => {
+    const component = mount(
+      <EuiSelectable options={options} searchable>
+        {(list, search) => (
+          <>
+            {list}
+            {search}
+          </>
+        )}
+      </EuiSelectable>
+    );
+
+    component.setState({
+      activeOptionIndex: 0,
+      isFocused: true,
+    });
+    expect(component.state()).toMatchSnapshot();
+
+    component.find('.euiSelectable').simulate('blur', {
+      relatedTarget: { firstChild: { id: 'generated-id_listbox' } },
+    });
+    component.update();
+    expect(component.state()).toMatchSnapshot();
+  });
+
   describe('props', () => {
     test('searchable', () => {
       const component = render(<EuiSelectable options={options} searchable />);
diff --git a/src/components/selectable/selectable.tsx b/src/components/selectable/selectable.tsx
index 409522a777d..d33c7e6698e 100644
--- a/src/components/selectable/selectable.tsx
+++ b/src/components/selectable/selectable.tsx
@@ -330,7 +330,12 @@ export class EuiSelectable<T = {}> extends Component<
 
   onContainerBlur = (e: React.FocusEvent) => {
     // Ignore blur events when moving from search to option to avoid activeOptionIndex conflicts
-    if (this.containerRef.current!.contains(e.relatedTarget as Node)) return;
+    if (
+      ((e.relatedTarget as Node)?.firstChild as HTMLElement)?.id ===
+      this.rootId('listbox')
+    ) {
+      return;
+    }
 
     this.setState({
       activeOptionIndex: undefined,