diff --git a/CHANGELOG.md b/CHANGELOG.md
index 003e11429f1..c7dd11a1dbd 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,6 +15,7 @@
 - Made boolean matching in `EuiSearchBar` more exact so it doesn't match words starting with booleans, like "truest" or "offer" ([#776](https://github.com/elastic/eui/pull/776))
 - `EuiComboBox` do not setState or call refs once component is unmounted ([807](https://github.com/elastic/eui/pull/807) and [#813](https://github.com/elastic/eui/pull/813))
 - Added better accessibility labeling to `EuiPagination`, `EuiSideNav`, `EuiPopover`, `EuiBottomBar` and `EuiBasicTable`.  ([#821](https://github.com/elastic/eui/pull/821))
+- Added `isDisabled` to `EuiComboBox`  ([#829](https://github.com/elastic/eui/pull/829))
 
 ## [`0.0.46`](https://github.com/elastic/eui/tree/v0.0.46)
 
diff --git a/src-docs/src/views/combo_box/combo_box_example.js b/src-docs/src/views/combo_box/combo_box_example.js
index e3d69e48c60..055b577d8b2 100644
--- a/src-docs/src/views/combo_box/combo_box_example.js
+++ b/src-docs/src/views/combo_box/combo_box_example.js
@@ -58,6 +58,10 @@ import Virtualized from './virtualized';
 const virtualizedSource = require('!!raw-loader!./virtualized');
 const virtualizedHtml = renderToHtml(Virtualized);
 
+import Disabled from './disabled';
+const disabledSource = require('!!raw-loader!./disabled');
+const disabledHtml = renderToHtml(Disabled);
+
 export const ComboBoxExample = {
   title: 'Combo Box',
   intro: (
@@ -98,6 +102,22 @@ export const ComboBoxExample = {
     }],
     props: { EuiComboBox },
     demo: <ComboBox />,
+  }, {
+    title: 'Disabled',
+    source: [{
+      type: GuideSectionTypes.JS,
+      code: disabledSource,
+    }, {
+      type: GuideSectionTypes.HTML,
+      code: disabledHtml,
+    }],
+    text: (
+      <p>
+        Set the prop <EuiCode>isDisabled</EuiCode> to make the combo box disabled.
+      </p>
+    ),
+    props: { EuiComboBox },
+    demo: <Disabled />,
   }, {
     title: 'Virtualized',
     source: [{
diff --git a/src-docs/src/views/combo_box/disabled.js b/src-docs/src/views/combo_box/disabled.js
new file mode 100644
index 00000000000..499ee32c47b
--- /dev/null
+++ b/src-docs/src/views/combo_box/disabled.js
@@ -0,0 +1,84 @@
+import React, { Component } from 'react';
+
+import {
+  EuiComboBox,
+} from '../../../../src/components';
+
+export default class extends Component {
+  constructor(props) {
+    super(props);
+
+    this.options = [{
+      label: 'Titan',
+      'data-test-subj': 'titanOption',
+    }, {
+      label: 'Enceladus is disabled',
+      disabled: true,
+    }, {
+      label: 'Mimas',
+    }, {
+      label: 'Dione',
+    }, {
+      label: 'Iapetus',
+    }, {
+      label: 'Phoebe',
+    }, {
+      label: 'Rhea',
+    }, {
+      label: 'Pandora is one of Saturn\'s moons, named for a Titaness of Greek mythology',
+    }, {
+      label: 'Tethys',
+    }, {
+      label: 'Hyperion',
+    }];
+
+    this.state = {
+      selectedOptions: [this.options[2], this.options[4]],
+    };
+  }
+
+  onChange = (selectedOptions) => {
+    this.setState({
+      selectedOptions,
+    });
+  };
+
+  onCreateOption = (searchValue, flattenedOptions) => {
+    const normalizedSearchValue = searchValue.trim().toLowerCase();
+
+    if (!normalizedSearchValue) {
+      return;
+    }
+
+    const newOption = {
+      label: searchValue,
+    };
+
+    // Create the option if it doesn't exist.
+    if (flattenedOptions.findIndex(option =>
+      option.label.trim().toLowerCase() === normalizedSearchValue
+    ) === -1) {
+      this.options.push(newOption);
+    }
+
+    // Select the option.
+    this.setState(prevState => ({
+      selectedOptions: prevState.selectedOptions.concat(newOption),
+    }));
+  };
+
+  render() {
+    const { selectedOptions } = this.state;
+    return (
+      <EuiComboBox
+        placeholder="Select or create options"
+        options={this.options}
+        selectedOptions={selectedOptions}
+        onChange={this.onChange}
+        onCreateOption={this.onCreateOption}
+        isClearable={true}
+        isDisabled
+      />
+    );
+  }
+}
diff --git a/src/components/combo_box/_combo_box.scss b/src/components/combo_box/_combo_box.scss
index c40ccdd6e50..abe866d0b39 100644
--- a/src/components/combo_box/_combo_box.scss
+++ b/src/components/combo_box/_combo_box.scss
@@ -64,4 +64,10 @@
       @include euiFormControlInvalidStyle;
     }
   }
+
+  &.euiComboBox-isDisabled {
+    .euiComboBox__inputWrap {
+      @include euiFormControlDisabledStyle;
+    }
+  }
 }
diff --git a/src/components/combo_box/combo_box.js b/src/components/combo_box/combo_box.js
index dd92923ec95..3e1faa2d24c 100644
--- a/src/components/combo_box/combo_box.js
+++ b/src/components/combo_box/combo_box.js
@@ -26,6 +26,7 @@ import {
 export class EuiComboBox extends Component {
   static propTypes = {
     id: PropTypes.string,
+    isDisabled: PropTypes.bool,
     className: PropTypes.string,
     placeholder: PropTypes.string,
     isLoading: PropTypes.bool,
@@ -433,6 +434,14 @@ export class EuiComboBox extends Component {
     }
   };
 
+  onClear = () => {
+    if (this.props.isClearable && this.clearSelectedOptions && !this.props.isDisabled) {
+      return this.clearSelectedOptions();
+    } else {
+      return undefined;
+    }
+  }
+
   autoSizeInputRef = node => {
     this.autoSizeInput = node;
   };
@@ -500,6 +509,7 @@ export class EuiComboBox extends Component {
   render() {
     const {
       id,
+      isDisabled,
       className,
       isLoading,
       options,
@@ -514,7 +524,7 @@ export class EuiComboBox extends Component {
       async, // eslint-disable-line no-unused-vars
       isInvalid,
       rowHeight,
-      isClearable,
+      isClearable, // eslint-disable-line no-unused-vars
       ...rest
     } = this.props;
 
@@ -523,6 +533,7 @@ export class EuiComboBox extends Component {
     const classes = classNames('euiComboBox', className, {
       'euiComboBox-isOpen': isListOpen,
       'euiComboBox-isInvalid': isInvalid,
+      'euiComboBox-isDisabled': isDisabled,
     });
 
     const value = selectedOptions.map(selectedOption => selectedOption.label).join(', ');
@@ -552,6 +563,7 @@ export class EuiComboBox extends Component {
             scrollToIndex={activeOptionIndex}
             onScroll={this.focusActiveOption}
             rowHeight={rowHeight}
+            isDisabled={isDisabled}
           />
         </EuiPortal>
       );
@@ -578,12 +590,13 @@ export class EuiComboBox extends Component {
           autoSizeInputRef={this.autoSizeInputRef}
           inputRef={this.searchInputRef}
           updatePosition={this.updateListPosition}
-          onClear={isClearable && this.clearSelectedOptions ? this.clearSelectedOptions : undefined}
+          onClear={this.onClear}
           hasSelectedOptions={selectedOptions.length > 0}
           isListOpen={isListOpen}
           onOpen={this.openList}
           onClose={this.closeList}
           singleSelection={singleSelection}
+          isDisabled={isDisabled}
         />
 
         {optionsList}
diff --git a/src/components/combo_box/combo_box_input/combo_box_input.js b/src/components/combo_box/combo_box_input/combo_box_input.js
index d8ce6f6d249..ac35ac3c9f2 100644
--- a/src/components/combo_box/combo_box_input/combo_box_input.js
+++ b/src/components/combo_box/combo_box_input/combo_box_input.js
@@ -29,6 +29,7 @@ export class EuiComboBoxInput extends Component {
     onOpen: PropTypes.func.isRequired,
     onClose: PropTypes.func.isRequired,
     singleSelection: PropTypes.bool,
+    isDisabled: PropTypes.bool,
   }
 
   constructor(props) {
@@ -87,6 +88,7 @@ export class EuiComboBoxInput extends Component {
       onOpen,
       onClose,
       singleSelection,
+      isDisabled,
     } = this.props;
 
     const pills = selectedOptions.map((option) => {
@@ -99,7 +101,7 @@ export class EuiComboBoxInput extends Component {
       return (
         <EuiComboBoxPill
           option={option}
-          onClose={singleSelection ? null : onRemoveOption}
+          onClose={(isDisabled || singleSelection) ? null : onRemoveOption}
           key={label.toLowerCase()}
           color={color}
           {...rest}
@@ -143,12 +145,18 @@ export class EuiComboBoxInput extends Component {
       );
     }
 
+    const clickProps = {};
+
+    if (!isDisabled) {
+      clickProps.onClear = hasSelectedOptions ? onClear : undefined;
+      clickProps.onIconClick = isListOpen ? onClose : onOpen;
+    }
+
     return (
       <EuiFormControlLayout
         icon="arrowDown"
         iconSide="right"
-        onIconClick={isListOpen ? onClose : onOpen}
-        onClear={hasSelectedOptions ? onClear : undefined}
+        {...clickProps}
       >
         <div
           className="euiComboBox__inputWrap"
@@ -168,6 +176,7 @@ export class EuiComboBoxInput extends Component {
             value={searchValue}
             ref={autoSizeInputRef}
             inputRef={inputRef}
+            disabled={isDisabled}
           />
           {removeOptionMessage}
         </div>