diff --git a/CMakeLists.txt b/CMakeLists.txt
index a009a11a5a..3bbf15a606 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -72,6 +72,27 @@ set(CMAKE_C_VISIBILITY_PRESET hidden)
 set(CMAKE_CXX_VISIBILITY_PRESET hidden)
 set(CMAKE_VISIBILITY_INLINES_HIDDEN YES)
 
+if(CMAKE_SYSTEM_PROCESSOR STREQUAL x86_64)
+    # Setup options for x86_64 micro-architecture levels.
+    # https://clang.llvm.org/docs/UsersManual.html#x86
+
+    set(EVMONE_X86_64_ARCH_LEVEL_INIT 2)
+    if(APPLE)
+        # On macos with Apple Silicon CPU (arm64) the x86 is emulated and SSE4.2 is not available.
+        set(EVMONE_X86_64_ARCH_LEVEL_INIT 1)
+    endif()
+
+    set(EVMONE_X86_64_ARCH_LEVEL ${EVMONE_X86_64_ARCH_LEVEL_INIT} CACHE STRING "The x86_64 micro-architecture level")
+    if(EVMONE_X86_64_ARCH_LEVEL GREATER_EQUAL 1 AND EVMONE_X86_64_ARCH_LEVEL LESS_EQUAL 4)
+        message(STATUS "x86_64 micro-architecture level: ${EVMONE_X86_64_ARCH_LEVEL}")
+        if(EVMONE_X86_64_ARCH_LEVEL GREATER_EQUAL 2)
+            add_compile_options(-march=x86-64-v${EVMONE_X86_64_ARCH_LEVEL})
+        endif()
+    else()
+        message(FATAL_ERROR "Invalid EVMONE_X86_64_ARCH_LEVEL: ${EVMONE_X86_64_ARCH_LEVEL}")
+    endif()
+endif()
+
 include(GNUInstallDirs)
 
 if(EVMONE_FUZZING)
@@ -89,7 +110,6 @@ if(EVMONE_FUZZING)
         # The coverage builds should be without fuzzing instrumentation to allow
         # running fuzzing corpus once and getting code coverage.
         set(fuzzing_flags -fsanitize=fuzzer-no-link,address,undefined,shift-exponent,implicit-conversion,nullability)
-#        set(fuzzing_flags -fsanitize=fuzzer-no-link)
         add_compile_options(${fuzzing_flags})
         set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} ${fuzzing_flags}")
     endif()
diff --git a/circle.yml b/circle.yml
index 8d7f7ee3b6..30b92be9de 100644
--- a/circle.yml
+++ b/circle.yml
@@ -586,14 +586,21 @@ jobs:
     executor: linux-gcc-latest
     environment:
       BUILD_TYPE: Release
-      CMAKE_OPTIONS: -DCMAKE_CROSSCOMPILING_EMULATOR=qemu-x86_64-static
       QEMU_CPU: core2duo  # The lowest 64-bit CPU I could find, but qemu64 should be good too.
     steps:
       - run:
           name: "Install qemu"
           command: sudo apt update -y && sudo apt install -y qemu-user-static
       - build
-      - test
+      - run:
+          name: "Check evmone.so"
+          working_directory: ~/build
+          command: (! qemu-x86_64-static bin/evmc run --vm ./lib/libevmone.so,trace 6000 2>&1) | grep "CPU does not support"
+      - run:
+          name: "Check unittests"
+          working_directory: ~/build
+          command: (! qemu-x86_64-static bin/evmone-unittests 2>&1) | grep "CPU does not support"
+
 
 
 workflows:
diff --git a/lib/evmone/CMakeLists.txt b/lib/evmone/CMakeLists.txt
index bffddd35b9..28c403f220 100644
--- a/lib/evmone/CMakeLists.txt
+++ b/lib/evmone/CMakeLists.txt
@@ -19,7 +19,7 @@ add_library(evmone
     baseline_instruction_table.cpp
     baseline_instruction_table.hpp
     eof.cpp
-    eof.hpp    
+    eof.hpp
     instructions.hpp
     instructions_calls.cpp
     instructions_opcodes.hpp
@@ -37,6 +37,13 @@ target_link_libraries(evmone PUBLIC evmc::evmc intx::intx PRIVATE ethash::keccak
 target_include_directories(evmone PUBLIC
     $<BUILD_INTERFACE:${include_dir}>$<INSTALL_INTERFACE:${CMAKE_INSTALL_INCLUDEDIR}>
 )
+
+if(EVMONE_X86_64_ARCH_LEVEL GREATER_EQUAL 2)
+    # Add CPU architecture runtime check. The EVMONE_X86_64_ARCH_LEVEL has a valid value.
+    target_sources(evmone PRIVATE cpu_check.cpp)
+    set_source_files_properties(cpu_check.cpp PROPERTIES COMPILE_DEFINITIONS EVMONE_X86_64_ARCH_LEVEL=${EVMONE_X86_64_ARCH_LEVEL})
+endif()
+
 if(CABLE_COMPILER_GNULIKE)
     target_compile_options(
         evmone PRIVATE
diff --git a/lib/evmone/cpu_check.cpp b/lib/evmone/cpu_check.cpp
new file mode 100644
index 0000000000..8e60630f69
--- /dev/null
+++ b/lib/evmone/cpu_check.cpp
@@ -0,0 +1,29 @@
+
+#define STRINGIFY_HELPER(X) #X
+#define STRINGIFY(X) STRINGIFY_HELPER(X)
+
+#if defined(__GNUC__) && __GNUC__ >= 12
+#define CPU_FEATURE "x86-64-v" STRINGIFY(EVMONE_X86_64_ARCH_LEVEL)
+#else
+// Clang 16 and GCC 11 does not support architecture levels in __builtin_cpu_supports().
+// Use approximations.
+#if EVMONE_X86_64_ARCH_LEVEL == 2
+#define CPU_FEATURE "sse4.2"
+#endif
+#endif
+
+#ifndef CPU_FEATURE
+#error "EVMONE_X86_64_ARCH_LEVEL: Unsupported x86-64 architecture level"
+#endif
+
+#include <cstdio>
+#include <cstdlib>
+
+static bool cpu_check = []() noexcept {
+    if (!__builtin_cpu_supports(CPU_FEATURE))
+    {
+        (void)std::fputs("CPU does not support " CPU_FEATURE "\n", stderr);
+        std::abort();
+    }
+    return false;
+}();