diff --git a/packages/react-client/src/ReactFlightClient.js b/packages/react-client/src/ReactFlightClient.js
index c0cec0db366cf..8a35e97b1679a 100644
--- a/packages/react-client/src/ReactFlightClient.js
+++ b/packages/react-client/src/ReactFlightClient.js
@@ -737,6 +737,15 @@ function parseModelString(
         const data = getOutlinedModel(response, id);
         return new Set(data);
       }
+      case 'B': {
+        // Blob
+        if (enableBinaryFlight) {
+          const id = parseInt(value.slice(2), 16);
+          const data = getOutlinedModel(response, id);
+          return new Blob(data.slice(1), {type: data[0]});
+        }
+        return undefined;
+      }
       case 'I': {
         // $Infinity
         return Infinity;
diff --git a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js
index 8304d9927d372..ada7bb35cae27 100644
--- a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js
+++ b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js
@@ -5,6 +5,7 @@
  * LICENSE file in the root directory of this source tree.
  *
  * @emails react-core
+ * @jest-environment ./scripts/jest/ReactDOMServerIntegrationEnvironment
  */
 
 'use strict';
@@ -14,6 +15,9 @@ global.ReadableStream =
   require('web-streams-polyfill/ponyfill/es6').ReadableStream;
 global.TextEncoder = require('util').TextEncoder;
 global.TextDecoder = require('util').TextDecoder;
+if (typeof Blob === 'undefined') {
+  global.Blob = require('buffer').Blob;
+}
 
 // Don't wait before processing work on the server.
 // TODO: we can replace this with FlightServer.act().
@@ -326,6 +330,28 @@ describe('ReactFlightDOMEdge', () => {
     expect(result).toEqual(buffers);
   });
 
+  // @gate enableBinaryFlight
+  it('should be able to serialize a blob', async () => {
+    const bytes = new Uint8Array([
+      123, 4, 10, 5, 100, 255, 244, 45, 56, 67, 43, 124, 67, 89, 100, 20,
+    ]);
+    const blob = new Blob([bytes, bytes], {
+      type: 'application/x-test',
+    });
+    const stream = passThrough(
+      ReactServerDOMServer.renderToReadableStream(blob),
+    );
+    const result = await ReactServerDOMClient.createFromReadableStream(stream, {
+      ssrManifest: {
+        moduleMap: null,
+        moduleLoading: null,
+      },
+    });
+    expect(result instanceof Blob).toBe(true);
+    expect(result.size).toBe(bytes.length * 2);
+    expect(await result.arrayBuffer()).toEqual(await blob.arrayBuffer());
+  });
+
   it('warns if passing a this argument to bind() of a server reference', async () => {
     const ServerModule = serverExports({
       greet: function () {},
diff --git a/packages/react-server/src/ReactFlightServer.js b/packages/react-server/src/ReactFlightServer.js
index a8c648881fe2c..4c8fa75fec9e9 100644
--- a/packages/react-server/src/ReactFlightServer.js
+++ b/packages/react-server/src/ReactFlightServer.js
@@ -239,6 +239,8 @@ export type ReactClientValue =
   | Array<ReactClientValue>
   | Map<ReactClientValue, ReactClientValue>
   | Set<ReactClientValue>
+  | $ArrayBufferView
+  | ArrayBuffer
   | Date
   | ReactClientObject
   | Promise<ReactClientValue>; // Thenable<ReactClientValue>
@@ -1229,6 +1231,46 @@ function serializeTypedArray(
   return serializeByValueID(bufferId);
 }
 
+function serializeBlob(request: Request, blob: Blob): string {
+  const id = request.nextChunkId++;
+  request.pendingChunks++;
+
+  const reader = blob.stream().getReader();
+
+  const model: Array<string | Uint8Array> = [blob.type];
+
+  function progress(
+    entry: {done: false, value: Uint8Array} | {done: true, value: void},
+  ): Promise<void> | void {
+    if (entry.done) {
+      const blobId = outlineModel(request, model);
+      const blobReference = '$B' + blobId.toString(16);
+      const processedChunk = encodeReferenceChunk(request, id, blobReference);
+      request.completedRegularChunks.push(processedChunk);
+      if (request.destination !== null) {
+        flushCompletedChunks(request, request.destination);
+      }
+      return;
+    }
+    // TODO: Emit the chunk early and refer to it later.
+    model.push(entry.value);
+    // $FlowFixMe[incompatible-call]
+    return reader.read().then(progress).catch(error);
+  }
+
+  function error(reason: mixed) {
+    const digest = logRecoverableError(request, reason);
+    emitErrorChunk(request, id, digest, reason);
+    if (request.destination !== null) {
+      flushCompletedChunks(request, request.destination);
+    }
+  }
+  // $FlowFixMe[incompatible-call]
+  reader.read().then(progress).catch(error);
+
+  return '$' + id.toString(16);
+}
+
 function escapeStringValue(value: string): string {
   if (value[0] === '$') {
     // We need to escape $ prefixed strings since we use those to encode
@@ -1606,6 +1648,10 @@ function renderModelDestructive(
       if (value instanceof DataView) {
         return serializeTypedArray(request, 'V', value);
       }
+      // TODO: Blob is not available in old Node. Remove the typeof check later.
+      if (typeof Blob === 'function' && value instanceof Blob) {
+        return serializeBlob(request, value);
+      }
     }
 
     const iteratorFn = getIteratorFn(value);
@@ -2146,6 +2192,10 @@ function renderConsoleValue(
       if (value instanceof DataView) {
         return serializeTypedArray(request, 'V', value);
       }
+      // TODO: Blob is not available in old Node. Remove the typeof check later.
+      if (typeof Blob === 'function' && value instanceof Blob) {
+        return serializeBlob(request, value);
+      }
     }
 
     const iteratorFn = getIteratorFn(value);