diff --git a/.eslintrc.js b/.eslintrc.js
index c91ba7e6e7fc4..603f20a3cacba 100644
--- a/.eslintrc.js
+++ b/.eslintrc.js
@@ -149,5 +149,6 @@ module.exports = {
     spyOnProd: true,
     __PROFILE__: true,
     __UMD__: true,
+    trustedTypes: true,
   },
 };
diff --git a/packages/react-dom/src/client/DOMPropertyOperations.js b/packages/react-dom/src/client/DOMPropertyOperations.js
index 6a2d0f7d244a6..72c99e67aa6ec 100644
--- a/packages/react-dom/src/client/DOMPropertyOperations.js
+++ b/packages/react-dom/src/client/DOMPropertyOperations.js
@@ -16,7 +16,9 @@ import {
   OVERLOADED_BOOLEAN,
 } from '../shared/DOMProperty';
 import sanitizeURL from '../shared/sanitizeURL';
+import {toStringOrTrustedType} from './ToStringValue';
 import {disableJavaScriptURLs} from 'shared/ReactFeatureFlags';
+import {setAttribute, setAttributeNS} from './setAttribute';
 
 import type {PropertyInfo} from '../shared/DOMProperty';
 
@@ -142,7 +144,7 @@ export function setValueForProperty(
       if (value === null) {
         node.removeAttribute(attributeName);
       } else {
-        node.setAttribute(attributeName, '' + (value: any));
+        setAttribute(node, attributeName, toStringOrTrustedType(value));
       }
     }
     return;
@@ -168,19 +170,21 @@ export function setValueForProperty(
     const {type} = propertyInfo;
     let attributeValue;
     if (type === BOOLEAN || (type === OVERLOADED_BOOLEAN && value === true)) {
+      // If attribute type is boolean, we know for sure it won't be an execution sink
+      // and we won't require Trusted Type here.
       attributeValue = '';
     } else {
       // `setAttribute` with objects becomes only `[object]` in IE8/9,
       // ('' + value) makes it output the correct toString()-value.
-      attributeValue = '' + (value: any);
+      attributeValue = toStringOrTrustedType(value);
       if (propertyInfo.sanitizeURL) {
-        sanitizeURL(attributeValue);
+        sanitizeURL(attributeValue.toString());
       }
     }
     if (attributeNamespace) {
-      node.setAttributeNS(attributeNamespace, attributeName, attributeValue);
+      setAttributeNS(node, attributeNamespace, attributeName, attributeValue);
     } else {
-      node.setAttribute(attributeName, attributeValue);
+      setAttribute(node, attributeName, attributeValue);
     }
   }
 }
diff --git a/packages/react-dom/src/client/ReactDOMComponent.js b/packages/react-dom/src/client/ReactDOMComponent.js
index ea178c13ab644..48b52eb195ea9 100644
--- a/packages/react-dom/src/client/ReactDOMComponent.js
+++ b/packages/react-dom/src/client/ReactDOMComponent.js
@@ -85,11 +85,16 @@ import possibleStandardNames from '../shared/possibleStandardNames';
 import {validateProperties as validateARIAProperties} from '../shared/ReactDOMInvalidARIAHook';
 import {validateProperties as validateInputProperties} from '../shared/ReactDOMNullInputValuePropHook';
 import {validateProperties as validateUnknownProperties} from '../shared/ReactDOMUnknownPropertyHook';
+import {toStringOrTrustedType} from './ToStringValue';
 
-import {enableFlareAPI} from 'shared/ReactFeatureFlags';
+import {
+  enableFlareAPI,
+  enableTrustedTypesIntegration,
+} from 'shared/ReactFeatureFlags';
 
 let didWarnInvalidHydration = false;
 let didWarnShadyDOM = false;
+let didWarnScriptTags = false;
 
 const DANGEROUSLY_SET_INNER_HTML = 'dangerouslySetInnerHTML';
 const SUPPRESS_CONTENT_EDITABLE_WARNING = 'suppressContentEditableWarning';
@@ -422,6 +427,18 @@ export function createElement(
       // Create the script via .innerHTML so its "parser-inserted" flag is
       // set to true and it does not execute
       const div = ownerDocument.createElement('div');
+      if (__DEV__) {
+        if (enableTrustedTypesIntegration && !didWarnScriptTags) {
+          warning(
+            false,
+            'Encountered a script tag while rendering React component. ' +
+              'Scripts inside React components are never executed when rendering ' +
+              'on the client. Consider using template tag instead ' +
+              '(https://developer.mozilla.org/en-US/docs/Web/HTML/Element/template).',
+          );
+          didWarnScriptTags = true;
+        }
+      }
       div.innerHTML = '<script><' + '/script>'; // eslint-disable-line
       // This is guaranteed to yield a script element.
       const firstChild = ((div.firstChild: any): HTMLScriptElement);
@@ -776,7 +793,10 @@ export function diffProperties(
       const lastHtml = lastProp ? lastProp[HTML] : undefined;
       if (nextHtml != null) {
         if (lastHtml !== nextHtml) {
-          (updatePayload = updatePayload || []).push(propKey, '' + nextHtml);
+          (updatePayload = updatePayload || []).push(
+            propKey,
+            toStringOrTrustedType(nextHtml),
+          );
         }
       } else {
         // TODO: It might be too late to clear this if we have children
diff --git a/packages/react-dom/src/client/ToStringValue.js b/packages/react-dom/src/client/ToStringValue.js
index 41826cd404e05..1cb8f60f0b5e7 100644
--- a/packages/react-dom/src/client/ToStringValue.js
+++ b/packages/react-dom/src/client/ToStringValue.js
@@ -7,6 +7,8 @@
  * @flow
  */
 
+import {enableTrustedTypesIntegration} from 'shared/ReactFeatureFlags';
+
 export opaque type ToStringValue =
   | boolean
   | number
@@ -35,3 +37,45 @@ export function getToStringValue(value: mixed): ToStringValue {
       return '';
   }
 }
+
+/**
+ * Returns true only if Trusted Types are available in global object and the value is a trusted type.
+ */
+let isTrustedTypesValue: (value: any) => boolean;
+// $FlowExpectedError - TrustedTypes are defined only in some browsers or with polyfill
+if (enableTrustedTypesIntegration && typeof trustedTypes !== 'undefined') {
+  isTrustedTypesValue = (value: any) =>
+    trustedTypes.isHTML(value) ||
+    trustedTypes.isScript(value) ||
+    trustedTypes.isScriptURL(value) ||
+    // TrustedURLs are deprecated and will be removed soon: https://github.com/WICG/trusted-types/pull/204
+    (trustedTypes.isURL && trustedTypes.isURL(value));
+} else {
+  isTrustedTypesValue = () => false;
+}
+
+/** Trusted value is a wrapper for "safe" values which can be assigned to DOM execution sinks. */
+export opaque type TrustedValue: {toString(): string, valueOf(): string} = {
+  toString(): string,
+  valueOf(): string,
+};
+
+/**
+ * We allow passing objects with toString method as element attributes or in dangerouslySetInnerHTML
+ * and we do validations that the value is safe. Once we do validation we want to use the validated
+ * value instead of the object (because object.toString may return something else on next call).
+ *
+ * If application uses Trusted Types we don't stringify trusted values, but preserve them as objects.
+ */
+export function toStringOrTrustedType(value: any): string | TrustedValue {
+  if (
+    enableTrustedTypesIntegration &&
+    // fast-path string values as it's most frequent usage of the function
+    typeof value !== 'string' &&
+    isTrustedTypesValue(value)
+  ) {
+    return value;
+  } else {
+    return '' + value;
+  }
+}
diff --git a/packages/react-dom/src/client/__tests__/trustedTypes-test.internal.js b/packages/react-dom/src/client/__tests__/trustedTypes-test.internal.js
new file mode 100644
index 0000000000000..3a9eb4c15d16c
--- /dev/null
+++ b/packages/react-dom/src/client/__tests__/trustedTypes-test.internal.js
@@ -0,0 +1,101 @@
+describe('when Trusted Types are available in global object', () => {
+  let React;
+  let ReactDOM;
+  let ReactFeatureFlags;
+  let container;
+
+  beforeEach(() => {
+    container = document.createElement('div');
+    window.trustedTypes = {
+      isHTML: () => true,
+      isScript: () => false,
+      isScriptURL: () => false,
+    };
+    ReactFeatureFlags = require('shared/ReactFeatureFlags');
+    ReactFeatureFlags.enableTrustedTypesIntegration = true;
+    React = require('react');
+    ReactDOM = require('react-dom');
+  });
+
+  afterEach(() => {
+    delete window.trustedTypes;
+    ReactFeatureFlags.enableTrustedTypesIntegration = false;
+  });
+
+  it('should not stringify trusted values', () => {
+    const trustedObject = {toString: () => 'I look like a trusted object'};
+    class Component extends React.Component {
+      state = {inner: undefined};
+      render() {
+        return <div dangerouslySetInnerHTML={{__html: this.state.inner}} />;
+      }
+    }
+
+    const isHTMLSpy = jest.spyOn(window.trustedTypes, ['isHTML']);
+    const instance = ReactDOM.render(<Component />, container);
+    instance.setState({inner: trustedObject});
+
+    expect(container.firstChild.innerHTML).toBe(trustedObject.toString());
+    expect(isHTMLSpy).toHaveBeenCalledWith(trustedObject);
+  });
+
+  describe('dangerouslySetInnerHTML in svg elements in Internet Explorer', () => {
+    let innerHTMLDescriptor;
+
+    // simulate svg elements in Internet Explorer which don't have 'innerHTML' property
+    beforeEach(() => {
+      innerHTMLDescriptor = Object.getOwnPropertyDescriptor(
+        Element.prototype,
+        'innerHTML',
+      );
+      delete Element.prototype.innerHTML;
+      Object.defineProperty(
+        HTMLDivElement.prototype,
+        'innerHTML',
+        innerHTMLDescriptor,
+      );
+    });
+
+    afterEach(() => {
+      delete HTMLDivElement.prototype.innerHTML;
+      Object.defineProperty(
+        Element.prototype,
+        'innerHTML',
+        innerHTMLDescriptor,
+      );
+    });
+
+    it('should log a warning', () => {
+      class Component extends React.Component {
+        render() {
+          return <svg dangerouslySetInnerHTML={{__html: 'unsafe html'}} />;
+        }
+      }
+      expect(() => {
+        ReactDOM.render(<Component />, container);
+      }).toWarnDev(
+        "Warning: Using 'dangerouslySetInnerHTML' in an svg element with " +
+          'Trusted Types enabled in an Internet Explorer will cause ' +
+          'the trusted value to be converted to string. Assigning string ' +
+          "to 'innerHTML' will throw an error if Trusted Types are enforced. " +
+          "You can try to wrap your svg element inside a div and use 'dangerouslySetInnerHTML' " +
+          'on the enclosing div instead.',
+      );
+    });
+  });
+
+  it('should warn once when rendering script tag in jsx on client', () => {
+    expect(() => {
+      ReactDOM.render(<script>alert("I am not executed")</script>, container);
+    }).toWarnDev(
+      'Warning: Encountered a script tag while rendering React component. ' +
+        'Scripts inside React components are never executed when rendering ' +
+        'on the client. Consider using template tag instead ' +
+        '(https://developer.mozilla.org/en-US/docs/Web/HTML/Element/template).\n' +
+        '    in script (at **)',
+    );
+
+    // check that the warning is print only once
+    ReactDOM.render(<script>alert("I am not executed")</script>, container);
+  });
+});
diff --git a/packages/react-dom/src/client/setAttribute.js b/packages/react-dom/src/client/setAttribute.js
new file mode 100644
index 0000000000000..8b9b0bd42a656
--- /dev/null
+++ b/packages/react-dom/src/client/setAttribute.js
@@ -0,0 +1,35 @@
+/**
+ * Copyright (c) Facebook, Inc. and its affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ * @flow
+ */
+
+import type {TrustedValue} from './ToStringValue';
+
+/**
+ * Set attribute for a node. The attribute value can be either string or
+ * Trusted value (if application uses Trusted Types).
+ */
+export function setAttribute(
+  node: Element,
+  attributeName: string,
+  attributeValue: string | TrustedValue,
+) {
+  node.setAttribute(attributeName, (attributeValue: any));
+}
+
+/**
+ * Set attribute with namespace for a node. The attribute value can be either string or
+ * Trusted value (if application uses Trusted Types).
+ */
+export function setAttributeNS(
+  node: Element,
+  attributeNamespace: string,
+  attributeName: string,
+  attributeValue: string | TrustedValue,
+) {
+  node.setAttributeNS(attributeNamespace, attributeName, (attributeValue: any));
+}
diff --git a/packages/react-dom/src/client/setInnerHTML.js b/packages/react-dom/src/client/setInnerHTML.js
index 0c328b17e0b2f..4fa94a4e95c92 100644
--- a/packages/react-dom/src/client/setInnerHTML.js
+++ b/packages/react-dom/src/client/setInnerHTML.js
@@ -9,6 +9,9 @@
 
 import {Namespaces} from '../shared/DOMNamespaces';
 import createMicrosoftUnsafeLocalFunction from '../shared/createMicrosoftUnsafeLocalFunction';
+import warning from 'shared/warning';
+import type {TrustedValue} from './ToStringValue';
+import {enableTrustedTypesIntegration} from 'shared/ReactFeatureFlags';
 
 // SVG temp container for IE lacking innerHTML
 let reusableSVGContainer;
@@ -22,25 +25,41 @@ let reusableSVGContainer;
  */
 const setInnerHTML = createMicrosoftUnsafeLocalFunction(function(
   node: Element,
-  html: string,
+  html: string | TrustedValue,
 ): void {
   // IE does not have innerHTML for SVG nodes, so instead we inject the
   // new markup in a temp node and then move the child nodes across into
   // the target node
-
-  if (node.namespaceURI === Namespaces.svg && !('innerHTML' in node)) {
-    reusableSVGContainer =
-      reusableSVGContainer || document.createElement('div');
-    reusableSVGContainer.innerHTML = '<svg>' + html + '</svg>';
-    const svgNode = reusableSVGContainer.firstChild;
-    while (node.firstChild) {
-      node.removeChild(node.firstChild);
+  if (node.namespaceURI === Namespaces.svg) {
+    if (enableTrustedTypesIntegration && __DEV__) {
+      warning(
+        // $FlowExpectedError - trustedTypes are defined only in some browsers or with polyfill
+        typeof trustedTypes === 'undefined',
+        "Using 'dangerouslySetInnerHTML' in an svg element with " +
+          'Trusted Types enabled in an Internet Explorer will cause ' +
+          'the trusted value to be converted to string. Assigning string ' +
+          "to 'innerHTML' will throw an error if Trusted Types are enforced. " +
+          "You can try to wrap your svg element inside a div and use 'dangerouslySetInnerHTML' " +
+          'on the enclosing div instead.',
+      );
     }
-    while (svgNode.firstChild) {
-      node.appendChild(svgNode.firstChild);
+    if (!('innerHTML' in node)) {
+      reusableSVGContainer =
+        reusableSVGContainer || document.createElement('div');
+      reusableSVGContainer.innerHTML =
+        '<svg>' + html.valueOf().toString() + '</svg>';
+      const svgNode = reusableSVGContainer.firstChild;
+      while (node.firstChild) {
+        node.removeChild(node.firstChild);
+      }
+      while (svgNode.firstChild) {
+        node.appendChild(svgNode.firstChild);
+      }
+    } else {
+      node.innerHTML = (html: any);
     }
   } else {
-    node.innerHTML = html;
+    node.innerHTML = (html: any);
   }
 });
 
diff --git a/packages/shared/ReactFeatureFlags.js b/packages/shared/ReactFeatureFlags.js
index 4121f9b6d7ef0..c7789e65fa0e2 100644
--- a/packages/shared/ReactFeatureFlags.js
+++ b/packages/shared/ReactFeatureFlags.js
@@ -100,3 +100,5 @@ export const warnAboutStringRefs = false;
 export const disableLegacyContext = false;
 
 export const disableSchedulerTimeoutBasedOnReactExpirationTime = false;
+
+export const enableTrustedTypesIntegration = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.native-fb.js b/packages/shared/forks/ReactFeatureFlags.native-fb.js
index c29f0c210a4d3..12e700b0dc46b 100644
--- a/packages/shared/forks/ReactFeatureFlags.native-fb.js
+++ b/packages/shared/forks/ReactFeatureFlags.native-fb.js
@@ -43,6 +43,7 @@ export const warnAboutDefaultPropsOnFunctionComponents = false;
 export const warnAboutStringRefs = false;
 export const disableLegacyContext = false;
 export const disableSchedulerTimeoutBasedOnReactExpirationTime = false;
+export const enableTrustedTypesIntegration = false;
 
 // Only used in www builds.
 export function addUserTimingListener() {
diff --git a/packages/shared/forks/ReactFeatureFlags.native-oss.js b/packages/shared/forks/ReactFeatureFlags.native-oss.js
index 876063c2c9287..cd7a5d91b13d5 100644
--- a/packages/shared/forks/ReactFeatureFlags.native-oss.js
+++ b/packages/shared/forks/ReactFeatureFlags.native-oss.js
@@ -38,6 +38,7 @@ export const warnAboutDefaultPropsOnFunctionComponents = false;
 export const warnAboutStringRefs = false;
 export const disableLegacyContext = false;
 export const disableSchedulerTimeoutBasedOnReactExpirationTime = false;
+export const enableTrustedTypesIntegration = false;
 
 // Only used in www builds.
 export function addUserTimingListener() {
diff --git a/packages/shared/forks/ReactFeatureFlags.persistent.js b/packages/shared/forks/ReactFeatureFlags.persistent.js
index dc6540b5d8199..0fb0154932e20 100644
--- a/packages/shared/forks/ReactFeatureFlags.persistent.js
+++ b/packages/shared/forks/ReactFeatureFlags.persistent.js
@@ -38,6 +38,7 @@ export const warnAboutDefaultPropsOnFunctionComponents = false;
 export const warnAboutStringRefs = false;
 export const disableLegacyContext = false;
 export const disableSchedulerTimeoutBasedOnReactExpirationTime = false;
+export const enableTrustedTypesIntegration = false;
 
 // Only used in www builds.
 export function addUserTimingListener() {
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.js
index 7aa962fa46e95..c30a8a2081be8 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.js
@@ -38,6 +38,7 @@ export const warnAboutDefaultPropsOnFunctionComponents = false;
 export const warnAboutStringRefs = false;
 export const disableLegacyContext = false;
 export const disableSchedulerTimeoutBasedOnReactExpirationTime = false;
+export const enableTrustedTypesIntegration = false;
 
 // Only used in www builds.
 export function addUserTimingListener() {
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
index 6083850599982..61144269cbca8 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
@@ -36,6 +36,7 @@ export const warnAboutDefaultPropsOnFunctionComponents = false;
 export const warnAboutStringRefs = false;
 export const disableLegacyContext = false;
 export const disableSchedulerTimeoutBasedOnReactExpirationTime = false;
+export const enableTrustedTypesIntegration = false;
 
 // Only used in www builds.
 export function addUserTimingListener() {
diff --git a/packages/shared/forks/ReactFeatureFlags.www.js b/packages/shared/forks/ReactFeatureFlags.www.js
index 7abb9c69e730f..a3d2295974de1 100644
--- a/packages/shared/forks/ReactFeatureFlags.www.js
+++ b/packages/shared/forks/ReactFeatureFlags.www.js
@@ -22,6 +22,7 @@ export const {
   enableUserBlockingEvents,
   disableLegacyContext,
   disableSchedulerTimeoutBasedOnReactExpirationTime,
+  enableTrustedTypesIntegration,
   warnAboutStringRefs,
   warnAboutDefaultPropsOnFunctionComponents,
 } = require('ReactFeatureFlags');
diff --git a/scripts/rollup/validate/eslintrc.cjs.js b/scripts/rollup/validate/eslintrc.cjs.js
index 2347fbb6cfe8d..6d1089b73788e 100644
--- a/scripts/rollup/validate/eslintrc.cjs.js
+++ b/scripts/rollup/validate/eslintrc.cjs.js
@@ -21,6 +21,8 @@ module.exports = {
     process: true,
     setImmediate: true,
     Buffer: true,
+    // Trusted Types
+    trustedTypes: true,
 
     // Scheduler profiling
     SharedArrayBuffer: true,
diff --git a/scripts/rollup/validate/eslintrc.fb.js b/scripts/rollup/validate/eslintrc.fb.js
index a32b7e38f0a37..57daf502c2218 100644
--- a/scripts/rollup/validate/eslintrc.fb.js
+++ b/scripts/rollup/validate/eslintrc.fb.js
@@ -22,6 +22,8 @@ module.exports = {
     // Node.js Server Rendering
     setImmediate: true,
     Buffer: true,
+    // Trusted Types
+    trustedTypes: true,
 
     // Scheduler profiling
     SharedArrayBuffer: true,
diff --git a/scripts/rollup/validate/eslintrc.rn.js b/scripts/rollup/validate/eslintrc.rn.js
index f211d9573f42e..9906dfb5b8ab6 100644
--- a/scripts/rollup/validate/eslintrc.rn.js
+++ b/scripts/rollup/validate/eslintrc.rn.js
@@ -21,6 +21,8 @@ module.exports = {
     // Fabric. See https://github.com/facebook/react/pull/15490
     // for more information
     nativeFabricUIManager: true,
+    // Trusted Types
+    trustedTypes: true,
 
     // Scheduler profiling
     SharedArrayBuffer: true,
diff --git a/scripts/rollup/validate/eslintrc.umd.js b/scripts/rollup/validate/eslintrc.umd.js
index 5b96526bba8ed..57645c7a34c67 100644
--- a/scripts/rollup/validate/eslintrc.umd.js
+++ b/scripts/rollup/validate/eslintrc.umd.js
@@ -24,6 +24,8 @@ module.exports = {
     define: true,
     require: true,
     global: true,
+    // Trusted Types
+    trustedTypes: true,
 
     // Scheduler profiling
     SharedArrayBuffer: true,