diff --git a/packages/react-dom-bindings/src/client/ReactDOMComponent.js b/packages/react-dom-bindings/src/client/ReactDOMComponent.js
index 715b241cdb02f..36a59f0850e7f 100644
--- a/packages/react-dom-bindings/src/client/ReactDOMComponent.js
+++ b/packages/react-dom-bindings/src/client/ReactDOMComponent.js
@@ -1301,7 +1301,7 @@ export function setInitialProperties(
             continue;
           }
           const propValue = props[propKey];
-          if (propValue == null) {
+          if (propValue === undefined) {
             continue;
           }
           setPropOnCustomElement(
@@ -1310,7 +1310,7 @@ export function setInitialProperties(
             propKey,
             propValue,
             props,
-            null,
+            undefined,
           );
         }
         return;
@@ -1741,14 +1741,14 @@ export function updateProperties(
           const lastProp = lastProps[propKey];
           if (
             lastProps.hasOwnProperty(propKey) &&
-            lastProp != null &&
+            lastProp !== undefined &&
             !nextProps.hasOwnProperty(propKey)
           ) {
             setPropOnCustomElement(
               domElement,
               tag,
               propKey,
-              null,
+              undefined,
               nextProps,
               lastProp,
             );
@@ -1760,7 +1760,7 @@ export function updateProperties(
           if (
             nextProps.hasOwnProperty(propKey) &&
             nextProp !== lastProp &&
-            (nextProp != null || lastProp != null)
+            (nextProp !== undefined || lastProp !== undefined)
           ) {
             setPropOnCustomElement(
               domElement,
diff --git a/packages/react-dom/src/__tests__/DOMPropertyOperations-test.js b/packages/react-dom/src/__tests__/DOMPropertyOperations-test.js
index 1ca571df71cc8..e6565d0097267 100644
--- a/packages/react-dom/src/__tests__/DOMPropertyOperations-test.js
+++ b/packages/react-dom/src/__tests__/DOMPropertyOperations-test.js
@@ -1230,7 +1230,7 @@ describe('DOMPropertyOperations', () => {
       });
       customelement.dispatchEvent(new Event('customevent'));
       expect(oncustomevent).toHaveBeenCalledTimes(2);
-      expect(customelement.oncustomevent).toBe(null);
+      expect(customelement.oncustomevent).toBe(undefined);
       expect(customelement.getAttribute('oncustomevent')).toBe(null);
     });
 
@@ -1290,12 +1290,33 @@ describe('DOMPropertyOperations', () => {
       await act(() => {
         root.render(<my-custom-element />);
       });
-      expect(customElement.foo).toBe(null);
+      expect(customElement.foo).toBe(undefined);
       await act(() => {
         root.render(<my-custom-element foo={myFunction} />);
       });
       expect(customElement.foo).toBe(myFunction);
     });
+
+    it('switching between null and undefined should update a property', async () => {
+      const container = document.createElement('div');
+      document.body.appendChild(container);
+      const root = ReactDOMClient.createRoot(container);
+      await act(() => {
+        root.render(<my-custom-element foo={undefined} />);
+      });
+      const customElement = container.querySelector('my-custom-element');
+      customElement.foo = undefined;
+
+      await act(() => {
+        root.render(<my-custom-element foo={null} />);
+      });
+      expect(customElement.foo).toBe(null);
+
+      await act(() => {
+        root.render(<my-custom-element foo={undefined} />);
+      });
+      expect(customElement.foo).toBe(undefined);
+    });
   });
 
   describe('deleteValueForProperty', () => {
@@ -1349,5 +1370,53 @@ describe('DOMPropertyOperations', () => {
       });
       expect(container.firstChild.getAttribute('size')).toBe('5px');
     });
+
+    it('custom elements should remove by setting undefined to restore defaults', async () => {
+      const container = document.createElement('div');
+      document.body.appendChild(container);
+      const root = ReactDOMClient.createRoot(container);
+      await act(() => {
+        root.render(<my-custom-element />);
+      });
+      const customElement = container.querySelector('my-custom-element');
+
+      // Non-setter but existing property to active the `in` heuristic
+      customElement.raw = 1;
+
+      // Install a setter to activate the `in` heuristic
+      Object.defineProperty(customElement, 'object', {
+        set: function (value = null) {
+          this._object = value;
+        },
+        get: function () {
+          return this._object;
+        },
+      });
+
+      Object.defineProperty(customElement, 'string', {
+        set: function (value = '') {
+          this._string = value;
+        },
+        get: function () {
+          return this._string;
+        },
+      });
+
+      const obj = {};
+      await act(() => {
+        root.render(<my-custom-element raw={2} object={obj} string="hi" />);
+      });
+      expect(customElement.raw).toBe(2);
+      expect(customElement.object).toBe(obj);
+      expect(customElement.string).toBe('hi');
+
+      // Removing the properties should reset to defaults by passing undefined
+      await act(() => {
+        root.render(<my-custom-element />);
+      });
+      expect(customElement.raw).toBe(undefined);
+      expect(customElement.object).toBe(null);
+      expect(customElement.string).toBe('');
+    });
   });
 });