diff --git a/sentry_sdk/integrations/bottle.py b/sentry_sdk/integrations/bottle.py
index 6dae8d9188..a2d6b51033 100644
--- a/sentry_sdk/integrations/bottle.py
+++ b/sentry_sdk/integrations/bottle.py
@@ -9,13 +9,19 @@
     parse_version,
     transaction_from_function,
 )
-from sentry_sdk.integrations import Integration, DidNotEnable
+from sentry_sdk.integrations import (
+    Integration,
+    DidNotEnable,
+    _DEFAULT_FAILED_REQUEST_STATUS_CODES,
+)
 from sentry_sdk.integrations.wsgi import SentryWsgiMiddleware
 from sentry_sdk.integrations._wsgi_common import RequestExtractor
 
 from typing import TYPE_CHECKING
 
 if TYPE_CHECKING:
+    from collections.abc import Set
+
     from sentry_sdk.integrations.wsgi import _ScopedResponse
     from typing import Any
     from typing import Dict
@@ -28,6 +34,7 @@
 try:
     from bottle import (
         Bottle,
+        HTTPResponse,
         Route,
         request as bottle_request,
         __version__ as BOTTLE_VERSION,
@@ -45,8 +52,13 @@ class BottleIntegration(Integration):
 
     transaction_style = ""
 
-    def __init__(self, transaction_style="endpoint"):
-        # type: (str) -> None
+    def __init__(
+        self,
+        transaction_style="endpoint",  # type: str
+        *,
+        failed_request_status_codes=_DEFAULT_FAILED_REQUEST_STATUS_CODES,  # type: Set[int]
+    ):
+        # type: (...) -> None
 
         if transaction_style not in TRANSACTION_STYLE_VALUES:
             raise ValueError(
@@ -54,6 +66,7 @@ def __init__(self, transaction_style="endpoint"):
                 % (transaction_style, TRANSACTION_STYLE_VALUES)
             )
         self.transaction_style = transaction_style
+        self.failed_request_status_codes = failed_request_status_codes
 
     @staticmethod
     def setup_once():
@@ -102,26 +115,29 @@ def _patched_handle(self, environ):
 
         old_make_callback = Route._make_callback
 
-        @ensure_integration_enabled(BottleIntegration, old_make_callback)
+        @functools.wraps(old_make_callback)
         def patched_make_callback(self, *args, **kwargs):
             # type: (Route, *object, **object) -> Any
-            client = sentry_sdk.get_client()
             prepared_callback = old_make_callback(self, *args, **kwargs)
 
+            integration = sentry_sdk.get_client().get_integration(BottleIntegration)
+            if integration is None:
+                return prepared_callback
+
             def wrapped_callback(*args, **kwargs):
                 # type: (*object, **object) -> Any
-
                 try:
                     res = prepared_callback(*args, **kwargs)
                 except Exception as exception:
-                    event, hint = event_from_exception(
-                        exception,
-                        client_options=client.options,
-                        mechanism={"type": "bottle", "handled": False},
-                    )
-                    sentry_sdk.capture_event(event, hint=hint)
+                    _capture_exception(exception, handled=False)
                     raise exception
 
+                if (
+                    isinstance(res, HTTPResponse)
+                    and res.status_code in integration.failed_request_status_codes
+                ):
+                    _capture_exception(res, handled=True)
+
                 return res
 
             return wrapped_callback
@@ -191,3 +207,13 @@ def event_processor(event, hint):
         return event
 
     return event_processor
+
+
+def _capture_exception(exception, handled):
+    # type: (BaseException, bool) -> None
+    event, hint = event_from_exception(
+        exception,
+        client_options=sentry_sdk.get_client().options,
+        mechanism={"type": "bottle", "handled": handled},
+    )
+    sentry_sdk.capture_event(event, hint=hint)
diff --git a/tests/integrations/bottle/test_bottle.py b/tests/integrations/bottle/test_bottle.py
index 9dd23cf45a..9cc436a229 100644
--- a/tests/integrations/bottle/test_bottle.py
+++ b/tests/integrations/bottle/test_bottle.py
@@ -3,12 +3,14 @@
 import logging
 
 from io import BytesIO
-from bottle import Bottle, debug as set_debug, abort, redirect
+from bottle import Bottle, debug as set_debug, abort, redirect, HTTPResponse
 from sentry_sdk import capture_message
+from sentry_sdk.integrations.bottle import BottleIntegration
 from sentry_sdk.serializer import MAX_DATABAG_BREADTH
 
 from sentry_sdk.integrations.logging import LoggingIntegration
 from werkzeug.test import Client
+from werkzeug.wrappers import Response
 
 import sentry_sdk.integrations.bottle as bottle_sentry
 
@@ -445,3 +447,80 @@ def test_span_origin(
     (_, event) = events
 
     assert event["contexts"]["trace"]["origin"] == "auto.http.bottle"
+
+
+@pytest.mark.parametrize("raise_error", [True, False])
+@pytest.mark.parametrize(
+    ("integration_kwargs", "status_code", "should_capture"),
+    (
+        ({}, None, False),
+        ({}, 400, False),
+        ({}, 451, False),  # Highest 4xx status code
+        ({}, 500, True),
+        ({}, 511, True),  # Highest 5xx status code
+        ({"failed_request_status_codes": set()}, 500, False),
+        ({"failed_request_status_codes": set()}, 511, False),
+        ({"failed_request_status_codes": {404, *range(500, 600)}}, 404, True),
+        ({"failed_request_status_codes": {404, *range(500, 600)}}, 500, True),
+        ({"failed_request_status_codes": {404, *range(500, 600)}}, 400, False),
+    ),
+)
+def test_failed_request_status_codes(
+    sentry_init,
+    capture_events,
+    integration_kwargs,
+    status_code,
+    should_capture,
+    raise_error,
+):
+    sentry_init(integrations=[BottleIntegration(**integration_kwargs)])
+    events = capture_events()
+
+    app = Bottle()
+
+    @app.route("/")
+    def handle():
+        if status_code is not None:
+            response = HTTPResponse(status=status_code)
+            if raise_error:
+                raise response
+            else:
+                return response
+        return "OK"
+
+    client = Client(app, Response)
+    response = client.get("/")
+
+    expected_status = 200 if status_code is None else status_code
+    assert response.status_code == expected_status
+
+    if should_capture:
+        (event,) = events
+        assert event["exception"]["values"][0]["type"] == "HTTPResponse"
+    else:
+        assert not events
+
+
+def test_failed_request_status_codes_non_http_exception(sentry_init, capture_events):
+    """
+    If an exception, which is not an instance of HTTPResponse, is raised, it should be captured, even if
+    failed_request_status_codes is empty.
+    """
+    sentry_init(integrations=[BottleIntegration(failed_request_status_codes=set())])
+    events = capture_events()
+
+    app = Bottle()
+
+    @app.route("/")
+    def handle():
+        1 / 0
+
+    client = Client(app, Response)
+
+    try:
+        client.get("/")
+    except ZeroDivisionError:
+        pass
+
+    (event,) = events
+    assert event["exception"]["values"][0]["type"] == "ZeroDivisionError"