diff --git a/main/main.cpp b/main/main.cpp
index 33878ab11637..450908a6f732 100644
--- a/main/main.cpp
+++ b/main/main.cpp
@@ -1590,7 +1590,6 @@ bool Main::start() {
 		}
 	}
 
-	String main_loop_type;
 #ifdef TOOLS_ENABLED
 	if (doc_tool_path != "") {
 		Engine::get_singleton()->set_editor_hint(true); // Needed to instance editor-only classes for their default values
@@ -1661,6 +1660,7 @@ bool Main::start() {
 	if (editor) {
 		main_loop = memnew(SceneTree);
 	};
+	String main_loop_type = GLOBAL_DEF("application/run/main_loop_type", "SceneTree");
 
 	if (test != "") {
 #ifdef TOOLS_ENABLED
@@ -1699,8 +1699,23 @@ bool Main::start() {
 			return false;
 		}
 
-	} else {
-		main_loop_type = GLOBAL_DEF("application/run/main_loop_type", "");
+	} else { // Not based on script path.
+		if (!editor && !ClassDB::class_exists(main_loop_type) && ScriptServer::is_global_class(main_loop_type)) {
+			String script_path = ScriptServer::get_global_class_path(main_loop_type);
+			Ref<Script> script_res = ResourceLoader::load(script_path, "Script", true);
+			StringName script_base = ScriptServer::get_global_class_native_base(main_loop_type);
+			Object *obj = ClassDB::instance(script_base);
+			MainLoop *script_loop = Object::cast_to<MainLoop>(obj);
+			if (!script_loop) {
+				if (obj) {
+					memdelete(obj);
+				}
+				OS::get_singleton()->alert("Error: Invalid MainLoop script base type: " + script_base);
+				ERR_FAIL_V_MSG(false, vformat("The global class %s does not inherit from SceneTree or MainLoop.", main_loop_type));
+			}
+			script_loop->set_init_script(script_res);
+			main_loop = script_loop;
+		}
 	}
 
 	if (!main_loop && main_loop_type == "") {