diff --git a/main/main.cpp b/main/main.cpp
index 5e54a52f617e..ceb2cbbae7e4 100644
--- a/main/main.cpp
+++ b/main/main.cpp
@@ -2208,11 +2208,13 @@ Error Main::setup(const char *execpath, int argc, char *argv[], bool p_second_ph
 		OS::get_singleton()->set_environment("DISABLE_MANGOHUD", "1"); // GH-57403.
 		OS::get_singleton()->set_environment("DISABLE_RTSS_LAYER", "1"); // GH-57937.
 		OS::get_singleton()->set_environment("DISABLE_VKBASALT", "1");
+		OS::get_singleton()->set_environment("DISABLE_VK_LAYER_reshade_1", "1"); // GH-70849.
 	} else {
 		// Re-allow using Vulkan overlays, disabled while using the editor.
 		OS::get_singleton()->unset_environment("DISABLE_MANGOHUD");
 		OS::get_singleton()->unset_environment("DISABLE_RTSS_LAYER");
 		OS::get_singleton()->unset_environment("DISABLE_VKBASALT");
+		OS::get_singleton()->unset_environment("DISABLE_VK_LAYER_reshade_1");
 	}
 #endif